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Aliases for SMG5 Gene

Aliases for SMG5 Gene

  • SMG5 Nonsense Mediated MRNA Decay Factor 2 3 5
  • LPTS-Interacting Protein 3 4
  • EST1-Like Protein B 3 4
  • LPTS-RP1 3 4
  • EST1B 3 4
  • Smg-5 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) 2
  • EST1 Telomerase Component Homolog B (S. Cerevisiae) 2
  • Smg-5 Homolog, Nonsense Mediated MRNA Decay Factor 3
  • EST1 Telomerase Component Homolog B 3
  • Ever Shorter Telomeres 1B 3
  • LPTS Interacting Protein 3
  • Est1p-Like Protein B 3
  • SMG-5 Homolog 4
  • KIAA1089 4
  • LPTSRP1 3
  • HSMG-5 4
  • SMG-5 3

External Ids for SMG5 Gene

Previous GeneCards Identifiers for SMG5 Gene

  • GC01M154485
  • GC01M156219
  • GC01M127580

Summaries for SMG5 Gene

Entrez Gene Summary for SMG5 Gene

  • SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SMG5 Gene

SMG5 (SMG5 Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of Telomerase. GO annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is SMG7.

UniProtKB/Swiss-Prot for SMG5 Gene

  • Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.

Gene Wiki entry for SMG5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMG5 Gene

Genomics for SMG5 Gene

Regulatory Elements for SMG5 Gene

Enhancers for SMG5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SMG5 on UCSC Golden Path with GeneCards custom track

Promoters for SMG5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SMG5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMG5 Gene

Chromosome:
1
Start:
156,249,224 bp from pter
End:
156,282,885 bp from pter
Size:
33,662 bases
Orientation:
Minus strand

Genomic View for SMG5 Gene

Genes around SMG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMG5 Gene

Proteins for SMG5 Gene

  • Protein details for SMG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPR3-SMG5_HUMAN
    Recommended name:
    Protein SMG5
    Protein Accession:
    Q9UPR3
    Secondary Accessions:
    • D3DVB7
    • Q5QJE7
    • Q659C7
    • Q8IXC0
    • Q8IY09
    • Q96IJ7

    Protein attributes for SMG5 Gene

    Size:
    1016 amino acids
    Molecular mass:
    113928 Da
    Quaternary structure:
    • Interacts with TERT, PPP2CA and SMG1. Part of a complex that contains SMG1, SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1. Not detected in complexes that contain unphosphorylated UPF1.
    SequenceCaution:
    • Sequence=BAA83041.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SMG5 Gene

neXtProt entry for SMG5 Gene

Proteomics data for SMG5 Gene at MOPED

Post-translational modifications for SMG5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMG5 Gene

Antibody Products

  • Abcam antibodies for SMG5

No data available for DME Specific Peptides for SMG5 Gene

Domains & Families for SMG5 Gene

Protein Domains for SMG5 Gene

Suggested Antigen Peptide Sequences for SMG5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPR3

UniProtKB/Swiss-Prot:

SMG5_HUMAN :
  • Contains 1 PINc domain.
Domain:
  • Contains 1 PINc domain.
genes like me logo Genes that share domains with SMG5: view

No data available for Gene Families for SMG5 Gene

Function for SMG5 Gene

Molecular function for SMG5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.

Gene Ontology (GO) - Molecular Function for SMG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 12699629
GO:0070182 DNA polymerase binding IPI 15857955
genes like me logo Genes that share ontologies with SMG5: view
genes like me logo Genes that share phenotypes with SMG5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMG5 Gene

Localization for SMG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMG5 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMG5 Gene COMPARTMENTS Subcellular localization image for SMG5 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SMG5 Gene

Pathways & Interactions for SMG5 Gene

genes like me logo Genes that share pathways with SMG5: view

Pathways by source for SMG5 Gene

Gene Ontology (GO) - Biological Process for SMG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS 16488880
GO:0035303 regulation of dephosphorylation IMP 14636577
genes like me logo Genes that share ontologies with SMG5: view

