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Aliases for SMIM11A Gene

Aliases for SMIM11A Gene

  • Small Integral Membrane Protein 11A 2 3 5
  • Family With Sequence Similarity 165, Member B 2 3
  • Small Integral Membrane Protein 11 2 3
  • C21orf51 3 4
  • FAM165B 3 4
  • SMIM11 3 4
  • Chromosome 21 Open Reading Frame 51 2
  • Protein FAM165B 3

External Ids for SMIM11A Gene

Previous HGNC Symbols for SMIM11A Gene

  • C21orf51
  • FAM165B
  • SMIM11

Summaries for SMIM11A Gene

GeneCards Summary for SMIM11A Gene

SMIM11A (Small Integral Membrane Protein 11A) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM11A Gene

Genomics for SMIM11A Gene

Regulatory Elements for SMIM11A Gene

Enhancers for SMIM11A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SMIM11A on UCSC Golden Path with GeneCards custom track

Promoters for SMIM11A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SMIM11A on UCSC Golden Path with GeneCards custom track

Genomic Location for SMIM11A Gene

34,375,450 bp from pter
34,407,866 bp from pter
32,417 bases
Plus strand

Genomic View for SMIM11A Gene

Genes around SMIM11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM11A Gene

Proteins for SMIM11A Gene

  • Protein details for SMIM11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small integral membrane protein 11A
    Protein Accession:

    Protein attributes for SMIM11A Gene

    58 amino acids
    Molecular mass:
    6886 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM11A Gene

Proteomics data for SMIM11A Gene at MOPED

Post-translational modifications for SMIM11A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM11A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM11A Gene

Domains & Families for SMIM11A Gene

Protein Domains for SMIM11A Gene


Suggested Antigen Peptide Sequences for SMIM11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SMIM11 family.
  • Belongs to the SMIM11 family.
genes like me logo Genes that share domains with SMIM11A: view

No data available for Gene Families for SMIM11A Gene

Function for SMIM11A Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM11A Gene

Localization for SMIM11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM11A Gene

Membrane; Single-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SMIM11A Gene

Pathways & Interactions for SMIM11A Gene

SuperPathways for SMIM11A Gene

No Data Available

Interacting Proteins for SMIM11A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000382231 P58511-SI11A_HUMAN for SMIM11A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SMIM11A Gene


No data available for Pathways by source and SIGNOR curated interactions for SMIM11A Gene

Drugs & Compounds for SMIM11A Gene

No Compound Related Data Available

Transcripts for SMIM11A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM11A Gene

No ASD Table

Relevant External Links for SMIM11A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMIM11A Gene

mRNA Expression by UniProt/SwissProt for SMIM11A Gene

Tissue specificity: Expressed in heart, spleen, liver, stomach, muscle, lung, testis, skin, PBL and bone marrow.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SMIM11A Gene

Orthologs for SMIM11A Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM11A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SMIM11 35
  • 79.31 (n)
  • 84.48 (a)
SMIM11 36
  • 84 (a)
(Canis familiaris)
Mammalia FAM165B 35
  • 86.21 (n)
  • 94.83 (a)
SMIM11 36
  • 95 (a)
(Pan troglodytes)
Mammalia FAM165B 35
  • 99.43 (n)
  • 100 (a)
SMIM11 36
  • 93 (a)
(Mus musculus)
Mammalia Smim11 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia SMIM11 36
  • 61 (a)
(Anolis carolinensis)
Reptilia SMIM11 36
  • 74 (a)
Species with no ortholog for SMIM11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM11A Gene

Gene Tree for SMIM11A (if available)
Gene Tree for SMIM11A (if available)

Paralogs for SMIM11A Gene

No data available for Paralogs for SMIM11A Gene

Variants for SMIM11A Gene

Sequence variations from dbSNP and Humsavar for SMIM11A Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs34016792 - 34,385,617(-) ATTGC(C/T)TCTTC reference, missense
rs7275518 -- 34,379,970(+) GTAGA(C/T)GCAGt intron-variant
rs8131160 -- 34,387,859(+) GAAAT(A/T)AAAAA intron-variant
rs8131582 -- 34,382,947(+) GTTAT(A/G)TTAGT intron-variant
rs8131595 -- 34,382,968(+) CGGCC(A/G)GGTGC intron-variant

Variation tolerance for SMIM11A Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SMIM11A Gene

Disorders for SMIM11A Gene

Relevant External Links for SMIM11A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SMIM11A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM11A Gene

Publications for SMIM11A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SMIM11A Gene

Sources for SMIM11A Gene