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SMG5 Gene

protein-coding   GIFtS: 53
GCID: GC01M156219

SMG5 Nonsense Mediated MRNA Decay Factor

(Previous names: smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SMG5 Nonsense Mediated MRNA Decay Factor1 2     RP11-54H19.72
EST1B2 3 5     SMG-52
LPTS-RP12 3     EST1 Telomerase Component Homolog B2
EST1-Like Protein B2 3     Est1p-Like Protein B2
hSMG-52 3     Ever Shorter Telomeres 1B2
LPTS-Interacting Protein2 3     LPTS Interacting Protein2
KIAA10893 5     Protein SMG52
EST1 Telomerase Component Homolog B (S. Cerevisiae)1     Smg-5 Homolog, Nonsense Mediated MRNA Decay Factor2
Smg-5 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans)1     SMG-5 Homolog3
LPTSRP12     

External Ids:    HGNC: 246441   Entrez Gene: 233812   Ensembl: ENSG000001989527   OMIM: 6109625   UniProtKB: Q9UPR33   

Export aliases for SMG5 gene to outside databases

Previous GC identifers: GC01M154485 GC01M127580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SMG5 Gene:
SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 (PubMed 14636577)).(supplied by OMIM, Mar
2008)

GeneCards Summary for SMG5 Gene:
SMG5 (SMG5 nonsense mediated mRNA decay factor) is a protein-coding gene. GO annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is SMG7.

UniProtKB/Swiss-Prot: SMG5_HUMAN, Q9UPR3
Function: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes
dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery
involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby
triggering UPF1 dephosphorylation. Necessary for TERT activity

Gene Wiki entry for SMG5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMG5 gene promoter:
         SRF   SRF (504 AA)   Lmo2   Nkx2-5   CUTL1   YY1   Max   PPAR-alpha   PPAR-gamma1   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMG5 promoter sequence
   Search Chromatin IP Primers for SMG5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21

SMG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMG5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156219:  view genomic region     (about GC identifiers)

Start:
156,219,015 bp from pter      End:
156,252,620 bp from pter
Size:
33,606 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SMG5_HUMAN, Q9UPR3 (See protein sequence)
Recommended Name: Protein SMG5  
Size: 1016 amino acids; 113928 Da
Subunit: Interacts with TERT, PPP2CA and SMG1. Part of a complex that contains SMG1, SMG5, SMG7, PPP2CA, a short
isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1. Not detected in complexes that
contain unphosphorylated UPF1
Sequence caution: Sequence=BAA83041.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for SMG5:
2HWY (3D)    
Secondary accessions: D3DVB7 Q5QJE7 Q659C7 Q8IXC0 Q8IY09 Q96IJ7

Explore the universe of human proteins at neXtProt for SMG5: NX_Q9UPR3

Explore proteomics data for SMG5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SMG5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056142.2  
    ENSEMBL proteins: 
     ENSP00000355261   ENSP00000357250  
    Reactome Protein details: Q9UPR3

    SMG5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR018834 DNA/RNA-bd_Est1-type
     IPR019458 EST1
     IPR002716 PIN_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPR3

    ProtoNet protein and cluster: Q9UPR3

    UniProtKB/Swiss-Prot: SMG5_HUMAN, Q9UPR3
    Similarity: Contains 1 PINc domain


    Find genes that share domains with SMG5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMG5_HUMAN, Q9UPR3
    Function: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes
    dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery
    involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby
    triggering UPF1 dephosphorylation. Necessary for TERT activity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12699629
    GO:0051721protein phosphatase 2A binding IDA14636577
         
    Find genes that share ontologies with SMG5           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SMG5

    miRNA
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    miRTarBase miRNAs that target SMG5:
    hsa-mir-331-3p (MIRT043281), hsa-mir-106b-3p (MIRT038568), hsa-mir-130b-5p (MIRT038311), hsa-mir-193b-3p (MIRT041477), hsa-mir-708-5p (MIRT037745)

