Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SMC6 Gene

protein-coding   GIFtS: 50
GCID: GC02M017845

Structural Maintenance Of Chromosomes 6

(Previous name: SMC6 structural maintenance of chromosomes 6-like 1 (yeast))
(Previous symbol: SMC6L1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Structural Maintenance Of Chromosomes 61 2     SMC Protein 62 3
SMC6L11 2 3 5     SMC6 Structural Maintenance Of Chromosomes 6-Like 1 (Yeast)1
SMC-62 3     SMC6 Structural Maintenance Of Chromosomes 6-Like 12
hSMC62 3     Structural Maintenance Of Chromosomes Protein 62

External Ids:    HGNC: 204661   Entrez Gene: 796772   Ensembl: ENSG000001630297   OMIM: 6093875   UniProtKB: Q96SB83   

Export aliases for SMC6 gene to outside databases

Previous GC identifer: GC02M017708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SMC6 Gene:
SMC6 (structural maintenance of chromosomes 6) is a protein-coding gene.

UniProtKB/Swiss-Prot: SMC6_HUMAN, Q96SB8
Function: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous
recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3
cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in
ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome)
components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).
Required for recruitment of telomeres to PML nuclear bodies

Gene Wiki entry for SMC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMC6 gene promoter:
         TBP   USF1   Sox5   AML1a   Pax-6   CUTL1   E4BP4   S8   TFIID   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMC6 promoter sequence
   Search Chromatin IP Primers for SMC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.2   Ensembl cytogenetic band:  2p24.2   HGNC cytogenetic band: 2p24.3

SMC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMC6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M017845:  view genomic region     (about GC identifiers)

Start:
17,845,079 bp from pter      End:
17,981,509 bp from pter
Size:
136,431 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SMC6_HUMAN, Q96SB8 (See protein sequence)
Recommended Name: Structural maintenance of chromosomes protein 6  
Size: 1091 amino acids; 126326 Da
Subunit: Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6,
NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2
Sequence caution: Sequence=AAH32675.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAB15236.1; Type=Frameshift; Positions=718;
Secondary accessions: A8K8Q6 D6W518 Q05BV4 Q9H0X3 Q9H6M0
Alternative splicing: 2 isoforms:  Q96SB8-1   Q96SB8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMC6: NX_Q96SB8

Explore proteomics data for SMC6 at MOPED

Post-translational modifications: 

  • Sumoylated by NSMCE2/MMS211
  • Ubiquitinated1
  • Ubiquitination2 at Lys230, Lys268, Lys658, Lys786, Lys862, Lys917, Lys928, Lys1060
  • Modification sites at PhosphoSitePlus

  • See SMC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135758.1  NP_078900.1  

    ENSEMBL proteins: 
     ENSP00000404092   ENSP00000323439   ENSP00000384539   ENSP00000408644   ENSP00000412246  
     ENSP00000415352   ENSP00000370672  

    SMC6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SMC6
    OriGene Protein Over-expression Lysate for SMC6
    OriGene MassSpec for SMC6
    OriGene Custom Protein Services for SMC6
    GenScript Custom Purified and Recombinant Proteins Services for SMC6
    Novus Biologicals SMC6 Protein
    Novus Biologicals SMC6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SMC6

     
    Search eBioscience for Proteins for SMC6 

    SMC6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SMC6
    Novus Biologicals SMC6 Antibodies
    Abcam antibodies for SMC6
    Cloud-Clone Corp. Antibodies for SMC6
    ThermoFisher Antibody for SMC6
    LSBio Antibodies in human, mouse, rat for SMC6

    SMC6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SMC6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SMC6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SMC6
    Cloud-Clone Corp. CLIAs for SMC6
    Search eBioscience for ELISAs for SMC6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SMC: Structural maintenance of chromosomes proteins

    3 InterPro protein domains:
     IPR003395 RecF/RecN/SMC_N
     IPR027132 SMC6
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q96SB8

    ProtoNet protein and cluster: Q96SB8

    UniProtKB/Swiss-Prot: SMC6_HUMAN, Q96SB8
    Domain: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the
    heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer (By similarity)
    Similarity: Belongs to the SMC family. SMC6 subfamily


    Find genes that share domains with SMC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMC6_HUMAN, Q96SB8
    Function: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous
    recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3
    cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in
    ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome)
    components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).
    Required for recruitment of telomeres to PML nuclear bodies

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14701739
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with SMC6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMC6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SMC6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SMC6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SMC6

    miRNA
    Products:
        
    miRTarBase miRNAs that target SMC6:
    hsa-mir-222-3p (MIRT046627), hsa-mir-125b-5p (MIRT045948)

    Block miRNA regulation of human, mouse, rat SMC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMC6 (see all 27):
    hsa-miR-623 hsa-miR-875-3p hsa-miR-137 hsa-miR-520d-5p hsa-miR-764 hsa-miR-371-5p hsa-miR-1323 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidSMC6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SMC6
    Predesigned siRNA for gene silencing in human, mouse, rat SMC6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SMC6

    Clone
    Products:
         
