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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SMG7 Gene

protein-coding GIFtS: 53
GCID: GC01P183441

smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)

(Previous name: chromosome 1 open reading frame 16 )
(Previous symbol: C1orf16)

Explore 5 diseases affiliated with
SMG7 via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Smg-7 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans)¹ ²		Chromosome 1 Open Reading Frame 16¹
EST1C¹ ² ³ ⁵		Breast Cancer-Associated Antigen SGA-56M²
C1orf16¹ ² ³		EST1 Telomerase Component Homolog C²
KIAA0250¹ ³ ⁵		Ever Shorter Telomeres 1C²
SGA56M¹ ²		Protein SMG7²
EST1-Like Protein C² ³		HSMG-7¹
SMG-7¹		SMG-7 Homolog³

External Ids:	HGNC: 16792¹	Entrez Gene: 9887²	Ensembl: ENSG00000116698⁷	OMIM: 610964⁵	UniProtKB: Q92540³

Export aliases for SMG7 gene to outside databases

Previous GC identifers: GC01P181708 GC01P154678

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SMG7:

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts

with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex

consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought

to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This

protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts.

Alternative splicing results in multiple transcript variants encoding distinct isoforms. (provided by RefSeq, Aug

2011)

UniProtKB/Swiss-Prot: SMG7_HUMAN, Q92540

Function: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with

SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as

an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation

Gene Wiki entry for SMG7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SMG7 gene promoter:
Bach1 TBP p53 AML1a Pbx1a Evi-1 Egr-4 HSF2 ZID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SMG7 promoter sequence

Search SABiosciences Chromatin IP Primers for SMG7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMG7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q25

SMG7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMG7 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P183441: view genomic region (about GC identifiers)

Start:	183,441,351 bp from pter	End:	183,567,381 bp from pter
Size:	126,031 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SMG7_HUMAN, Q92540 (See protein sequence)

Recommended Name: Protein SMG7

Size: 1137 amino acids; 127282 Da

Subunit: Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform

UPF3AL) and phosphorylated UPF1

Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and

cytoplasm

Sequence caution: Sequence=BAA13381.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

1 PDB 3D structure from and Proteopedia for SMG7:

1YA0 (3D)

Secondary accessions: Q5T1Q0 Q6PIE0 Q7Z7H9 Q8IXC1 Q8IXC2

Alternative splicing: 3 isoforms: Q92540-1 Q92540-2 Q92540-4

Explore the universe of human proteins at neXtProt for SMG7: NX_Q92540

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92540

SMG7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001167532.1 NP_775179.1 NP_963862.1 NP_963863.2

ENSEMBL proteins:

ENSP00000410254 ENSP00000356507 ENSP00000422742 ENSP00000426915 ENSP00000400220

ENSP00000388390 ENSP00000340766 ENSP00000425133 ENSP00000421358 ENSP00000422056

ENSP00000407629

Reactome Protein details: Q92540
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	Uscn Proteins for SMG7

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	14636577
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0045111	intermediate filament cytoskeleton	IDA	--

SMG7 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SMG7 for domains About GeneDecksing

3 InterPro domains/families:

IPR011990 TPR-like_helical

IPR018834 DNA/RNA-bd_Est1-type

IPR019458 EST1

Graphical View of Domain Structure for InterPro Entry Q92540

ProtoNet protein and cluster: Q92540

UniProtKB/Swiss-Prot: SMG7_HUMAN, Q92540

Similarity: Contains 2 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SMG7_HUMAN, Q92540

Function: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with

SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as

an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SMG7 Browse MicroRNA Expression Plasmids
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		hsa-miR-21* hsa-miR-320a hsa-miR-4291 hsa-miR-3673 hsa-miR-517a hsa-miR-517c hsa-miR-629* hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: SMG7 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMG7

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14636577
GO:0051721	protein phosphatase 2A binding	IDA	14636577

SMG7 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

	SMG6 Cleaves mRNA with Premature Termination Codon	0.80			Nonsense Mediated Decay Enhanced by the Exon Junction Complex	0.77
	Nonsense-Mediated Decay	0.77			Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A	0.77

