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Aliases for SMIM14 Gene

Aliases for SMIM14 Gene

  • Small Integral Membrane Protein 14 2 3
  • C4orf34 3 4
  • Chromosome 4 Open Reading Frame 34 2

External Ids for SMIM14 Gene

Previous HGNC Symbols for SMIM14 Gene

  • C4orf34

Summaries for SMIM14 Gene

GeneCards Summary for SMIM14 Gene

SMIM14 (Small Integral Membrane Protein 14) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM14 Gene

Genomics for SMIM14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SMIM14 Gene

39,546,330 bp from pter
39,639,090 bp from pter
92,761 bases
Minus strand

Genomic View for SMIM14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMIM14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM14 Gene

No data available for Regulatory Elements for SMIM14 Gene

Proteins for SMIM14 Gene

  • Protein details for SMIM14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small integral membrane protein 14
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SMIM14 Gene

    99 amino acids
    Molecular mass:
    10710 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM14 Gene

Proteomics data for SMIM14 Gene at MOPED

Post-translational modifications for SMIM14 Gene

  • Ubiquitination at Lys83
  • Modification sites at PhosphoSitePlus

Other Protein References for SMIM14 Gene

No data available for DME Specific Peptides for SMIM14 Gene

Domains for SMIM14 Gene

Protein Domains for SMIM14 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM14: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM14 Gene

Function for SMIM14 Gene

Animal Model Products

CRISPR Products

miRNA for SMIM14 Gene

miRTarBase miRNAs that target SMIM14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMIM14

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SMIM14 Gene

Localization for SMIM14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM14 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 24499674
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM14: view

No data available for Subcellular locations from COMPARTMENTS for SMIM14 Gene

Pathways for SMIM14 Gene

SuperPathways for SMIM14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SMIM14 Gene


No data available for Pathways by source for SMIM14 Gene

Transcripts for SMIM14 Gene

Unigene Clusters for SMIM14 Gene

Small integral membrane protein 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMIM14

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP2: - -
SP3: -
SP4: - - -
SP5: - -
SP6: - - - -

Relevant External Links for SMIM14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMIM14 Gene

mRNA expression in normal human tissues for SMIM14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMIM14 Gene

This gene is overexpressed in Liver (4.4).

SOURCE GeneReport for Unigene cluster for SMIM14 Gene Hs.576320

genes like me logo Genes that share expressions with SMIM14: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for SMIM14 Gene

Orthologs for SMIM14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMIM14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMIM14 35
  • 91.92 (n)
  • 92.93 (a)
SMIM14 36
  • 93 (a)
(Canis familiaris)
Mammalia SMIM14 35
  • 93.94 (n)
  • 94.95 (a)
SMIM14 36
  • 94 (a)
(Mus musculus)
Mammalia Smim14 35
  • 82.49 (n)
  • 89.9 (a)
Smim14 16
Smim14 36
  • 90 (a)
(Pan troglodytes)
Mammalia SMIM14 35
  • 98.65 (n)
  • 97.98 (a)
SMIM14 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Smim14 35
  • 83.84 (n)
  • 89.9 (a)
(Monodelphis domestica)
Mammalia SMIM14 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia SMIM14 36
  • 84 (a)
(Gallus gallus)
Aves C4ORF34 35
  • 81.14 (n)
  • 82.83 (a)
SMIM14 36
  • 80 (a)
(Anolis carolinensis)
Reptilia SMIM14 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia smim14 35
  • 68.35 (n)
  • 71.72 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12233 35
(Danio rerio)
Actinopterygii Dr.9013 35
smim14 35
  • 67.34 (n)
  • 70.71 (a)
smim14 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13585 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea C34C12.4 36
  • 38 (a)
Species with no ortholog for SMIM14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMIM14 Gene

Gene Tree for SMIM14 (if available)
Gene Tree for SMIM14 (if available)

Paralogs for SMIM14 Gene Pseudogenes for SMIM14 Gene

genes like me logo Genes that share paralogs with SMIM14: view

No data available for Paralogs for SMIM14 Gene

Variants for SMIM14 Gene

Sequence variations from dbSNP and Humsavar for SMIM14 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs900832 -- 39,609,284(+) CTGTA(C/T)TGTAC intron-variant
rs900833 -- 39,609,486(+) TGTGA(C/G)ACTTG intron-variant
rs956418 -- 39,609,808(+) GTAGG(C/T)AGAGG intron-variant
rs956419 -- 39,609,829(+) AAAAT(C/G)CTCTT intron-variant
rs977385 -- 39,636,206(+) TGTGA(C/T)GTGTA intron-variant

Relevant External Links for SMIM14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMIM14 Gene

Disorders for SMIM14 Gene

No disorders were found for SMIM14 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SMIM14 Gene

Publications for SMIM14 Gene

  1. Characterization of the cellular localization of C4orf34 as a novel endoplasmic reticulum resident protein. (PMID: 24499674) Jun M.H. … Jang D.J. (BMB Rep 2014) 2 3 4
  2. MISP: The missing link between extracellular matrix and astral microtubules. (PMID: 23759569) Nain A.S. … Cimini D. (Cell Cycle 2013) 2 3
  3. A protein interaction framework for human mRNA degradation. (PMID: 15231747) Lehner B. … Sanderson C.M. (Genome Res. 2004) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for SMIM14 Gene

Sources for SMIM14 Gene

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