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Aliases for SMEK1 Gene

Aliases for SMEK1 Gene

  • SMEK Homolog 1, Suppressor Of Mek1 (Dictyostelium) 2 3
  • KIAA2010 2 3 4 6
  • PP4R3A 3 4 6
  • Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 3A 3
  • SMEK Homolog 1 4
  • MSTP033 3
  • PPP4R3A 4
  • FLFL1 3
  • Smk-1 3
  • Smk1 3

External Ids for SMEK1 Gene

Previous HGNC Symbols for SMEK1 Gene

  • KIAA2010

Previous GeneCards Identifiers for SMEK1 Gene

  • GC14M090994
  • GC14M091923
  • GC14M072100

Summaries for SMEK1 Gene

GeneCards Summary for SMEK1 Gene

SMEK1 (SMEK Homolog 1, Suppressor Of Mek1 (Dictyostelium)) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway.

UniProtKB/Swiss-Prot for SMEK1 Gene

  • Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMEK1 Gene

Genomics for SMEK1 Gene

Regulatory Elements for SMEK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SMEK1 Gene

Start:
91,457,481 bp from pter
End:
91,510,554 bp from pter
Size:
53,074 bases
Orientation:
Minus strand

Genomic View for SMEK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMEK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMEK1 Gene

Proteins for SMEK1 Gene

  • Protein details for SMEK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IN85-P4R3A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 4 regulatory subunit 3A
    Protein Accession:
    Q6IN85
    Secondary Accessions:
    • Q69YK6
    • Q86U23
    • Q86YI7
    • Q8IVG1
    • Q9H3F1
    • Q9H7U8
    • Q9NV01
    • Q9NWP1

    Protein attributes for SMEK1 Gene

    Size:
    833 amino acids
    Molecular mass:
    95368 Da
    Quaternary structure:
    • Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A. Interacts with PPP4C; the interaction requires PPP4R2.
    SequenceCaution:
    • Sequence=AAG39284.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAA91960.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91960.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence={ECO:0000305}; Sequence=BAB14877.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC23106.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SMEK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMEK1 Gene

Proteomics data for SMEK1 Gene at MOPED

Post-translational modifications for SMEK1 Gene

  • Ubiquitination at Lys566, Lys576, and Lys585
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SMEK1 Gene

Domains for SMEK1 Gene

Protein Domains for SMEK1 Gene

Suggested Antigen Peptide Sequences for SMEK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IN85

UniProtKB/Swiss-Prot:

P4R3A_HUMAN :
  • Q6IN85
Domain:
  • Contains 1 WH1 domain.
Family:
  • Belongs to the SMEK family.
genes like me logo Genes that share domains with SMEK1: view

No data available for Gene Families for SMEK1 Gene

Function for SMEK1 Gene

Molecular function for SMEK1 Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.

Gene Ontology (GO) - Molecular Function for SMEK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SMEK1: view
genes like me logo Genes that share phenotypes with SMEK1: view

Animal Model Products

CRISPR Products

miRNA for SMEK1 Gene

miRTarBase miRNAs that target SMEK1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMEK1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SMEK1 Gene

Localization for SMEK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMEK1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMEK1 Gene COMPARTMENTS Subcellular localization image for SMEK1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SMEK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton --
GO:0030289 protein phosphatase 4 complex IEA --
genes like me logo Genes that share ontologies with SMEK1: view

Pathways for SMEK1 Gene

genes like me logo Genes that share pathways with SMEK1: view

Pathways by source for SMEK1 Gene

1 BioSystems pathway for SMEK1 Gene

Interacting Proteins for SMEK1 Gene

Gene Ontology (GO) - Biological Process for SMEK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0045722 positive regulation of gluconeogenesis IEA --
genes like me logo Genes that share ontologies with SMEK1: view

