Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMC5 Gene

protein-coding   GIFtS: 53
GCID: GC09P072873

Structural Maintenance Of Chromosomes 5

(Previous name: SMC5 structural maintenance of chromosomes 5-like 1 (yeast))
(Previous symbol: SMC5L1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Structural Maintenance Of Chromosomes 51 2     KIAA05943 5
SMC5L11 2 3 5     SMC5 Structural Maintenance Of Chromosomes 5-Like 1 (Yeast)1
SMC-52 3     SMC5 Structural Maintenance Of Chromosomes 5-Like 12
hSMC52 3     Structural Maintenance Of Chromosomes Protein 52
SMC Protein 52 3     

External Ids:    HGNC: 204651   Entrez Gene: 231372   Ensembl: ENSG000001988877   OMIM: 6093865   UniProtKB: Q8IY183   

Export aliases for SMC5 gene to outside databases

Previous GC identifers: GC09P072063 GC09P042713


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SMC5 Gene: 
SMC5 (structural maintenance of chromosomes 5) is a protein-coding gene. Diseases associated with SMC5 include pneumonia, and tuberculosis. GO annotations related to this gene include protein binding and ATP binding.

UniProtKB/Swiss-Prot: SMC5_HUMAN, Q8IY18
Function: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by
homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the
SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via
recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin
complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML
bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid
cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6

Gene Wiki entry for SMC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SMC5 gene promoter:
         AP-2alpha isoform 3   RREB-1   AP-2alpha isoform 2   HSF2   c-Myb   FOXO1a   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SMC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.12   Ensembl cytogenetic band:  9q21.12   HGNC cytogenetic band: 9q21.11

SMC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMC5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P072873:  view genomic region     (about GC identifiers)

Start:
72,873,878 bp from pter      End:
72,969,804 bp from pter
Size:
95,927 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SMC5_HUMAN, Q8IY18 (See protein sequence)
Recommended Name: Structural maintenance of chromosomes protein 5  
Size: 1101 amino acids; 128806 Da
Subunit: Forms a heterodimer with SMC6. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6,
NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2
Subcellular location: Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML
nuclear bodies in ALT cell lines
Sequence caution: Sequence=AAH17666.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: A6NM81 O60335 Q05D92 Q5VZ60 Q96SB9

Explore the universe of human proteins at neXtProt for SMC5: NX_Q8IY18

Explore proteomics data for SMC5 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated
  • UniProtKB: Ubiquitinated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IY18

  • SMC5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SMC5 Protein Expression
    REFSEQ proteins: NP_055925.2  
    ENSEMBL proteins: 
     ENSP00000354957  

    Human Recombinant Protein Products for SMC5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SMC5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SMC5
    GenScript Custom Purified and Recombinant Proteins Services for SMC5
    Novus Biologicals SMC5 Protein
    Novus Biologicals SMC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SMC5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IDA17589526
    GO:0005634nucleus ISS--
    GO:0016605PML body IDA17589526
    GO:0030915Smc5-Smc6 complex IDA18086888

    SMC5 for ontologies           About GeneDecksing



    SMC5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SMC5
    GenScript Custom Superior Antibodies Services for SMC5
    Novus Biologicals SMC5 Antibodies
    Abcam antibodies for SMC5
    Cloud-Clone Corp. Antibodies for SMC5 
    ThermoFisher Antibodies for SMC5
    LSBio Antibodies in human, mouse, rat for SMC5 

    Assay Products for SMC5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SMC5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SMC5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SMC5 
    Cloud-Clone Corp. CLIAs for SMC5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SMC: Structural maintenance of chromosomes proteins

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR003395 RecF/RecN/SMC
     IPR027131 SMC5

    Graphical View of Domain Structure for InterPro Entry Q8IY18

    ProtoNet protein and cluster: Q8IY18

    UniProtKB/Swiss-Prot: SMC5_HUMAN, Q8IY18
    Domain: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the
    heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer (By similarity)
    Similarity: Belongs to the SMC family. SMC5 subfamily


    SMC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMC5_HUMAN, Q8IY18
    Function: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by
    homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the
    SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via
    recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin
    complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML
    bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid
    cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15601840
    GO:0005524ATP binding IEA--
         
