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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMG8 Gene

protein-coding   GIFtS: 46
GCID: GC17P057288

SMG8 Nonsense Mediated MRNA Decay Factor

(Previous names: chromosome 17 open reading frame 71, smg-8 homolog, nonsense...)
(Previous symbol: C17orf71)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SMG8 Nonsense Mediated MRNA Decay Factor1 2     Smg-8 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans)1
C17orf711 2 3 5     Protein SMG82
Amplified In Breast Cancer Gene 2 Protein2 3     Smg-8 Homolog, Nonsense Mediated MRNA Decay Factor2
Protein Smg-8 Homolog2 3     ABC23
Chromosome 17 Open Reading Frame 711     

External Ids:    HGNC: 255511   Entrez Gene: 551812   Ensembl: ENSG000001674477   OMIM: 6131755   UniProtKB: Q8ND043   

Export aliases for SMG8 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SMG8 Gene: 
SMG8 (SMG8 nonsense mediated mRNA decay factor) is a protein-coding gene. Diseases associated with SMG8 include breast cancer, and among its related super-pathways are Metabolism of RNA and Nonsense Mediated Decay Independent of the Exon Junction Complex. GO annotations related to this gene include protein binding. An important paralog of this gene is ENSG00000265303.

UniProtKB/Swiss-Prot: SMG8_HUMAN, Q8ND04
Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by
release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and,
in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress
SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator
of kinase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SMG8
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SMG8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMG8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

SMG8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMG8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P057288:  view genomic region     (about GC identifiers)

Start:
57,286,761 bp from pter      End:
57,292,611 bp from pter
Size:
5,851 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SMG8_HUMAN, Q8ND04 (See protein sequence)
Recommended Name: Protein SMG8  
Size: 991 amino acids; 109684 Da
Subunit: Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1
N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic
domain. Forms heterodimers with SMG9; this assembly form may represent a SMG1C intermediate form
Sequence caution: Sequence=AAH20957.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91699.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8N5U5 Q8TDN0 Q9H5P5 Q9NVQ1
Alternative splicing: 3 isoforms:  Q8ND04-1   Q8ND04-2   Q8ND04-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMG8: NX_Q8ND04

Explore proteomics data for SMG8 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by SMG1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8ND04

  • SMG8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SMG8 Protein Expression
    REFSEQ proteins: NP_060619.4  
    ENSEMBL proteins: 
     ENSP00000438748   ENSP00000462119   ENSP00000462931   ENSP00000463175   ENSP00000300917  
    Reactome Protein details: Q8ND04
    Human Recombinant Protein Products for SMG8: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    SMG8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019354 Smg8/Smg9

    Graphical View of Domain Structure for InterPro Entry Q8ND04

    ProtoNet protein and cluster: Q8ND04

    UniProtKB/Swiss-Prot: SMG8_HUMAN, Q8ND04
    Similarity: Belongs to the SMG8 family


    SMG8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMG8_HUMAN, Q8ND04
    Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by
    release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and,
    in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress
    SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator
    of kinase activity

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19417104
         
    SMG8 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SMG8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism of mRNA
    Metabolism of RNA0.92
    Metabolism of mRNA0.92
    2Viral mRNA Translation
    Nonsense-Mediated Decay0.84
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.84
    3Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for SMG8
        Nonsense-Mediated Decay
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression



    SMG8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMG8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/74 Interacting proteins for SMG8 (Q8ND041 ENSP000003009174) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMG9Q9H0W81, ENSP000002700664EBI-3903643,EBI-2872322 STRING: ENSP00000270066
    SMG1ENSP000004025154STRING: ENSP00000402515
    EIF4A3ENSP000002693494STRING: ENSP00000269349
    ETF1ENSP000003537414STRING: ENSP00000353741
    NCBP1ENSP000003642894STRING: ENSP00000364289
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--
    GO:0045859regulation of protein kinase activity IMP19417104

    SMG8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SMG8

    Search CenterWatch for drugs/clinical trials and news about SMG8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SMG8 gene: 
    NM_018149.6  

    Unigene Cluster for SMG8:

    Smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
    Hs.7296  [show with all ESTs]
    Unigene Representative Sequence: AL834490
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543872 ENST00000578922 ENST00000580498 ENST00000582469 ENST00000580798
    ENST00000300917(uc002ixi.3)
    miRNA
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    hsa-miR-200c hsa-miR-429 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidSMG8 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK001449.1 AK026858.1 AL834490.1 BC020957.1 BC031604.1 

