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Aliases for SMCO3 Gene

Aliases for SMCO3 Gene

  • Single-Pass Membrane Protein With Coiled-Coil Domains 3 2 3 5
  • C12orf69 3 4
  • Single-Pass Membrane And Coiled-Coil Domain-Containing Protein 3 3
  • Chromosome 12 Open Reading Frame 69 2

External Ids for SMCO3 Gene

Previous HGNC Symbols for SMCO3 Gene

  • C12orf69

Previous GeneCards Identifiers for SMCO3 Gene

  • GC12M014961

Summaries for SMCO3 Gene

GeneCards Summary for SMCO3 Gene

SMCO3 (Single-Pass Membrane Protein With Coiled-Coil Domains 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMCO3 Gene

Genomics for SMCO3 Gene

Regulatory Elements for SMCO3 Gene

Enhancers for SMCO3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F014869 0.4 Ensembl 11 -54.9 -54919 0.2 NFE2 FOS FOSL2 KLF4 PDE6H ENSG00000256339 SMCO3 GC12M014862 ART4
GH12F014755 1.2 Ensembl ENCODE 10.9 +57.5 57463 2.1 CTCF SCRT2 NFE2 RAD21 MAFK SP7 C12orf60 GUCY2C SMCO3 WBP11 ENSG00000261324 GC12M014736
GH12F014883 0.2 ENCODE 10.5 -70.8 -70790 3.2 PKNOX1 CTBP1 GATA3 POLR2A CBX5 RCOR1 MTA2 CBFB DPF2 TBX21 ENSG00000256339 ERP27 PDE6H ART4 SMCO3 ARHGDIB H2AFJ HIST4H4 WBP11 C12orf60
GH12F014881 0.5 Ensembl 10.5 -67.0 -67019 0.4 SPI1 GABPA ART4 ENSG00000256339 SMCO3 ARHGDIB WBP11 C12orf60 PDE6H MGP GC12M014862
GH12F014999 0.6 ENCODE 10.5 -185.4 -185414 0.2 CTCF JUND RAD21 ART4 PDE6H ENSG00000256339 ARHGDIB ERP27 SMCO3 C12orf60 MGP LINC01489 LOC105369670
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SMCO3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMCO3 Gene

Chromosome:
12
Start:
14,803,723 bp from pter
End:
14,814,182 bp from pter
Size:
10,460 bases
Orientation:
Minus strand

Genomic View for SMCO3 Gene

Genes around SMCO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMCO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMCO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMCO3 Gene

Proteins for SMCO3 Gene

  • Protein details for SMCO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RU48-SMCO3_HUMAN
    Recommended name:
    Single-pass membrane and coiled-coil domain-containing protein 3
    Protein Accession:
    A2RU48
    Secondary Accessions:
    • Q8NAI5

    Protein attributes for SMCO3 Gene

    Size:
    225 amino acids
    Molecular mass:
    24877 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03930.1; Type=Frameshift; Positions=219; Evidence={ECO:0000305};

neXtProt entry for SMCO3 Gene

Post-translational modifications for SMCO3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMCO3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMCO3 Gene

Domains & Families for SMCO3 Gene

Protein Domains for SMCO3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMCO3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMCO3 Gene

Function for SMCO3 Gene

Gene Ontology (GO) - Molecular Function for SMCO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SMCO3: view

Phenotypes for SMCO3 Gene

GenomeRNAi human phenotypes for SMCO3:
genes like me logo Genes that share phenotypes with SMCO3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMCO3 Gene

Localization for SMCO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMCO3 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMCO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMCO3: view

No data available for Subcellular locations from COMPARTMENTS for SMCO3 Gene

Pathways & Interactions for SMCO3 Gene

SuperPathways for SMCO3 Gene

No Data Available

Interacting Proteins for SMCO3 Gene

Gene Ontology (GO) - Biological Process for SMCO3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMCO3 Gene

Transcripts for SMCO3 Gene

mRNA/cDNA for SMCO3 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMCO3 Gene

Single-pass membrane protein with coiled-coil domains 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMCO3 Gene

No ASD Table

Relevant External Links for SMCO3 Gene

GeneLoc Exon Structure for
SMCO3
ECgene alternative splicing isoforms for
SMCO3

Expression for SMCO3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMCO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMCO3 Gene

This gene is overexpressed in Nerve - Tibial (x9.9) and Kidney - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for SMCO3 Gene

This gene is overexpressed in Plasma (56.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SMCO3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SMCO3 Gene:

SMCO3

SOURCE GeneReport for Unigene cluster for SMCO3 Gene:

Hs.220931
genes like me logo Genes that share expression patterns with SMCO3: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SMCO3 Gene

Orthologs for SMCO3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMCO3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMCO3 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia SMCO3 34 35
  • 92.3 (n)
cow
(Bos Taurus)
Mammalia SMCO3 34 35
  • 89.63 (n)
mouse
(Mus musculus)
Mammalia Smco3 34 16 35
  • 83.56 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912527 34
  • 80 (n)
oppossum
(Monodelphis domestica)
Mammalia SMCO3 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF69 34
  • 64.3 (n)
SMCO3 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMCO3 35
  • 54 (a)
OneToOne
Species where no ortholog for SMCO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMCO3 Gene

ENSEMBL:
Gene Tree for SMCO3 (if available)
TreeFam:
Gene Tree for SMCO3 (if available)

Paralogs for SMCO3 Gene

No data available for Paralogs for SMCO3 Gene

Variants for SMCO3 Gene

Sequence variations from dbSNP and Humsavar for SMCO3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10846061 -- 14,812,361(+) atggc(A/G)tgagc intron-variant
rs10846062 -- 14,812,847(+) GATCC(C/T)GTCAC intron-variant
rs111455009 -- 14,817,558(+) TCCCA(C/T)TTATG intron-variant, upstream-variant-2KB
rs112718429 -- 14,808,492(+) GGACC(A/G)TATGT intron-variant, upstream-variant-2KB
rs112861905 -- 14,807,741(+) TAATC(-/AT)GTGAT intron-variant

Variation tolerance for SMCO3 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMCO3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMCO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMCO3 Gene

Disorders for SMCO3 Gene

Relevant External Links for SMCO3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMCO3

No disorders were found for SMCO3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMCO3 Gene

Publications for SMCO3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PMID: 23449627) Cousminer D.L. … WidAcn E. (Hum. Mol. Genet. 2013) 3 64

Products for SMCO3 Gene

Sources for SMCO3 Gene

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