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Aliases for SMG9 Gene

Aliases for SMG9 Gene

  • SMG9 Nonsense Mediated MRNA Decay Factor 2 3
  • Protein Smg-9 Homolog 3 4
  • C19orf61 3 4
  • Smg-9 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) 2
  • Smg-9 Homolog, Nonsense Mediated MRNA Decay Factor 3
  • Chromosome 19 Open Reading Frame 61 2
  • Protein SMG9 3
  • C19orf61, 6
  • F17127_1 3

External Ids for SMG9 Gene

Previous Symbols for SMG9 Gene

  • C19orf61

Summaries for SMG9 Gene

GeneCards Summary for SMG9 Gene

SMG9 (SMG9 Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for SMG9 Gene

  • Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMG9 Gene

Genomics for SMG9 Gene

Genomic Location for SMG9 Gene

Start:
43,727,992 bp from pter
End:
43,754,990 bp from pter
Size:
26,999 bases
Orientation:
Minus strand

Genomic View for SMG9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMG9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMG9 Gene

No data available for Regulatory Elements for SMG9 Gene

Proteins for SMG9 Gene

  • Protein details for SMG9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0W8-SMG9_HUMAN
    Recommended name:
    Protein SMG9
    Protein Accession:
    Q9H0W8
    Secondary Accessions:
    • O60429
    • Q9H9A9

    Protein attributes for SMG9 Gene

    Size:
    520 amino acids
    Molecular mass:
    57651 Da
    Quaternary structure:
    • Component of the SMG1C complex composed of SMG1, SMG8 and SMG9. Self-associates to form homodimers and forms heterodimers with SMG8; these assembly forms may represent SMG1C intermediate forms.
    SequenceCaution:
    • Sequence=AAC17932.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SMG9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMG9 Gene

Proteomics data for SMG9 Gene at MOPED

Post-translational modifications for SMG9 Gene

Other Protein References for SMG9 Gene

No data available for DME Specific Peptides for SMG9 Gene

Domains for SMG9 Gene

Protein Domains for SMG9 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SMG9_HUMAN
Family:
  • Belongs to the SMG9 family.:
    • Q9H0W8
genes like me logo Genes that share domains with SMG9: view

No data available for Gene Families for SMG9 Gene

Function for SMG9 Gene

Molecular function for SMG9 Gene

UniProtKB/Swiss-Prot Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8.

Gene Ontology (GO) - Molecular Function for SMG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19417104
GO:0042802 identical protein binding IPI 20817927
genes like me logo Genes that share ontologies with SMG9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SMG9 Gene

Localization for SMG9 Gene

Gene Ontology (GO) - Cellular Components for SMG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SMG9: view

Pathways for SMG9 Gene

genes like me logo Genes that share pathways with SMG9: view

Pathways by source for SMG9 Gene

Gene Ontology (GO) - Biological Process for SMG9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
GO:0016071 mRNA metabolic process --
genes like me logo Genes that share ontologies with SMG9: view

Transcripts for SMG9 Gene

Unigene Clusters for SMG9 Gene

Smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMG9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3:
SP4:
SP5: - - - - - -
SP6: - - - - -
SP7: - -
SP8: -
SP9:
SP10:
SP11:

ExUns: 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SMG9 Gene

GeneLoc Exon Structure for
SMG9
ECgene alternative splicing isoforms for
SMG9

Expression for SMG9 Gene

mRNA expression in normal human tissues for SMG9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMG9 Gene

SOURCE GeneReport for Unigene cluster for SMG9 Gene Hs.466875

genes like me logo Genes that share expressions with SMG9: view

Orthologs for SMG9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMG9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMG9 36
  • 99.49 (n)
  • 100 (a)
SMG9 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SMG9 36
  • 91.15 (n)
  • 96.92 (a)
SMG9 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMG9 36
  • 92.69 (n)
  • 98.27 (a)
SMG9 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smg9 36
  • 88.14 (n)
  • 97.31 (a)
Smg9 16
Smg9 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SMG9 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMG9 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smg9 36
  • 87.31 (n)
  • 96.92 (a)
lizard
(Anolis carolinensis)
Reptilia SMG9 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia smg9 36
  • 70.58 (n)
  • 75.15 (a)
Str.16189 36
zebrafish
(Danio rerio)
Actinopterygii si:dkey-79d12.3 36
  • 69.77 (n)
  • 75.91 (a)
SMG9 37
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3857 37
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea smg-9 37
  • 22 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os06g0114600 36
  • 47.68 (n)
  • 33.54 (a)
Species with no ortholog for SMG9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMG9 Gene

ENSEMBL:
Gene Tree for SMG9 (if available)
TreeFam:
Gene Tree for SMG9 (if available)

Paralogs for SMG9 Gene

No data available for Paralogs for SMG9 Gene

Variants for SMG9 Gene

Sequence variations from dbSNP and Humsavar for SMG9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs9612 -- 43,731,365(+) GGGCT(A/G)CCCCA utr-variant-3-prime, intron-variant
rs12669 -- 43,731,383(+) TTTGG(A/G)GTGGG utr-variant-3-prime, intron-variant
rs164069 -- 43,756,047(+) CCTCC(C/T)AAAGT upstream-variant-2KB
rs164071 -- 43,750,998(+) tttta(C/T)atttt intron-variant
rs164072 -- 43,751,104(+) acaga(C/T)gtgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMG9 Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV Loss 17160897
nsv509745 CNV Insertion 20534489

Relevant External Links for SMG9 Gene

HapMap Linkage Disequilibrium report
SMG9

Disorders for SMG9 Gene

No disorders were found for SMG9 Gene.

No data available for UniProtKB/Swiss-Prot for SMG9 Gene

Publications for SMG9 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PMID: 19417104) Yamashita A. … Ohno S. (Genes Dev. 2009) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Characterization of SMG-9, an essential component of the nonsense- mediated mRNA decay SMG1C complex. (PMID: 20817927) Fernandez I.S. … Llorca O. (Nucleic Acids Res. 2011) 3 4
  5. Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex. (PMID: 21640080) Takeda S. … Konishi H. (Biochem. Biophys. Res. Commun. 2011) 3

Products for SMG9 Gene

Sources for SMG9 Gene

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