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Aliases for SMCO1 Gene

Aliases for SMCO1 Gene

  • Single-Pass Membrane Protein With Coiled-Coil Domains 1 2 3 4
  • C3orf43 3 4
  • Single-Pass Membrane And Coiled-Coil Domain-Containing Protein 1 3
  • Chromosome 3 Open Reading Frame 43 2

External Ids for SMCO1 Gene

Previous HGNC Symbols for SMCO1 Gene

  • C3orf43

Previous GeneCards Identifiers for SMCO1 Gene

  • GC03M196234

Summaries for SMCO1 Gene

GeneCards Summary for SMCO1 Gene

SMCO1 (Single-Pass Membrane Protein With Coiled-Coil Domains 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMCO1 Gene

Genomics for SMCO1 Gene

Genomic Location for SMCO1 Gene

196,506,877 bp from pter
196,515,366 bp from pter
8,490 bases
Minus strand

Genomic View for SMCO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMCO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMCO1 Gene

No data available for Regulatory Elements for SMCO1 Gene

Proteins for SMCO1 Gene

  • Protein details for SMCO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Single-pass membrane and coiled-coil domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KW20

    Protein attributes for SMCO1 Gene

    214 amino acids
    Molecular mass:
    24598 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMCO1 Gene

Proteomics data for SMCO1 Gene at MOPED

Post-translational modifications for SMCO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMCO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMCO1 Gene

Domains for SMCO1 Gene

Protein Domains for SMCO1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMCO1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMCO1 Gene

Function for SMCO1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMCO1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMCO1 Gene

Localization for SMCO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMCO1 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMCO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMCO1: view

No data available for Subcellular locations from COMPARTMENTS for SMCO1 Gene

Pathways for SMCO1 Gene

SuperPathways for SMCO1 Gene

No Data Available

Interacting Proteins for SMCO1 Gene

Gene Ontology (GO) - Biological Process for SMCO1 Gene


No data available for Pathways by source for SMCO1 Gene

Transcripts for SMCO1 Gene

mRNA/cDNA for SMCO1 Gene

(2) REFSEQ mRNAs :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMCO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMCO1 Gene

No ASD Table

Relevant External Links for SMCO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMCO1 Gene

mRNA expression in normal human tissues for SMCO1 Gene

mRNA differential expression in normal tissues according to GTEx for SMCO1 Gene

This gene is overexpressed in Heart - Left Ventricle (28.0), Muscle - Skeletal (13.8), and Heart - Atrial Appendage (8.3).

Protein differential expression in normal tissues for SMCO1 Gene

This gene is overexpressed in Stomach (45.2) and Colon muscle (23.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SMCO1 Gene

genes like me logo Genes that share expressions with SMCO1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for SMCO1 Gene

Orthologs for SMCO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMCO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C1H3orf43 35
  • 86.45 (n)
  • 80.84 (a)
MGC152484 36
  • 81 (a)
(Canis familiaris)
Mammalia C33H3orf43 35
  • 87.23 (n)
  • 83.64 (a)
SMCO1 36
  • 84 (a)
(Mus musculus)
Mammalia Smco1 35
  • 80.37 (n)
  • 75.7 (a)
2310010M20Rik 16
Smco1 36
  • 76 (a)
(Pan troglodytes)
Mammalia C3H3orf43 35
  • 98.91 (n)
  • 98.13 (a)
SMCO1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC100911042 35
  • 81.31 (n)
  • 77.1 (a)
(Monodelphis domestica)
Mammalia SMCO1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia SMCO1 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c3orf43 35
  • 46.77 (n)
  • 27.86 (a)
Species with no ortholog for SMCO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMCO1 Gene

Gene Tree for SMCO1 (if available)
Gene Tree for SMCO1 (if available)

Paralogs for SMCO1 Gene

No data available for Paralogs for SMCO1 Gene

Variants for SMCO1 Gene

Sequence variations from dbSNP and Humsavar for SMCO1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs190593956 -- 196,509,456(+) ATTTT(G/T)CAATG intron-variant
rs190324581 -- 196,516,762(+) AGCTA(C/G)CTTGG upstream-variant-2KB
rs189871634 -- 196,511,923(+) GAAAC(C/T)TGCCT intron-variant
rs189648816 -- 196,512,808(+) CGGCC(C/T)AGAGA intron-variant
rs189259904 -- 196,509,300(+) ACCTC(A/G)TGATC intron-variant

Relevant External Links for SMCO1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMCO1 Gene

Disorders for SMCO1 Gene

No disorders were found for SMCO1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SMCO1 Gene

Publications for SMCO1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SMCO1 Gene

Sources for SMCO1 Gene

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