    SMC5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SMC5:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SMC5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SMC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SMC5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SMC5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMC5
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SMC5 (see all 25):
    hsa-miR-4311 hsa-miR-607 hsa-miR-4251 hsa-miR-539 hsa-miR-657 hsa-miR-200a hsa-miR-3653 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidSMC5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SMC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMC5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SMC5
    Sirion Biotech Customized adenovirus for overexpression of SMC5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SMC5 (see all 8)
    OriGene ORF clones in mouse, rat for SMC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SMC5 (NM_002805)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC5
    Sirion Biotech Customized lentivirus for stable overexpression of SMC5 
                         Customized lentivirus expression plasmids for stable overexpression of SMC5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SMC5
    Search LifeMap BioReagents cell lines for SMC5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SMC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for SMC5 (Q8IY181, 2, 3 ENSP000003549574) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271531 I2D: score=2 
    SMN2Q166372, 3MINT-8271531 I2D: score=2 
    TK1P041832, 3MINT-8274104 I2D: score=2 
    SMC6Q96SB81, 3, ENSP000003234394EBI-605405,EBI-605415 I2D: score=2 STRING: ENSP00000323439
    YWHAZP631043, ENSP000003095034I2D: score=1 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000722telomere maintenance via recombination IMP17589526
    GO:0000724double-strand break repair via homologous recombination IMP16810316
    GO:0006303NOT double-strand break repair via nonhomologous end joining IMP16810316
    GO:0007067mitosis IEA--
    GO:0034184positive regulation of maintenance of mitotic sister chromatid cohesion IMP19502785

    SMC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SMC5

    Search CenterWatch for drugs/clinical trials and news about SMC5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SMC5 gene: 
    NM_015110.3  

    Unigene Cluster for SMC5:

    Structural maintenance of chromosomes 5
    Hs.534189  [show with all ESTs]
    Unigene Representative Sequence: NM_015110
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361138(uc004ahr.2 uc011lry.1) ENST00000475540 ENST00000471372

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMC5
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SMC5 (see all 25):
    hsa-miR-4311 hsa-miR-607 hsa-miR-4251 hsa-miR-539 hsa-miR-657 hsa-miR-200a hsa-miR-3653 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidSMC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SMC5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMC5
    Clone
    Products:
         
    OriGene clones in human, mouse for SMC5 (see all 8)
    OriGene ORF clones in mouse, rat for SMC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SMC5 (NM_002805)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC5
    Sirion Biotech Customized lentivirus for stable overexpression of SMC5 
                         Customized lentivirus expression plasmids for stable overexpression of SMC5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SMC5
    OriGene qSTAR qPCR primer pairs in human, mouse for SMC5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMC5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMC5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMC5

    Additional mRNA sequence: 

    AB011166.2 AJ310550.1 AK304133.1 BC017666.1 BC020393.1 BC034441.1 BC038225.1 

    15 DOTS entries:

    DT.454029  DT.121184426  DT.121184477  DT.205446  DT.92429131  DT.92060153  DT.97832103  DT.99970591 
    DT.100648277  DT.100775599  DT.100752047  DT.121184397  DT.121184425  DT.91897130  DT.100752045 

    24/144 AceView cDNA sequences (see all 144):

    AA934963 BU179094 BM988057 BE504535 Z38496 CN479061 AW023926 BM467945 
    BM930312 BM683779 AI061139 CK430331 AJ310550 BQ029028 BM836679 BU160490 
    BC017666 AA813586 BC038225 AB011166 CA414542 AL704994 AI245427 AL704617 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMC5 expression in normal human tissues (normalized intensities)      SMC5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTATTTTCT
    SMC5 Expression
    About this image


    SMC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             fetal cartilage   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
             cd49a+ cells   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac

    See SMC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMC5

    SOURCE GeneReport for Unigene cluster: Hs.534189

    UniProtKB/Swiss-Prot: SMC5_HUMAN, Q8IY18
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for SMC5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SMC5
    OriGene qSTAR qPCR primer pairs in human, mouse for SMC5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMC5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMC5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMC5 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smc51 , 5 structural maintenance of chromosomes 51, 5 87.06(n)1
    89.55(a)1
      19 (18.04 cM)5
    2260261  NM_001252684.11  NP_001239613.11 
     232064415 
    chicken
    (Gallus gallus)
    Aves SMC51 structural maintenance of chromosomes 5 70.12(n)
    64.63(a)
      431608  NM_001039335.1  NP_001034424.1 
    lizard
    (Anolis carolinensis)
    Reptilia SMC56
    Uncharacterized protein
    62(a)
    1 ↔ 1
    2(49140661-49208389)
    African clawed frog
    (Xenopus laevis)
    Amphibia smc52 structural maintenance of chromosomes protein 5 74.57(n)    AB103030.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055623.12   -- 75.8(n)   394185  BC055623.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Smc51 CG32438-PA 43.35(n)
    30.24(a)
      326215  NM_206419.2  NP_996141.2 
    worm
    (Caenorhabditis elegans)
    Secernentea smc-56
    Protein SMC-5
    27(a)
    1 ↔ 1
    II(5062129-5067129)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMC51 Smc5p 45.53(n)
    29.94(a)
      854123   NP_014608.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SMC51 structural maintenance of chromosomes 5 45.68(n)
    34.33(a)
      831449  NM_121597.2  NP_197096.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05966001 hypothetical protein 46.42(n)
    34.97(a)
      4339821  NM_001063056.1  NP_001056521.1 


