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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMEK2 Gene

protein-coding   GIFtS: 51
GCID: GC02M055775

SMEK homolog 2, suppressor of mek1 (Dictyostelium)
 Explore 3 diseases affiliated with
SMEK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SMEK2    

Aliases
for SMEK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SMEK Homolog 2, Suppressor Of Mek1 (Dictyostelium)1 2     FLJ314741
FLFL21 2     Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 3B2
PSY21 2     Smk11
KIAA13871 3     PPP4R3B3
PP4R3B2 3     SMEK Homolog 23

External Ids:    HGNC: 292671   Entrez Gene: 572232   Ensembl: ENSG000001380417   OMIM: 6103525   UniProtKB: Q5MIZ73   

Export aliases for SMEK2 gene to outside databases

Previous GC identifers: GC02M055688 GC02M055629 GC02M055510


Summaries
for SMEK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: P4R3B_HUMAN, Q5MIZ7
Function: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at
centrosomal microtubule organizing centers

Gene Wiki entry for SMEK2


Genomic Views
for SMEK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SMEK2 gene promoter:
         AhR   p53   AML1a   NCX/Ncx   XBP-1   Arnt   YY1   Evi-1   E47   SRY   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SMEK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SMEK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMEK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p16.1

SMEK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMEK2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M055775:  view genomic region     (about GC identifiers)

Start:
 55,774,428 bp from pter      End:
 55,846,015 bp from pter
Size:
 71,588 bases      Orientation:
 minus strand

Proteins
for SMEK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: P4R3B_HUMAN, Q5MIZ7 (See protein sequence)
Recommended Name: Serine/threonine-protein phosphatase 4 regulatory subunit 3B  
Size: 849 amino acids; 97458 Da
Subunit: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more
regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3B
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Nucleus. Note=In interphase localized in the
cytoplasm and (with higher levels) the nucleus. During metaphase located in pericentriolar regions
Sequence caution: Sequence=BAA92625.1; Type=Erroneous initiation;
Secondary accessions: Q6P9B0 Q86XB8 Q9BQJ0 Q9BRK2 Q9H913 Q9P2G0
Alternative splicing: 5 isoforms:  Q5MIZ7-1   Q5MIZ7-2   Q5MIZ7-3   Q5MIZ7-4   Q5MIZ7-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMEK2: NX_Q5MIZ7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5MIZ7

    • SMEK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116436.1  NP_065196.1  

    ENSEMBL proteins: 
     ENSP00000272313   ENSP00000385912   ENSP00000339769  

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    Novus Biologicals SMEK2 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SMEK2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0030289protein phosphatase 4 complex IEA--


    SMEK2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SMEK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SMEK2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006887 DUF625
     IPR011993 PH_like_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q5MIZ7

    ProtoNet protein and cluster: Q5MIZ7

    UniProtKB/Swiss-Prot: P4R3B_HUMAN, Q5MIZ7
    Similarity: Belongs to the SMEK family
    Similarity: Contains 1 WH1 domain


    Function
    for SMEK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: P4R3B_HUMAN, Q5MIZ7
    Function: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at
    centrosomal microtubule organizing centers

    miRNA
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    hsa-miR-300 hsa-miR-29a hsa-miR-218 hsa-miR-374c hsa-miR-889 hsa-miR-4330 hsa-miR-23a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: SMEK2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for SMEK2

    In Situ Assay
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    Pathways & Interactions
    for SMEK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrated Breast Cancer Pathway
    		Integrated Breast Cancer Pathway1.00


    1 BioSystems Pathway for SMEK2 
        Integrated Breast Cancer Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMEK2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/52 Interacting proteins for SMEK2 (Q5MIZ72, 3 ENSP000003397694) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FEZ1Q996892, 3MINT-65316 I2D: score=5 
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IEA--
    GO:0045722positive regulation of gluconeogenesis IEA--


    SMEK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SMEK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SMEK2
    Search CenterWatch for drugs/clinical trials and news about SMEK2 / P4R3B 

    Transcripts
    for SMEK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SMEK2 gene (2 alternative transcripts): 
    NM_001122964.1  NM_020463.2  

    Unigene Cluster for SMEK2:

    SMEK homolog 2, suppressor of mek1 (Dictyostelium)
    Hs.516182  [show with all ESTs]
    Unigene Representative Sequence: NM_001122964
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272313 ENST00000407823(uc002ryz.3 uc002rza.3 uc002rzb.3 uc002rzd.3)
    ENST00000345102(uc002rzc.3) ENST00000482826 ENST00000470801 ENST00000477749


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMEK2
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate SMEK2 (see all 40):
    hsa-miR-300 hsa-miR-29a hsa-miR-218 hsa-miR-374c hsa-miR-889 hsa-miR-4330 hsa-miR-23a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: SMEK2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMEK2
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    Additional cDNA sequence: 

    AB037808.1 AK023148.1 AK026437.1 AK056036.1 AK056503.1 AK098321.1 AK296481.1 AL122106.1 
    AL136556.1 AY825268.1 AY825269.1 BC006215.2 BC032531.1 BC045714.1 BC060855.1 

    17 DOTS entries:

    DT.314086  DT.99941547  DT.100810415  DT.91754194  DT.101984410  DT.102845489  DT.91754206  DT.40112761 
    DT.100821557  DT.423238  DT.100821556  DT.431101  DT.100821558  DT.75158776  DT.95083390  DT.121005563 
    DT.75124167 

    24/341 AceView cDNA sequences (see all 341):

