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SMC5 Gene

protein-coding   GIFtS: 53
GCID: GC09P072873

Structural Maintenance Of Chromosomes 5

(Previous name: SMC5 structural maintenance of chromosomes 5-like 1 (yeast))
(Previous symbol: SMC5L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Structural Maintenance Of Chromosomes 51 2     KIAA05943 5
SMC5L11 2 3 5     SMC5 Structural Maintenance Of Chromosomes 5-Like 1 (Yeast)1
SMC-52 3     SMC5 Structural Maintenance Of Chromosomes 5-Like 12
hSMC52 3     Structural Maintenance Of Chromosomes Protein 52
SMC Protein 52 3     

External Ids:    HGNC: 204651   Entrez Gene: 231372   Ensembl: ENSG000001988877   OMIM: 6093865   UniProtKB: Q8IY183   

Export aliases for SMC5 gene to outside databases

Previous GC identifers: GC09P072063 GC09P042713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SMC5 Gene:
SMC5 (structural maintenance of chromosomes 5) is a protein-coding gene.

UniProtKB/Swiss-Prot: SMC5_HUMAN, Q8IY18
Function: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by
homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the
SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via
recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin
complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML
bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid
cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6

Gene Wiki entry for SMC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMC5 gene promoter:
         AP-2alpha isoform 3   RREB-1   AP-2alpha isoform 2   HSF2   c-Myb   FOXO1a   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMC5 promoter sequence
   Search Chromatin IP Primers for SMC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.12   Ensembl cytogenetic band:  9q21.12   HGNC cytogenetic band: 9q21.11

SMC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMC5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P072873:  view genomic region     (about GC identifiers)

Start:
72,873,878 bp from pter      End:
72,969,804 bp from pter
Size:
95,927 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SMC5_HUMAN, Q8IY18 (See protein sequence)
Recommended Name: Structural maintenance of chromosomes protein 5  
Size: 1101 amino acids; 128806 Da
Subunit: Forms a heterodimer with SMC6. Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6,
NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2
Sequence caution: Sequence=AAH17666.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: A6NM81 O60335 Q05D92 Q5VZ60 Q96SB9

Explore the universe of human proteins at neXtProt for SMC5: NX_Q8IY18

Explore proteomics data for SMC5 at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Ubiquitinated1
  • Ubiquitination2 at Lys192, Lys238, Lys498, Lys558
  • Modification sites at PhosphoSitePlus

  • See SMC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055925.2  
    ENSEMBL proteins: 
     ENSP00000354957  

    SMC5 Human Recombinant Protein Products:

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    Novus Biologicals SMC5 Protein
    Novus Biologicals SMC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SMC5

     
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    antibodies-online proteins for SMC5 (2 products) 

     
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    antibodies-online antibodies for SMC5 (21 products) 

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    antibodies-online kits for SMC5 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SMC: Structural maintenance of chromosomes proteins

    3 InterPro protein domains:
     IPR003395 RecF/RecN/SMC_N
     IPR027131 SMC5
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q8IY18

    ProtoNet protein and cluster: Q8IY18

    UniProtKB/Swiss-Prot: SMC5_HUMAN, Q8IY18
    Domain: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the
    heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer (By similarity)
    Similarity: Belongs to the SMC family. SMC5 subfamily


    Find genes that share domains with SMC5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMC5_HUMAN, Q8IY18
    Function: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by
    homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the
    SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via
    recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin
    complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML
    bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid
    cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15601840
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with SMC5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SMC5:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SMC5

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SMC5 (see all 25):
    hsa-miR-4311 hsa-miR-607 hsa-miR-4251 hsa-miR-539 hsa-miR-657 hsa-miR-200a hsa-miR-3653 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidSMC5 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat SMC5

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    GenScript: all cDNA clones in your preferred vector (see all 2): SMC5 (NM_002805)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SMC5_HUMAN, Q8IY18: Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML
    nuclear bodies in ALT cell lines
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IDA17589526
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0016605PML body IDA17589526
    GO:0030054cell junction IDA--

    Find genes that share ontologies with SMC5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMC5
    Interactions:

        GeneGlobe Interaction Network for SMC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SMC5 (Q8IY181, 2, 3 ENSP000003549574) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271531 I2D: score=2 
    SMN2Q166372, 3MINT-8271531 I2D: score=2 
    TK1P041832, 3MINT-8274104 I2D: score=2 
    SMC6Q96SB81, 3, ENSP000003234394EBI-605405,EBI-605415 I2D: score=2 STRING: ENSP00000323439
    YWHAZP631043, ENSP000003095034I2D: score=1 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000722telomere maintenance via recombination IMP17589526
    GO:0000724double-strand break repair via homologous recombination IMP16810316
    GO:0006303NOT double-strand break repair via nonhomologous end joining IMP16810316
    GO:0007067mitosis IEA--
    GO:0034184positive regulation of maintenance of mitotic sister chromatid cohesion IMP19502785

    Find genes that share ontologies with SMC5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMC5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SMC5 gene: 
    NM_015110.3  

    Unigene Cluster for SMC5:

    Structural maintenance of chromosomes 5
    Hs.534189  [show with all ESTs]
    Unigene Representative Sequence: NM_015110
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361138(uc004ahr.2 uc011lry.1) ENST00000475540 ENST00000471372

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SMC5 (see all 25):
    hsa-miR-4311 hsa-miR-607 hsa-miR-4251 hsa-miR-539 hsa-miR-657 hsa-miR-200a hsa-miR-3653 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidSMC5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SMC5
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SMC5 (NM_002805)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC5
    Primer
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    OriGene qPCR primer pairs and template standards for SMC5
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SMC5
      QuantiTect SYBR Green Assays in human, mouse, rat SMC5
      QuantiFast Probe-based Assays in human, mouse, rat SMC5

