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Aliases for SMG8 Gene

Aliases for SMG8 Gene

  • SMG8 Nonsense Mediated MRNA Decay Factor 2 3
  • Amplified In Breast Cancer Gene 2 Protein 3 4
  • Protein Smg-8 Homolog 3 4
  • C17orf71 3 4
  • Smg-8 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) 2
  • Smg-8 Homolog, Nonsense Mediated MRNA Decay Factor 3
  • Chromosome 17 Open Reading Frame 71 2
  • Protein SMG8 3
  • C17orf71, 6
  • ABC2 4

External Ids for SMG8 Gene

Previous Symbols for SMG8 Gene

  • C17orf71

Summaries for SMG8 Gene

GeneCards Summary for SMG8 Gene

SMG8 (SMG8 Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Diseases associated with SMG8 include breast cancer. Among its related pathways are Gene Expression and Influenza Viral RNA Transcription and Replication. An important paralog of this gene is ENSG00000265303.

UniProtKB/Swiss-Prot for SMG8 Gene

  • Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMG8 Gene

Genomics for SMG8 Gene

Genomic Location for SMG8 Gene

Start:
59,209,400 bp from pter
End:
59,215,250 bp from pter
Size:
5,851 bases
Orientation:
Plus strand

Genomic View for SMG8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMG8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMG8 Gene

No data available for Regulatory Elements for SMG8 Gene

Proteins for SMG8 Gene

  • Protein details for SMG8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND04-SMG8_HUMAN
    Recommended name:
    Protein SMG8
    Protein Accession:
    Q8ND04
    Secondary Accessions:
    • Q8N5U5
    • Q8TDN0
    • Q9H5P5
    • Q9NVQ1

    Protein attributes for SMG8 Gene

    Size:
    991 amino acids
    Molecular mass:
    109684 Da
    Quaternary structure:
    • Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Forms heterodimers with SMG9; this assembly form may represent a SMG1C intermediate form.
    SequenceCaution:
    • Sequence=AAH20957.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91699.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SMG8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMG8 Gene

Proteomics data for SMG8 Gene at MOPED

Post-translational modifications for SMG8 Gene

Other Protein References for SMG8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SMG8 Gene

Domains for SMG8 Gene

Protein Domains for SMG8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMG8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8ND04

UniProtKB/Swiss-Prot:

SMG8_HUMAN
Family:
  • Belongs to the SMG8 family.:
    • Q8ND04
genes like me logo Genes that share domains with SMG8: view

No data available for Gene Families for SMG8 Gene

Function for SMG8 Gene

Molecular function for SMG8 Gene

UniProtKB/Swiss-Prot Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

Gene Ontology (GO) - Molecular Function for SMG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19417104
genes like me logo Genes that share ontologies with SMG8: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SMG8 Gene

Localization for SMG8 Gene

Gene Ontology (GO) - Cellular Components for SMG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SMG8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for SMG8 Gene

Pathways for SMG8 Gene

genes like me logo Genes that share pathways with SMG8: view

Pathways by source for SMG8 Gene

Gene Ontology (GO) - Biological Process for SMG8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
GO:0016071 mRNA metabolic process --
GO:0045859 regulation of protein kinase activity IMP 19417104
genes like me logo Genes that share ontologies with SMG8: view

Transcripts for SMG8 Gene

mRNA/cDNA for SMG8 Gene

Unigene Clusters for SMG8 Gene

Smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMG8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2:

Relevant External Links for SMG8 Gene

GeneLoc Exon Structure for
SMG8
ECgene alternative splicing isoforms for
SMG8

Expression for SMG8 Gene

mRNA expression in normal human tissues for SMG8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMG8 Gene

SOURCE GeneReport for Unigene cluster for SMG8 Gene Hs.7296

genes like me logo Genes that share expressions with SMG8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMG8 Gene

Orthologs for SMG8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMG8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMG8 35
  • 99.76 (n)
  • 99.8 (a)
SMG8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SMG8 35
  • 92.13 (n)
  • 96.87 (a)
dog
(Canis familiaris)
Mammalia SMG8 35
  • 93.04 (n)
  • 97.58 (a)
mouse
(Mus musculus)
Mammalia Smg8 35
  • 88.87 (n)
  • 96.06 (a)
Smg8 16
Smg8 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Smg8 35
  • 88.53 (n)
  • 95.36 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 85 (a)
OneToMany
SMG8 35
  • 74.48 (n)
  • 86.44 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.9776 35
tropical clawed frog
(Silurana tropicalis)
Amphibia smg8 35
  • 70.01 (n)
  • 76.96 (a)
zebrafish
(Danio rerio)
Actinopterygii smg8 35
  • 65.18 (n)
  • 73.08 (a)
smg8 36
  • 69 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010179 35
  • 42.76 (n)
  • 32.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6729 35
  • 44.24 (n)
  • 33.85 (a)
CG6729 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea smg-8 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for SMG8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMG8 Gene

ENSEMBL:
Gene Tree for SMG8 (if available)
TreeFam:
Gene Tree for SMG8 (if available)

Paralogs for SMG8 Gene

Paralogs for SMG8 Gene

genes like me logo Genes that share paralogs with SMG8: view

Variants for SMG8 Gene

Sequence variations from dbSNP and Humsavar for SMG8 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs998343 -- 59,211,293(-) TGCCA(C/T)AGGAA reference, synonymous-codon
rs3060946 -- 59,211,215(+) CGACA(-/ACA)ACTTT cds-indel
rs3744383 -- 59,213,022(-) TTTGG(C/T)CTCTT synonymous-codon, reference
rs4584889 -- 59,211,544(+) AGAAA(A/G)CCGAT reference, missense
rs6503905 -- 59,210,093(+) GGAGC(A/G)TCAGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SMG8 Gene

Variant ID Type Subtype PubMed ID
nsv908644 CNV Loss 21882294
nsv833499 CNV Loss 17160897
dgv995e1 CNV Complex 17122850
dgv3237n71 CNV Loss 21882294
nsv833500 CNV Loss 17160897
nsv908649 CNV Gain 21882294

Relevant External Links for SMG8 Gene

HapMap Linkage Disequilibrium report
SMG8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMG8 Gene

Disorders for SMG8 Gene

(1) MalaCards Diseases for SMG8 Gene

Search for SMG8 Gene in MalaCards »
genes like me logo Genes that share disorders with SMG8: view

No data available for UniProtKB/Swiss-Prot for SMG8 Gene

Publications for SMG8 Gene

  1. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PMID: 19417104) Yamashita A. … Ohno S. (Genes Dev. 2009) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large- scale conformational changes controlled by SMG-8. (PMID: 21245168) Arias-Palomo E. … Llorca O. (Genes Dev. 2011) 3 4
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for SMG8 Gene

Sources for SMG8 Gene

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