    BQ881107 AI301852 BE882739 BF445509 AA768533 N21995 BU754218 R24411 
    BC060855 AI879959 BM129757 BQ217562 AA150067 BE048382 AI826718 CR594222 
    AL136556 AA345680 AU131164 BM804246 CA392166 AA805613 BM930750 AU117284 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SMEK2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^
    SP1:                                      -           -     -                                                                                   -           -   
    SP2:                                      -           -     -                                                           -                       -           -   
    SP3:                                      -           -     -                                                           -           -     -     -           -   
    SP4:                                                                                                                    -           -     -     -           -   
    SP5:                                                                                                                                            -           -   

    ExUns: 18a · 18b · 18c ^ 19a · 19b ^ 20 ^ 21a · 21b
    SP1:  -                                             
    SP2:  -                                             
    SP3:  -                                             
    SP4:  -                 -                           
    SP5:  -                 -                           


    ECgene alternative splicing isoforms for SMEK2

    Expression
    for SMEK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMEK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGTGATATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SMEK2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungLung BudLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SMEK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMEK2

    SOURCE GeneReport for Unigene cluster: Hs.516182

    UniProtKB/Swiss-Prot: P4R3B_HUMAN, Q5MIZ7
    Tissue specificity: Moderately expressed in tissues and specific brain regions examined

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    In Situ
    Assay Products:     
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    Orthologs
    for SMEK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMEK2 gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SMEK21 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 85.91(n)
    95.59(a)    		   426680  XM_424305.3  XP_424305.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SMEK26
    		 --
    		 92(a)
    		 1 ↔ 1
    		 1(256023058-256061305)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC531592 hypothetical protein MGC53159 82.59(n)    BC047970.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii smek21 SMEK homolog 2, suppressor of mek1 (Dictyostelium) 67.83(n)
    77.94(a)    		   336198  NM_200001.2  NP_956295.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta flfl6
    		 falafel
    		 45(a)
    		 1 → many
    		 3R(9509680-9519629)
    worm
    (Caenorhabditis elegans)    		 Secernentea smk-16
    		 SMEK (Dictyostelium Suppressor of MEK null) homolo...
    		 27(a)
    		 1 → many
    		 V(8607778-8615057)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G493706
    AT5G493806
    (see all 4)    		 uncharacterized protein
    (see all 4)    		 42(a)
    33(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 5(20023456-20024530)
    5(20025565-20027078)
    rice
    (Oryza sativa)    		 Liliopsida Os.165492 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.48(n)    NM_183913.1 


    ENSEMBL Gene Tree for SMEK2 (if available)
    TreeFam Gene Tree for SMEK2 (if available) 

    Paralogs
    for SMEK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SMEK2 gene
    SMEK12  
    2 SIMAP similar genes for SMEK2 using alignment to 1 protein entry:     P4R3B_HUMAN:
    SMEK1    SMEK3P

    SMEK2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for SMEK2
    PGOHUM00000249278 PGOHUM00000249582 PGOHUM00000241218


    Genomic Variants
    for SMEK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1312 NCBI SNPs in SMEK2 are shown (see all 1312)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs349527731,2
    		C,--55542128(+) ACTTT-/AAAATA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs10585821,2
    		F,--55775069(-) TCCTAA/GTTACT 2 -- int1 ds50013Minor allele frequency- G:0.43MN NA 188
    rs1876861671,2
    		C,--55775243(+) TTACTA/GTATGT 2 -- ds5001 int10--------
    rs1495038521,2
    		--55775383(+) ATTGGA/GGTATG 2 -- ds5001 int10--------
    rs1443031011,2
    		--55775395(+) TCTAGC/TAGTTT 2 -- ds5001 int10--------
    rs1922923161,2
    		--55775539(+) TTAATG/TCCTGA 2 -- ut310--------
    rs80801,2
    		C,F,H,--55775724(-) CTGTTT/CTGGAG 2 -- ut3116Minor allele frequency- C:0.23MN NS EA NA WA 1878
    rs1430225821,2
    		--55775730(+) AACAGG/TGGAAA 2 -- ut310--------
    rs115533731,2
    		C--55775804(+) GATTGT/GGGCTG 2 -- ut31 ese31Minor allele frequency- G:0.00NA 2
    rs1843037111,2
    		C,--55776028(+) AAAGCA/TGCTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SMEK2 (55774428 - 55846015 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SMEK2
         1 CNV: 3357

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    Disorders / Diseases
    for SMEK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SMEK2 for disorders           About GeneDecksing

    OMIM gene information: 610352    OMIM disorders: --

    3 diseases for SMEK2:    About MalaCards
    teratocarcinoma    hepatitis    neuronitis


    Export disorders for SMEK2 gene to outside databases

    Publications
    for SMEK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMEK2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SMEK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. (PubMed id 18614045)1, 2, 3 Chowdhury D.... Lieberman J. (2008)
    2. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PubMed id 16085932)1, 2, 3 Gingras A.-C.... Aebersold R. (2005)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. (PubMed id 15616564)1, 2 Kittler R....Buchholz F. (2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    9. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    10. Genome-wide screen for metabolic syndrome susceptibili ty Loci reveals strong lipid gene contribution but no evidence for common geneti c basis for clustering of metabolic syndrome traits. (PubMed id 22399527)1 Kristiansson K....Salomaa V. (2012)

    External Searches for SMEK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing SMEK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57223 HGNC: 29267 AceView: KIAA1387 Ensembl:ENSG00000138041 euGenes: HUgn57223
    ECgene: SMEK2 H-InvDB: SMEK2

    Other Databases showing SMEK2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1387

    Specialized Databases showing SMEK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMEK2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SMEK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SMEK2 gene:
    Search GeneIP for patents involving SMEK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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