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Aliases for SMDT1 Gene

Aliases for SMDT1 Gene

  • Single-Pass Membrane Protein With Aspartate-Rich Tail 1 2 3
  • C22orf32 3 4 6
  • EMRE 3 4 6
  • Single-Pass Membrane Protein With Aspartate-Rich Tail 1, Mitochondrial 3 4
  • UPF0466 Protein C22orf32, Mitochondrial 3
  • Essential MCU Regulator, Mitochondrial 3
  • Chromosome 22 Open Reading Frame 32 2
  • Essential MCU Regulator 2
  • DJ186O1.1 3
  • DDDD 3

External Ids for SMDT1 Gene

Previous HGNC Symbols for SMDT1 Gene

  • C22orf32

Previous GeneCards Identifiers for SMDT1 Gene

  • GC22P042476

Summaries for SMDT1 Gene

GeneCards Summary for SMDT1 Gene

SMDT1 (Single-Pass Membrane Protein With Aspartate-Rich Tail 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SMDT1 Gene

  • Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMDT1 Gene

Genomics for SMDT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SMDT1 Gene

42,079,691 bp from pter
42,084,284 bp from pter
4,594 bases
Plus strand

Genomic View for SMDT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMDT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMDT1 Gene

No data available for Regulatory Elements for SMDT1 Gene

Proteins for SMDT1 Gene

  • Protein details for SMDT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Essential MCU regulator, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2R5D1
    • Q8TAB9

    Protein attributes for SMDT1 Gene

    107 amino acids
    Molecular mass:
    11441 Da
    Quaternary structure:
    • Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1.

neXtProt entry for SMDT1 Gene

Proteomics data for SMDT1 Gene at MOPED

Post-translational modifications for SMDT1 Gene

No Post-translational modifications

Other Protein References for SMDT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMDT1 Gene

Domains for SMDT1 Gene

Protein Domains for SMDT1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9H4I9
  • Belongs to the SMDT1/EMRE family.
genes like me logo Genes that share domains with SMDT1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SMDT1 Gene

Function for SMDT1 Gene

Molecular function for SMDT1 Gene

UniProtKB/Swiss-Prot Function: Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU.

Phenotypes for SMDT1 Gene

GenomeRNAi human phenotypes for SMDT1:
genes like me logo Genes that share phenotypes with SMDT1: view

Animal Model Products

CRISPR Products

miRNA for SMDT1 Gene

miRTarBase miRNAs that target SMDT1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SMDT1 Gene

Localization for SMDT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMDT1 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0031305 integral component of mitochondrial inner membrane IDA 24231807
GO:1990246 uniplex complex IDA 22925203
genes like me logo Genes that share ontologies with SMDT1: view

No data available for Subcellular locations from COMPARTMENTS for SMDT1 Gene

Pathways for SMDT1 Gene

SuperPathways for SMDT1 Gene

No Data Available

Interacting Proteins for SMDT1 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000327467 for SMDT1 Gene via STRING

Gene Ontology (GO) - Biological Process for SMDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006851 mitochondrial calcium ion transport IMP 24231807
GO:0036444 calcium ion transmembrane import into mitochondrion IMP 22925203
GO:0051560 mitochondrial calcium ion homeostasis IMP 24231807
genes like me logo Genes that share ontologies with SMDT1: view

No data available for Pathways by source for SMDT1 Gene

Transcripts for SMDT1 Gene

Unigene Clusters for SMDT1 Gene

Single-pass membrane protein with aspartate-rich tail 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMDT1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMDT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b
SP1: - -
SP2: -

Relevant External Links for SMDT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMDT1 Gene

mRNA expression in normal human tissues for SMDT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SMDT1 Gene

SOURCE GeneReport for Unigene cluster for SMDT1 Gene Hs.306083

genes like me logo Genes that share expressions with SMDT1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMDT1 Gene

Orthologs for SMDT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMDT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C22H22orf32 35
  • 98.35 (n)
  • 97.03 (a)
SMDT1 36
  • 97 (a)
(Bos Taurus)
Mammalia SMDT1 35
  • 90.43 (n)
  • 87.13 (a)
SMDT1 36
  • 88 (a)
(Canis familiaris)
Mammalia SMDT1 35
  • 91.09 (n)
  • 91.09 (a)
SMDT1 36
  • 92 (a)
(Mus musculus)
Mammalia 1500032L24Rik 16
Smdt1 35
  • 85.15 (n)
  • 80.2 (a)
Smdt1 36
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 48 (a)
-- 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia SMDT1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Smdt1 35
  • 85.15 (n)
  • 79.21 (a)
(Gallus gallus)
Aves C22ORF32 35
  • 66.67 (n)
  • 75.58 (a)
SMDT1 36
  • 67 (a)
(Anolis carolinensis)
Reptilia SMDT1 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia smdt1 35
  • 62.72 (n)
  • 67.11 (a)
Str.8588 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13565 35
(Danio rerio)
Actinopterygii Dr.29472 35
smdt1 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17680 36
  • 43 (a)
Species with no ortholog for SMDT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMDT1 Gene

Gene Tree for SMDT1 (if available)
Gene Tree for SMDT1 (if available)

Paralogs for SMDT1 Gene

No data available for Paralogs for SMDT1 Gene

Variants for SMDT1 Gene

Sequence variations from dbSNP and Humsavar for SMDT1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs14645 -- 42,083,148(-) ATTCT(C/T)CAGTT utr-variant-3-prime
rs137166 -- 42,083,208(+) GGAAG(-/G)CCCTC utr-variant-3-prime
rs2071711 -- 42,081,646(+) TAGTA(C/G)AGACG intron-variant
rs5996107 -- 42,080,684(+) AAGCT(A/G)GTCTA intron-variant
rs6002592 -- 42,080,750(+) ATCAA(A/C)ACAGT intron-variant

Relevant External Links for SMDT1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMDT1 Gene

Disorders for SMDT1 Gene

No disorders were found for SMDT1 Gene.

No data available for UniProtKB/Swiss-Prot for SMDT1 Gene

Publications for SMDT1 Gene

  1. EMRE is an essential component of the mitochondrial calcium uniporter complex. (PMID: 24231807) Sancak Y. … Mootha V.K. (Science 2013) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for SMDT1 Gene

Sources for SMDT1 Gene

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