Aliases for SMC6 Gene
External Ids for SMC6 Gene
Previous Symbols for SMC6 Gene
GeneCards Summary for SMC6 Gene
SMC6 (Structural Maintenance Of Chromosomes 6) is a Protein Coding gene.
UniProtKB/Swiss-Prot for SMC6 Gene
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies.