SMC6 Gene
protein-coding GIFtS: 46
GCID: GC02M017845
|
|
structural maintenance of chromosomes 6(Previous name: SMC6 structural maintenance of chromosomes 6-like 1 (yeast)...)
(Previous symbol: SMC6L1)
| |
Aliases
for SMC6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Structural Maintenance Of Chromosomes 61 2 | | FLJ221161 | | SMC6L11 2 3 5 | | SMC6 Structural Maintenance Of Chromosomes 6-Like 1 (Yeast)1 | | SMC-62 3 | | SMC6 Structural Maintenance Of Chromosomes 6-Like 12 | | HSMC61 | | Structural Maintenance Of Chromosomes Protein 62 | | SMC Protein 62 3 | | |
Export aliases for SMC6 gene to outside databasesPrevious GC identifer: GC02M017708 |
Summaries
for SMC6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SMC6_HUMAN, Q96SB8Function: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologousrecombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesincomplex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) componentswhich is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required forrecruitment of telomeres to PML nuclear bodies
Gene Wiki entry for SMC6
|
Genomic Views
for SMC6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_015926.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SMC6 gene promoter:
TBP USF1 Sox5 AML1a Pax-6 CUTL1 E4BP4 S8 TFIID USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SMC6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMC6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p24.2 Ensembl cytogenetic band: 2p24.2 HGNC cytogenetic band: 2p24.3SMC6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M017845: view genomic region
(about GC identifiers)
Start:
|
17,845,079 bp from pter |
End:
|
17,981,509 bp from pter |
Size:
|
136,431 bases |
Orientation:
|
minus strand |
|
Proteins
for SMC6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMC6_HUMAN, Q96SB8 (See
protein sequence)Recommended Name: Structural maintenance of chromosomes protein 6 Size: 1091 amino acids; 126326 Da
Subunit: Forms a heterodimer with SMC5. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6,NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2
Subcellular location: Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PMLnuclear bodies in ALT cell lines
Sequence caution: Sequence=AAH32675.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=BAB15236.1; Type=Frameshift; Positions=718;
Secondary accessions: A8K8Q6 D6W518 Q05BV4 Q9H0X3 Q9H6M0Alternative splicing: 2 isoforms: Q96SB8-1 Q96SB8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SMC6: NX_Q96SB8
Post-translational modifications:
Sumoylated by NSMCE2/MMS211
Ubiquitinated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96SB8
SMC6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001135758.1 NP_078900.1
ENSEMBL proteins: ENSP00000404092 ENSP00000323439 ENSP00000384539 ENSP00000408644 ENSP00000412246 ENSP00000415352 ENSP00000370672
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SMC6 for ontologies About GeneDecksing
SMC6 Antibody Products:
Assay Products for SMC6: |
Protein
Domains /
Families
for SMC6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SMC6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96SB8ProtoNet protein and cluster: Q96SB8 UniProtKB/Swiss-Prot: SMC6_HUMAN, Q96SB8Domain: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypicinteraction with the corresponding domain of SMC5, forming a V-shaped heterodimer (By similarity)Similarity: Belongs to the SMC family. SMC6 subfamily |
Function
for SMC6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SMC6_HUMAN, Q96SB8Function: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologousrecombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesincomplex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) componentswhich is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required forrecruitment of telomeres to PML nuclear bodies
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMC6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMC6 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SMC6 (NM_002806) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMC6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SMC6 for ontologies About GeneDecksing
|
Pathways & Interactions
for SMC6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SMC6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/58 Interacting proteins for SMC6 (Q96SB81, 3 ENSP000003234394) via UniProtKB, MINT, STRING, and/or I2D (see all 58)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SMC6 for ontologies About GeneDecksing
|
Drugs & Compounds
for SMC6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SMC6
Search CenterWatch for drugs/clinical trials and news about SMC6
|
Transcripts
for SMC6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SMC6 gene (2 alternative transcripts): NM_001142286.1 NM_024624.5 Unigene Cluster for SMC6: Structural maintenance of chromosomes 6 Hs.526728 [show with all ESTs]Unigene Representative Sequence: NM_0011422869 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000448223(uc002rco.3) ENST00000351948(uc002rcn.3 uc010exo.3)
ENST00000481708 ENST00000402989 ENST00000446852(uc002rcr.1) ENST00000430591
ENST00000428868 ENST00000489535 ENST00000381272(uc002rcp.1 uc002rcq.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMC6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMC6 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SMC6 (NM_002806) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMC6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC6 |