    5 DOTS entries:

    DT.448274  DT.100775930  DT.97777244  DT.120930702  DT.100775933 

    24/142 AceView cDNA sequences (see all 142):

    Z46118 BE387356 AI921995 D81364 AI870977 AA027312 Z45623 AA971553 
    BU195636 AL834490 BM796387 NM_018149 AA908771 AA310504 AI191038 BM825889 
    BC020957 AI186560 AI088942 BC031604 BM740153 F01808 BP353147 AI333834 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SMG8    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
    SP1:              -                           
    SP2:                                          


    ECgene alternative splicing isoforms for SMG8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMG8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCGGTATTC
    SMG8 Expression
    About this image


    See SMG8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMG8

    SOURCE GeneReport for Unigene cluster: Hs.7296
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SMG8 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smg81 , 5 RIKEN cDNA 1200011M11 gene5
    smg-8 homolog, nonsense mediated mRNA decay factor more1
    88.87(n)1
    96.06(a)1
      11 (51.89 cM)5
    741331  NM_024262.11  NP_077224.11 
     870777325 
    chicken
    (Gallus gallus)
    Aves SMG81 smg-8 homolog, nonsense mediated mRNA decay factor more 74.75(n)
    87.01(a)
      417630  XM_415875.3  XP_415875.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    81(a)
    1 → many
    AAWZ02037458(3490-16317)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.97762 Xenopus laevis transcribed sequence with weak similarity more 74.76(n)    BG364213.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AI658057.12   -- 73.35(n)    AI658057.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67291 CG6729 44.4(n)
    33.62(a)
      34484  NM_135605.2  NP_609449.1 
    worm
    (Caenorhabditis elegans)
    Secernentea smg-86
    Protein smg-8
    22(a)
    1 → many
    II(14441435-14447219)


    ENSEMBL Gene Tree for SMG8 (if available)
    TreeFam Gene Tree for SMG8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SMG8 gene
    ENSG000002653032  

    SMG8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/237 SNPs in SMG8 are shown (see all 237)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869926831,2
    --57285462(+) TGGGCA/GTGGTG 1 -- us2k10--------
    rs1902215381,2
    --57285491(+) AGCTAC/TTTGGG 1 -- us2k10--------
    rs1414446751,2
    --57285609(+) AGACTC/GTGTCT 1 -- us2k10--------
    rs2013965021,2
    --57285627(+) AAAAA-/GAAAAA 1 -- us2k10--------
    rs753393211,2
    F--57285641(+) TTTTAG/AGCCGG 1 -- us2k11Minor allele frequency- A:0.33NA 6
    rs1463098831,2
    --57285787(+) TAGCCA/GCCCAT 1 -- us2k10--------
    rs1395500361,2
    C--57285925(+) TCTGTC/TTCAAA 1 -- us2k10--------
    rs1441898791,2
    --57285927(+) TGTCTC/GAAAAT 1 -- us2k10--------
    rs1466484201,2
    --57286012(+) TATATA/GTAATA 1 -- us2k10--------
    rs72248191,2
    C,F--57286014(+) tatatA/Gatata 1 -- us2k11Minor allele frequency- G:0.22WA 118

    HapMap Linkage Disequilibrium report for SMG8 (57286761 - 57292611 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SMG8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908644CNV Loss21882294
    dgv3237n71CNV Loss21882294
    nsv833500CNV Loss17160897
    nsv833499CNV Loss17160897
    nsv908649CNV Gain21882294
    dgv995e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613175    OMIM disorders: --

    2 diseases for SMG8:    About MalaCards
    breast cancer    


    SMG8 for disorders           About GeneDecksing


    Export disorders for SMG8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMG8 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SMG8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PubMed id 19417104)1, 2, 3 Yamashita A....Ohno S. (2009)
    2. The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large- scale conformational changes controlled by SMG-8. (PubMed id 21245168)1, 2 Arias-Palomo E.... Llorca O. (2011)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Genome-wide and gene-centric analyses of circulating m yeloperoxidase levels in the charge and care consortia. (PubMed id 23620142)1 Reiner A.P....Allayee H. (2013)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Characterization of SMG-9, an essential component of the nonsense- mediated mRNA decay SMG1C complex. (PubMed id 20817927)2 Fernandez I.S.... Llorca O. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55181 HGNC: 25551 AceView: FLJ10587 Ensembl:ENSG00000167447 euGenes: HUgn55181
    ECgene: SMG8 H-InvDB: SMG8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMG8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SMG8 gene:
    Search GeneIP for patents involving SMG8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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