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Aliases for SMCO2 Gene

Aliases for SMCO2 Gene

  • Single-Pass Membrane Protein With Coiled-Coil Domains 2 2 3
  • C12orf70 3 4
  • Single-Pass Membrane And Coiled-Coil Domain-Containing Protein 2 3
  • Chromosome 12 Open Reading Frame 70 2

External Ids for SMCO2 Gene

Previous HGNC Symbols for SMCO2 Gene

  • C12orf70

Previous GeneCards Identifiers for SMCO2 Gene

  • GC12P027620

Summaries for SMCO2 Gene

GeneCards Summary for SMCO2 Gene

SMCO2 (Single-Pass Membrane Protein With Coiled-Coil Domains 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMCO2 Gene

Genomics for SMCO2 Gene

Genomic Location for SMCO2 Gene

27,466,810 bp from pter
27,502,185 bp from pter
35,376 bases
Plus strand

Genomic View for SMCO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMCO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMCO2 Gene

No data available for Regulatory Elements for SMCO2 Gene

Proteins for SMCO2 Gene

  • Protein details for SMCO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Single-pass membrane and coiled-coil domain-containing protein 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SMCO2 Gene

    343 amino acids
    Molecular mass:
    39487 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMCO2 Gene

Proteomics data for SMCO2 Gene at MOPED

Post-translational modifications for SMCO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMCO2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMCO2 Gene

Domains for SMCO2 Gene

Protein Domains for SMCO2 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMCO2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMCO2 Gene

Function for SMCO2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SMCO2 Gene

Localization for SMCO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMCO2 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMCO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMCO2: view

No data available for Subcellular locations from COMPARTMENTS for SMCO2 Gene

Pathways for SMCO2 Gene

SuperPathways for SMCO2 Gene

No Data Available

Interacting Proteins for SMCO2 Gene

Gene Ontology (GO) - Biological Process for SMCO2 Gene


No data available for Pathways by source for SMCO2 Gene

Transcripts for SMCO2 Gene

mRNA/cDNA for SMCO2 Gene

(5) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMCO2 Gene

Single-pass membrane protein with coiled-coil domains 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMCO2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMCO2 Gene

No ASD Table

Relevant External Links for SMCO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMCO2 Gene

mRNA expression in normal human tissues for SMCO2 Gene

mRNA differential expression in normal tissues according to GTEx for SMCO2 Gene

This gene is overexpressed in Esophagus - Mucosa (4.8) and Testis (4.5).

Protein differential expression in normal tissues for SMCO2 Gene

This gene is overexpressed in Plasma (64.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SMCO2 Gene

SOURCE GeneReport for Unigene cluster for SMCO2 Gene Hs.282121

genes like me logo Genes that share expressions with SMCO2: view

Expression partners for SMCO2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SMCO2 Gene

Orthologs for SMCO2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMCO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C5H12orf70 35
  • 78.2 (n)
  • 60.9 (a)
SMCO2 36
  • 54 (a)
(Canis familiaris)
Mammalia SMCO2 35
  • 77.61 (n)
  • 59.1 (a)
SMCO2 36
  • 54 (a)
(Mus musculus)
Mammalia Smco2 35
  • 66.05 (n)
  • 50.62 (a)
1700023A16Rik 16
Smco2 36
  • 46 (a)
(Pan troglodytes)
Mammalia SMCO2 35
  • 98.74 (n)
  • 97.08 (a)
SMCO2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia LOC100361371 35
  • 64.12 (n)
  • 46.18 (a)
Species with no ortholog for SMCO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMCO2 Gene

Gene Tree for SMCO2 (if available)
Gene Tree for SMCO2 (if available)

Paralogs for SMCO2 Gene

No data available for Paralogs for SMCO2 Gene

Variants for SMCO2 Gene

Sequence variations from dbSNP and Humsavar for SMCO2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs182522 -- 27,501,399(+) cgaaa(A/G)agtga intron-variant
rs188632 -- 27,501,231(+) ctaac(A/C)cggtg intron-variant
rs191041 -- 27,496,924(+) AAGAT(A/G)CTCAT intron-variant
rs192796 -- 27,501,376(+) gcgcc(A/C)ctgca intron-variant
rs192797 -- 27,501,343(+) cccaa(A/G)aggca intron-variant

Relevant External Links for SMCO2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMCO2 Gene

Disorders for SMCO2 Gene

No disorders were found for SMCO2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SMCO2 Gene

Publications for SMCO2 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4

Products for SMCO2 Gene

Sources for SMCO2 Gene

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