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Aliases for SMIM15 Gene

Aliases for SMIM15 Gene

  • Small Integral Membrane Protein 15 2 3 5
  • C5orf43 3 4
  • Chromosome 5 Open Reading Frame 43 2
  • UPF0542 Protein C5orf43 3

External Ids for SMIM15 Gene

Previous HGNC Symbols for SMIM15 Gene

  • C5orf43

Previous GeneCards Identifiers for SMIM15 Gene

  • GC05M060454

Summaries for SMIM15 Gene

GeneCards Summary for SMIM15 Gene

SMIM15 (Small Integral Membrane Protein 15) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM15 Gene

Genomics for SMIM15 Gene

Regulatory Elements for SMIM15 Gene

Enhancers for SMIM15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SMIM15 on UCSC Golden Path with GeneCards custom track

Promoters for SMIM15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SMIM15 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMIM15 Gene

61,157,709 bp from pter
61,162,475 bp from pter
4,767 bases
Minus strand

Genomic View for SMIM15 Gene

Genes around SMIM15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM15 Gene

Proteins for SMIM15 Gene

  • Protein details for SMIM15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small integral membrane protein 15
    Protein Accession:
    Secondary Accessions:
    • B9EJC4

    Protein attributes for SMIM15 Gene

    74 amino acids
    Molecular mass:
    8625 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM15 Gene

Proteomics data for SMIM15 Gene at MOPED

Post-translational modifications for SMIM15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM15 Gene

Domains & Families for SMIM15 Gene

Protein Domains for SMIM15 Gene


Suggested Antigen Peptide Sequences for SMIM15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SMIM15 family.
  • Belongs to the SMIM15 family.
genes like me logo Genes that share domains with SMIM15: view

No data available for Gene Families for SMIM15 Gene

Function for SMIM15 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM15 Gene

Localization for SMIM15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM15 Gene

Membrane; Single-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SMIM15 Gene

Pathways & Interactions for SMIM15 Gene

SuperPathways for SMIM15 Gene

No Data Available

Interacting Proteins for SMIM15 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000339324 for SMIM15 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SMIM15 Gene


No data available for Pathways by source and SIGNOR curated interactions for SMIM15 Gene

Drugs & Compounds for SMIM15 Gene

No Compound Related Data Available

Transcripts for SMIM15 Gene

mRNA/cDNA for SMIM15 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM15 Gene

Small integral membrane protein 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM15 Gene

No ASD Table

Relevant External Links for SMIM15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMIM15 Gene

mRNA expression in normal human tissues for SMIM15 Gene

Protein differential expression in normal tissues from HIPED for SMIM15 Gene

This gene is overexpressed in Placenta (16.0), Ovary (14.0), Rectum (8.4), Prostate (8.0), Adrenal (6.4), and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SMIM15 Gene

SOURCE GeneReport for Unigene cluster for SMIM15 Gene Hs.508479

genes like me logo Genes that share expression patterns with SMIM15: view

Protein tissue co-expression partners for SMIM15 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMIM15 Gene

Orthologs for SMIM15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C7H5orf43 35
  • 94.14 (n)
  • 98.65 (a)
SMIM15 36
  • 99 (a)
(Canis familiaris)
Mammalia SMIM15 35
  • 94.59 (n)
  • 100 (a)
SMIM15 36
  • 96 (a)
(Mus musculus)
Mammalia Smim15 35
  • 91.44 (n)
  • 98.65 (a)
Smim15 16
Smim15 36
  • 99 (a)
(Pan troglodytes)
Mammalia SMIM15 35
  • 100 (n)
  • 100 (a)
SMIM15 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Smim15 35
  • 90.09 (n)
  • 97.3 (a)
(Monodelphis domestica)
Mammalia SMIM15 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia SMIM15 36
  • 92 (a)
(Gallus gallus)
Aves CZH5ORF43 35
  • 78.83 (n)
  • 83.78 (a)
SMIM15 36
  • 84 (a)
(Anolis carolinensis)
Reptilia SMIM15 36
  • 94 (a)
(Danio rerio)
Actinopterygii smim15 35
  • 73.42 (n)
  • 90.54 (a)
smim15 36
  • 91 (a)
Species with no ortholog for SMIM15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMIM15 Gene

Gene Tree for SMIM15 (if available)
Gene Tree for SMIM15 (if available)

Paralogs for SMIM15 Gene

genes like me logo Genes that share paralogs with SMIM15: view

No data available for Paralogs for SMIM15 Gene

Variants for SMIM15 Gene

Sequence variations from dbSNP and Humsavar for SMIM15 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs4546328 - 61,160,105(+) TGTAA(A/G)GAAGC reference, missense
rs1043204 -- 61,158,741(-) TATTC(A/C)CTGTT utr-variant-3-prime
rs298629 -- 61,157,335(+) TTGCT(C/T)TGTCG downstream-variant-500B
rs33918253 -- 61,158,589(+) AAAAA(-/AA)TCCAG utr-variant-3-prime
rs608487 -- 61,158,757(+) ATTGG(A/C)CCATG utr-variant-3-prime

Variation tolerance for SMIM15 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM15 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMIM15 Gene

Disorders for SMIM15 Gene

Relevant External Links for SMIM15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SMIM15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM15 Gene

Publications for SMIM15 Gene

  1. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SMIM15 Gene

Sources for SMIM15 Gene