No data available for SIGNOR curated interactions for SMG5 Gene

Drugs & Compounds for SMG5 Gene

No Compound Related Data Available

Transcripts for SMG5 Gene

Unigene Clusters for SMG5 Gene

Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMG5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^
SP1: - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SMG5 Gene

GeneLoc Exon Structure for
SMG5
ECgene alternative splicing isoforms for
SMG5

Expression for SMG5 Gene

mRNA expression in normal human tissues for SMG5 Gene

Protein differential expression in normal tissues from HIPED for SMG5 Gene

This gene is overexpressed in Lung (44.0), Placenta (9.2), and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMG5 Gene



SOURCE GeneReport for Unigene cluster for SMG5 Gene Hs.516837

mRNA Expression by UniProt/SwissProt for SMG5 Gene

Q9UPR3-SMG5_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SMG5: view

Protein tissue co-expression partners for SMG5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SMG5 Gene

Orthologs for SMG5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMG5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMG5 35
  • 93.01 (n)
  • 96.16 (a)
SMG5 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMG5 35
  • 90.87 (n)
  • 95.05 (a)
SMG5 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smg5 35
  • 88.18 (n)
  • 92.71 (a)
Smg5 16
Smg5 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMG5 35
  • 99.84 (n)
  • 99.61 (a)
SMG5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smg5 35
  • 87.95 (n)
  • 92.71 (a)
oppossum
(Monodelphis domestica)
Mammalia SMG5 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMG5 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMG5 35
  • 75.35 (n)
  • 80.04 (a)
SMG5 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMG5 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia smg5 35
  • 71.21 (n)
  • 74.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16535 35
zebrafish
(Danio rerio)
Actinopterygii smg5 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Smg5 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
Species with no ortholog for SMG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMG5 Gene

ENSEMBL:
Gene Tree for SMG5 (if available)
TreeFam:
Gene Tree for SMG5 (if available)

Paralogs for SMG5 Gene

Paralogs for SMG5 Gene

Pseudogenes.org Pseudogenes for SMG5 Gene

genes like me logo Genes that share paralogs with SMG5: view

Variants for SMG5 Gene

Sequence variations from dbSNP and Humsavar for SMG5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17853821 - 156,250,628(+) AACAT(C/T)CTTGA reference, missense
rs759328 -- 156,261,475(-) GCTTT(C/G)CTTGC intron-variant
rs759329 -- 156,261,145(-) CTGTA(C/T)TGTGG intron-variant, downstream-variant-500B
rs933489 -- 156,265,329(-) GCATC(A/G)TTCTA intron-variant
rs1208917 -- 156,272,797(-) cacga(C/G)gtcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMG5 Gene

Variant ID Type Subtype PubMed ID
nsv509524 CNV Insertion 20534489
nsv872470 CNV Loss 21882294

Variation tolerance for SMG5 Gene

Residual Variation Intolerance Score: 4.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SMG5 Gene

Disorders for SMG5 Gene

Relevant External Links for SMG5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMG5

No disorders were found for SMG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMG5 Gene

Publications for SMG5 Gene

  1. Functional conservation of the telomerase protein Est1p in humans. (PMID: 12699629) Snow B.E. … Harrington L. (Curr. Biol. 2003) 2 3 4 67
  2. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. (PMID: 15721257) Fukuhara N. … Conti E. (Mol. Cell 2005) 3 23
  3. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. (PMID: 15546618) Unterholzner L. … Izaurralde E. (Mol. Cell 2004) 3 23
  4. A human homolog of yeast est1 associates with telomerase and uncaps chromosome ends when overexpressed. (PMID: 12676087) Reichenbach P. … Lingner J. (Curr. Biol. 2003) 2 3
  5. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. (PMID: 14636577) Ohnishi T. … Ohno S. (Mol. Cell 2003) 3 23

Products for SMG5 Gene

Sources for SMG5 Gene

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