Metabolism of mRNA

Metabolism of mRNA

1.00

Metabolism of RNA

0.92

Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex

Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex

1.00

mRNA surveillance pathway

mRNA surveillance pathway

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for SMG7 (see all 8)

	Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex
	Nonsense-Mediated Decay
	SMG6 Cleaves mRNA with Premature Termination Codon
	Nonsense Mediated Decay Enhanced by the Exon Junction Complex
	Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A

1 Kegg Pathway (Kegg details for SMG7):

mRNA surveillance pathway

SMG7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SMG7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/133 Interacting proteins for SMG7 (Q92540^{2, 3} ENSP00000340766⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 133)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMG5	Q9UPR3²^,³, ENSP00000355261⁴	MINT-8415355 I2D: score=3 STRING: ENSP00000355261
UPF1	Q92900³, ENSP00000262803⁴	I2D: score=2 STRING: ENSP00000262803
RPL5	P46777², ENSP00000359345⁴	MINT-8415355 STRING: ENSP00000359345
FGFR3	P22607³	I2D: score=4
NFKB1	P19838³	I2D: score=2

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	--
GO:0006406	mRNA export from nucleus	TAS	16488880
GO:0010467	gene expression	TAS	--
GO:0016070	RNA metabolic process	TAS	--
GO:0016071	mRNA metabolic process	TAS	--

SMG7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SMG7
Search CenterWatch for drugs/clinical trials and news about SMG7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SMG7 gene (5 alternative transcripts):

NM_001174061.1 NM_173156.2 NM_201568.2 NM_201569.2 NM_014837.3

Unigene Cluster for SMG7:

Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)

Hs.591463 [show with all ESTs]

Unigene Representative Sequence: NM_001174061

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000440812 ENST00000367537(uc010pob.2 uc001gqf.3 uc001gqh.3 uc010poc.2)

ENST00000507691 ENST00000508461 ENST00000444547 ENST00000419169 ENST00000347615(uc001gqg.3)

ENST00000507469 ENST00000515829 ENST00000367538 ENST00000502375 ENST00000493609

ENST00000507406 ENST00000493045 ENST00000495321 ENST00000456731(uc021pga.1)

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		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate SMG7 (see all 29):
		hsa-miR-21* hsa-miR-320a hsa-miR-4291 hsa-miR-3673 hsa-miR-517a hsa-miR-517c hsa-miR-629* hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: SMG7 3' UTR sequence

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Additional cDNA sequence:

AB085674.1 AK056035.1 AK074297.1 AK091477.1 AK297207.1 AK299178.1 AK307394.1 AL833675.1

AY386363.1 BC009281.2 BC015788.1 BC036381.1 BC052565.1 D87437.2

16 DOTS entries:

DT.418190 DT.100823914 DT.100717574 DT.95279202 DT.86847465 DT.121377214 DT.100823915 DT.121377184

DT.100029452 DT.100734427 DT.100656508 DT.40108564 DT.65284174 DT.86847464 DT.95279197 DT.95279210

24/348 AceView cDNA sequences (see all 348):

AU123452 AI695679 BU149856 CD626208 BF509873 BQ008704 CR596132 BM793100

AA431827 BX399305 BQ053135 AI198685 BU628503 BG403389 BU501197 BC009281

BQ221879 AL537588 BM982134 CB045657 AK056035 AL043077 AI301791 W93161

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SMG7 (see all 9) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17a	·	17b	^	18a	·
SP1:											-						-						-																										-
SP2:											-						-						-																										-
SP3:																	-						-
SP4:					-		-				-						-						-																										-
SP5:																	-

ExUns:	18b	^	19	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25	^	26a	·	26b
SP1:	-																		-
SP2:	-								-
SP3:	-								-
SP4:	-
SP5:

ECgene alternative splicing isoforms for SMG7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SMG7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTCTCCAA

About this image
See SMG7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMG7

