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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMG7 Gene

protein-coding   GIFtS: 55
GCID: GC01P183441

SMG7 Nonsense Mediated MRNA Decay Factor

(Previous names: chromosome 1 open reading frame 16, smg-7 homolog, nonsense...)
(Previous symbol: C1orf16)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SMG7 Nonsense Mediated MRNA Decay Factor1 2     SGA56M2
C1orf161 2 3     Breast Cancer-Associated Antigen SGA-56M2
EST1C2 3 5     EST1 Telomerase Component Homolog C2
EST1-Like Protein C2 3     Ever Shorter Telomeres 1C2
KIAA02503 5     Protein SMG72
Chromosome 1 Open Reading Frame 161     Smg-7 Homolog, Nonsense Mediated MRNA Decay Factor2
EST1 Telomerase Component Homolog C (S. Cerevisiae)1     hSMG-73
Smg-7 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans)1     SMG-7 Homolog3

External Ids:    HGNC: 167921   Entrez Gene: 98872   Ensembl: ENSG000001166987   OMIM: 6109645   UniProtKB: Q925403   

Export aliases for SMG7 gene to outside databases

Previous GC identifers: GC01P181708 GC01P154678


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SMG7 Gene:
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby
transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The
mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of
this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with
the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the
degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding
distinct isoforms. (provided by RefSeq, Aug 2011)

GeneCards Summary for SMG7 Gene: 
SMG7 (SMG7 nonsense mediated mRNA decay factor) is a protein-coding gene. Diseases associated with SMG7 include breast cancer, and hepatitis b, and among its related super-pathways are Metabolism of RNA and Nonsense Mediated Decay Independent of the Exon Junction Complex. GO annotations related to this gene include protein binding and protein phosphatase 2A binding. An important paralog of this gene is SMG5.

UniProtKB/Swiss-Prot: SMG7_HUMAN, Q92540
Function: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together
with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and
to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation

Gene Wiki entry for SMG7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SMG7 gene promoter:
         Bach1   TBP   p53   AML1a   Pbx1a   Evi-1   Egr-4   HSF2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMG7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SMG7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMG7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

SMG7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMG7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P183441:  view genomic region     (about GC identifiers)

Start:
183,441,351 bp from pter      End:
183,567,381 bp from pter
Size:
126,031 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SMG7_HUMAN, Q92540 (See protein sequence)
Recommended Name: Protein SMG7  
Size: 1137 amino acids; 127282 Da
Subunit: Part of a complex that contains SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not
isoform UPF3AL) and phosphorylated UPF1
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus
and cytoplasm
Sequence caution: Sequence=BAA13381.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for SMG7:
1YA0 (3D)    
Secondary accessions: B4DRB2 E9PCI0 E9PEH2 Q5T1Q0 Q6PIE0 Q7Z7H9 Q8IXC1 Q8IXC2
Alternative splicing: 4 isoforms:  Q92540-1   Q92540-2   Q92540-4   Q92540-5   (Ref.5 (AAH36381) sequence is in conflict in positions: 854:V->I, 898:P->T)

Explore the universe of human proteins at neXtProt for SMG7: NX_Q92540

Explore proteomics data for SMG7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92540

  • SMG7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SMG7 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001167532.1  NP_775179.1  NP_963862.1  NP_963863.2  

    ENSEMBL proteins: 
     ENSP00000410254   ENSP00000356507   ENSP00000422742   ENSP00000426915   ENSP00000400220  
     ENSP00000388390   ENSP00000340766   ENSP00000425133   ENSP00000421358   ENSP00000422056  
     ENSP00000407629  
    Reactome Protein details: Q92540
    Human Recombinant Protein Products for SMG7: 
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    Cloud-Clone Corp. Proteins for SMG7 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14636577
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0045111intermediate filament cytoskeleton IDA--

    SMG7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR018834 DNA/RNA-bd_Est1-type
     IPR019458 EST1

