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Aliases for SMC4 Gene

Aliases for SMC4 Gene

  • Structural Maintenance Of Chromosomes 4 2 3
  • CAPC 3 4 6
  • Chromosome-Associated Polypeptide C 3 4
  • XCAP-C Homolog 3 4
  • SMC Protein 4 3 4
  • SMC4L1 3 4
  • HCAP-C 3 4
  • SMC-4 3 4
  • SMC4 (Structural Maintenance Of Chromosomes 4, Yeast)-Like 1 2
  • SMC4 Structural Maintenance Of Chromosomes 4-Like 1 (Yeast) 2
  • SMC4 Structural Maintenance Of Chromosomes 4-Like 1 3
  • Structural Maintenance Of Chromosomes Protein 4 3
  • CAP-C 3

External Ids for SMC4 Gene

Previous Symbols for SMC4 Gene

  • SMC4L1

Summaries for SMC4 Gene

Entrez Gene Summary for SMC4 Gene

  • Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]

GeneCards Summary for SMC4 Gene

SMC4 (Structural Maintenance Of Chromosomes 4) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for SMC4 Gene

  • Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Wiki entry for SMC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMC4 Gene

Genomics for SMC4 Gene

Genomic Location for SMC4 Gene

Start:
160,399,274 bp from pter
End:
160,434,967 bp from pter
Size:
35,694 bases
Orientation:
Plus strand

Genomic View for SMC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMC4 Gene

Regulatory Elements for SMC4 Gene

Proteins for SMC4 Gene

  • Protein details for SMC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTJ3-SMC4_HUMAN
    Recommended name:
    Structural maintenance of chromosomes protein 4
    Protein Accession:
    Q9NTJ3
    Secondary Accessions:
    • A6NLT9
    • D3DNL8
    • O95752
    • Q8NDL4
    • Q9UNT9

    Protein attributes for SMC4 Gene

    Size:
    1288 amino acids
    Molecular mass:
    147182 Da
    Quaternary structure:
    • Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.

    Alternative splice isoforms for SMC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMC4 Gene

Proteomics data for SMC4 Gene at MOPED

Post-translational modifications for SMC4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys93, Lys207, Lys239, Lys268, Lys332, Lys389, Lys413, Lys680, Lys1112, Lys1187, and Lys1267

No data available for DME Specific Peptides for SMC4 Gene

Domains for SMC4 Gene

Gene Families for SMC4 Gene

HGNC:
  • SMC :Structural maintenance of chromosomes proteins

Protein Domains for SMC4 Gene

UniProtKB/Swiss-Prot:

SMC4_HUMAN
Domain:
  • The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer.:
    • Q9NTJ3
Family:
  • Belongs to the SMC family. SMC4 subfamily.:
    • Q9NTJ3
genes like me logo Genes that share domains with SMC4: view

Function for SMC4 Gene

Molecular function for SMC4 Gene

UniProtKB/Swiss-Prot Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Ontology (GO) - Molecular Function for SMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0005515 protein binding IPI 17113138
GO:0005524 ATP binding TAS 11136719
GO:0046982 protein heterodimerization activity IPI 9789013
genes like me logo Genes that share ontologies with SMC4: view
genes like me logo Genes that share phenotypes with SMC4: view

miRNA for SMC4 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SMC4 Gene

Localization for SMC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMC4 Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensins association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMC4 Gene COMPARTMENTS Subcellular localization image for SMC4 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000796 condensin complex TAS 11850403
GO:0005634 nucleus TAS 11850403
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SMC4: view

Pathways for SMC4 Gene

genes like me logo Genes that share pathways with SMC4: view

Pathways by source for SMC4 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for SMC4 Gene
2 Cell Signaling Technology pathways for SMC4 Gene
1 BioSystems pathway for SMC4 Gene

Gene Ontology (GO) - Biological Process for SMC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation TAS 11321372
GO:0000278 mitotic cell cycle TAS --
GO:0006935 chemotaxis --
GO:0007076 mitotic chromosome condensation IDA 11136719
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with SMC4: view

Transcripts for SMC4 Gene

Unigene Clusters for SMC4 Gene

Structural maintenance of chromosomes 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMC4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^
SP1:
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: - - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - -
SP13: -
SP14:
SP15:
SP16: - - - - - - -
SP17:
SP18:
SP19:
SP20:
SP21:

ExUns: 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for SMC4 Gene

GeneLoc Exon Structure for
SMC4
ECgene alternative splicing isoforms for
SMC4

Expression for SMC4 Gene

mRNA expression in normal human tissues for SMC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMC4 Gene

