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SMC4 Gene

protein-coding   GIFtS: 64
GCID: GC03P160117

Structural Maintenance Of Chromosomes 4

(Previous names: SMC4 (structural maintenance of chromosomes 4, yeast)-like...)
(Previous symbol: SMC4L1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Structural Maintenance Of Chromosomes 41 2     XCAP-C Homolog2 3
SMC4L11 2 3     SMC4 (Structural Maintenance Of Chromosomes 4, Yeast)-Like 11
CAPC2 3 5     SMC4 Structural Maintenance Of Chromosomes 4-Like 1 (Yeast)1
Chromosome-Associated Polypeptide C2 3     CAP-C2
SMC-42 3     SMC4 Structural Maintenance Of Chromosomes 4-Like 12
hCAP-C2 3     Structural Maintenance Of Chromosomes Protein 42
SMC Protein 42 3     

External Ids:    HGNC: 140131   Entrez Gene: 100512   Ensembl: ENSG000001138107   OMIM: 6055755   UniProtKB: Q9NTJ33   

Export aliases for SMC4 gene to outside databases

Previous GC identifers: GC03P161601 GC03P157516


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SMC4 Gene:
Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for
mitotic chromosome condensation in frogs and for DNA repair in mammals.(supplied by OMIM, Nov 2010)

GeneCards Summary for SMC4 Gene:
SMC4 (structural maintenance of chromosomes 4) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot: SMC4_HUMAN, Q9NTJ3
Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin
into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into
relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the
presence of type II topoisomerases

Gene Wiki entry for SMC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMC4 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   HTF   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SMC4 promoter sequence
   Search Chromatin IP Primers for SMC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.1   Ensembl cytogenetic band:  3q25.33   HGNC cytogenetic band: 3q26.1

SMC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMC4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P160117:  view genomic region     (about GC identifiers)

Start:
160,117,062 bp from pter      End:
160,152,750 bp from pter
Size:
35,689 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SMC4_HUMAN, Q9NTJ3 (See protein sequence)
Recommended Name: Structural maintenance of chromosomes protein 4  
Size: 1288 amino acids; 147182 Da
Subunit: Forms a heterodimer with SMC2. Component of the condensin complex, which contains the SMC2 and SMC4
heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG
Secondary accessions: A6NLT9 D3DNL8 O95752 Q8NDL4 Q9UNT9
Alternative splicing: 2 isoforms:  Q9NTJ3-1   Q9NTJ3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMC4: NX_Q9NTJ3

Explore proteomics data for SMC4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys93, Lys207, Lys239, Lys268, Lys332, Lys389, Lys413, Lys680, Lys1112, Lys1187,
                                 Lys1267
  • Modification sites at PhosphoSitePlus

  • See SMC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001002800.1  NP_001275682.1  NP_005487.3  

    ENSEMBL proteins: 
     ENSP00000418820   ENSP00000349961   ENSP00000419247   ENSP00000420644   ENSP00000417999  
     ENSP00000419360   ENSP00000417964   ENSP00000418434   ENSP00000420121   ENSP00000420734  
     ENSP00000420817   ENSP00000417612   ENSP00000341382   ENSP00000353225  
    Reactome Protein details: Q9NTJ3

    SMC4 Human Recombinant Protein Products:

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    Novus Biologicals SMC4 Protein
    Novus Biologicals SMC4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SMC4

     
    Search eBioscience for Proteins for SMC4 

     
    antibodies-online proteins for SMC4 (2 products) 

     
    antibodies-online peptides for SMC4

    SMC4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SMC4
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    Abcam antibodies for SMC4
    Cloud-Clone Corp. Antibodies for SMC4
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    antibodies-online antibodies for SMC4 (35 products) 

    SMC4 Assay Products:

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    Cloud-Clone Corp. ELISAs for SMC4
    Cloud-Clone Corp. CLIAs for SMC4
    Search eBioscience for ELISAs for SMC4 
    antibodies-online kits for SMC4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SMC: Structural maintenance of chromosomes proteins

