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Aliases for SMCP Gene

Aliases for SMCP Gene

  • Sperm Mitochondria-Associated Cysteine-Rich Protein 2 3
  • MCSP 3 4 6
  • MCS 3 4 6
  • Mitochondrial Capsule Selenoprotein 2 3
  • Sperm Mitochondrial-Associated Cysteine-Rich Protein 3
  • HSMCSGEN1 3

External Ids for SMCP Gene

Previous HGNC Symbols for SMCP Gene

  • MCSP

Previous GeneCards Identifiers for SMCP Gene

  • GC01P149664
  • GC01P151117
  • GC01P124213

Summaries for SMCP Gene

Entrez Gene Summary for SMCP Gene

  • Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]

GeneCards Summary for SMCP Gene

SMCP (Sperm Mitochondria-Associated Cysteine-Rich Protein) is a Protein Coding gene. Diseases associated with SMCP include hard palate cancer.

UniProtKB/Swiss-Prot for SMCP Gene

  • Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).

Gene Wiki entry for SMCP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMCP Gene

Genomics for SMCP Gene

Regulatory Elements for SMCP Gene

Genomic Location for SMCP Gene

Start:
152,878,317 bp from pter
End:
152,885,047 bp from pter
Size:
6,731 bases
Orientation:
Plus strand

Genomic View for SMCP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMCP Gene

Proteins for SMCP Gene

  • Protein details for SMCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49901-MCSP_HUMAN
    Recommended name:
    Sperm mitochondrial-associated cysteine-rich protein
    Protein Accession:
    P49901
    Secondary Accessions:
    • Q96A42

    Protein attributes for SMCP Gene

    Size:
    116 amino acids
    Molecular mass:
    12767 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMCP Gene

Proteomics data for SMCP Gene at MOPED

Post-translational modifications for SMCP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMCP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SMCP Gene

Domains for SMCP Gene

Protein Domains for SMCP Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMCP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SMCP Gene

Function for SMCP Gene

Molecular function for SMCP Gene

UniProtKB/Swiss-Prot Function:
Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).

Gene Ontology (GO) - Molecular Function for SMCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SMCP: view

Phenotypes for SMCP Gene

MGI mutant phenotypes for SMCP:
inferred from 1 alleles
GenomeRNAi human phenotypes for SMCP:
genes like me logo Genes that share phenotypes with SMCP: view

Animal Models for SMCP Gene

MGI Knock Outs for SMCP:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMCP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SMCP Gene

Localization for SMCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMCP Gene

Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMCP Gene COMPARTMENTS Subcellular localization image for SMCP gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 3

Gene Ontology (GO) - Cellular Components for SMCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion ISS --
GO:0016020 membrane --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with SMCP: view

Pathways for SMCP Gene

SuperPathways for SMCP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SMCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007341 penetration of zona pellucida ISS --
GO:0030317 sperm motility ISS --
genes like me logo Genes that share ontologies with SMCP: view

No data available for Pathways by source for SMCP Gene

Compounds for SMCP Gene

(2) Novoseek inferred chemical compound relationships for SMCP Gene

Compound -log(P) Hits PubMed IDs
cystine 61.7 1
cysteine 40.9 5
genes like me logo Genes that share compounds with SMCP: view

Transcripts for SMCP Gene

mRNA/cDNA for SMCP Gene

(39) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMCP Gene

Sperm mitochondria-associated cysteine-rich protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMCP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMCP Gene

No ASD Table

Relevant External Links for SMCP Gene

GeneLoc Exon Structure for
SMCP
ECgene alternative splicing isoforms for
SMCP

Expression for SMCP Gene

mRNA expression in normal human tissues for SMCP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMCP Gene

This gene is overexpressed in Testis (52.4).

Protein differential expression in normal tissues for SMCP Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SMCP Gene

SOURCE GeneReport for Unigene cluster for SMCP Gene Hs.111850

mRNA Expression by UniProt/SwissProt for SMCP Gene

P49901-MCSP_HUMAN
Tissue specificity: Testis. Is selectively expressed in the spermatids of seminiferous tubules.
genes like me logo Genes that share expressions with SMCP: view

Expression partners for SMCP Gene

In Situ Assay Products

Orthologs for SMCP Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMCP 35
  • 97.99 (n)
  • 95.69 (a)
SMCP 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smcp 16
cow
(Bos Taurus)
Mammalia SMCP 36
  • 47 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMCP 36
  • 42 (a)
OneToOne
Species with no ortholog for SMCP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMCP Gene

ENSEMBL:
Gene Tree for SMCP (if available)
TreeFam:
Gene Tree for SMCP (if available)

Paralogs for SMCP Gene

No data available for Paralogs for SMCP Gene

Variants for SMCP Gene

Sequence variations from dbSNP and Humsavar for SMCP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2339384 -- 152,876,362(+) ATCTC(C/T)GTATA upstream-variant-2KB
rs3737861 -- 152,878,462(-) GACAA(G/T)GTTTC intron-variant
rs3737862 -- 152,878,430(-) ACACA(C/T)ACAAT utr-variant-5-prime
rs4363387 -- 152,882,656(+) ACTTA(C/G)GTGCA intron-variant
rs4845489 -- 152,876,363(+) TCTCC(A/G)TATAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SMCP Gene

Variant ID Type Subtype PubMed ID
dgv131e1 CNV Complex 17122850
nsv831592 CNV Gain 17160897
esv7910 CNV Gain 19470904

Relevant External Links for SMCP Gene

HapMap Linkage Disequilibrium report
SMCP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMCP Gene

Disorders for SMCP Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SMCP Gene in MalaCards »

(1) Diseases for SMCP Gene including...

(2) University of Copenhagen DISEASES for SMCP Gene

Relevant External Links for SMCP

Genetic Association Database (GAD)
SMCP
genes like me logo Genes that share disorders with SMCP: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SMCP Gene

Publications for SMCP Gene

  1. Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP). (PMID: 8833144) Aho H. … Adham I.M. (Genomics 1996) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene. (PMID: 16325371) Hawthorne S.K. … Kleene K.C. (Genomics 2006) 3 23
  4. Function and redox state of mitochondrial localized cysteine-rich proteins important in the assembly of cytochrome c oxidase. (PMID: 18070608) Khalimonchuk O. … Winge D.R. (Biochim. Biophys. Acta 2008) 23
  5. Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons. (PMID: 1418626) Karimpour I. … Kleene K.C. (DNA Cell Biol. 1992) 3

Products for SMCP Gene

Sources for SMCP Gene

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