    OriGene clones in human, mouse for SMC6 (see all 13)
    OriGene ORF clones in mouse, rat for SMC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SMC6 (NM_002806)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SMC6
    Browse ESI BIO Cell Lines and PureStem Progenitors for SMC6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SMC6_HUMAN, Q96SB8: Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML
    nuclear bodies in ALT cell lines
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IDA17589526
    GO:0005622intracellular IDA--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0016605PML body IDA17589526

    Find genes that share ontologies with SMC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMC6
    Interactions:

        GeneGlobe Interaction Network for SMC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SMC6 (Q96SB81, 3 ENSP000003234394) via UniProtKB, MINT, STRING, and/or I2D (see all 152)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000722telomere maintenance via recombination IMP17589526
    GO:0000724double-strand break repair via homologous recombination IEA--
    GO:0090398cellular senescence IMP17589526

    Find genes that share ontologies with SMC6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMC6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SMC6 gene (2 alternative transcripts): 
    NM_001142286.1  NM_024624.5  

    Unigene Cluster for SMC6:

    Structural maintenance of chromosomes 6
    Hs.526728  [show with all ESTs]
    Unigene Representative Sequence: NM_001142286
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448223(uc002rco.3) ENST00000351948(uc002rcn.3 uc010exo.3)
    ENST00000481708 ENST00000402989 ENST00000446852(uc002rcr.1) ENST00000430591
    ENST00000428868 ENST00000489535 ENST00000381272(uc002rcp.1 uc002rcq.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SMC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMC6 (see all 27):
    hsa-miR-623 hsa-miR-875-3p hsa-miR-137 hsa-miR-520d-5p hsa-miR-764 hsa-miR-371-5p hsa-miR-1323 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidSMC6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SMC6
    Predesigned siRNA for gene silencing in human, mouse, rat SMC6
    Clone
    Products:
         
    OriGene clones in human, mouse for SMC6 (see all 13)
    OriGene ORF clones in mouse, rat for SMC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SMC6 (NM_002806)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SMC6
    OriGene qSTAR qPCR primer pairs in human, mouse for SMC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SMC6
      QuantiTect SYBR Green Assays in human, mouse, rat SMC6
      QuantiFast Probe-based Assays in human, mouse, rat SMC6

    Additional mRNA sequence: 

    AJ310551.1 AK025769.1 AK092853.1 AK098325.1 AK292421.1 AL136544.1 AL832979.1 BC011389.1 
    BC022998.1 BC032675.1 BC039828.1 HM243533.1 

    7 DOTS entries:

    DT.447128  DT.101965580  DT.97790814  DT.99939706  DT.100740587  DT.40279713  DT.437499 

    Selected AceView cDNA sequences (see all 145):

    BM978448 BM831097 CB158124 AL136544 C00625 AK092853 AW104532 NM_024624 
    BF939186 AJ310551 BC011389 CA446198 BM801991 AL832979 AX747768 BF446150 
    CA390923 BX476614 BM450250 AA830067 BC039828 BM720269 CB159479 CR618309 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SMC6 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                                                                                                                                -                           
    SP2:                                                                                                                                                            
    SP3:                    -                                                                                                                                       
    SP4:                                                                                                                                -                           
    SP5:              -     -                                                                                                                                       

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b ^ 29a · 29b
    SP1:                                -                 -                     
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for SMC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SMC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SMC6 Expression
    About this image

    SMC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.526728

    UniProtKB/Swiss-Prot: SMC6_HUMAN, Q96SB8
    Tissue specificity: Widely expressed. Overexpressed in testis

        Custom PCR Arrays for SMC6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SMC6
    OriGene qSTAR qPCR primer pairs in human, mouse for SMC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SMC6
    QuantiTect SYBR Green Assays in human, mouse, rat SMC6
    QuantiFast Probe-based Assays in human, mouse, rat SMC6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMC6 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smc61 , 5 structural maintenance of chromosomes 61, 5 89.09(n)1
    90.81(a)1
      12 (5.58 cM)5
    672411  NM_025695.41  NP_079971.21 
     112658865 
    chicken
    (Gallus gallus)
    Aves SMC61 structural maintenance of chromosomes 6 68.05(n)
    60.11(a)
      421950  XM_004935781.1  XP_004935838.1 
    lizard
    (Anolis carolinensis)
    Reptilia SMC66
    structural maintenance of chromosomes 6
    57(a)
    1 ↔ 1
    1(143049145-143120224)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689302 hypothetical protein MGC68930 74.75(n)    AB103031.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-119f1.11 si:dkey-119f1.1 56.74(n)
    52.28(a)
      557127  NM_001128334.1  NP_001121806.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55241 CG5524 42.99(n)
    30.83(a)
      42876  NM_142971.3  NP_651228.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C23H4.66
    smc-66
    Protein SMC-6 (smc-6) mRNA, complete cds
    23(a)
    22(a)
    many → 1
    many → 1
    X(12235621-12240799) WBGene00007694
    II(11578716-11582758) WBGene00010056
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMC6(YLR383W)4 Protein involved in structural maintenance of chromosomes; more   --   12(885288-888632) 851099  NP_013487.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MIM1 MIM 45.91(n)
    30.32(a)
      836267  NM_125539.1  NP_200954.1 
    rice
    (Oryza sativa)
    Liliopsida Os.223772 Oryza sativa mRNA for SMC6 protein 71.67(n)    AJ535213.1 


