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Aliases for SMCO4 Gene

Aliases for SMCO4 Gene

  • Single-Pass Membrane Protein With Coiled-Coil Domains 4 2 3 5
  • C11orf75 3 4
  • FN5 3 4
  • Single-Pass Membrane And Coiled-Coil Domain-Containing Protein 4 3
  • Chromosome 11 Open Reading Frame 75 2
  • UPF0443 Protein C11orf75 3
  • Protein FN5 4

External Ids for SMCO4 Gene

Previous HGNC Symbols for SMCO4 Gene

  • C11orf75

Previous GeneCards Identifiers for SMCO4 Gene

  • GC11M093212

Summaries for SMCO4 Gene

GeneCards Summary for SMCO4 Gene

SMCO4 (Single-Pass Membrane Protein With Coiled-Coil Domains 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMCO4 Gene

Genomics for SMCO4 Gene

Regulatory Elements for SMCO4 Gene

Enhancers for SMCO4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F093523 1.6 FANTOM5 Ensembl ENCODE 27.2 +58.6 58576 10.6 HDGF TBP PKNOX1 WRNIP1 ARID4B RAD21 RARA RFX5 YY1 ZNF121 SMCO4 MED17 SLC36A4 C11orf54 GPR83 DEUP1 ENSG00000234106 GC11M093401
GH11F093515 0.8 FANTOM5 Ensembl 25.1 +71.1 71093 0.5 CTCF IKZF1 RAD21 SMCO4 SLC36A4 ENSG00000234106 GC11M093401
GH11F093497 0.7 Ensembl ENCODE 26.5 +88.3 88283 1.5 JUND HLF SMCO4 C11orf54 ENSG00000234106 GC11M093401
GH11F093476 0.7 ENCODE 25.4 +109.1 109054 2.7 RFX1 TEAD4 HLF CEBPB MAFG REST ZNF316 SMARCA4 POLR2A NFE2 SMCO4 GC11M093401 ENSG00000234106
GH11F093520 0.9 FANTOM5 Ensembl 10.6 +65.6 65576 1.0 SMARCA4 CEBPA MAFG CEBPB NFE2 CEBPG NFE2L2 SMCO4 SLC36A4 ENSG00000234106 GC11M093401
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMCO4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMCO4 Gene

Chromosome:
11
Start:
93,478,472 bp from pter
End:
93,586,855 bp from pter
Size:
108,384 bases
Orientation:
Minus strand

Genomic View for SMCO4 Gene

Genes around SMCO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMCO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMCO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMCO4 Gene

Proteins for SMCO4 Gene

  • Protein details for SMCO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRQ5-SMCO4_HUMAN
    Recommended name:
    Single-pass membrane and coiled-coil domain-containing protein 4
    Protein Accession:
    Q9NRQ5

    Protein attributes for SMCO4 Gene

    Size:
    59 amino acids
    Molecular mass:
    6738 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMCO4 Gene

Post-translational modifications for SMCO4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SMCO4 Gene

Domains & Families for SMCO4 Gene

Protein Domains for SMCO4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMCO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRQ5

UniProtKB/Swiss-Prot:

SMCO4_HUMAN :
  • Belongs to the SMCO4 family.
Family:
  • Belongs to the SMCO4 family.
genes like me logo Genes that share domains with SMCO4: view

No data available for Gene Families for SMCO4 Gene

Function for SMCO4 Gene

Gene Ontology (GO) - Molecular Function for SMCO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with SMCO4: view
genes like me logo Genes that share phenotypes with SMCO4: view

Animal Model Products

miRNA for SMCO4 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMCO4 Gene

Localization for SMCO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMCO4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMCO4 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SMCO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMCO4: view

Pathways & Interactions for SMCO4 Gene

SuperPathways for SMCO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SMCO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SMCO4: view

No data available for Pathways by source and SIGNOR curated interactions for SMCO4 Gene

Transcripts for SMCO4 Gene

Unigene Clusters for SMCO4 Gene

Single-pass membrane protein with coiled-coil domains 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMCO4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2: - -

Relevant External Links for SMCO4 Gene

GeneLoc Exon Structure for
SMCO4
ECgene alternative splicing isoforms for
SMCO4

Expression for SMCO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMCO4 Gene

mRNA differential expression in normal tissues according to GTEx for SMCO4 Gene

This gene is overexpressed in Liver (x4.4).

Protein differential expression in normal tissues from HIPED for SMCO4 Gene

This gene is overexpressed in Spleen (42.8), Ovary (11.1), Liver (8.1), and Adrenal (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SMCO4 Gene



Protein tissue co-expression partners for SMCO4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMCO4 Gene:

SMCO4

SOURCE GeneReport for Unigene cluster for SMCO4 Gene:

Hs.438064
genes like me logo Genes that share expression patterns with SMCO4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SMCO4 Gene

Orthologs for SMCO4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMCO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMCO4 34 35
  • 98.31 (n)
mouse
(Mus musculus)
Mammalia Smco4 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SMCO4 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SMCO4 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves C11ORF75 35
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMCO4 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.438 34
zebrafish
(Danio rerio)
Actinopterygii SMCO4 35
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1110 34
Species where no ortholog for SMCO4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMCO4 Gene

ENSEMBL:
Gene Tree for SMCO4 (if available)
TreeFam:
Gene Tree for SMCO4 (if available)

Paralogs for SMCO4 Gene

No data available for Paralogs for SMCO4 Gene

Variants for SMCO4 Gene

Sequence variations from dbSNP and Humsavar for SMCO4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10128553 -- 93,542,271(+) CTCGA(A/G)GCTGT intron-variant
rs10466331 -- 93,497,971(+) TATAA(A/C)AGTTA intron-variant
rs10466332 -- 93,498,080(+) CAGGA(A/T)ATACA intron-variant
rs10466333 -- 93,498,118(+) TACAC(G/T)TCAAA intron-variant
rs10466368 -- 93,496,590(+) CTGTC(C/T)ATCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMCO4 Gene

Variant ID Type Subtype PubMed ID
nsv1070065 CNV deletion 25765185
nsv1039134 CNV loss 25217958
esv3627294 CNV gain 21293372
esv2760208 CNV loss 21179565
dgv79n21 CNV loss 19592680

Variation tolerance for SMCO4 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMCO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMCO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMCO4 Gene

Disorders for SMCO4 Gene

Relevant External Links for SMCO4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMCO4

No disorders were found for SMCO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMCO4 Gene

Publications for SMCO4 Gene

  1. Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts. (PMID: 10863097) Kehrer-Sawatzki H. … Krone W. (Gene 2000) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for SMCO4 Gene

Sources for SMCO4 Gene

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