SOURCE GeneReport for Unigene cluster: Hs.591463

SABiosciences Custom PCR Arrays for SMG7

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMG7 gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Smg7^{1 , 5}	Smg-7 homolog, nonsense mediated mRNA decay factor more^{1, 5}	93.7(n)¹ 96.19(a)¹		1 (65.07 cM)⁵ 226517¹ NM_001160256.1¹ NP_001153728.1¹ 152836996⁵
chicken (Gallus gallus)	Aves	SMG7¹	Smg-7 homolog, nonsense mediated mRNA decay factor more	84.96(n) 91.13(a)		424444 XM_422287.3 XP_422287.3
lizard (Anolis carolinensis)	Reptilia	SMG7⁶	--	87(a)	1 ↔ 1	GL343203.1(4100711-4149504)
African clawed frog (Xenopus laevis)	Amphibia	BJ065114.1²	--	77.81(n)		BJ065114.1
zebrafish (Danio rerio)	Actinopterygii	57051491²	--	78.55(n)		57051491
honey bee (Apis mellifera)	Insecta	--	--	24(a)	1 ↔ 1	GroupUn.5696(1473-5921)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G28260⁶ SMG7⁶	Telomerase activating protein Est1	13(a) 12(a)	many ↔ many many ↔ many	1(9875600-9879267) 5(6540003-6545015)
rice (Oryza sativa)	Liliopsida	--	cig3, putative, expressed	14(a)	1 → many	8(12722126-12730478)

ENSEMBL Gene Tree for SMG7 (if available)
TreeFam Gene Tree for SMG7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SMG7 gene

SMG5² SMG6²

1 SIMAP similar gene for SMG7 using alignment to 10 protein entries: SMG7_HUMAN (see all proteins):

SGA56M

SMG7 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145118457^1,2		--	183439531(+)	`ATTTCG/TTTAAT`	5	--	us2k¹ int¹		0	--	--	--	--
rs113765994^1,2		--	183439546(+)	`ATCTGC/TCCTTG`	5	--	int¹ us2k¹		1		CSA	2
rs185225132^1,2		--	183439626(+)	`GGTATA/GGTCTT`	5	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs77996280^1,2	F,	--	183439788(+)	`TGGAAG/AGTTTT`	5	--	us2k¹ int¹		1		NA	4
rs74598524^1,2	F,	--	183439985(+)	`GACACA/GAAACA`	5	--	us2k¹ nc-transcript-variant		1		NA	120
rs184188264^1,2		--	183440046(+)	`CTAGAC/TTCCTT`	5	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs186604665^1,2		--	183440198(+)	`ACTTGA/GAGGTC`	5	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs41272536^1,2	F,	--	183440531(+)	`GCCCAA/GGGCAG`	5	--	us2k¹ nc-transcript-variant		1		NA	120
rs191968096^1,2		--	183440557(+)	`TTGCCC/TTTCCT`	5	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs182510350^1,2		--	183440563(+)	`TTCCTC/TGCCGC`	5	--	nc-transcript-variantus2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SMG7 (183441351 - 183567381 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SMG7: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SMG7 for disorders           About GeneDecksing

OMIM gene information: 610964    OMIM disorders: --

5 diseases for SMG7:    About MalaCards

breast cancer hepatitis b prostate cancer hepatitis

prostatitis

Human Genome Epidemiology (HuGE) Navigator: SMG7 (1 document)

Export disorders for SMG7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SMG7 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with SMG7)

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world of online information

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. (PubMed id 15721257)^{1, 2, 3, 9} Fukuhara N....Conti E. (2005)
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. (PubMed id 14636577)^{1, 2, 3, 9} Ohnishi T.... Ohno S. (2003)
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. (PubMed id 15546618)^{1, 2, 9} Unterholzner L. and Izaurralde E. (2004)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2} Nagase T....Nomura N. (1996)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9887	HGNC: 16792	AceView: C1orf16	Ensembl:ENSG00000116698	euGenes: HUgn9887
ECgene: SMG7	Kegg: 9887	H-InvDB: SMG7

(According to HUGE)
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HUGE: KIAA0250

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SMG7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SMG7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SMG7 gene:
Search GeneIP for patents involving SMG7

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)

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SMG7 Gene

smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)

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