Aliases for SMC4 Gene
External Ids for SMC4 Gene
Previous HGNC Symbols for SMC4 Gene
Previous GeneCards Identifiers for SMC4 Gene
This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016]
GeneCards Summary for SMC4 Gene
SMC4 (Structural Maintenance Of Chromosomes 4) is a Protein Coding gene. Diseases associated with SMC4 include Pleural Empyema. Among its related pathways are Aurora B signaling and Mitotic Prophase. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity.
UniProtKB/Swiss-Prot for SMC4 Gene
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.