Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMG9 Gene

protein-coding   GIFtS: 44
GCID: GC19M044236

smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)

(Previous name: chromosome 19 open reading frame 61 )
(Previous symbol: C19orf61)
  Search for SMG9
in our new
 Human Malady Compendium 
Biological research products
for SMG9
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Smg-9 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans)1 2     Chromosome 19 Open Reading Frame 611
C19orf611 2 3 5     F17127_12
Protein Smg-9 Homolog2 3     Protein SMG92
FLJ128861     

External Ids:    HGNC: 257631   Entrez Gene: 560062   Ensembl: ENSG000001057717   OMIM: 6131765   UniProtKB: Q9H0W83   

Export aliases for SMG9 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SMG9_HUMAN, Q9H0W8
Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release
factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C
complex, is required for the efficient association between SMG1 and SMG8




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SMG9
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMG9 promoter sequence
   Search SABiosciences Chromatin IP Primers for SMG9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMG9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.31

SMG9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMG9 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M044236:  view genomic region     (about GC identifiers)

Start:
44,235,301 bp from pter      End:
44,259,142 bp from pter
Size:
23,842 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SMG9_HUMAN, Q9H0W8 (See protein sequence)
Recommended Name: Protein SMG9  
Size: 520 amino acids; 57651 Da
Subunit: Component of the SMG1C complex composed of SMG1, SMG8 and SMG9. Self-associates to form homodimers and forms
heterodimers with SMG8; these assembly forms may represent SMG1C intermediate forms
Sequence caution: Sequence=AAC17932.1; Type=Erroneous gene model prediction;
Secondary accessions: O60429 Q9H9A9
Alternative splicing: 2 isoforms:  Q9H0W8-1   Q9H0W8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMG9: NX_Q9H0W8

Post-translational modifications:

  • Phosphorylated by SMG11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H0W8

  • SMG9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061981.2  
    ENSEMBL proteins: 
     ENSP00000270066  
    Reactome Protein details: Q9H0W8
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for SMG9 
    GenScript Custom Purified and Recombinant Proteins Services for SMG9
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SMG9

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005829cytosol TAS--


    SMG9 for ontologies           About GeneDecksing



    SMG9 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SMG9 
    GenScript Custom Superior Antibodies Services for SMG9
    Novus Biologicals SMG9 Antibodies
    Search for Antibodies for SMG9 at Abcam  
    Uscn Antibodies for SMG9
    ThermoFisher Antibody for SMG9

    Assay Products for SMG9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SMG9
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SMG9


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SMG9 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019354 Smg8/Smg9

    Graphical View of Domain Structure for InterPro Entry Q9H0W8

    ProtoNet protein and cluster: Q9H0W8

    UniProtKB/Swiss-Prot: SMG9_HUMAN, Q9H0W8
    Similarity: Belongs to the SMG9 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SMG9_HUMAN, Q9H0W8
    Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release
    factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C
    complex, is required for the efficient association between SMG1 and SMG8

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: SMG9
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMG9
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SMG9:
    hsa-miR-370 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidSMG9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMG9 (see all 4)
    OriGene shRNA RFP: SMG9
    OriGene siRNA: SMG9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMG9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SMG9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMG9 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMG9 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for SMG9
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMG9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMG9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SMG9
    Search LifeMap BioReagents cell lines for SMG9

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMG9

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0042802identical protein binding IPI--


    SMG9 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    Nonsense-Mediated Decay0.77
    Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A0.77
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.77
    2Metabolism of mRNA
    Metabolism of mRNA1.00
    Metabolism of RNA0.92
    3Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for SMG9 (see all 6)
        Nonsense-Mediated Decay
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex
    Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A
    Metabolism of RNA
    Metabolism of mRNA



    SMG9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMG9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/74 Interacting proteins for SMG9 (Q9H0W81 ENSP000002700664) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMG8Q8ND041, ENSP000003009174EBI-2872322,EBI-3903643 STRING: ENSP00000300917
    SMG9Q9H0W81EBI-2872322,EBI-2872322
    SMG1ENSP000004025154STRING: ENSP00000402515
    EIF4A3ENSP000002693494STRING: ENSP00000269349
    ETF1ENSP000003537414STRING: ENSP00000353741
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--


    SMG9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SMG9
    Search CenterWatch for drugs/clinical trials and news about SMG9 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SMG9 gene: 
    NM_019108.2  

    Unigene Cluster for SMG9:

    Smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
    Hs.466875  [show with all ESTs]
    Unigene Representative Sequence: AK022948
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000270066(uc002oxj.2 uc002oxk.2 uc010eiy.1)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: SMG9
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMG9
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SMG9:
    hsa-miR-370 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidSMG9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMG9 (see all 4)
    OriGene shRNA RFP: SMG9
    OriGene siRNA: SMG9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMG9
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMG9 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMG9 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for SMG9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMG9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMG9 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMG9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMG9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMG9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMG9

    Additional cDNA sequence: 

    AK022948.1 AK309830.1 AL136606.1 BC008869.2 

    11 DOTS entries:

    DT.413229  DT.95147742  DT.100804910  DT.121495394  DT.100804904  DT.95360168  DT.100753702  DT.91742478 
    DT.121495391  DT.86845895  DT.99997111 

    24/190 AceView cDNA sequences (see all 190):

