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Aliases for SMG7 Gene

Aliases for SMG7 Gene

  • SMG7 Nonsense Mediated MRNA Decay Factor 2 3 5
  • EST1-Like Protein C 3 4
  • C1orf16 3 4
  • EST1C 3 4
  • Smg-7 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) 2
  • EST1 Telomerase Component Homolog C (S. Cerevisiae) 2
  • Smg-7 Homolog, Nonsense Mediated MRNA Decay Factor 3
  • Breast Cancer-Associated Antigen SGA-56M 3
  • EST1 Telomerase Component Homolog C 3
  • Chromosome 1 Open Reading Frame 16 2
  • Ever Shorter Telomeres 1C 3
  • SMG-7 Homolog 4
  • KIAA0250 4
  • SGA56M 3
  • HSMG-7 4

External Ids for SMG7 Gene

Previous HGNC Symbols for SMG7 Gene

  • C1orf16

Previous GeneCards Identifiers for SMG7 Gene

  • GC01P181708
  • GC01P154678

Summaries for SMG7 Gene

Entrez Gene Summary for SMG7 Gene

  • This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

GeneCards Summary for SMG7 Gene

SMG7 (SMG7 Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA surveillance pathway. GO annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is SMG5.

UniProtKB/Swiss-Prot for SMG7 Gene

  • Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.

Gene Wiki entry for SMG7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMG7 Gene

Genomics for SMG7 Gene

Regulatory Elements for SMG7 Gene

Genomic Location for SMG7 Gene

Chromosome:
1
Start:
183,472,216 bp from pter
End:
183,598,246 bp from pter
Size:
126,031 bases
Orientation:
Plus strand

Genomic View for SMG7 Gene

Genes around SMG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMG7 Gene

Proteins for SMG7 Gene

  • Protein details for SMG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92540-SMG7_HUMAN
    Recommended name:
    Protein SMG7
    Protein Accession:
    Q92540
    Secondary Accessions:
    • B4DRB2
    • E9PCI0
    • E9PEH2
    • Q5T1Q0
    • Q6PIE0
    • Q7Z7H9
    • Q8IXC1
    • Q8IXC2

    Protein attributes for SMG7 Gene

    Size:
    1137 amino acids
    Molecular mass:
    127282 Da
    Quaternary structure:
    • Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1.
    SequenceCaution:
    • Sequence=BAA13381.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SMG7 Gene

    Alternative splice isoforms for SMG7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMG7 Gene

Proteomics data for SMG7 Gene at MOPED

Post-translational modifications for SMG7 Gene

  • Ubiquitination at Lys 66, Lys 77, Lys 438, and Lys 817
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SMG7 Gene

Domains & Families for SMG7 Gene

Protein Domains for SMG7 Gene

Graphical View of Domain Structure for InterPro Entry

Q92540

UniProtKB/Swiss-Prot:

SMG7_HUMAN :
  • Contains 2 TPR repeats.
Similarity:
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with SMG7: view

No data available for Gene Families for SMG7 Gene

Function for SMG7 Gene

Molecular function for SMG7 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.

Gene Ontology (GO) - Molecular Function for SMG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 14636577
genes like me logo Genes that share ontologies with SMG7: view

Phenotypes for SMG7 Gene

genes like me logo Genes that share phenotypes with SMG7: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMG7 Gene

Localization for SMG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMG7 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMG7 Gene COMPARTMENTS Subcellular localization image for SMG7 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SMG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 14636577
genes like me logo Genes that share ontologies with SMG7: view

Pathways & Interactions for SMG7 Gene

genes like me logo Genes that share pathways with SMG7: view

Pathways by source for SMG7 Gene

Gene Ontology (GO) - Biological Process for SMG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS 16488880
genes like me logo Genes that share ontologies with SMG7: view

No data available for SIGNOR curated interactions for SMG7 Gene

Drugs & Compounds for SMG7 Gene

No Compound Related Data Available

Transcripts for SMG7 Gene

Unigene Clusters for SMG7 Gene

Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMG7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a ·
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - - -
SP5: -
SP6: -
SP7: -
SP8:
SP9:

ExUns: 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SMG7 Gene

GeneLoc Exon Structure for
SMG7
ECgene alternative splicing isoforms for
SMG7

Expression for SMG7 Gene

mRNA expression in normal human tissues for SMG7 Gene

Protein differential expression in normal tissues from HIPED for SMG7 Gene

This gene is overexpressed in Plasma (28.7), Spleen (7.3), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMG7 Gene



SOURCE GeneReport for Unigene cluster for SMG7 Gene Hs.591463

genes like me logo Genes that share expression patterns with SMG7: view

Protein tissue co-expression partners for SMG7 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMG7 Gene

Orthologs for SMG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMG7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMG7 35
  • 94.52 (n)
  • 96.13 (a)
SMG7 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMG7 35
  • 95.01 (n)
  • 96.63 (a)
SMG7 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smg7 35
  • 93.3 (n)
  • 95.15 (a)
Smg7 16
Smg7 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMG7 35
  • 99.79 (n)
  • 99.82 (a)
SMG7 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smg7 35
  • 92.82 (n)
  • 95.93 (a)
oppossum
(Monodelphis domestica)
Mammalia SMG7 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMG7 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMG7 35
  • 84.1 (n)
  • 89.68 (a)
SMG7 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMG7 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76113 35
smg7 35
  • 69.42 (n)
  • 72.56 (a)
zebrafish
(Danio rerio)
Actinopterygii smg7 35
  • 67.79 (n)
  • 71.21 (a)
smg7 36
  • 66 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9583 35
Species with no ortholog for SMG7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMG7 Gene

ENSEMBL:
Gene Tree for SMG7 (if available)
TreeFam:
Gene Tree for SMG7 (if available)

Paralogs for SMG7 Gene

Paralogs for SMG7 Gene

(1) SIMAP similar genes for SMG7 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SMG7: view

Variants for SMG7 Gene

Sequence variations from dbSNP and Humsavar for SMG7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34221194 - 183,544,390(+) AGTGT(C/T)TGAAG reference, missense
rs2298083 - 183,546,293(+) CAGGA(A/G)TCTTC reference, missense
rs140840 -- 183,515,271(-) TTCCT(-/AA)GATAC intron-variant
rs15929 -- 183,545,159(+) CCACC(C/T)TCCCA reference, synonymous-codon
rs699245 -- 183,552,148(+) GGGCC(C/T)TCCGG intron-variant, utr-variant-3-prime

Variation tolerance for SMG7 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.99; 87.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMG7 Gene

HapMap Linkage Disequilibrium report
SMG7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMG7 Gene

Disorders for SMG7 Gene

Relevant External Links for SMG7

Human Genome Epidemiology (HuGE) Navigator
SMG7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMG7

No disorders were found for SMG7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMG7 Gene

Publications for SMG7 Gene

  1. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. (PMID: 15721257) Fukuhara N. … Conti E. (Mol. Cell 2005) 2 3 4 23 67
  2. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. (PMID: 14636577) Ohnishi T. … Ohno S. (Mol. Cell 2003) 2 3 23
  3. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. (PMID: 15546618) Unterholzner L. … Izaurralde E. (Mol. Cell 2004) 3 23
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SMG7 Gene

Sources for SMG7 Gene

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