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Aliases for SMCO3 Gene

Aliases for SMCO3 Gene

  • Single-Pass Membrane Protein With Coiled-Coil Domains 3 2 3
  • C12orf69 3 4
  • Single-Pass Membrane And Coiled-Coil Domain-Containing Protein 3 3
  • Chromosome 12 Open Reading Frame 69 2

External Ids for SMCO3 Gene

Previous HGNC Symbols for SMCO3 Gene

  • C12orf69

Previous GeneCards Identifiers for SMCO3 Gene

  • GC12M014961

Summaries for SMCO3 Gene

GeneCards Summary for SMCO3 Gene

SMCO3 (Single-Pass Membrane Protein With Coiled-Coil Domains 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMCO3 Gene

Genomics for SMCO3 Gene

Genomic Location for SMCO3 Gene

14,804,650 bp from pter
14,814,182 bp from pter
9,533 bases
Minus strand

Genomic View for SMCO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMCO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMCO3 Gene

No data available for Regulatory Elements for SMCO3 Gene

Proteins for SMCO3 Gene

  • Protein details for SMCO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Single-pass membrane and coiled-coil domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q8NAI5

    Protein attributes for SMCO3 Gene

    225 amino acids
    Molecular mass:
    24877 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03930.1; Type=Frameshift; Positions=219; Evidence={ECO:0000305};

neXtProt entry for SMCO3 Gene

Proteomics data for SMCO3 Gene at MOPED

Post-translational modifications for SMCO3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMCO3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMCO3 Gene

Domains for SMCO3 Gene

Protein Domains for SMCO3 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMCO3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMCO3 Gene

Function for SMCO3 Gene

Gene Ontology (GO) - Molecular Function for SMCO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SMCO3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMCO3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SMCO3 Gene

Localization for SMCO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMCO3 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMCO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMCO3: view

No data available for Subcellular locations from COMPARTMENTS for SMCO3 Gene

Pathways for SMCO3 Gene

SuperPathways for SMCO3 Gene

No Data Available

Interacting Proteins for SMCO3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000381895 A2RU48-SMCO3_HUMAN for SMCO3 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SMCO3 Gene


No data available for Pathways by source for SMCO3 Gene

Transcripts for SMCO3 Gene

mRNA/cDNA for SMCO3 Gene

(15) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMCO3 Gene

Single-pass membrane protein with coiled-coil domains 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMCO3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SMCO3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMCO3 Gene

No ASD Table

Relevant External Links for SMCO3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMCO3 Gene

mRNA expression in normal human tissues for SMCO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMCO3 Gene

This gene is overexpressed in Nerve - Tibial (9.9) and Kidney - Cortex (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SMCO3 Gene

SOURCE GeneReport for Unigene cluster for SMCO3 Gene Hs.220931

genes like me logo Genes that share expressions with SMCO3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SMCO3 Gene

Orthologs for SMCO3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMCO3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMCO3 35
  • 99.7 (n)
  • 100 (a)
SMCO3 36
  • 100 (a)
(Bos Taurus)
Mammalia SMCO3 35
  • 89.63 (n)
  • 91.56 (a)
SMCO3 36
  • 92 (a)
(Canis familiaris)
Mammalia SMCO3 35
  • 92.3 (n)
  • 92.89 (a)
SMCO3 36
  • 93 (a)
(Mus musculus)
Mammalia C030030A07Rik 16
Smco3 35
  • 83.56 (n)
  • 84.89 (a)
Smco3 36
  • 85 (a)
(Monodelphis domestica)
Mammalia SMCO3 36
  • 76 (a)
(Rattus norvegicus)
Mammalia LOC100912527 35
  • 80 (n)
  • 81.33 (a)
(Gallus gallus)
Aves C1H12ORF69 35
  • 64.3 (n)
  • 58.22 (a)
SMCO3 36
  • 58 (a)
(Anolis carolinensis)
Reptilia SMCO3 36
  • 54 (a)
Species with no ortholog for SMCO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMCO3 Gene

Gene Tree for SMCO3 (if available)
Gene Tree for SMCO3 (if available)

Paralogs for SMCO3 Gene

No data available for Paralogs for SMCO3 Gene

Variants for SMCO3 Gene

Sequence variations from dbSNP and Humsavar for SMCO3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_043558 -
VAR_043559 -

Relevant External Links for SMCO3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMCO3 Gene

Disorders for SMCO3 Gene

No disorders were found for SMCO3 Gene.

No data available for UniProtKB/Swiss-Prot for SMCO3 Gene

Publications for SMCO3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PMID: 23449627) Cousminer D.L. … WidAcn E. (Hum. Mol. Genet. 2013) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4

Products for SMCO3 Gene

Sources for SMCO3 Gene

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