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Aliases for SMIM18 Gene

Aliases for SMIM18 Gene

  • Small Integral Membrane Protein 18 2 3 5

External Ids for SMIM18 Gene

Previous GeneCards Identifiers for SMIM18 Gene

  • GC08P030497

Summaries for SMIM18 Gene

GeneCards Summary for SMIM18 Gene

SMIM18 (Small Integral Membrane Protein 18) is a Protein Coding gene.

Additional gene information for SMIM18 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM18 Gene

Genomics for SMIM18 Gene

GeneHancer (GH) Regulatory Elements for SMIM18 Gene

Promoters and enhancers for SMIM18 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I030638 Promoter 0.8 EPDnew 550.8 0.0 -10 0.1 ATF4 POLR2A CEBPG PRDM10 SMIM18 GTF2E2 ENSG00000253112
GH08I030643 Promoter 0.8 EPDnew 550.4 +5.1 5070 0.1 BCOR ZNF121 ATF4 CEBPG ZBTB33 ZNF24 GC08P030645 RNU5A-3P SMIM18 GTF2E2
GH08I030652 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 7.9 +17.5 17486 6.3 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 GTF2E2 WRN SMIM18 PPP2CB RNU5A-3P
GH08I030616 Enhancer 0.9 ENCODE 11.9 -21.6 -21604 1.2 ELF3 PKNOX1 FOXA2 ARID4B DMAP1 THRB RAD21 RARA YY1 CREM SMIM18 ENSG00000253112 RNU5A-3P GTF2E2
GH08I030644 Enhancer 1.1 Ensembl ENCODE 7.8 +9.1 9059 6.3 HDGF FOXA2 PKNOX1 RAD21 YY1 ZNF335 ZNF121 SCRT2 FOS CREM SMIM18 GTF2E2 PPP2CB RNU5A-3P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SMIM18 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SMIM18 Gene

Genomic Locations for SMIM18 Gene
7,465 bases
Plus strand

Genomic View for SMIM18 Gene

Genes around SMIM18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM18 Gene

Proteins for SMIM18 Gene

  • Protein details for SMIM18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small integral membrane protein 18
    Protein Accession:

    Protein attributes for SMIM18 Gene

    95 amino acids
    Molecular mass:
    11088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM18 Gene

Post-translational modifications for SMIM18 Gene

No Post-translational modifications

Other Protein References for SMIM18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM18 Gene

Domains & Families for SMIM18 Gene

Gene Families for SMIM18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SMIM18 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM18: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM18 Gene

Function for SMIM18 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM18 Gene

Localization for SMIM18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM18 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SMIM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM18: view

No data available for Subcellular locations from COMPARTMENTS for SMIM18 Gene

Pathways & Interactions for SMIM18 Gene

SuperPathways for SMIM18 Gene

No Data Available

Interacting Proteins for SMIM18 Gene

Gene Ontology (GO) - Biological Process for SMIM18 Gene


No data available for Pathways by source and SIGNOR curated interactions for SMIM18 Gene

Drugs & Compounds for SMIM18 Gene

No Compound Related Data Available

Transcripts for SMIM18 Gene

mRNA/cDNA for SMIM18 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM18 Gene

Small integral membrane protein 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM18 Gene

No ASD Table

Relevant External Links for SMIM18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMIM18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMIM18 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.5), Brain - Cerebellar Hemisphere (x5.3), Brain - Cerebellum (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of SMIM18 Gene:


SOURCE GeneReport for Unigene cluster for SMIM18 Gene:


Evidence on tissue expression from TISSUES for SMIM18 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with SMIM18: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM18 Gene

Orthologs for SMIM18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMIM18 34
  • 100 (a)
(Canis familiaris)
Mammalia SMIM18 33
  • 94.39 (n)
(Bos Taurus)
Mammalia SMIM18 33
  • 93.68 (n)
(Rattus norvegicus)
Mammalia LOC100909793 33
  • 90.18 (n)
(Mus musculus)
Mammalia Smim18 33 16 34
  • 87.81 (n)
(Gallus gallus)
Aves SMIM18 33
  • 79.79 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia smim18 33
  • 69.82 (n)
Species where no ortholog for SMIM18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM18 Gene

Gene Tree for SMIM18 (if available)
Gene Tree for SMIM18 (if available)

Paralogs for SMIM18 Gene

No data available for Paralogs for SMIM18 Gene

Variants for SMIM18 Gene

Sequence variations from dbSNP and Humsavar for SMIM18 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000259393 -- 30,643,713(+) T/C intron_variant
rs1000315878 -- 30,637,129(+) T/C upstream_transcript_variant
rs1000347021 -- 30,637,323(+) G/C upstream_transcript_variant
rs1000543383 -- 30,641,657(+) A/C intron_variant
rs1000544624 -- 30,641,601(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM18 Gene

Variant ID Type Subtype PubMed ID
nsv526509 CNV gain 19592680

Variation tolerance for SMIM18 Gene

Gene Damage Index Score: 0.90; 18.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMIM18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM18 Gene

Disorders for SMIM18 Gene

Additional Disease Information for SMIM18

No disorders were found for SMIM18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM18 Gene

Publications for SMIM18 Gene

  1. Discovery of 342 putative new genes from the analysis of 5'-end-sequenced full-length-enriched cDNA human transcripts. (PMID: 15885500) Dalla E … Schneider C (Genomics 2005) 3 4 58
  2. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli ET … Goldstein DB (European journal of human genetics : EJHG 2010) 3 58
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for SMIM18 Gene

Sources for SMIM18 Gene

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