    Additional mRNA sequence: 

    AB011166.2 AJ310550.1 AK304133.1 BC017666.1 BC020393.1 BC034441.1 BC038225.1 

    15 DOTS entries:

    DT.454029  DT.121184426  DT.121184477  DT.205446  DT.92429131  DT.92060153  DT.97832103  DT.99970591 
    DT.100648277  DT.100775599  DT.100752047  DT.121184397  DT.121184425  DT.91897130  DT.100752045 

    Selected AceView cDNA sequences (see all 144):

    AA934963 BU179094 BM988057 BE504535 Z38496 CN479061 AW023926 BM467945 
    BM930312 BM683779 AI061139 CK430331 AJ310550 BQ029028 BM836679 BU160490 
    BC017666 AA813586 BC038225 AB011166 CA414542 AL704994 AL704617 AI245427 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SMC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTATTTTCT
    SMC5 Expression
    About this image


    SMC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    SMC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534189

    UniProtKB/Swiss-Prot: SMC5_HUMAN, Q8IY18
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMC5 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smc51 , 5 structural maintenance of chromosomes 51, 5 87.06(n)1
    89.55(a)1
      19 (18.04 cM)5
    2260261  NM_001252684.11  NP_001239613.11 
     232064415 
    chicken
    (Gallus gallus)
    Aves SMC51 structural maintenance of chromosomes 5 70.12(n)
    64.63(a)
      431608  NM_001039335.1  NP_001034424.1 
    lizard
    (Anolis carolinensis)
    Reptilia SMC56
    structural maintenance of chromosomes 5
    62(a)
    1 ↔ 1
    2(49140661-49208389)
    African clawed frog
    (Xenopus laevis)
    Amphibia smc52 structural maintenance of chromosomes protein 5 74.57(n)    AB103030.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055623.12   -- 75.8(n)   394185  BC055623.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Smc51 Smc5 43.55(n)
    30.85(a)
      326215  NM_206419.3  NP_996141.2 
    worm
    (Caenorhabditis elegans)
    Secernentea smc-56
    Protein SMC-5 (smc-5) mRNA, complete cds
    27(a)
    1 ↔ 1
    II(5062129-5067129) WBGene00016151
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMC51 SMC5 59.01(n)
    52.7(a)
      854123   NP_014608.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SMC51 SMC5 46.1(n)
    35.3(a)
      831449  NM_121597.2  NP_197096.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05966001 Os05g0596600 46.39(n)
    35.26(a)
      4339821  NM_001063056.1  NP_001056521.1 


    ENSEMBL Gene Tree for SMC5 (if available)
    TreeFam Gene Tree for SMC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMC5 gene

    Find genes that share paralogs with SMC5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SMC5
    PGOHUM00000249254


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMC5 (see all 1801)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349198231,2
    C--72803389(+) TCGTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs715053811,2
    C--72847204(+) CTTTCT/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1136970411,2
    F--72861064(+) CTGAATA/-TATAT 1 -- int12Minor allele frequency- -:0.50CSA 6
    rs790809131,2
    F--72875811(+) GTACCA/CTACCT 1 -- int11Minor allele frequency- C:0.08NA 120
    rs747743151,2
    C,F--72875966(+) ATAGGA/GAAGTC 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1882568441,2
    --72875967(+) TAGGAA/CAGTCT 1 -- int10--------
    rs756535901,2
    F--72876204(+) GTGTTA/TTTCTG 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1807091081,2
    --72876424(+) AGCAGA/TTTGAG 1 -- int10--------
    rs1495888881,2
    --72876475(+) TCCTTG/TGTGGC 1 -- int10--------
    rs1853290131,2
    --72876625(+) ATGAAC/TTGAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SMC5 (72873878 - 72969804 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SMC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2484591CNV Deletion19546169
    nsv6555CNV Insertion18451855
    nsv507515CNV Insertion20534489
    nsv831615CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609386    OMIM disorders: --


    Find genes that share disorders with SMC5           About GenesLikeMe

    Genetic Association Database (GAD): SMC5
    Human Genome Epidemiology (HuGE) Navigator: SMC5 (2 documents)

    Export disorders for SMC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMC5 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SMC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Predisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes. (PubMed id 19861517)1, 4 Luedeke M....Maier C. (amp 2009)
    4. SMC5 and MMS21 are required for chromosome cohesion and mitotic progression. (PubMed id 19502785)1, 2 Behlke-Steinert S.... Margolis R.L. (Cell Cycle 2009)
    5. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PubMed id 18086888)1, 2 Taylor E.M.... Lehmann A.R. (Mol. Cell. Biol. 2008)
    6. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. (PubMed id 17589526)1, 2 Potts P.R. and Yu H. (Nat. Struct. Mol. Biol. 2007)
    7. Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double- strand breaks. (PubMed id 16810316)1, 2 Potts P.R.... Yu H. (EMBO J. 2006)
    8. Human MMS21/NSE2 is a SUMO ligase required for DNA repair. (PubMed id 16055714)1, 2 Potts P.R. and Yu H. (Mol. Cell. Biol. 2005)
    9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23137 HGNC: 20465 AceView: SMC5L1 Ensembl:ENSG00000198887 euGenes: HUgn23137
    ECgene: SMC5 H-InvDB: SMC5

    (According to HUGE)
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    HUGE: KIAA0594

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SMC5 gene:
    Search GeneIP for patents involving SMC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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