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Aliases for SMIM18 Gene

Aliases for SMIM18 Gene

  • Small Integral Membrane Protein 18 2 3 5

External Ids for SMIM18 Gene

Previous GeneCards Identifiers for SMIM18 Gene

  • GC08P030497

Summaries for SMIM18 Gene

GeneCards Summary for SMIM18 Gene

SMIM18 (Small Integral Membrane Protein 18) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM18 Gene

Genomics for SMIM18 Gene

Regulatory Elements for SMIM18 Gene

Enhancers for SMIM18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G030652 1.4 Ensembl ENCODE 7.9 +17.5 17486 6.3 HDGF HNRNPUL1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 WRN GTF2E2 SMIM18 PPP2CB RNU5A-3P
GH08G030616 0.9 ENCODE 11.9 -21.6 -21605 1.2 ELF3 PKNOX1 FOXA2 ARID4B DMAP1 THRB RAD21 RARA YY1 CREM SMIM18 ENSG00000253112 RNU5A-3P
GH08G030561 1.5 Ensembl ENCODE dbSUPER 7 -72.9 -72938 8.8 ATF1 FOXA2 ARNT ZNF133 YY1 TCF12 GATA2 ELK1 FOS REST RBPMS ENSG00000253112 RBPMS-AS1 SMIM18 GTF2E2 PIR39743
GH08G030644 1.3 Ensembl ENCODE 7.8 +9.1 9060 6.3 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B DMAP1 YY1 ZNF121 SLC30A9 WRN SMIM18 GTF2E2 PPP2CB RNU5A-3P
GH08G030588 1 ENCODE dbSUPER 6.9 -49.1 -49087 1.7 ZNF146 PKNOX1 ZSCAN4 FEZF1 RAD21 HIC1 CTBP1 ZNF366 SCRT2 ZSCAN5C SMIM18 PPP2CB GTF2E2 ENSG00000253112 PIR39743
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMIM18 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMIM18 Gene

Chromosome:
8
Start:
30,638,600 bp from pter
End:
30,646,064 bp from pter
Size:
7,465 bases
Orientation:
Plus strand

Genomic View for SMIM18 Gene

Genes around SMIM18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM18 Gene

Proteins for SMIM18 Gene

  • Protein details for SMIM18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DKX4-SIM18_HUMAN
    Recommended name:
    Small integral membrane protein 18
    Protein Accession:
    P0DKX4

    Protein attributes for SMIM18 Gene

    Size:
    95 amino acids
    Molecular mass:
    11088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM18 Gene

Post-translational modifications for SMIM18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM18 Gene

Domains & Families for SMIM18 Gene

Protein Domains for SMIM18 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM18: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM18 Gene

Function for SMIM18 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM18 Gene

Localization for SMIM18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM18 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM18: view

No data available for Subcellular locations from COMPARTMENTS for SMIM18 Gene

Pathways & Interactions for SMIM18 Gene

SuperPathways for SMIM18 Gene

No Data Available

Interacting Proteins for SMIM18 Gene

Gene Ontology (GO) - Biological Process for SMIM18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM18 Gene

Drugs & Compounds for SMIM18 Gene

No Compound Related Data Available

Transcripts for SMIM18 Gene

mRNA/cDNA for SMIM18 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM18 Gene

Small integral membrane protein 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM18 Gene

No ASD Table

Relevant External Links for SMIM18 Gene

GeneLoc Exon Structure for
SMIM18
ECgene alternative splicing isoforms for
SMIM18

Expression for SMIM18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMIM18 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.5), Brain - Cerebellar Hemisphere (x5.3), Brain - Cerebellum (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of SMIM18 Gene:

SMIM18

SOURCE GeneReport for Unigene cluster for SMIM18 Gene:

Hs.659493

Evidence on tissue expression from TISSUES for SMIM18 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with SMIM18: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM18 Gene

Orthologs for SMIM18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMIM18 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMIM18 34
  • 94.39 (n)
cow
(Bos Taurus)
Mammalia SMIM18 34
  • 93.68 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909793 34
  • 90.18 (n)
mouse
(Mus musculus)
Mammalia Smim18 34 16 35
  • 87.81 (n)
chicken
(Gallus gallus)
Aves SMIM18 34
  • 79.79 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia smim18 34
  • 69.82 (n)
Species where no ortholog for SMIM18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM18 Gene

ENSEMBL:
Gene Tree for SMIM18 (if available)
TreeFam:
Gene Tree for SMIM18 (if available)

Paralogs for SMIM18 Gene

No data available for Paralogs for SMIM18 Gene

Variants for SMIM18 Gene

Sequence variations from dbSNP and Humsavar for SMIM18 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000259393 -- 30,643,713(+) GATCA(C/T)ACAAA intron-variant
rs1000315878 -- 30,637,129(+) AACCC(C/T)GTAAT intron-variant, upstream-variant-2KB
rs1000347021 -- 30,637,323(+) CAAAT(C/G)GCCAA intron-variant, upstream-variant-2KB
rs1000543383 -- 30,641,657(+) GGATT(A/C)CCTGA intron-variant
rs1000544624 -- 30,641,601(+) CCAGG(C/T)GCGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM18 Gene

Variant ID Type Subtype PubMed ID
nsv526509 CNV gain 19592680

Variation tolerance for SMIM18 Gene

Gene Damage Index Score: 0.90; 18.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM18 Gene

Disorders for SMIM18 Gene

Relevant External Links for SMIM18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM18

No disorders were found for SMIM18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM18 Gene

Publications for SMIM18 Gene

  1. Discovery of 342 putative new genes from the analysis of 5'-end- sequenced full-length-enriched cDNA human transcripts. (PMID: 15885500) Dalla E. … Schneider C. (Genomics 2005) 3 4 64
  2. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 64
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for SMIM18 Gene

Sources for SMIM18 Gene

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