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Aliases for SMIM17 Gene

Aliases for SMIM17 Gene

  • Small Integral Membrane Protein 17 2 3 5

External Ids for SMIM17 Gene

Previous GeneCards Identifiers for SMIM17 Gene

  • GC19P057154

Summaries for SMIM17 Gene

GeneCards Summary for SMIM17 Gene

SMIM17 (Small Integral Membrane Protein 17) is a Protein Coding gene.

Additional gene information for SMIM17 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM17 Gene

Genomics for SMIM17 Gene

Regulatory Elements for SMIM17 Gene

Enhancers for SMIM17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H056594 1 ENCODE 43.7 -47.7 -47705 1 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 YY1 ETS1 U2AF2 ZNF17 ZNF264 ZNF773 ZNF543 ZNF549 ENSG00000269696 ZNF550 ZFP28 ZNF470
GH19H057599 1.1 ENCODE 19 +956.9 956893 1 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 ZHX2 MXD4 ZNF606 ZNF549 ZNF135 ZNF132 ZNF418 ZNF417 ZNF446 ZNF17 LOC105372482 LOC100128398
GH19H057388 1.1 ENCODE 13.3 +746.9 746855 2 PKNOX1 FOXA2 SIN3A DMAP1 YY1 ZNF143 FOS SP3 CEBPZ SP5 ZNF264 ZSCAN18 ENSG00000269696 LOC100128398 ZNF835 ZNF470 ZNF805 ZNF582-AS1 ZNF583 ZNF543
GH19H057476 1 ENCODE 13.3 +834.3 834333 1 PKNOX1 FOXA2 ATF1 MLX ARID4B SIN3A DMAP1 YY1 ETS1 SLC30A9 ZNF773 ZNF417 VN1R1 ZNF446 ZNF606 ZNF134 ZNF17 ZNF543 ZNF548 ZNF274
GH19H057526 1 ENCODE 12.2 +884.3 884330 1 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 YY1 ETS1 ELK1 ZNF302 ZNF548 ZNF417 ZNF134 ZNF773 ZNF256 VN1R1 LOC105372483 ZNF264 ENSG00000268543 ENSG00000268678
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMIM17 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMIM17 Gene

Chromosome:
19
Start:
56,643,145 bp from pter
End:
56,657,246 bp from pter
Size:
14,102 bases
Orientation:
Plus strand

Genomic View for SMIM17 Gene

Genes around SMIM17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM17 Gene

Proteins for SMIM17 Gene

  • Protein details for SMIM17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DL12-SIM17_HUMAN
    Recommended name:
    Small integral membrane protein 17
    Protein Accession:
    P0DL12

    Protein attributes for SMIM17 Gene

    Size:
    118 amino acids
    Molecular mass:
    13332 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM17 Gene

Post-translational modifications for SMIM17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM17 Gene

Domains & Families for SMIM17 Gene

Gene Families for SMIM17 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SMIM17 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM17: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM17 Gene

Function for SMIM17 Gene

Phenotypes From GWAS Catalog for SMIM17 Gene

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM17 Gene

Localization for SMIM17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM17 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SMIM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM17: view

No data available for Subcellular locations from COMPARTMENTS for SMIM17 Gene

Pathways & Interactions for SMIM17 Gene

SuperPathways for SMIM17 Gene

No Data Available

Interacting Proteins for SMIM17 Gene

Selected Interacting proteins: P0DL12-SIM17_HUMAN for SMIM17 Gene via IID

Symbol External ID(s) Details
DCUN1D1

Gene Ontology (GO) - Biological Process for SMIM17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM17 Gene

Drugs & Compounds for SMIM17 Gene

No Compound Related Data Available

Transcripts for SMIM17 Gene

mRNA/cDNA for SMIM17 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM17 Gene

Small integral membrane protein 17:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM17 Gene

No ASD Table

Relevant External Links for SMIM17 Gene

GeneLoc Exon Structure for
SMIM17
ECgene alternative splicing isoforms for
SMIM17

Expression for SMIM17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM17 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM17 Gene

This gene is overexpressed in Brain - Hypothalamus (x7.0), Brain - Anterior cingulate cortex (BA24) (x5.9), and Brain - Frontal Cortex (BA9) (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of SMIM17 Gene:

SMIM17

SOURCE GeneReport for Unigene cluster for SMIM17 Gene:

Hs.336588
genes like me logo Genes that share expression patterns with SMIM17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM17 Gene

Orthologs for SMIM17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMIM17 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SMIM17 33
  • 87.07 (n)
mouse
(Mus musculus)
Mammalia Gm16532 33
  • 86.54 (n)
Smim17 16 34
  • 84 (a)
Gm20715 34
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Smim17 33
  • 86.54 (n)
cow
(Bos Taurus)
Mammalia SMIM17 33
  • 85.34 (n)
Species where no ortholog for SMIM17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM17 Gene

ENSEMBL:
Gene Tree for SMIM17 (if available)
TreeFam:
Gene Tree for SMIM17 (if available)

Paralogs for SMIM17 Gene

No data available for Paralogs for SMIM17 Gene

Variants for SMIM17 Gene

Sequence variations from dbSNP and Humsavar for SMIM17 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000133054 -- 56,654,257(+) GCATA(A/G)TGCAG intron-variant
rs1000230907 -- 56,640,673(+) GCATG(A/G)TGGTG intron-variant
rs1000262626 -- 56,649,617(+) GGGGA(C/G)TGAGA intron-variant
rs1000312546 -- 56,651,883(+) CGGAT(C/T)GCTTA intron-variant
rs1000395072 -- 56,645,888(+) AATTG(G/T)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM17 Gene

Variant ID Type Subtype PubMed ID
esv2763212 CNV loss 21179565
nsv1055357 CNV gain 25217958
nsv138064 CNV deletion 16902084
nsv580388 CNV loss 21841781

Variation tolerance for SMIM17 Gene

Gene Damage Index Score: 1.33; 26.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM17 Gene

Disorders for SMIM17 Gene

Relevant External Links for SMIM17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM17

No disorders were found for SMIM17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM17 Gene

Publications for SMIM17 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60

Products for SMIM17 Gene

Sources for SMIM17 Gene

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