    Graphical View of Domain Structure for InterPro Entry Q92540

    ProtoNet protein and cluster: Q92540

    UniProtKB/Swiss-Prot: SMG7_HUMAN, Q92540
    Similarity: Contains 2 TPR repeats


    SMG7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMG7_HUMAN, Q92540
    Function: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together
    with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and
    to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14636577
    GO:0051721protein phosphatase 2A binding IDA14636577
         
    SMG7 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidSMG7 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SMG7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism of mRNA
    Metabolism of RNA0.92
    Metabolism of mRNA0.92
    2Viral mRNA Translation
    Nonsense-Mediated Decay0.84
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.84
    3Generic Transcription Pathway
    Gene Expression0.47
    4mRNA surveillance pathway
    mRNA surveillance pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for SMG7
        Nonsense-Mediated Decay
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    1         Kegg Pathway  (Kegg details for SMG7):
        mRNA surveillance pathway


    SMG7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SMG7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/146 Interacting proteins for SMG7 (Q925402, 3 ENSP000003407664) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMG5Q9UPR32, 3, ENSP000003552614MINT-8415355 I2D: score=3 STRING: ENSP00000355261
    UPF1Q929003, ENSP000002628034I2D: score=2 STRING: ENSP00000262803
    RPL5P467772, ENSP000003593454MINT-8415355 STRING: ENSP00000359345
    FGFR3P226073I2D: score=4 
    NFKB1P198383I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS16488880
    GO:0006406mRNA export from nucleus TAS16488880
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    SMG7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SMG7

    Search CenterWatch for drugs/clinical trials and news about SMG7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SMG7 gene (5 alternative transcripts): 
    NM_001174061.1  NM_173156.2  NM_201568.2  NM_201569.2  NM_014837.3  

    Unigene Cluster for SMG7:

    Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
    Hs.591463  [show with all ESTs]
    Unigene Representative Sequence: NM_001174061
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440812 ENST00000367537(uc010pob.2 uc001gqf.3 uc001gqh.3 uc010poc.2)
    ENST00000507691 ENST00000508461 ENST00000444547 ENST00000419169 ENST00000347615(uc001gqg.3)
    ENST00000507469 ENST00000515829 ENST00000367538 ENST00000502375 ENST00000493609
    ENST00000507406 ENST00000493045 ENST00000495321 ENST00000456731(uc021pga.1)

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    hsa-miR-21* hsa-miR-320a hsa-miR-4291 hsa-miR-3673 hsa-miR-517a hsa-miR-517c hsa-miR-629* hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidSMG7 3' UTR sequence
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    Additional mRNA sequence: 

    AB085674.1 AK056035.1 AK074297.1 AK091477.1 AK297207.1 AK299178.1 AK307394.1 AL833675.1 
    AY386363.1 BC009281.2 BC015788.1 BC036381.1 BC052565.1 D87437.2 

    16 DOTS entries:

    DT.418190  DT.100823914  DT.100717574  DT.95279202  DT.86847465  DT.121377214  DT.100823915  DT.121377184 
    DT.100029452  DT.100734427  DT.100656508  DT.40108564  DT.65284174  DT.86847464  DT.95279197  DT.95279210 

    24/348 AceView cDNA sequences (see all 348):

    CB215144 BU628503 AI198685 BG403389 BE503674 CR602776 BF509873 CN479993 
    CD626208 BM982134 AW473678 AU100200 CB045657 BM917038 BQ008704 CR596132 
    BU149856 NM_014837 AU123452 BG231724 AI695679 NM_201568 AA282419 AK091477 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SMG7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a ·
    SP1:                                -                 -                 -                                                                             -         
    SP2:                                -                 -                 -                                                                             -         
    SP3:                                                  -                 -                                                                                       
    SP4:              -     -           -                 -                 -                                                                             -         
    SP5:                                                  -                                                                                                         

