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Aliases for SMIM11 Gene

Aliases for SMIM11 Gene

  • Small Integral Membrane Protein 11 2 3
  • Family With Sequence Similarity 165, Member B 2 3
  • C21orf51 3 4
  • FAM165B 3 4
  • Chromosome 21 Open Reading Frame 51 2
  • Protein FAM165B 3

External Ids for SMIM11 Gene

Previous HGNC Symbols for SMIM11 Gene

  • C21orf51
  • FAM165B

Previous GeneCards Identifiers for SMIM11 Gene

  • GC21P035748

Summaries for SMIM11 Gene

GeneCards Summary for SMIM11 Gene

SMIM11 (Small Integral Membrane Protein 11) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM11 Gene

Genomics for SMIM11 Gene

Genomic Location for SMIM11 Gene

34,375,450 bp from pter
34,407,866 bp from pter
32,417 bases
Plus strand

Genomic View for SMIM11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMIM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM11 Gene

No data available for Regulatory Elements for SMIM11 Gene

Proteins for SMIM11 Gene

  • Protein details for SMIM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small integral membrane protein 11
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SMIM11 Gene

    58 amino acids
    Molecular mass:
    6886 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM11 Gene

Proteomics data for SMIM11 Gene at MOPED

Post-translational modifications for SMIM11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM11 Gene

Domains for SMIM11 Gene

Protein Domains for SMIM11 Gene


Graphical View of Domain Structure for InterPro Entry



  • P58511
  • Belongs to the SMIM11 family.
genes like me logo Genes that share domains with SMIM11: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SMIM11 Gene

Function for SMIM11 Gene

Gene Ontology (GO) - Molecular Function for SMIM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SMIM11: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SMIM11 Gene

Localization for SMIM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM11 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMIM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM11: view

No data available for Subcellular locations from COMPARTMENTS for SMIM11 Gene

Pathways for SMIM11 Gene

SuperPathways for SMIM11 Gene

No Data Available

Interacting Proteins for SMIM11 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000382231 P58511-SIM11_HUMAN for SMIM11 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SMIM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SMIM11: view

No data available for Pathways by source for SMIM11 Gene

Transcripts for SMIM11 Gene

Unigene Clusters for SMIM11 Gene

Small integral membrane protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM11 Gene

No ASD Table

Relevant External Links for SMIM11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMIM11 Gene

mRNA expression in normal human tissues for SMIM11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMIM11 Gene

SOURCE GeneReport for Unigene cluster for SMIM11 Gene Hs.656195

mRNA Expression by UniProt/SwissProt for SMIM11 Gene

Tissue specificity: Expressed in heart, spleen, liver, stomach, muscle, lung, testis, skin, PBL and bone marrow
genes like me logo Genes that share expressions with SMIM11: view

No data available for mRNA differential expression in normal tissues for SMIM11 Gene

Orthologs for SMIM11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM165B 35
  • 99.43 (n)
  • 100 (a)
SMIM11 36
  • 93 (a)
(Bos Taurus)
Mammalia SMIM11 35
  • 79.31 (n)
  • 84.48 (a)
SMIM11 36
  • 84 (a)
(Canis familiaris)
Mammalia FAM165B 35
  • 86.21 (n)
  • 94.83 (a)
SMIM11 36
  • 95 (a)
(Mus musculus)
Mammalia Smim11 16
Smim11 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia SMIM11 36
  • 61 (a)
(Anolis carolinensis)
Reptilia SMIM11 36
  • 74 (a)
Species with no ortholog for SMIM11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM11 Gene

Gene Tree for SMIM11 (if available)
Gene Tree for SMIM11 (if available)

Paralogs for SMIM11 Gene

Selected SIMAP similar genes for SMIM11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SMIM11: view

No data available for Paralogs for SMIM11 Gene

Variants for SMIM11 Gene

Sequence variations from dbSNP and Humsavar for SMIM11 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs762159 -- 34,375,490(+) GGGAC(C/G)TGTAG utr-variant-5-prime
rs2012713 -- 34,389,652(+) CCTAG(G/T)AGCCA downstream-variant-500B
rs2275968 -- 34,375,786(+) AACCC(C/G)TTGAG intron-variant
rs3949179 -- 34,375,303(+) GGACT(G/T)CAGCC upstream-variant-2KB
rs7275518 -- 34,379,970(+) GTAGA(C/T)GCAGt intron-variant

Relevant External Links for SMIM11 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMIM11 Gene

Disorders for SMIM11 Gene

No disorders were found for SMIM11 Gene.

No data available for UniProtKB/Swiss-Prot for SMIM11 Gene

Publications for SMIM11 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  2. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A. … Antonarakis S.E. (Genomics 2001) 3 4
  3. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K. … Davisson M. (Genomics 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for SMIM11 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SMIM11
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SMIM11
    • Block miRNA regulation of SMIM11 using miScript Target Protectors

    Sources for SMIM11 Gene

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