    Block miRNA regulation of human, mouse, rat SMG5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMG5 (see all 49):
    hsa-miR-3678-3p hsa-miR-1321 hsa-miR-1184 hsa-miR-654-5p hsa-miR-4293 hsa-miR-4309 hsa-miR-761 hsa-miR-877
    SwitchGear 3'UTR luciferase reporter plasmidSMG5 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SMG5_HUMAN, Q9UPR3: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus
    and cytoplasm. Detected in cytoplasmic mRNA decay bodies
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14636577
    GO:0005737cytoplasm IDA14636577
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SMG5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SMG5 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    Nonsense-Mediated Decay0.89
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    2Gene Expression
    Gene Expression0.40
    3Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I
    4Regulation of Telomerase
    Regulation of Telomerase
    5mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with SMG5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SMG5
        Signaling events mediated by HDAC Class I
    Regulation of Telomerase

    1 Reactome Pathway for SMG5
        Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


    1 Kegg Pathway  (Kegg details for SMG5):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMG5
    Interactions:

        GeneGlobe Interaction Network for SMG5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SMG5 (Q9UPR31, 2, 3 ENSP000003552614) via UniProtKB, MINT, STRING, and/or I2D (see all 190)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF1Q92900-21, ENSP000002628034EBI-3400861,EBI-373492 I2D: score=1 STRING: ENSP00000262803
    SMG7Q925402, 3, ENSP000003407664MINT-8415355 I2D: score=3 STRING: ENSP00000340766
    SMG1Q96Q153, ENSP000004025154I2D: score=2 STRING: ENSP00000402515
    SMG6Q86US83, ENSP000002630734I2D: score=1 STRING: ENSP00000263073
    TERTO147463, ENSP000003095724I2D: score=2 STRING: ENSP00000309572
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS16488880
    GO:0006406mRNA export from nucleus TAS16488880
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    Find genes that share ontologies with SMG5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMG5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SMG5 gene: 
    NM_015327.2  

    Unigene Cluster for SMG5:

    Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
    Hs.516837  [show with all ESTs]
    Unigene Representative Sequence: BC038296
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361813(uc001foc.4) ENST00000476954 ENST00000473643 ENST00000468993
    ENST00000489907 ENST00000368267
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SMG5 (see all 49):
    hsa-miR-3678-3p hsa-miR-1321 hsa-miR-1184 hsa-miR-654-5p hsa-miR-4293 hsa-miR-4309 hsa-miR-761 hsa-miR-877
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      QuantiTect SYBR Green Assays in human, mouse, rat SMG5
      QuantiFast Probe-based Assays in human, mouse, rat SMG5

    Additional mRNA sequence: 

    AB029012.2 AB085691.1 AK025988.1 AK026395.1 AK027486.1 AK092183.1 AL137738.1 AY168922.1 
    AY336728.1 BC007292.1 BC007453.2 BC038296.1 CR933677.1 

    20 DOTS entries:

    DT.442532  DT.40106647  DT.97847598  DT.92447184  DT.95122520  DT.100661546  DT.121384731  DT.75141513 
    DT.97847599  DT.100037536  DT.100795979  DT.100795987  DT.121610897  DT.40106648  DT.91669724  DT.92447180 
    DT.92447182  DT.97768450  DT.121609976  DT.40201439 

    Selected AceView cDNA sequences (see all 312):

    CD743190 AW514413 BM728292 BE298449 BC007453 BM800105 BU527452 BU556974 
    AY168922 AI885104 BP378210 AW000913 CO249731 BQ433906 BI752105 CK000707 
    BU158333 BF001221 BQ231299 AI022142 AB085691 BE878104 CR592010 BC007292 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SMG5 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^
    SP1:                                                                                      -                       -                       -                     
    SP2:                                                                          -     -     -     -     -           -                                             
    SP3:                                                                                                                                      -                     
    SP4:                                                                                -     -                                                                     
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c
    SP1:                    -                                 
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for SMG5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SMG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAGCTCAG
    SMG5 Expression
    About this image

    SMG5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMG5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516837

