SMG8 Gene
protein-coding GIFtS: 45
GCID: GC17P057288
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smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)(Previous name: chromosome 17 open reading frame 71 )
(Previous symbol: C17orf71)
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Aliases
for SMG8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Smg-8 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans)1 2 | | FLJ232051 | | C17orf711 2 3 5 | | Chromosome 17 Open Reading Frame 711 | | Amplified In Breast Cancer Gene 2 Protein2 3 | | Protein SMG82 | | Protein Smg-8 Homolog2 3 | | ABC23 | | FLJ105871 | | |
Export aliases for SMG8 gene to outside databases |
Summaries
for SMG8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SMG8_HUMAN, Q8ND04Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by releasefactors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1Ccomplex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinaseactivity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinaseactivity
|
Genomic Views
for SMG8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SMG8
Other transcription factors
Search SABiosciences Chromatin IP Primers for SMG8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMG8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q23.2SMG8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P057288: view genomic region
(about GC identifiers)
Start:
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57,286,761 bp from pter |
End:
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57,292,611 bp from pter |
Size:
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5,851 bases |
Orientation:
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plus strand |
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Proteins
for SMG8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMG8_HUMAN, Q8ND04 (See
protein sequence)Recommended Name: Protein SMG8 Size: 991 amino acids; 109684 Da
Subunit: Component of the SMG1C complex composed of SMG1, SMG8 and SMG9; the recruitment of SMG8 to SMG1 N-terminusinduces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain. Formsheterodimers with SMG9; this assembly form may represent a SMG1C intermediate form
Sequence caution: Sequence=AAH20957.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAA91699.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8N5U5 Q8TDN0 Q9H5P5 Q9NVQ1Alternative splicing: 3 isoforms: Q8ND04-1 Q8ND04-2 Q8ND04-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SMG8: NX_Q8ND04
Post-translational modifications:
Phosphorylated by SMG11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8ND04
SMG8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060619.4
ENSEMBL proteins: ENSP00000438748 ENSP00000462119 ENSP00000462931 ENSP00000463175 ENSP00000300917 Reactome Protein details: Q8ND04
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SMG8 for ontologies About GeneDecksing
SMG8 Antibody Products:
Assay Products for SMG8: |
Protein
Domains /
Families
for SMG8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SMG8 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8ND04ProtoNet protein and cluster: Q8ND04 UniProtKB/Swiss-Prot: SMG8_HUMAN, Q8ND04Similarity: Belongs to the SMG8 family |
Function
for SMG8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SMG8_HUMAN, Q8ND04Function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by releasefactors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1Ccomplex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinaseactivity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinaseactivity
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMG8 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SMG8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMG8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMG8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
SMG8 for ontologies About GeneDecksing
|
Pathways & Interactions
for SMG8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Metabolism of mRNA | | | 3 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 
Reactome Pathways for SMG8 (see all 6)
SMG8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMG8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/74 Interacting proteins for SMG8 (Q8ND041 ENSP000003009174) via UniProtKB, MINT, STRING, and/or I2D (see all 74)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SMG8 for ontologies About GeneDecksing
|
Drugs & Compounds
for SMG8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SMG8
Search CenterWatch for drugs/clinical trials and news about SMG8
|
Transcripts
for SMG8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SMG8 gene: NM_018149.6 Unigene Cluster for SMG8: Smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans) Hs.7296 [show with all ESTs]Unigene Representative Sequence: AL8344906 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000543872 ENST00000578922 ENST00000580498 ENST00000582469 ENST00000580798
ENST00000300917(uc002ixi.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMG8 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMG8 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SMG8 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMG8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMG8 |
Additional cDNA sequence: AK001449.1 AK026858.1 AL834490.1 BC020957.1 BC031604.1 5 DOTS entries: DT.448274 DT.100775930 DT.97777244 DT.120930702 DT.100775933 24/142 AceView cDNA sequences (see all 142): AL834490 BM796387 AI088942 AI884492 AW079908 BM825889 F04521 F01808 Z46118 AA825342 Z45623 BC020957 NM_018149 AI333834 BE387356 AA971553 AI921995 D81364 AI870977 AA027312 BU195636 BC031604 AW069065 AI191038
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for SMG8 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 |
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| SP1: | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SMG8
|
Expression
for SMG8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMG8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCGGTATTC
About this image
See SMG8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMG8
SOURCE GeneReport for Unigene cluster: Hs.7296
SABiosciences Custom PCR Arrays for SMG8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMG8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMG8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMG8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMG8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMG8 |
Orthologs
for SMG8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SMG8 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for SMG8 (if available)
TreeFam Gene Tree for SMG8 (if available) |
Paralogs
for SMG8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SMG8 gene
- ENSG000002653032
SMG8 for paralogs About GeneDecksing
|
Genomic Variants
for SMG8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SMG8 (57286761 - 57292611 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SMG8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMG8 |
|
Disorders
/ Diseases
for SMG8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SMG8 for disorders About GeneDecksing
OMIM gene information: 613175
OMIM disorders: --
1  disease for SMG8: About MalaCardsbreast cancer
Export disorders for SMG8 gene to outside databases
|
Publications
for SMG8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMG8 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SMG8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. (PubMed id 19417104)1, 2, 3 Yamashita A....Ohno S. (2009)
- The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large- scale conformational changes controlled by SMG-8. (PubMed id 21245168)1, 2 Arias-Palomo E.... Llorca O. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Characterization of SMG-9, an essential component of the nonsense- mediated mRNA decay SMG1C complex. (PubMed id 20817927)2 Fernandez I.S.... Llorca O. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for SMG8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SMG8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SMG8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SMG8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SMG8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SMG8 gene:
Search GeneIP for patents involving SMG8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SMG8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SMG8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMG8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMG8 | | | OriGene Protein Over-expression Lysate for SMG8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SMG8 | | OriGene 3'-UTR Clone for SMG8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMG8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMG8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SMG8 | | OriGene Custom Protein Services for SMG8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMG8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMG8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMG8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMG8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMG8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMG8 |
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| | | | Search Tocris compounds for SMG8 |
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 | | | SMG8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMG8 |
|  |  |  | | | | ThermoFisher Antibodies for SMG8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMG8 |
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