    ExUns: 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
    SP1:  -                                                     -         
    SP2:  -                       -                                       
    SP3:  -                       -                                       
    SP4:  -                                                               
    SP5:                                                                  


    ECgene alternative splicing isoforms for SMG7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMG7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCTCCAA
    SMG7 Expression
    About this image


    See SMG7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMG7

    SOURCE GeneReport for Unigene cluster: Hs.591463
        SABiosciences Custom PCR Arrays for SMG7
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMG7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SMG7 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smg71 , 5 Smg-7 homolog, nonsense mediated mRNA decay factor more1, 5 93.7(n)1
    96.19(a)1
      1 (65.07 cM)5
    2265171  NM_001160256.11  NP_001153728.11 
     1528369965 
    chicken
    (Gallus gallus)
    Aves SMG71 Smg-7 homolog, nonsense mediated mRNA decay factor more 84.96(n)
    91.13(a)
      424444  XM_422287.3  XP_422287.3 
    lizard
    (Anolis carolinensis)
    Reptilia SMG76
    smg-7 homolog, nonsense mediated mRNA decay factor...
    83(a)
    1 ↔ 1
    GL343203.1(4100711-4169148)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ065114.12   -- 77.81(n)    BJ065114.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570514912   -- 78.55(n)    57051491 


    ENSEMBL Gene Tree for SMG7 (if available)
    TreeFam Gene Tree for SMG7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SMG7 gene
    SMG52  SMG62  
    1 SIMAP similar gene for SMG7 using alignment to 8 protein entries:     SMG7_HUMAN (see all proteins):
    SGA56M

    SMG7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1531 SNPs in SMG7 are shown (see all 1531)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431570381,2
    C--183446533(+) TGTTT-/TGTGTGT 4 -- int10--------
    rs711306191,2
    C--183446534(-) CACAT-/AC/CA 
            
    ACACA
    4 -- int11NA 2
    rs115836521,2
    C,H--183446715(+) CATATA/GTACGT 4 -- int10--------
    rs107124601,2
    C--183447888(+) ATTTT-/TGTATT 4 -- int10--------
    rs1134267161,2
    F--183455702(+) CACCAA/C/TGCCTG 4 -- int11CSA 2
    rs764078151,2
    C--183462237(+) GTCTA-/GGACTA 4 -- int10--------
    rs354421251,2
    C--183462284(+) CAAACT/-TTTTT 4 -- int11Minor allele frequency- -:0.00NA 2
    rs109113461,2
    C,F,A,H--183468420(+) tagagT/Gcatat 4 -- int116Minor allele frequency- G:0.08NS EA NA 1934
    rs2018152961,2
    C--183475788(+) AAAAA-/ACACGA 4 -- int10--------
    rs711306221,2
    C--183476011(-) TCTCCA/-AAAAA 4 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for SMG7 (183441351 - 183567381 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SMG7: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SMG7
    DNA2.0 Custom Variant and Variant Library Synthesis for SMG7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610964    OMIM disorders: --

    5 diseases for SMG7:    About MalaCards
    breast cancer    hepatitis b    hepatitis    prostate cancer
    prostatitis


    SMG7 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SMG7 (1 document)

    Export disorders for SMG7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMG7 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with SMG7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. (PubMed id 15721257)1, 2, 3, 9 Fukuhara N....Conti E. (2005)
    2. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. (PubMed id 14636577)1, 2, 3, 9 Ohnishi T.... Ohno S. (2003)
    3. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. (PubMed id 15546618)1, 2, 9 Unterholzner L. and Izaurralde E. (2004)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    9. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9887 HGNC: 16792 AceView: C1orf16 Ensembl:ENSG00000116698 euGenes: HUgn9887
    ECgene: SMG7 Kegg: 9887 H-InvDB: SMG7

    (According to HUGE)
    About This Section
    HUGE: KIAA0250

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMG7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SMG7 gene:
    Search GeneIP for patents involving SMG7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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