Additional cDNA sequence: AJ310551.1 AK025769.1 AK092853.1 AK098325.1 AK292421.1 AL136544.1 AL832979.1 BC011389.1 BC022998.1 BC032675.1 BC039828.1 HM243533.1 7 DOTS entries: DT.447128 DT.101965580 DT.97790814 DT.99939706 DT.100740587 DT.40279713 DT.437499 24/145 AceView cDNA sequences (see all 145): BF446150 BM801991 AA804905 BC011389 AA830067 AW603259 CA390923 BM720269 BM831097 BC022998 NM_024624 AA947903 AK092853 AL136544 BM991666 BM450250 AJ310551 CA446198 CR618309 BC039828 CB158124 CB159479 BX476614 AW104532
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SMC6 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SMC6
|
Expression
for SMC6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMC6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SMC6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMC6
SOURCE GeneReport for Unigene cluster: Hs.526728
UniProtKB/Swiss-Prot: SMC6_HUMAN, Q96SB8Tissue specificity: Widely expressed. Overexpressed in testis
SABiosciences Custom PCR Arrays for SMC6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMC6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMC6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMC6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMC6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC6 |
Orthologs
for SMC6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SMC6 gene from 9/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SMC61 |
structural maintenance of chromosomes 6 |
68.05(n)
60.11(a) |
|
421950 XM_419962.2 XP_419962.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SMC66 |
-- |
59(a) |
1 ↔ 1 |
1(143056022-143117244) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC689302 |
hypothetical protein MGC68930 |
74.75(n) |
|
AB103031.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-119f1.11 |
si:dkey-119f1.1 |
56.74(n)
52.28(a) |
|
557127 NM_001128334.1 NP_001121806.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG55241 |
CG5524 |
41.88(n)
28.98(a) |
|
42876 NM_142971.2 NP_651228.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
C23H4.61 |
Protein C23H4.6 |
44.66(n)
28.59(a) |
|
181384 NM_077640.2 NP_510041.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SMC6(YLR383W)4
SMC61 |
Protein involved in structural maintenance of chromosomes; more4
Smc6p1 |
44.06(n)1
26.86(a)1 |
|
12(885288-888632)4
8510991, 4 NP_013487.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
MIM1 |
protein MIM |
45.62(n)
29.6(a) |
|
836267 NM_125539.1 NP_200954.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.223772 |
Oryza sativa mRNA for SMC6 protein |
71.67(n) |
|
AJ535213.1 |
ENSEMBL Gene Tree for SMC6 (if available)
TreeFam Gene Tree for SMC6 (if available) |
Paralogs
for SMC6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SMC6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SMC6 (17845079 - 17981509 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SMC6
2 CNVs: 2372 97781 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMC6 |
|
Disorders
/ Diseases
for SMC6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SMC6 for disorders About GeneDecksing
OMIM gene information: 609387
OMIM disorders: --
5  diseases for SMC6: About MalaCardspancreatic cancer pancreatitis pneumonia tuberculosis
mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: SMC6 (1 document)
Export disorders for SMC6 gene to outside databases
|
Publications
for SMC6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMC6 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with SMC6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PubMed id 18086888)1, 2 Taylor E.M....Lehmann A.R. (2008)
- The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. (PubMed id 17589526)1, 2 Potts P.R. and Yu H. (2007)
- Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double- strand breaks. (PubMed id 16810316)1, 2 Potts P.R.... Yu H. (2006)
- Human MMS21/NSE2 is a SUMO ligase required for DNA repair. (PubMed id 16055714)1, 2 Potts P.R. and Yu H. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- Coordination of DNA damage responses via the Smc5/Smc6 complex. (PubMed id 14701739)1, 2 Harvey S.H.... O'Connell M.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex. (PubMed id 11408570)1, 2 Taylor E.M....Lehmann A.R. (2001)
|
External Searches for SMC6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SMC6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SMC6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SMC6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SMC6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SMC6 gene:
Search GeneIP for patents involving SMC6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SMC6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SMC6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMC6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMC6 | | | OriGene Protein Over-expression Lysate for SMC6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SMC6 | | OriGene 3'-UTR Clone for SMC6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMC6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMC6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SMC6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SMC6 | | OriGene Custom Protein Services for SMC6 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMC6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMC6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMC6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMC6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMC6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMC6 |
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| | | | Search Tocris compounds for SMC6 |
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 | | | SMC6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC6 |
|  |  |  | | | | Search ThermoFisher Antibodies for SMC6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC6 |
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