    UniProtKB/Swiss-Prot: SMG5_HUMAN, Q9UPR3
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMG5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SMG5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smg51 , 5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) less1, 5 88.18(n)1
    92.71(a)1
      3 (38.80 cM)5
    2295121  NM_178246.31  NP_839977.21 
     883362605 
    chicken
    (Gallus gallus)
    Aves SMG51 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) less 75.35(n)
    80.04(a)
      425473  XM_423228.4  XP_423228.4 
    lizard
    (Anolis carolinensis)
    Reptilia SMG56
    SMG5 nonsense mediated mRNA decay factor
    70(a)
    1 ↔ 1
    GL344815.1(308-15707)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165352 Xenopus laevis transcribed sequences 79.45(n)    BG812790.1 
    zebrafish
    (Danio rerio)
    Actinopterygii smg56
    Smg-5 homolog, nonsense mediated mRNA decay factor...
    63(a)
    1 ↔ 1
    16(48757476-48798276) ENSDARG00000041481
    fruit fly
    (Drosophila melanogaster)
    Insecta Smg56
    Smg5
    19(a)
    1 ↔ 1
    2L(13899353-13904659)


    ENSEMBL Gene Tree for SMG5 (if available)
    TreeFam Gene Tree for SMG5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMG5 gene
    SMG72  SMG62  

    Find genes that share paralogs with SMG5           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SMG5
    PGOHUM00000242487 PGOHUM00000249778


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMG5 (see all 734)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1126111161,2
    C,F--156219920(+) AATCAC/TTCAGA 1 -- ut312Minor allele frequency- T:0.02CSA WA 120
    rs1930274141,2
    --156220043(+) CAGAGA/TTCCAA 1 -- ut310--------
    rs10431651,2
    C,F,A,H--156220056(-) CTGGAA/GTGGGT 1 -- ut3120Minor allele frequency- G:0.41MN NS EA NA WA CSA 2520
    rs1454813461,2
    C--156220137(+) CAGGGA/GCCCAC 1 -- ut310--------
    rs1472960901,2
    C,F--156220334(+) GGCAGG/AAGAGA 1 -- ut311Minor allele frequency- A:0.01EU 591
    rs1489496381,2
    C--156220455(+) CTGCAG/CGGCTG 2 /L /V mis11Minor allele frequency- C:0.00NA 4552
    rs2015373731,2
    C--156220607(+) ACCTCA/GTCCCT 1 -- int10--------
    rs1477167221,2
    C--156220659(+) TGGGGC/ACTGAA 2 /G /V mis11Minor allele frequency- A:0.00NA 4550
    rs2006655891,2
    --156220740(+) CCCCCG/TGGGCC 2 Q P mis10--------
    rs2006152181,2
    C--156220780(+) CTTATA/GGAGAG 2 H Y mis10--------

    HapMap Linkage Disequilibrium report for SMG5 (156219015 - 156252620 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SMG5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509524CNV Insertion20534489
    nsv872470CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SMG5
    DNA2.0 Custom Variant and Variant Library Synthesis for SMG5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610962    OMIM disorders: --


    Find genes that share disorders with SMG5           About GenesLikeMe


    Export disorders for SMG5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMG5 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with SMG5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional conservation of the telomerase protein Est1p in humans. (PubMed id 12699629)1, 2, 3 Snow B.E.... Harrington L. (Curr. Biol. 2003)
    2. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. (PubMed id 15546618)1, 2, 9 Unterholzner L. and Izaurralde E. (Mol. Cell 2004)
    3. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. (PubMed id 14636577)1, 2, 9 Ohnishi T.... Ohno S. (Mol. Cell 2003)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. (PubMed id 17053788)1, 2 Glavan F.... Conti E. (EMBO J. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A human homolog of yeast est1 associates with telomerase and uncaps chromosome ends when overexpressed. (PubMed id 12676087)1, 3 Reichenbach P....Lingner J. (Curr. Biol. 2003)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    10. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. (PubMed id 15721257)1, 9 Fukuhara N....Conti E. (Mol. Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23381 HGNC: 24644 AceView: EST1B Ensembl:ENSG00000198952 euGenes: HUgn23381
    ECgene: SMG5 Kegg: 23381 H-InvDB: SMG5

    (According to HUGE)
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    HUGE: KIAA1089

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMG5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SMG5 gene:
    Search GeneIP for patents involving SMG5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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