Transcripts for SMEK1 Gene

Unigene Clusters for SMEK1 Gene

SMEK homolog 1, suppressor of mek1 (Dictyostelium):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMEK1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SMEK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMEK1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - - - - - -
SP5:
SP6:
SP7: - -
SP8: -
SP9: -
SP10: -

ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for SMEK1 Gene

GeneLoc Exon Structure for
SMEK1
ECgene alternative splicing isoforms for
SMEK1

Expression for SMEK1 Gene

mRNA expression in normal human tissues for SMEK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SMEK1 Gene

SOURCE GeneReport for Unigene cluster for SMEK1 Gene Hs.533887

genes like me logo Genes that share expressions with SMEK1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMEK1 Gene

Orthologs for SMEK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMEK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
SMEK1 35
  • 99.72 (n)
  • 100 (a)
SMEK1 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SMEK1 35
  • 94.35 (n)
  • 98.78 (a)
SMEK1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMEK1 35
  • 95.53 (n)
  • 99.39 (a)
SMEK1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smek1 35
  • 93.29 (n)
  • 99.27 (a)
Smek1 16
Smek1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SMEK1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMEK1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smek1 35
  • 92.36 (n)
  • 99.02 (a)
chicken
(Gallus gallus)
Aves SMEK1 35
  • 85.65 (n)
  • 97.56 (a)
SMEK1 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMEK1 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485426 35
  • 80.85 (n)
  • 92.07 (a)
zebrafish
(Danio rerio)
Actinopterygii smek1 35
  • 74.37 (n)
  • 88.21 (a)
smek1 36
  • 89 (a)
OneToOne
wufj55c11 35
fruit fly
(Drosophila melanogaster)
Insecta flfl 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea smk-1 35
  • 51.68 (n)
  • 43.76 (a)
smk-1 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSY2 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G06670 35
  • 48.13 (n)
  • 36.88 (a)
rice
(Oryza sativa)
Liliopsida Os01g0337600 35
  • 49 (n)
  • 35.48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11315 35
  • 43.37 (n)
  • 30.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC216.01c 35
  • 47.9 (n)
  • 35.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4515 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for SMEK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMEK1 Gene

ENSEMBL:
Gene Tree for SMEK1 (if available)
TreeFam:
Gene Tree for SMEK1 (if available)

Paralogs for SMEK1 Gene

Selected SIMAP similar genes for SMEK1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SMEK1: view

No data available for Paralogs for SMEK1 Gene

Variants for SMEK1 Gene

Sequence variations from dbSNP and Humsavar for SMEK1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs10329 -- 91,457,644(-) CTTTT(G/T)AATAA utr-variant-3-prime
rs876561 -- 91,478,567(-) TGCTT(C/T)CCTGT intron-variant
rs997169 -- 91,467,959(-) AGATA(C/T)TTGTG intron-variant
rs1063851 -- 91,458,250(-) GGGCG(A/G/T)GTATA utr-variant-3-prime
rs1951250 -- 91,510,722(+) CTGGC(C/T)TGCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SMEK1 Gene

Variant ID Type Subtype PubMed ID
esv2555842 CNV Deletion 19546169
esv2333297 CNV Deletion 18987734
esv2662799 CNV Deletion 23128226

Relevant External Links for SMEK1 Gene

HapMap Linkage Disequilibrium report
SMEK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMEK1 Gene

Disorders for SMEK1 Gene

Relevant External Links for SMEK1

Genetic Association Database (GAD)
SMEK1
genes like me logo Genes that share disorders with SMEK1: view

No data available for UniProtKB/Swiss-Prot for SMEK1 Gene

Publications for SMEK1 Gene

  1. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. (PMID: 18487071) Martin-Granados C. … Cohen P.T.W. (Int. J. Biochem. Cell Biol. 2008) 2 3 4
  2. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. (PMID: 16085932) Gingras A.-C. … Aebersold R. (Mol. Cell. Proteomics 2005) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SMEK1 Gene

Sources for SMEK1 Gene

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