    4 InterPro protein domains:
     IPR003395 RecF/RecN/SMC_N
     IPR027417 P-loop_NTPase
     IPR024704 SMC
     IPR010935 SMC_hinge

    Graphical View of Domain Structure for InterPro Entry Q9NTJ3

    ProtoNet protein and cluster: Q9NTJ3

    1 Blocks protein domain: IPB010935 SMCs flexible hinge

    UniProtKB/Swiss-Prot: SMC4_HUMAN, Q9NTJ3
    Domain: The hinge domain, which separates the large intramolecular coiled coil regions, allows the
    heterodimerization with SMC2, forming a V-shaped heterodimer (By similarity)
    Similarity: Belongs to the SMC family. SMC4 subfamily


    Find genes that share domains with SMC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMC4_HUMAN, Q9NTJ3
    Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin
    into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into
    relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the
    presence of type II topoisomerases

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0005515protein binding IPI17113138
    GO:0005524ATP binding TAS11136719
    GO:0046982protein heterodimerization activity IPI9789013
         
    Find genes that share ontologies with SMC4           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SMC4:
     Cell division defect  Increased G2M DNA content  Increased cell death in breast  Increased number of mitotic ce 
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SMC4

    miRNA
    Products:
        
    miRTarBase miRNAs that target SMC4:
    hsa-mir-26b-5p (MIRT029636), hsa-mir-1 (MIRT023841), hsa-mir-484 (MIRT042211), hsa-mir-215-5p (MIRT024583), hsa-mir-192-5p (MIRT026547)

    Block miRNA regulation of human, mouse, rat SMC4 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SMC4:
    hsa-miR-374c hsa-miR-520d-5p hsa-miR-655 hsa-miR-526b hsa-miR-524-5p hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidSMC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SMC4
    Predesigned siRNA for gene silencing in human, mouse, rat SMC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SMC4

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SMC4 (NM_153001)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SMC4_HUMAN, Q9NTJ3: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin
    complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation
    of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the
    condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the
    complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome
    condensation. Dissociation from chromosomes is observed in late telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000796condensin complex TAS11850403
    GO:0005634nucleus TAS11850403
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome ----
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with SMC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SMC4 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    2Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Condensation of Prometaphase Chromosomes0.00
    3RNA Polymerase I Promoter Opening
    Condensation of Prophase Chromosomes0.78
    Mitotic Prophase0.56
    4Cell Cycle / Checkpoint Control
    DNA Damage0.32
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with SMC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for SMC4
        Chromatin Regulation / Acetylation
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for SMC4
        Cell cycle Chromosome condensation in prometaphase

    1 BioSystems Pathway for SMC4
        Aurora B signaling

    2 Reactome Pathways for SMC4
        Condensation of Prophase Chromosomes
    Condensation of Prometaphase Chromosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMC4
    Interactions:

        GeneGlobe Interaction Network for SMC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SMC4 (Q9NTJ31, 2, 3 ENSP000003413824) via UniProtKB, MINT, STRING, and/or I2D (see all 907)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAPD2Q150212, 3, ENSP000003250174MINT-7945693 MINT-7947479 I2D: score=7 STRING: ENSP00000325017
    SMC3Q9UQE72, 3, ENSP000003547204MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000354720
    HDAC1Q135472, 3, ENSP000003626494MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000362649
    POLR1CO151602, 3MINT-7945693 MINT-7947479 I2D: score=3 
    EIF2S3P410912, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000070mitotic sister chromatid segregation TAS11321372
    GO:0000278mitotic cell cycle TAS--
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006935chemotaxis ----

    Find genes that share ontologies with SMC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMC4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SMC4 gene (4 alternative transcripts): 
    NM_001002799.1  NM_001002800.2  NM_001288753.1  NM_005496.3  

    Unigene Cluster for SMC4:

    Structural maintenance of chromosomes 4
    Hs.58992  [show with all ESTs]
    Unigene Representative Sequence: NM_005496
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000497311 ENST00000357388(uc003fdh.3 uc003fdi.3) ENST00000465903
    ENST00000485645 ENST00000472991 ENST00000472282 ENST00000467468 ENST00000468653(uc003fdf.1)
    ENST00000469762 ENST00000469858 ENST00000489573(uc003fdg.1) ENST00000462787
    ENST00000490207 ENST00000485867 ENST00000344722(uc003fdj.3 uc010hwd.3)
    ENST00000470240 ENST00000497984 ENST00000487747
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate SMC4:
    hsa-miR-374c hsa-miR-520d-5p hsa-miR-655 hsa-miR-526b hsa-miR-524-5p hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidSMC4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SMC4
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SMC4 (NM_153001)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SMC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SMC4
      QuantiTect SYBR Green Assays in human, mouse, rat SMC4
      QuantiFast Probe-based Assays in human, mouse, rat SMC4

    Additional mRNA sequence: 

    AB019987.1 AF092564.1 AK002200.1 AK026361.1 AK122939.1 AK128143.1 AK225437.1 AK307508.1 
    AK315070.1 AL136877.1 AL833949.1 BC001557.1 BC065259.1 BC070161.1 BC106033.1 

    Selected DOTS entries (see all 34):

    DT.99955215  DT.100828674  DT.414134  DT.100828681  DT.102836850  DT.120858692  DT.95140820  DT.91769223 
    DT.91769218  DT.120858646  DT.70101144  DT.91895203  DT.100828669  DT.120858612  DT.95140864  DT.100828672 
    DT.95140873  DT.95282587  DT.97848386  DT.113472  DT.120858472  DT.120858504  DT.120858541  DT.120858560 

    Selected AceView cDNA sequences (see all 412):

    BE748487 AI270305 BU192855 AA283006 BE503265 BM782323 BM508219 AW504211 
    AW978783 BG260368 CB161397 AL136877 NM_001002800 BU508914 CA448210 BM827310 
    AW025933 AA279156 AI888623 BF115592 BM457851 CB127113 BF244486 BU193679 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SMC4 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^
    SP1:                                                                                                                                                            
    SP2:                                      -     -     -                                               -                                         -               
    SP3:                                      -     -     -                                               -                                                         
    SP4:                                      -     -                                                     -                                         -               
    SP5:                                                                                                                                                            

    ExUns: 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29
    SP1:                                                  -                                                                 -                                       
    SP2:  -                                                                                                                                                         
    SP3:  -                                                                                                                                                         
    SP4:  -                                                                                                                                                         
    SP5:                                                  -                                                                                                         


    ECgene alternative splicing isoforms for SMC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SMC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTTTAAA
    SMC4 Expression
    About this image


    SMC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Thymus (Hematopoietic System)
             Thymus
    SMC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.58992

    UniProtKB/Swiss-Prot: SMC4_HUMAN, Q9NTJ3
    Tissue specificity: Widely expressed. Higher expression in testis, colon, thymus

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMC4 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smc41 , 5 structural maintenance of chromosomes 41, 5 87.64(n)1
    89.66(a)1
      3 (32.14 cM)5
    700991  NM_133786.31  NP_598547.11 
     690047385 
    chicken
    (Gallus gallus)
    Aves SMC41 structural maintenance of chromosomes 4 75.62(n)
    76.97(a)
      395189  NM_204518.1  NP_989849.1 
    lizard
    (Anolis carolinensis)
    Reptilia SMC46
    structural maintenance of chromosomes 4
    76(a)
    1 ↔ 1
    3(12995253-13043223)
    African clawed frog
    (Xenopus laevis)
    Amphibia XCAP-C2 (XCAP-C) 75.81(n)    U13673.1 
    zebrafish
    (Danio rerio)
    Actinopterygii smc4l12 MC4 structural maintenance of chromosomes 4-like 1 more 69.52(n)   192332  AY099521.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta glu1 gluon 47.17(n)
    40.77(a)
      35001  NM_165180.2  NP_723996.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dpy-276
    smc-46
    Protein SMC-4 (smc-4) mRNA, complete cds
    24(a)
    24(a)
    many → 1
    many → 1
    III(3813553-3819679) WBGene00001086
    III(4587506-4593123) WBGene00004874
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMC4(YLR086W)4
    SMC41
    Subunit of the condensin complex; reorganizes chromosomes more4
    SMC41
    49.61(n)1
    39.14(a)1
      12(302243-306499)4
    8507751, 4  NP_013187.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SMC31 SMC3 51.83(n)
    44.26(a)
      834917  NM_001203563.1  NP_001190492.1 
    rice
    (Oryza sativa)
    Liliopsida Os.198622 Oryza sativa mRNA for SMC4 protein 74.45(n)    AJ488495.1 


