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Aliases for SMEK2 Gene

Aliases for SMEK2 Gene

  • SMEK Homolog 2, Suppressor Of Mek1 (Dictyostelium) 2 3
  • PP4R3B 3 4 6
  • Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 3B 3
  • SMEK Homolog 2 4
  • KIAA1387 4
  • PPP4R3B 4
  • FLFL2 3
  • Smk1 3
  • PSY2 3

External Ids for SMEK2 Gene

Previous GeneCards Identifiers for SMEK2 Gene

  • GC02M055688
  • GC02M055629
  • GC02M055775

Summaries for SMEK2 Gene

GeneCards Summary for SMEK2 Gene

SMEK2 (SMEK Homolog 2, Suppressor Of Mek1 (Dictyostelium)) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway.

UniProtKB/Swiss-Prot for SMEK2 Gene

  • Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers

Gene Wiki entry for SMEK2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMEK2 Gene

Genomics for SMEK2 Gene

Regulatory Elements for SMEK2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SMEK2 Gene

Start:
55,547,292 bp from pter
End:
55,618,880 bp from pter
Size:
71,589 bases
Orientation:
Minus strand

Genomic View for SMEK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMEK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMEK2 Gene

Proteins for SMEK2 Gene

  • Protein details for SMEK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MIZ7-P4R3B_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 4 regulatory subunit 3B
    Protein Accession:
    Q5MIZ7
    Secondary Accessions:
    • Q6P9B0
    • Q86XB8
    • Q9BQJ0
    • Q9BRK2
    • Q9H913
    • Q9P2G0

    Protein attributes for SMEK2 Gene

    Size:
    849 amino acids
    Molecular mass:
    97458 Da
    Quaternary structure:
    • Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3B.
    SequenceCaution:
    • Sequence=BAA92625.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SMEK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMEK2 Gene

Proteomics data for SMEK2 Gene at MOPED

Post-translational modifications for SMEK2 Gene

  • Ubiquitination at Lys601
  • Modification sites at PhosphoSitePlus

Other Protein References for SMEK2 Gene

No data available for DME Specific Peptides for SMEK2 Gene

Domains for SMEK2 Gene

Protein Domains for SMEK2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMEK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5MIZ7

UniProtKB/Swiss-Prot:

P4R3B_HUMAN :
  • Contains 1 WH1 domain.
  • Belongs to the SMEK family.
Domain:
  • Contains 1 WH1 domain.
Family:
  • Belongs to the SMEK family.
genes like me logo Genes that share domains with SMEK2: view

No data available for Gene Families for SMEK2 Gene

Function for SMEK2 Gene

Molecular function for SMEK2 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers

Gene Ontology (GO) - Molecular Function for SMEK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SMEK2: view

Animal Model Products

miRNA for SMEK2 Gene

miRTarBase miRNAs that target SMEK2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMEK2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for SMEK2 Gene

Localization for SMEK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMEK2 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMEK2 Gene COMPARTMENTS Subcellular localization image for SMEK2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SMEK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with SMEK2: view

Pathways for SMEK2 Gene

genes like me logo Genes that share pathways with SMEK2: view

Pathways by source for SMEK2 Gene

1 BioSystems pathway for SMEK2 Gene

Interacting Proteins for SMEK2 Gene

Selected Interacting proteins: Q5MIZ7-P4R3B_HUMAN for SMEK2 Gene via I2D MINT

Gene Ontology (GO) - Biological Process for SMEK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0019216 regulation of lipid metabolic process IEA --
GO:0045722 positive regulation of gluconeogenesis IEA --
genes like me logo Genes that share ontologies with SMEK2: view

Transcripts for SMEK2 Gene

Unigene Clusters for SMEK2 Gene

SMEK homolog 2, suppressor of mek1 (Dictyostelium):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMEK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMEK2 Gene

No ASD Table

Relevant External Links for SMEK2 Gene

GeneLoc Exon Structure for
SMEK2
ECgene alternative splicing isoforms for
SMEK2

Expression for SMEK2 Gene

mRNA expression in normal human tissues for SMEK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SMEK2 Gene

This gene is overexpressed in Plasma (13.6), Liver, secretome (13.5), Platelet (11.7), and Lung (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SMEK2 Gene

SOURCE GeneReport for Unigene cluster for SMEK2 Gene Hs.516182

mRNA Expression by UniProt/SwissProt for SMEK2 Gene

Q5MIZ7-P4R3B_HUMAN
Tissue specificity: Moderately expressed in tissues and specific brain regions examined.
genes like me logo Genes that share expressions with SMEK2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for SMEK2 Gene

Orthologs for SMEK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMEK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMEK2 35
  • 94.24 (n)
  • 96.99 (a)
dog
(Canis familiaris)
Mammalia SMEK2 35
  • 95.72 (n)
  • 98.64 (a)
mouse
(Mus musculus)
Mammalia Smek2 35
  • 93.15 (n)
  • 96.7 (a)
Smek2 16
chimpanzee
(Pan troglodytes)
Mammalia SMEK2 35
  • 99.73 (n)
  • 99.41 (a)
rat
(Rattus norvegicus)
Mammalia Smek2 35
  • 93.88 (n)
  • 97.8 (a)
chicken
(Gallus gallus)
Aves SMEK2 35
  • 85.21 (n)
  • 94.73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia smek2 35
  • 82.29 (n)
  • 93.02 (a)
Str.10217 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53159 35
zebrafish
(Danio rerio)
Actinopterygii smek2 35
  • 67.65 (n)
  • 77.25 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003402 35
  • 59.04 (n)
  • 61.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta flfl 35
  • 59.95 (n)
  • 61.09 (a)
rice
(Oryza sativa)
Liliopsida Os.16549 35
Species with no ortholog for SMEK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMEK2 Gene

ENSEMBL:
Gene Tree for SMEK2 (if available)
TreeFam:
Gene Tree for SMEK2 (if available)

Paralogs for SMEK2 Gene

(2) SIMAP similar genes for SMEK2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SMEK2: view

No data available for Paralogs for SMEK2 Gene

Variants for SMEK2 Gene

Sequence variations from dbSNP and Humsavar for SMEK2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs60683757 -- 55,583,381(+) AAACA(C/T)TGAGA intron-variant
rs60555175 -- 55,585,591(+) AACTG(C/T)TTCTA intron-variant
rs60379480 -- 55,581,912(+) AGAAG(-/AAG)GAGGA intron-variant
rs60356354 -- 55,606,775(+) CGAGA(C/T)TGCAT intron-variant
rs59987759 -- 55,576,446(+) AGTTT(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMEK2 Gene

Variant ID Type Subtype PubMed ID
nsv520581 CNV Loss 19592680
nsv874160 CNV Loss 21882294
nsv525434 CNV Loss 19592680
nsv834080 CNV Loss 17160897
dgv1185e1 CNV Complex 17122850
nsv829430 CNV Loss 20364138

Relevant External Links for SMEK2 Gene

HapMap Linkage Disequilibrium report
SMEK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMEK2 Gene

Disorders for SMEK2 Gene

Relevant External Links for SMEK2

Genetic Association Database (GAD)
SMEK2

No disorders were found for SMEK2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SMEK2 Gene

Publications for SMEK2 Gene

  1. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PMID: 16085932) Gingras A.-C. … Aebersold R. (Mol. Cell. Proteomics 2005) 2 3 4
  2. A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. (PMID: 18614045) Chowdhury D. … Lieberman J. (Mol. Cell 2008) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SMEK2 Gene

Sources for SMEK2 Gene

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