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Aliases for SMIM12 Gene

Aliases for SMIM12 Gene

  • Small Integral Membrane Protein 12 2 3 5
  • C1orf212 3 4
  • Chromosome 1 Open Reading Frame 212 2
  • Alternative Protein C1orf212 3
  • UPF0767 Protein C1orf212 3

External Ids for SMIM12 Gene

Previous HGNC Symbols for SMIM12 Gene

  • C1orf212

Previous GeneCards Identifiers for SMIM12 Gene

  • GC01M035179

Summaries for SMIM12 Gene

GeneCards Summary for SMIM12 Gene

SMIM12 (Small Integral Membrane Protein 12) is a Protein Coding gene.

Additional gene information for SMIM12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM12 Gene

Genomics for SMIM12 Gene

GeneHancer (GH) Regulatory Elements for SMIM12 Gene

Promoters and enhancers for SMIM12 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I034858 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 555.2 +0.4 374 2.3 PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SMIM12 GC01P034859 ZMYM1 SFPQ LOC653160 ZMYM6 ENSG00000230163 RPL5P4
GH01I034852 Enhancer 1.2 ENCODE dbSUPER 6.9 +7.0 6970 1.1 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF766 CBX5 E2F8 ZMYM1 ENSG00000230163 SFPQ LOC653160 ZMYM6 RPL5P4 TMEM35B SMIM12 GC01P034859
GH01I034884 Enhancer 0.7 Ensembl ENCODE 11.6 -25.8 -25777 1.6 RING1 CTCF NCOA6 POLR2A ZNF143 RAD21 EZH2 ZMYM4 ZMYM6 ENSG00000230163 SMIM12 LOC653160 SFPQ GC01P034879 DLGAP3
GH01I034825 Enhancer 1.1 Ensembl ENCODE 7 +34.2 34180 0.9 FOXA2 ARID4B SIN3A ZNF48 RAD21 RARA YY1 RCOR1 FOS CREM GJB3 GJB4 SMIM12 GC01P034835 GJA4
GH01I034842 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.4 +15.3 15264 3.9 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 CBX5 GATA2 ATF7 RXRA ENSG00000230163 SMIM12 GJA4 GC01P034835
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SMIM12 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SMIM12 Gene

Genomic Locations for SMIM12 Gene
147,080 bases
Minus strand

Genomic View for SMIM12 Gene

Genes around SMIM12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM12 Gene

Proteins for SMIM12 Gene

  • Protein details for SMIM12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small integral membrane protein 12
    Protein Accession:
    Secondary Accessions:
    • D3DPR5
    • Q49AP7
    • Q52LP9
    • Q8NCB4

    Protein attributes for SMIM12 Gene

    92 amino acids
    Molecular mass:
    10799 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH11880.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAH73851.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAH93838.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAI07422.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAI12232.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAC11246.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=EAX07437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX07438.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX07439.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SMIM12 Gene

Post-translational modifications for SMIM12 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SMIM12 Gene

Domains & Families for SMIM12 Gene

Gene Families for SMIM12 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SMIM12 Gene


Suggested Antigen Peptide Sequences for SMIM12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SMIM12 family.
  • Belongs to the SMIM12 family.
genes like me logo Genes that share domains with SMIM12: view

Function for SMIM12 Gene

Phenotypes From GWAS Catalog for SMIM12 Gene

genes like me logo Genes that share phenotypes with SMIM12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM12 Gene

Localization for SMIM12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM12 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SMIM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM12: view

No data available for Subcellular locations from COMPARTMENTS for SMIM12 Gene

Pathways & Interactions for SMIM12 Gene

SuperPathways for SMIM12 Gene

No Data Available

Interacting Proteins for SMIM12 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96EX1-SIM12_HUMAN ENSP00000428541 for SMIM12 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SMIM12 Gene


No data available for Pathways by source and SIGNOR curated interactions for SMIM12 Gene

Drugs & Compounds for SMIM12 Gene

No Compound Related Data Available

Transcripts for SMIM12 Gene

Unigene Clusters for SMIM12 Gene

Small integral membrane protein 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM12 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -

Relevant External Links for SMIM12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMIM12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM12 Gene

Protein differential expression in normal tissues from HIPED for SMIM12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5), Platelet (10.1), and Bone (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SMIM12 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMIM12 Gene:


SOURCE GeneReport for Unigene cluster for SMIM12 Gene:


Evidence on tissue expression from TISSUES for SMIM12 Gene

  • Lung(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SMIM12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM12 Gene

Orthologs for SMIM12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1orf212 33
  • 100 (n)
SMIM12 34
  • 100 (a)
(Bos Taurus)
Mammalia SMIM12 33 34
  • 91.3 (n)
(Canis familiaris)
Mammalia SMIM12 33 34
  • 91.3 (n)
(Rattus norvegicus)
Mammalia Smim12 33
  • 91.3 (n)
(Monodelphis domestica)
Mammalia SMIM12 34
  • 91 (a)
(Mus musculus)
Mammalia Smim12 33 16 34
  • 89.49 (n)
(Ornithorhynchus anatinus)
Mammalia SMIM12 34
  • 89 (a)
(Gallus gallus)
Aves SMIM12 33
  • 76.81 (n)
(Anolis carolinensis)
Reptilia SMIM12 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734635 33
  • 67.77 (n)
Str.10215 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18745 33
(Danio rerio)
Actinopterygii smim12 33 34
  • 69.96 (n)
wufi25c11 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12654 33
Species where no ortholog for SMIM12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMIM12 Gene

Gene Tree for SMIM12 (if available)
Gene Tree for SMIM12 (if available)

Paralogs for SMIM12 Gene

(1) SIMAP similar genes for SMIM12 Gene using alignment to 2 proteins: Pseudogenes for SMIM12 Gene

genes like me logo Genes that share paralogs with SMIM12: view

No data available for Paralogs for SMIM12 Gene

Variants for SMIM12 Gene

Sequence variations from dbSNP and Humsavar for SMIM12 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000140165 -- 34,857,807(-) GGGGG/GGGG 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000298447 -- 34,858,272(-) G/A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000412452 -- 34,857,981(-) C/G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000492477 -- 34,858,070(-) A/ 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000653466 -- 34,853,401(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM12 Gene

Variant ID Type Subtype PubMed ID
esv3585711 CNV loss 21293372
nsv1012995 CNV gain 25217958

Variation tolerance for SMIM12 Gene

Gene Damage Index Score: 0.07; 1.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMIM12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM12 Gene

Disorders for SMIM12 Gene

Additional Disease Information for SMIM12

No disorders were found for SMIM12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM12 Gene

Publications for SMIM12 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58

Products for SMIM12 Gene

Sources for SMIM12 Gene

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