    ENSEMBL Gene Tree for SMC5 (if available)
    TreeFam Gene Tree for SMC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SMC5 gene

    SMC5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SMC5
    PGOHUM00000249254


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1801 SNPs in SMC5 are shown (see all 1801)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349198231,2
    C--72803389(+) TCGTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs715053811,2
    C--72847204(+) CTTTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1136970411,2
    F--72861064(+) CTGAATA/-TATAT 1 -- int12Minor allele frequency- -:0.50CSA 6
    rs790809131,2
    F--72875811(+) GTACCA/CTACCT 1 -- int11Minor allele frequency- C:0.08NA 120
    rs747743151,2
    C,F--72875966(+) ATAGGA/GAAGTC 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1882568441,2
    --72875967(+) TAGGAA/CAGTCT 1 -- int10--------
    rs756535901,2
    F--72876204(+) GTGTTA/TTTCTG 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1807091081,2
    --72876424(+) AGCAGA/TTTGAG 1 -- int10--------
    rs1495888881,2
    --72876475(+) TCCTTG/TGTGGC 1 -- int10--------
    rs1853290131,2
    --72876625(+) ATGAAC/TTGAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SMC5 (72873878 - 72969804 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SMC5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2484591CNV Deletion19546169
    nsv6555CNV Insertion18451855
    nsv507515CNV Insertion20534489
    nsv831615CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SMC5
    DNA2.0 Custom Variant and Variant Library Synthesis for SMC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609386    OMIM disorders: --

    3 diseases for SMC5:    About MalaCards
    pneumonia    tuberculosis    prostatitis


    SMC5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SMC5
    Human Genome Epidemiology (HuGE) Navigator: SMC5 (2 documents)

    Export disorders for SMC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMC5 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with SMC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Predisposition for TMPRSS2-ERG fusion in prostate can cer by variants in DNA repair genes. (PubMed id 19861517)1, 4 Luedeke M....Maier C. (2009)
    4. SMC5 and MMS21 are required for chromosome cohesion a nd mitotic progression. (PubMed id 19502785)1, 2 Behlke-Steinert S....Margolis R.L. (2009)
    5. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PubMed id 18086888)1, 2 Taylor E.M....Lehmann A.R. (2008)
    6. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. (PubMed id 17589526)1, 2 Potts P.R. and Yu H. (2007)
    7. Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double- strand breaks. (PubMed id 16810316)1, 2 Potts P.R.... Yu H. (2006)
    8. Human MMS21/NSE2 is a SUMO ligase required for DNA repair. (PubMed id 16055714)1, 2 Potts P.R. and Yu H. (2005)
    9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23137 HGNC: 20465 AceView: SMC5L1 Ensembl:ENSG00000198887 euGenes: HUgn23137
    ECgene: SMC5 H-InvDB: SMC5

    (According to HUGE)
    About This Section
    HUGE: KIAA0594

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SMC5 gene:
    Search GeneIP for patents involving SMC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SMC5  
     OriGene qPCR primer pairs and template standards for SMC5   OriGene Protein Over-expression Lysate for SMC5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SMC5  
     OriGene qSTAR qPCR primer pairs in human, mouse for SMC5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SMC5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SMC5   OriGene Custom Protein Services for SMC5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMC5
     QIAGEN SeqTarget long-range PCR primers for resequencing SMC5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMC5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMC5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMC5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMC5
     GenScript Custom Purified and Recombinant Proteins Services for SMC5 GenScript cDNA clones with any tag delivered in your preferred vector for SMC5
     GenScript Custom Assay Services for SMC5 GenScript Custom Superior Antibodies Services for SMC5
     GenScript Custom overexpressing Cell Line Services for SMC5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SMC5 promoter
     Search Chromatin IP Primers for SMC5
     RT2 qPCR Primer Assay in human, mouse, rat SMC5
     GNC Network for SMC5
     SABiosciences Custom PCR Arrays for SMC5
     Search Tocris compounds for SMC5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SMC5 antibodies
     SMC5 proteins
     SMC5 lysates
     Antibodies for SMC5
     See all of Abcam's Antibodies, Kits and Proteins for SMC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SMC5
     Antibodies for SMC5
     ELISAs for SMC5
     CLIAs for SMC5
     Search LifeMap BioReagents cell lines for SMC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC5
     SwitchGear 3'UTR luciferase reporter plasmids for SMC5
     SwitchGear Promoter luciferase reporter plasmids for SMC5
     ThermoFisher Antibodies for SMC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SMC5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SMC5
    Customized:
     lentivirus for stable overexpression of SMC5
     lentivirus expression plasmids for stable overexpression of SMC5
     adenovirus for overexpression of SMC5
     LSBio Antibodies in human, mouse, rat for SMC5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SMC5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4