SOURCE GeneReport for Unigene cluster for SMC4 Gene Hs.58992

mRNA Expression by UniProt/SwissProt for SMC4 Gene

Q9NTJ3-SMC4_HUMAN
Tissue specificity: Widely expressed. Higher expression in testis, colon, thymus.
genes like me logo Genes that share expressions with SMC4: view

Orthologs for SMC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMC4 36
  • 99.59 (n)
  • 99.53 (a)
SMC4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SMC4 36
  • 92.31 (n)
  • 93.24 (a)
SMC4 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMC4 36
  • 92.74 (n)
  • 94.4 (a)
SMC4 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smc4 36
  • 87.64 (n)
  • 89.66 (a)
Smc4 16
Smc4 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 75 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Smc4 36
  • 87.66 (n)
  • 89.66 (a)
chicken
(Gallus gallus)
Aves SMC4 36
  • 75.62 (n)
  • 76.97 (a)
SMC4 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMC4 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XCAP-C 36
tropical clawed frog
(Silurana tropicalis)
Amphibia smc4 36
  • 73.5 (n)
  • 78.09 (a)
Str.8927 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9052 36
zebrafish
(Danio rerio)
Actinopterygii smc4 36
  • 63.88 (n)
  • 70.19 (a)
smc4 37
  • 68 (a)
OneToOne
smc4l1 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007826 36
  • 49.13 (n)
  • 46.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta glu 36
  • 47.17 (n)
  • 40.77 (a)
glu 37
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dpy-27 37
  • 24 (a)
OneToMany
smc-4 37
  • 24 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR089C 36
  • 49.45 (n)
  • 40.98 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMC4 36
  • 49.61 (n)
  • 39.14 (a)
SMC4 37
  • 31 (a)
OneToOne
SMC4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19085g 36
  • 49.27 (n)
  • 38.75 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9522 36
thale cress
(Arabidopsis thaliana)
eudicotyledons SMC3 36
  • 51.83 (n)
  • 44.26 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10104 36
corn
(Zea mays)
Liliopsida Zm.16936 36
rice
(Oryza sativa)
Liliopsida Os.19862 36
Os05g0497100 36
  • 53.63 (n)
  • 48.12 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7603 36
bread mold
(Neurospora crassa)
Ascomycetes NCU09063 36
  • 47.89 (n)
  • 42.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut3 36
  • 48.73 (n)
  • 39.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4807 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2292 37
  • 38 (a)
OneToOne
Species with no ortholog for SMC4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SMC4 Gene

ENSEMBL:
Gene Tree for SMC4 (if available)
TreeFam:
Gene Tree for SMC4 (if available)

Paralogs for SMC4 Gene

Pseudogenes.org Pseudogenes for SMC4 Gene

genes like me logo Genes that share paralogs with SMC4: view

No data available for Paralogs for SMC4 Gene

Variants for SMC4 Gene

Sequence variations from dbSNP and Humsavar for SMC4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10923 -- 160,434,908(+) TGTAA(A/G)CACAT utr-variant-3-prime
rs13403 -- 160,434,511(+) TTATC(A/C)GGGTA utr-variant-3-prime
rs191757 -- 160,423,265(-) catgt(G/T)tgtgg intron-variant
rs1451760 -- 160,417,640(-) TATTC(A/G)ATTTA intron-variant
rs1451761 -- 160,413,879(-) ATTAA(A/C)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMC4 Gene

Variant ID Type Subtype PubMed ID
nsv822305 CNV Gain 20364138

Relevant External Links for SMC4 Gene

HapMap Linkage Disequilibrium report
SMC4
Human Gene Mutation Database (HGMD)
SMC4

Disorders for SMC4 Gene

Relevant External Links for SMC4

Genetic Association Database (GAD)
SMC4
Human Genome Epidemiology (HuGE) Navigator
SMC4
genes like me logo Genes that share disorders with SMC4: view

No data available for UniProtKB/Swiss-Prot for SMC4 Gene

Publications for SMC4 Gene

  1. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. (PMID: 9789013) Schmiesing J.A. … Yokomori K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  2. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. (PMID: 10958694) Schmiesing J.A. … Yokomori K. (Mol. Cell. Biol. 2000) 3 4 23
  3. Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family. (PMID: 10319587) Nishiwaki T. … Nakamura Y. (J. Hum. Genet. 1999) 2 3 4
  4. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PMID: 11136719) Kimura K. … Hirano T. (J. Biol. Chem. 2001) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for SMC4 Gene

Sources for SMC4 Gene

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