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Aliases for SMG9 Gene

Aliases for SMG9 Gene

  • SMG9 Nonsense Mediated MRNA Decay Factor 2 3 5
  • Protein Smg-9 Homolog 3 4
  • C19orf61 3 4
  • Smg-9 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) 2
  • Smg-9 Homolog, Nonsense Mediated MRNA Decay Factor 3
  • Chromosome 19 Open Reading Frame 61 2
  • F17127_1 3

External Ids for SMG9 Gene

Previous HGNC Symbols for SMG9 Gene

  • C19orf61

Previous GeneCards Identifiers for SMG9 Gene

  • GC19M044236

Summaries for SMG9 Gene

GeneCards Summary for SMG9 Gene

SMG9 (SMG9 Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and Viral mRNA Translation. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for SMG9 Gene

  • Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMG9 Gene

Genomics for SMG9 Gene

Regulatory Elements for SMG9 Gene

Enhancers for SMG9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SMG9 on UCSC Golden Path with GeneCards custom track

Promoters for SMG9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SMG9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMG9 Gene

Chromosome:
19
Start:
43,727,992 bp from pter
End:
43,754,990 bp from pter
Size:
26,999 bases
Orientation:
Minus strand

Genomic View for SMG9 Gene

Genes around SMG9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMG9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMG9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMG9 Gene

Proteins for SMG9 Gene

  • Protein details for SMG9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0W8-SMG9_HUMAN
    Recommended name:
    Protein SMG9
    Protein Accession:
    Q9H0W8
    Secondary Accessions:
    • O60429
    • Q9H9A9

    Protein attributes for SMG9 Gene

    Size:
    520 amino acids
    Molecular mass:
    57651 Da
    Quaternary structure:
    • Component of the SMG1C complex composed of SMG1, SMG8 and SMG9. Self-associates to form homodimers and forms heterodimers with SMG8; these assembly forms may represent SMG1C intermediate forms.
    SequenceCaution:
    • Sequence=AAC17932.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SMG9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMG9 Gene

Proteomics data for SMG9 Gene at MOPED

Post-translational modifications for SMG9 Gene

No data available for DME Specific Peptides for SMG9 Gene

Domains & Families for SMG9 Gene

Protein Domains for SMG9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMG9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0W8

UniProtKB/Swiss-Prot:

SMG9_HUMAN :
  • Belongs to the SMG9 family.
Family:
  • Belongs to the SMG9 family.
genes like me logo Genes that share domains with SMG9: view

No data available for Gene Families for SMG9 Gene

Function for SMG9 Gene

Molecular function for SMG9 Gene

UniProtKB/Swiss-Prot Function:
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMG9 Gene

Localization for SMG9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMG9 Gene COMPARTMENTS Subcellular localization image for SMG9 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for SMG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
genes like me logo Genes that share ontologies with SMG9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SMG9 Gene

Pathways & Interactions for SMG9 Gene

genes like me logo Genes that share pathways with SMG9: view

Gene Ontology (GO) - Biological Process for SMG9 Gene

None

No data available for SIGNOR curated interactions for SMG9 Gene

Drugs & Compounds for SMG9 Gene

No Compound Related Data Available

Transcripts for SMG9 Gene

Unigene Clusters for SMG9 Gene

Smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMG9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5: - - - - - -
SP6: - - - - -
SP7: - -
SP8: -
SP9:
SP10:
SP11:

ExUns: 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SMG9 Gene

GeneLoc Exon Structure for
SMG9
ECgene alternative splicing isoforms for
SMG9

Expression for SMG9 Gene

mRNA expression in normal human tissues for SMG9 Gene

Protein differential expression in normal tissues from HIPED for SMG9 Gene

This gene is overexpressed in CD8 Tcells (10.8), Pancreas (8.4), Fetal Brain (7.9), and Lymph node (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMG9 Gene



SOURCE GeneReport for Unigene cluster for SMG9 Gene Hs.466875

genes like me logo Genes that share expression patterns with SMG9: view

Protein tissue co-expression partners for SMG9 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMG9 Gene

Orthologs for SMG9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMG9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMG9 35
  • 91.15 (n)
  • 96.92 (a)
SMG9 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMG9 35
  • 92.69 (n)
  • 98.27 (a)
SMG9 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smg9 35
  • 88.14 (n)
  • 97.31 (a)
Smg9 16
Smg9 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMG9 35
  • 99.49 (n)
  • 100 (a)
SMG9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smg9 35
  • 87.31 (n)
  • 96.92 (a)
oppossum
(Monodelphis domestica)
Mammalia SMG9 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMG9 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMG9 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia smg9 35
  • 70.58 (n)
  • 75.15 (a)
Str.16189 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-79d12.3 35
  • 69.77 (n)
  • 75.91 (a)
SMG9 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3857 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea smg-9 36
  • 22 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os06g0114600 35
  • 47.68 (n)
  • 33.54 (a)
Species with no ortholog for SMG9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMG9 Gene

ENSEMBL:
Gene Tree for SMG9 (if available)
TreeFam:
Gene Tree for SMG9 (if available)

Paralogs for SMG9 Gene

No data available for Paralogs for SMG9 Gene

Variants for SMG9 Gene

Sequence variations from dbSNP and Humsavar for SMG9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256472 -- 43,742,818(+) aggca(C/T)ggtgg intron-variant
rs8103276 -- 43,735,870(+) TGTGC(C/T)GGCCT intron-variant
rs8105041 -- 43,754,306(+) AAGGG(A/G)GCCTC intron-variant
rs16976743 -- 43,732,259(+) TCCAA(C/T)TTTTC intron-variant
rs16976747 -- 43,734,000(+) AGAGC(A/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMG9 Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV Loss 17160897
nsv509745 CNV Insertion 20534489

Variation tolerance for SMG9 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SMG9 Gene

Disorders for SMG9 Gene

Relevant External Links for SMG9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMG9

No disorders were found for SMG9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMG9 Gene

Publications for SMG9 Gene

  1. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PMID: 19417104) Yamashita A. … Ohno S. (Genes Dev. 2009) 2 3 4 67
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SMG9 Gene

Sources for SMG9 Gene

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