    ENSEMBL Gene Tree for SMC6 (if available)
    TreeFam Gene Tree for SMC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SMC6 (see all 1941)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358754
    A breast cancer sample4--see VAR_0358752 A V mis40--------
    rs1898081101,2
    --17844589(+) AGAGTC/TGGCAA 2 -- int10--------
    rs1814551391,2
    --17844924(+) CAAGTA/GAGCCT 2 -- int10--------
    rs1865651731,2
    --17844988(+) GGTTGA/GAGAGT 2 -- int10--------
    rs1413808211,2
    C--17845025(+) ATTCAC/TGGAGG 2 -- int10--------
    rs1906172271,2
    --17845127(+) TTAAAA/GGAACA 2 -- ut310--------
    rs1809937131,2
    --17845131(+) AAGAAA/CAATTT 2 -- ut310--------
    rs1861751221,2
    --17845182(+) AACATC/TAAAGG 2 -- ut310--------
    rs1469805431,2
    C--17845192(+) GAAGAC/TATTTT 2 -- ut310--------
    rs1910262861,2
    --17845214(+) GTTGAA/CATCAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SMC6 (17845079 - 17981509 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SMC6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719749CNV Deletion23290073
    dgv685e199CNV Deletion23128226
    esv2439754CNV Deletion19546169
    nsv522195CNV Loss19592680
    dgv4062n71CNV Gain21882294
    dgv1157e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SMC6
    DNA2.0 Custom Variant and Variant Library Synthesis for SMC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609387    OMIM disorders: --


    Find genes that share disorders with SMC6           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SMC6 (1 document)

    Export disorders for SMC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SMC6 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with SMC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PubMed id 18086888)1, 2 Taylor E.M.... Lehmann A.R. (Mol. Cell. Biol. 2008)
    3. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. (PubMed id 17589526)1, 2 Potts P.R. and Yu H. (Nat. Struct. Mol. Biol. 2007)
    4. Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double- strand breaks. (PubMed id 16810316)1, 2 Potts P.R.... Yu H. (EMBO J. 2006)
    5. Human MMS21/NSE2 is a SUMO ligase required for DNA repair. (PubMed id 16055714)1, 2 Potts P.R. and Yu H. (Mol. Cell. Biol. 2005)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. Coordination of DNA damage responses via the Smc5/Smc6 complex. (PubMed id 14701739)1, 2 Harvey S.H.... O'Connell M.J. (Mol. Cell. Biol. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex. (PubMed id 11408570)1, 2 Taylor E.M....Lehmann A.R. (Mol. Biol. Cell 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79677 HGNC: 20466 AceView: SMC6L1 Ensembl:ENSG00000163029 euGenes: HUgn79677
    ECgene: SMC6 H-InvDB: SMC6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SMC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SMC6 gene:
    Search GeneIP for patents involving SMC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SMC6  
     OriGene qPCR primer pairs and template standards for SMC6   OriGene Protein Over-expression Lysate for SMC6  
     OriGene MassSpec something-or-other for SMC6   OriGene clones in human, mouse for SMC6  
     OriGene qSTAR qPCR primer pairs in human, mouse for SMC6   OriGene Purified Protein for SMC6  
     OriGene ORF clones in mouse, rat for SMC6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SMC6   OriGene Custom Protein Services for SMC6  

     
     
     Block miRNA regulation of human, mouse, rat SMC6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SMC6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMC6 Predesigned siRNA for gene silencing in human, mouse, rat SMC6
     QuantiFast Probe-based Assays in human, mouse, rat SMC6 QuantiTect SYBR Green Assays in human, mouse, rat SMC6
     Custom PCR Arrays for SMC6 Search Chromatin IP Primers for SMC6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SMC6  GeneGlobe Interaction Network for SMC6
     Regulatory tfbs in SMC6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SMC6 GenScript cDNA clones with any tag delivered in your preferred vector for SMC6
     GenScript Custom Assay Services for SMC6 GenScript Custom overexpressing Cell Line Services for SMC6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SMC6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SMC6 antibodies
     SMC6 proteins
     SMC6 lysates
     Antibodies for SMC6
     See all of Abcam's Antibodies, Kits and Proteins for SMC6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SMC6
     Antibodies for SMC6
     ELISAs for SMC6
     CLIAs for SMC6



     Browse ESI BIO Cell Lines and PureStem Progenitors for SMC6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC6
     SwitchGear 3'UTR luciferase reporter plasmids for SMC6
     SwitchGear Promoter luciferase reporter plasmids for SMC6
     ThermoFisher Antibody for SMC6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMC6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SMC6
     LSBio Antibodies in human, mouse, rat for SMC6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SMC6
      Search eBioscience for proteins for SMC6
      Search eBioscience for elisas for SMC6
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SMC6 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4