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Aliases for SMCO1 Gene

Aliases for SMCO1 Gene

  • Single-Pass Membrane Protein With Coiled-Coil Domains 1 2 3 4 5
  • C3orf43 3 4
  • Single-Pass Membrane And Coiled-Coil Domain-Containing Protein 1 3
  • Chromosome 3 Open Reading Frame 43 2

External Ids for SMCO1 Gene

Previous HGNC Symbols for SMCO1 Gene

  • C3orf43

Previous GeneCards Identifiers for SMCO1 Gene

  • GC03M196234

Summaries for SMCO1 Gene

GeneCards Summary for SMCO1 Gene

SMCO1 (Single-Pass Membrane Protein With Coiled-Coil Domains 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMCO1 Gene

Genomics for SMCO1 Gene

Regulatory Elements for SMCO1 Gene

Enhancers for SMCO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SMCO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMCO1 Gene

196,506,877 bp from pter
196,515,366 bp from pter
8,490 bases
Minus strand

Genomic View for SMCO1 Gene

Genes around SMCO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMCO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMCO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMCO1 Gene

Proteins for SMCO1 Gene

  • Protein details for SMCO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Single-pass membrane and coiled-coil domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KW20

    Protein attributes for SMCO1 Gene

    214 amino acids
    Molecular mass:
    24598 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMCO1 Gene

Post-translational modifications for SMCO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMCO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMCO1 Gene

Domains & Families for SMCO1 Gene

Protein Domains for SMCO1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMCO1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMCO1 Gene

Function for SMCO1 Gene

Phenotypes for SMCO1 Gene

GenomeRNAi human phenotypes for SMCO1:
genes like me logo Genes that share phenotypes with SMCO1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMCO1 Gene

Localization for SMCO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMCO1 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMCO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMCO1: view

No data available for Subcellular locations from COMPARTMENTS for SMCO1 Gene

Pathways & Interactions for SMCO1 Gene

SuperPathways for SMCO1 Gene

No Data Available

Interacting Proteins for SMCO1 Gene

Selected Interacting proteins: Q147U7-SMCO1_HUMAN for SMCO1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SMCO1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SMCO1 Gene

Drugs & Compounds for SMCO1 Gene

No Compound Related Data Available

Transcripts for SMCO1 Gene

mRNA/cDNA for SMCO1 Gene

(2) REFSEQ mRNAs :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMCO1 Gene

No ASD Table

Relevant External Links for SMCO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMCO1 Gene

mRNA expression in normal human tissues for SMCO1 Gene

mRNA differential expression in normal tissues according to GTEx for SMCO1 Gene

This gene is overexpressed in Heart - Left Ventricle (x28.0), Muscle - Skeletal (x13.8), and Heart - Atrial Appendage (x8.3).

Protein differential expression in normal tissues from HIPED for SMCO1 Gene

This gene is overexpressed in Stomach (45.2) and Colon muscle (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMCO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMCO1 Gene:

genes like me logo Genes that share expression patterns with SMCO1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SMCO1 Gene

Orthologs for SMCO1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMCO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C1H3orf43 34
  • 86.45 (n)
  • 80.84 (a)
MGC152484 35
  • 81 (a)
(Canis familiaris)
Mammalia C33H3orf43 34
  • 87.23 (n)
  • 83.64 (a)
SMCO1 35
  • 84 (a)
(Mus musculus)
Mammalia Smco1 34
  • 80.37 (n)
  • 75.7 (a)
Smco1 16
Smco1 35
  • 76 (a)
(Pan troglodytes)
Mammalia C3H3orf43 34
  • 98.91 (n)
  • 98.13 (a)
SMCO1 35
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC100911042 34
  • 81.31 (n)
  • 77.1 (a)
(Monodelphis domestica)
Mammalia SMCO1 35
  • 63 (a)
(Anolis carolinensis)
Reptilia SMCO1 35
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c3orf43 34
  • 46.77 (n)
  • 27.86 (a)
Species where no ortholog for SMCO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMCO1 Gene

Gene Tree for SMCO1 (if available)
Gene Tree for SMCO1 (if available)

Paralogs for SMCO1 Gene

No data available for Paralogs for SMCO1 Gene

Variants for SMCO1 Gene

Sequence variations from dbSNP and Humsavar for SMCO1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9869292 - 196,509,662(+) TTTGT(A/G)GTCTA reference, missense
rs11926701 - 196,509,530(+) TGCCC(A/G)AACTG reference, missense
rs11914954 -- 196,509,207(+) accac(A/G)cccgg intron-variant
rs11918122 -- 196,511,108(+) GGAAA(C/T)TTGCC intron-variant
rs11925828 -- 196,509,211(+) caccc(A/G)gctaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMCO1 Gene

Variant ID Type Subtype PubMed ID
esv2053432 CNV deletion 18987734
nsv1003066 CNV gain 25217958
nsv469831 CNV gain 16826518

Variation tolerance for SMCO1 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.73; 83.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMCO1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMCO1 Gene

Disorders for SMCO1 Gene

Relevant External Links for SMCO1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SMCO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMCO1 Gene

Publications for SMCO1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for SMCO1 Gene

Sources for SMCO1 Gene

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