Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SMCO4 Gene

Aliases for SMCO4 Gene

  • Single-Pass Membrane Protein With Coiled-Coil Domains 4 2 3
  • C11orf75 3 4 6
  • FN5 3 4 6
  • Single-Pass Membrane And Coiled-Coil Domain-Containing Protein 4 3
  • Chromosome 11 Open Reading Frame 75 2
  • UPF0443 Protein C11orf75 3
  • Protein FN5 4

External Ids for SMCO4 Gene

Previous HGNC Symbols for SMCO4 Gene

  • C11orf75

Previous GeneCards Identifiers for SMCO4 Gene

  • GC11M093212

Summaries for SMCO4 Gene

GeneCards Summary for SMCO4 Gene

SMCO4 (Single-Pass Membrane Protein With Coiled-Coil Domains 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMCO4 Gene

Genomics for SMCO4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SMCO4 Gene

93,478,472 bp from pter
93,543,508 bp from pter
65,037 bases
Minus strand

Genomic View for SMCO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMCO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMCO4 Gene

No data available for Regulatory Elements for SMCO4 Gene

Proteins for SMCO4 Gene

  • Protein details for SMCO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Single-pass membrane and coiled-coil domain-containing protein 4
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SMCO4 Gene

    59 amino acids
    Molecular mass:
    6738 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMCO4 Gene

Proteomics data for SMCO4 Gene at MOPED

Post-translational modifications for SMCO4 Gene

No Post-translational modifications

Other Protein References for SMCO4 Gene

No data available for DME Specific Peptides for SMCO4 Gene

Domains for SMCO4 Gene

Protein Domains for SMCO4 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9NRQ5
  • Belongs to the SMCO4 family.
genes like me logo Genes that share domains with SMCO4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for SMCO4 Gene

Function for SMCO4 Gene

Gene Ontology (GO) - Molecular Function for SMCO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with SMCO4: view
genes like me logo Genes that share phenotypes with SMCO4: view

Animal Model Products

CRISPR Products

miRNA for SMCO4 Gene

miRTarBase miRNAs that target SMCO4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMCO4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SMCO4 Gene

Localization for SMCO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMCO4 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMCO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMCO4: view

No data available for Subcellular locations from COMPARTMENTS for SMCO4 Gene

Pathways for SMCO4 Gene

SuperPathways for SMCO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SMCO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SMCO4: view

No data available for Pathways by source for SMCO4 Gene

Transcripts for SMCO4 Gene

Unigene Clusters for SMCO4 Gene

Single-pass membrane protein with coiled-coil domains 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMCO4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMCO4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c
SP2: - -

Relevant External Links for SMCO4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMCO4 Gene

mRNA expression in normal human tissues for SMCO4 Gene

mRNA differential expression in normal tissues according to GTEx for SMCO4 Gene

This gene is overexpressed in Liver (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SMCO4 Gene

SOURCE GeneReport for Unigene cluster for SMCO4 Gene Hs.438064

genes like me logo Genes that share expressions with SMCO4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SMCO4 Gene

Orthologs for SMCO4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMCO4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMCO4 35
  • 98.31 (n)
  • 98.31 (a)
SMCO4 36
  • 98 (a)
(Bos Taurus)
Mammalia SMCO4 36
  • 93 (a)
(Mus musculus)
Mammalia BC017612 16
Smco4 36
  • 97 (a)
(Monodelphis domestica)
Mammalia SMCO4 36
  • 95 (a)
(Gallus gallus)
Aves C11ORF75 36
  • 95 (a)
(Anolis carolinensis)
Reptilia SMCO4 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.438 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1110 35
(Danio rerio)
Actinopterygii SMCO4 36
  • 81 (a)
Species with no ortholog for SMCO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMCO4 Gene

Gene Tree for SMCO4 (if available)
Gene Tree for SMCO4 (if available)

Paralogs for SMCO4 Gene

No data available for Paralogs for SMCO4 Gene

Variants for SMCO4 Gene

Sequence variations from dbSNP and Humsavar for SMCO4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7365 -- 93,478,598(+) AAAGA(A/G)GCATG utr-variant-3-prime
rs16834 -- 93,482,796(+) CTTCC(A/G)GTAGC intron-variant
rs897554 -- 93,485,319(+) AGCCT(C/T)ACCAC intron-variant
rs897555 -- 93,481,457(+) ATGGA(A/G)TAGGA intron-variant
rs897556 -- 93,514,443(+) CAAAG(A/G)TCACC intron-variant

Relevant External Links for SMCO4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMCO4 Gene

Disorders for SMCO4 Gene

No disorders were found for SMCO4 Gene.

No data available for UniProtKB/Swiss-Prot for SMCO4 Gene

Publications for SMCO4 Gene

  1. Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts. (PMID: 10863097) Kehrer-Sawatzki H. … Krone W. (Gene 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SMCO4 Gene

Sources for SMCO4 Gene

Back to Top