    ENSEMBL Gene Tree for SMC4 (if available)
    TreeFam Gene Tree for SMC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMC4 gene
    1 SIMAP similar gene for SMC4 using alignment to 13 protein entries:     SMC4_HUMAN (see all proteins):
    SMC1A

    Find genes that share paralogs with SMC4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SMC4
    PGOHUM00000240962


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMC4 (see all 721)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs609074641,2
    C--157525660(+) AAAAA-/A/AAA 
            
    GACTG
    2 -- int12NA 4
    rs749544721,2
    C,F--160119346(+) TAGGAT/ATTAAC 2 -- int11Minor allele frequency- A:0.05WA 118
    rs1860776771,2
    --160119452(+) ATAGAA/GTTTTG 2 -- int10--------
    rs1897336521,2
    C--160119520(+) AGTCAA/CCCCCG 2 -- int10--------
    rs412729471,2
    C,F--160119525(+) CCCCCA/GTGAGT 2 -- int112Minor allele frequency- G:0.47NA WA CSA EA 376
    rs589150281,2
    C,F--160119568(+) AGACTC/TCTAAG 2 -- int15Minor allele frequency- T:0.06NA WA EA 246
    rs586540321,2
    C,F--160119631(+) TTCTCC/GGAACT 2 -- int15Minor allele frequency- G:0.06NA WA EA 246
    rs766950241,2
    C,F--160119660(+) TTTTCC/TCCCGC 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1813340501,2
    C--160119699(+) CTGACA/TTAGAG 2 -- int10--------
    rs1410896541,2
    C--160119716(+) AGTGAG/AGAACT 4 /E syn11Minor allele frequency- A:0.00NA 4508

    HapMap Linkage Disequilibrium report for SMC4 (160117062 - 160152750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SMC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822305CNV Gain20364138

    Human Gene Mutation Database (HGMD): SMC4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SMC4
    DNA2.0 Custom Variant and Variant Library Synthesis for SMC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605575    OMIM disorders: --


    Find genes that share disorders with SMC4           About GenesLikeMe

    Genetic Association Database (GAD): SMC4
    Human Genome Epidemiology (HuGE) Navigator: SMC4 (1 document)

    Export disorders for SMC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMC4 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with SMC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. (PubMed id 9789013)1, 2, 3, 9 Schmiesing J.A....Yokomori K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family. (PubMed id 10319587)1, 2, 3 Nishiwaki T.... Nakamura Y. (J. Hum. Genet. 1999)
    3. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. (PubMed id 10958694)1, 2, 9 Schmiesing J.A.... Yokomori K. (Mol. Cell. Biol. 2000)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PubMed id 11136719)1, 2 Kimura K.... Hirano T. (J. Biol. Chem. 2001)
    7. Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma. (PubMed id 17488335)1, 9 Ham M.F....Aozasa K. (Cancer Sci. 2007)
    8. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    9. TopBP1 controls BLM protein level to maintain genome stability. (PubMed id 24239288)1 Wang J....Gong Z. (Mol. Cell 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10051 HGNC: 14013 AceView: SMC4L1 Ensembl:ENSG00000113810 euGenes: HUgn10051
    ECgene: SMC4 H-InvDB: SMC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SMC4 gene:
    Search GeneIP for patents involving SMC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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