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Aliases for SMIM13 Gene

Aliases for SMIM13 Gene

  • Small Integral Membrane Protein 13 2 3 5
  • C6orf228 3 4
  • Chromosome 6 Open Reading Frame 228 2
  • UPF0766 Protein C6orf228 3

External Ids for SMIM13 Gene

Previous HGNC Symbols for SMIM13 Gene

  • C6orf228

Previous GeneCards Identifiers for SMIM13 Gene

  • GC06P011097
  • GC06P011099

Summaries for SMIM13 Gene

GeneCards Summary for SMIM13 Gene

SMIM13 (Small Integral Membrane Protein 13) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM13 Gene

Genomics for SMIM13 Gene

Regulatory Elements for SMIM13 Gene

Enhancers for SMIM13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G010588 1 Ensembl dbSUPER 9.8 -505.3 -505333 0.2 SMARCA5 HDGF MCM3 ZSCAN4 ZIK1 NFXL1 SALL2 CDC5L NONO POLR2A SMIM13 RPL21P63 PIR63050
GH06G011116 0.6 Ensembl 12.2 +22.3 22268 0.2 PKNOX1 ZFHX2 IKZF1 KLF9 CUX1 FOS IKZF2 EGR2 SMIM13 ERVFRD-1 GC06P011137
GH06G011092 1.2 ENCODE 0.7 +0.5 515 3.8 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 RNA5SP203 ERVFRD-1 SMIM13
GH06G011110 1.1 Ensembl ENCODE 0.4 +17.7 17681 2.0 HDAC1 CBX3 PKNOX1 CHAMP1 GATA2 ZBTB2 CEBPB ELF4 USF2 ZEB2 ERVFRD-1 SMIM13
GH06G011086 0.4 ENCODE 0.4 -7.8 -7831 0.2 EMSY PIR40503 SMIM13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMIM13 on UCSC Golden Path with GeneCards custom track

Promoters for SMIM13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000193065 267 2601 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143

Genomic Location for SMIM13 Gene

Chromosome:
6
Start:
11,094,033 bp from pter
End:
11,138,738 bp from pter
Size:
44,706 bases
Orientation:
Plus strand

Genomic View for SMIM13 Gene

Genes around SMIM13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM13 Gene

Proteins for SMIM13 Gene

  • Protein details for SMIM13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DJ93-SIM13_HUMAN
    Recommended name:
    Small integral membrane protein 13
    Protein Accession:
    P0DJ93
    Secondary Accessions:
    • G3V581

    Protein attributes for SMIM13 Gene

    Size:
    91 amino acids
    Molecular mass:
    10351 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM13 Gene

Post-translational modifications for SMIM13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM13 Gene

Domains & Families for SMIM13 Gene

Protein Domains for SMIM13 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0DJ93

UniProtKB/Swiss-Prot:

SIM13_HUMAN :
  • Belongs to the SMIM13 family.
Family:
  • Belongs to the SMIM13 family.
genes like me logo Genes that share domains with SMIM13: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SMIM13 Gene

Function for SMIM13 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM13 Gene

Localization for SMIM13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM13 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM13: view

No data available for Subcellular locations from COMPARTMENTS for SMIM13 Gene

Pathways & Interactions for SMIM13 Gene

SuperPathways for SMIM13 Gene

No Data Available

Interacting Proteins for SMIM13 Gene

Gene Ontology (GO) - Biological Process for SMIM13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM13 Gene

Drugs & Compounds for SMIM13 Gene

No Compound Related Data Available

Transcripts for SMIM13 Gene

mRNA/cDNA for SMIM13 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM13 Gene

Small integral membrane protein 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM13 Gene

No ASD Table

Relevant External Links for SMIM13 Gene

GeneLoc Exon Structure for
SMIM13
ECgene alternative splicing isoforms for
SMIM13

Expression for SMIM13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM13 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM13 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for SMIM13 Gene

This gene is overexpressed in Fetal Brain (10.5), Frontal cortex (9.4), Retina (8.2), Bone (7.8), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SMIM13 Gene



Protein tissue co-expression partners for SMIM13 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SMIM13 Gene:

SMIM13

SOURCE GeneReport for Unigene cluster for SMIM13 Gene:

Hs.656600

Evidence on tissue expression from TISSUES for SMIM13 Gene

  • Bone marrow(4)
genes like me logo Genes that share expression patterns with SMIM13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM13 Gene

Orthologs for SMIM13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf228 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia SMIM13 34
  • 89.66 (n)
cow
(Bos Taurus)
Mammalia SMIM13 34 35
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Smim13 34 16 35
  • 88.51 (n)
rat
(Rattus norvegicus)
Mammalia LOC690806 34
  • 87.74 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488147 34
  • 61.63 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-206d17.5 34
  • 65.87 (n)
SMIM13 (1 of 2) 35
  • 61 (a)
OneToMany
SMIM13 (2 of 2) 35
  • 61 (a)
OneToMany
Species where no ortholog for SMIM13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMIM13 Gene

ENSEMBL:
Gene Tree for SMIM13 (if available)
TreeFam:
Gene Tree for SMIM13 (if available)

Paralogs for SMIM13 Gene

No data available for Paralogs for SMIM13 Gene

Variants for SMIM13 Gene

Sequence variations from dbSNP and Humsavar for SMIM13 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000019683 -- 11,105,671(+) TTTCA(A/G)ATAGG intron-variant
rs1000088105 -- 11,104,046(+) TTAAC(A/T)TGTCT intron-variant, reference, missense
rs1000089314 -- 11,131,760(+) CTTAT(A/G)CCAAA intron-variant
rs1000160074 -- 11,133,294(+) TCAGC(A/G)CTCAA intron-variant
rs1000209663 -- 11,102,869(+) GTTTT(A/G)TAGCA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SMIM13 Gene

Variant ID Type Subtype PubMed ID
esv3608091 CNV loss 21293372
nsv1161335 CNV deletion 26073780

Variation tolerance for SMIM13 Gene

Gene Damage Index Score: 0.00; 0.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMIM13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM13 Gene

Disorders for SMIM13 Gene

Relevant External Links for SMIM13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMIM13

No disorders were found for SMIM13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM13 Gene

Publications for SMIM13 Gene

  1. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai D.C. … Hagoort P. (Genes Brain Behav. 2014) 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SMIM13 Gene

Sources for SMIM13 Gene

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