Aliases for SMC6 Gene
External Ids for SMC6 Gene
Previous HGNC Symbols for SMC6 Gene
Previous GeneCards Identifiers for SMC6 Gene
GeneCards Summary for SMC6 Gene
SMC6 (Structural Maintenance Of Chromosomes 6) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and SUMOylation.
UniProtKB/Swiss-Prot for SMC6 Gene
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).