    BE208560 BQ054000 CD366067 BE501275 AI652894 AI652907 AA889396 BG055242 
    AA505782 AL136606 AU141667 CB988933 BM715791 BE221137 BE468188 BM714782 
    BQ182080 AI339032 AJ430434 CR606035 BX453604 BM981890 AK022948 NM_019108 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SMG9 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
    SP1:                    -     -     -     -     -                                                                                   -     -                     
    SP2:                    -     -     -     -     -                                                                                   -     -                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -                 -                                                                                             

    ExUns: 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17
    SP1:        -                             -         
    SP2:        -                                       
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for SMG9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMG9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAGCCTGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SMG9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMG9

    SOURCE GeneReport for Unigene cluster: Hs.466875
        SABiosciences Custom PCR Arrays for SMG9
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMG9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMG9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMG9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMG9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMG9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMG9 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smg91 , 5 RIKEN cDNA 1500002O20 gene5
    smg-9 homolog, nonsense mediated mRNA decay factor more1
    88.14(n)1
    97.31(a)1
      7 (10.54 cM)5
    719971  NM_028047.21  NP_082323.11 
     243996195 
    lizard
    (Anolis carolinensis)
    Reptilia SMG96
    --
    82(a)
    1 ↔ 1
    LGf(67565-77190)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.161892 Transcribed sequence with moderate similarity to protein more 75.61(n)    CF242158.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fj67f051 wu:fj67f05 68.6(n)
    74.25(a)
      562557  XM_001923780.3  XP_001923815.2 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    38(a)
    1 ↔ 1
    Group8.9(106627-108391)
    worm
    (Caenorhabditis elegans)
    Secernentea smg-96
    Protein smg-9
    22(a)
    1 ↔ 1
    II(14747833-14752415)
    rice
    (Oryza sativa)
    Liliopsida Os06g01146001 hypothetical protein 46.23(n)
    31.05(a)
      4339915  NM_001063140.1  NP_001056605.1 


    ENSEMBL Gene Tree for SMG9 (if available)
    TreeFam Gene Tree for SMG9 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/471 NCBI SNPs in SMG9 are shown (see all 471    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3465491,2
    --44234861(+) caggcA/Gtgcgc 1 -- int10--------
    rs1886698881,2
    --44234940(+) GTCTCA/GAACTC 1 -- int10--------
    rs1459615841,2
    --44235129(+) TTTTCC/GCATCC 1 -- int10--------
    rs1927275151,2
    --44235148(+) CACAGG/TGGAGG 1 -- int10--------
    rs104235711,2
    C,H--44235152(+) GGGGAG/CGCTTG 1 -- int14Minor allele frequency- C:0.00NS EA 416
    rs1850904531,2
    --44235178(+) ACAGAA/CTAACC 1 -- int10--------
    rs1900723551,2
    --44235455(+) CCGGGC/GTTCCT 1 -- ut310--------
    rs96121,2
    C,F,A,H,--44235517(+) GGGCTA/GCCCCA 1 -- ut3127Minor allele frequency- G:0.25MN NS EA NA WA CSA 3141
    rs126691,2
    C,F,A,H,--44235535(+) TTTGGG/AGTGGG 1 -- ut31 ese320Minor allele frequency- A:0.20MN NS EA NA WA 2698
    rs1822482441,2
    --44235695(+) CCCTCA/GCAGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SMG9 (44235301 - 44259142 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SMG9: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMG9
    DNA2.0 Custom Variant and Variant Library Synthesis for SMG9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SMG9 for disorders           About MalaCards

    SMG9 for disorders           About GeneDecksing

    OMIM gene information: 613176    OMIM disorders: --


    Export disorders for SMG9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMG9 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SMG9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PubMed id 19417104)1, 2, 3 Yamashita A....Ohno S. (2009)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large- scale conformational changes controlled by SMG-8. (PubMed id 21245168)2 Arias-Palomo E.... Llorca O. (2011)
    5. Role of a tyrosine phosphorylation of SMG-9 in bindin g of SMG-9 to IQGAP and the NMD complex. (PubMed id 21640080)1 Takeda S....Konishi H. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Characterization of SMG-9, an essential component of the nonsense- mediated mRNA decay SMG1C complex. (PubMed id 20817927)2 Fernandez I.S.... Llorca O. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56006 HGNC: 25763 AceView: FLJ12886 Ensembl:ENSG00000105771 euGenes: HUgn56006
    ECgene: SMG9 H-InvDB: SMG9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMG9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SMG9 gene:
    Search GeneIP for patents involving SMG9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SMG9  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMG9   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMG9  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SMG9   OriGene 3'-UTR Clone for SMG9  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMG9   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMG9  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SMG9   OriGene Custom Protein Services for SMG9  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMG9
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMG9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMG9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMG9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMG9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMG9
     GenScript Custom Purified and Recombinant Proteins Services for SMG9 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SMG9
     GenScript Custom Assay Services for SMG9 GenScript Custom Superior Antibodies Services for SMG9
     GenScript Custom overexpressing Cell Line Services for SMG9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for SMG9
     Search Chromatin IP Primers for SMG9
     RT2 qPCR Primer Assay in human, mouse, rat SMG9
     Search GNC Networks for SMG9
     SABiosciences Custom PCR Arrays for SMG9
     Search Tocris compounds for SMG9
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SMG9 antibodies
     Search for Antibodies for SMG9 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SMG9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SMG9 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SMG9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMG9
     SwitchGear 3'UTR luciferase reporter plasmids for SMG9
     SwitchGear Promoter luciferase reporter plasmids for SMG9
     ThermoFisher Antibody for SMG9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMG9
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SMG9 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4