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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SMC2 Gene

protein-coding GIFtS: 59
GCID: GC09P106856

structural maintenance of chromosomes 2

(Previous names: SMC2 (structural maintenance of chromosomes 2, yeast)-like...)
(Previous symbol: SMC2L1)

Explore 7 diseases affiliated with
SMC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Structural Maintenance Of Chromosomes 2¹ ²		SMC-2² ³
SMC2L1¹ ² ³		SMC Protein 2² ³
CAPE² ³ ⁵		XCAP-E Homolog² ³
CAP-E¹ ²		SMC2 Structural Maintenance Of Chromosomes 2-Like 1 (Yeast)¹
SMC2 (Structural Maintenance Of Chromosomes 2, Yeast)-Like 1¹ ²		Structural Maintenance Of Chromosomes (SMC) Family Member, Chromosome-Associated Protein E²
HCAP-E¹		Structural Maintenance Of Chromosomes Protein 2²
Chromosome-Associated Protein E² ³

External Ids:	HGNC: 14011¹	Entrez Gene: 10592²	Ensembl: ENSG00000136824⁷	OMIM: 605576⁵	UniProtKB: O95347³

Export aliases for SMC2 gene to outside databases

Previous GC identifers: GC09P105896 GC09P076458

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SMC2:

Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic

chromosome condensation in frogs and for DNA repair in mammals.(supplied by OMIM, Nov 2010)

UniProtKB/Swiss-Prot: SMC2_HUMAN, O95347

Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into

mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in

the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II

topoisomerases

Gene Wiki entry for SMC2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SMC2 gene promoter:
GATA-6 AP-1 ATF-2 RelA c-Jun C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SMC2 promoter sequence

Search SABiosciences Chromatin IP Primers for SMC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.1 Ensembl cytogenetic band: 9q31.1 HGNC cytogenetic band: 9q31.1

SMC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMC2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P106856: view genomic region (about GC identifiers)

Start:	106,856,541 bp from pter	End:	106,903,700 bp from pter
Size:	47,160 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SMC2_HUMAN, O95347 (See protein sequence)

Recommended Name: Structural maintenance of chromosomes protein 2

Size: 1197 amino acids; 135656 Da

Subunit: Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4

heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG

Subcellular location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex

is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the

complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin

complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are

phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation.

Dissociation from chromosomes is observed in late telophase

Sequence caution: Sequence=AAC72360.1; Type=Frameshift; Positions=890, 908; Sequence=AAF29579.1; Type=Erroneous

initiation;

Secondary accessions: Q6IEE0 Q9P1P2

Alternative splicing: 2 isoforms: O95347-1 O95347-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMC2: NX_O95347

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95347

SMC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001036015.1 NP_001036016.1 NP_001252531.1 NP_006435.2

ENSEMBL proteins:

ENSP00000414999 ENSP00000363925 ENSP00000363919 ENSP00000431534 ENSP00000286398

ENSP00000306152

Reactome Protein details: O95347
Human Recombinant Protein Products for SMC2:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	GenScript Custom Purified and Recombinant Proteins Services for SMC2
	Novus Biologicals SMC2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SMC2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000228	nuclear chromosome	IDA	10958694
GO:0000793	condensed chromosome	IDA	12589063
GO:0000796	condensin complex	IDA	10958694
GO:0005634	nucleus	IDA	12589063
GO:0005737	cytoplasm	IDA	12589063

SMC2 for ontologies About GeneDecksing

SMC2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SMC2
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for SMC2 (SMC2L1)
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	GenScript Custom Superior Antibodies Services for SMC2
	Novus Biologicals SMC2 Antibodies
	Abcam antibodies for SMC2
	Uscn Antibodies for SMC2
	ThermoFisher Antibodies for SMC2

Assay Products for SMC2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SMC2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SMC2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SMC2 for domains About GeneDecksing

4 InterPro domains/families:

IPR003395 RecF/RecN/SMC

IPR024704 SMC

IPR010935 SMC_hinge

IPR027120 Smc2

Graphical View of Domain Structure for InterPro Entry O95347

ProtoNet protein and cluster: O95347

1 Blocks protein family: IPB010935 SMCs flexible hinge

UniProtKB/Swiss-Prot: SMC2_HUMAN, O95347

Domain: The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization

with SMC4, forming a V-shaped heterodimer (By similarity)

Similarity: Belongs to the SMC family. SMC2 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SMC2_HUMAN, O95347

Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into

mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in

the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II

topoisomerases

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12589063
GO:0005524	ATP binding	IEA	--
GO:0046982	protein heterodimerization activity	IPI	9789013

SMC2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SMC2:

Decreased viability

1 MGI phenotypic allele

for Smc2 (no phenotypes)

SMC2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Smc2^tm1Lex for SMC2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SMC2

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SMC2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMC2
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SMC2 (see all 11):
		hsa-miR-3163 hsa-miR-7-2* hsa-miR-211 hsa-miR-570 hsa-miR-204 hsa-miR-7-1* hsa-miR-3151 hsa-miR-3143

		SwitchGear 3'UTR luciferase reporter plasmid: SMC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMC2 (see all 7) OriGene shRNA RFP: SMC2 OriGene siRNA: SMC2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMC2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SMC2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SMC2
			Sirion Biotech Customized adenovirus for overexpression of SMC2 Sirion Biotech Customized adenovirus for potent knockdown of SMC2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMC2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMC2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SMC2 (NM_001204453)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SMC2
		Search LifeMap BioReagents cell lines for SMC2
		Sirion Biotech Customized stable knockdown cell line services for SMC2 Sirion Biotech Customized inducible knockdown cell line services for SMC2 Sirion Biotech Customized stable overexpressing cell line services for SMC2 Sirion Biotech Customized inducible overexpressing cell line services for SMC2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell cycle Chromosome condensation in prometaphase

	Cell cycle_Chromosome condensation in prometaphase	1.00			Condensation of Prometaphase Chromosomes	0.22
	Cell cycle Chromosome condensation in prometaphase	1.00

M Phase

M Phase

1.00

Mitotic M-M/G1 phases

0.88

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

DNA Damage

DNA Damage

1.00

Cell Cycle / Checkpoint Control

Cell Cycle / Checkpoint Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SMC2

Cell cycle Chromosome condensation in prometaphase

3 Cell Signaling Technology (CST) Pathways for SMC2

	Chromatin Regulation / Acetylation
	Cell Cycle / Checkpoint Control
	DNA Damage

1 GeneGo (Thomson Reuters) Pathway for SMC2

Cell cycle Chromosome condensation in prometaphase

1 BioSystems Pathway for SMC2

Aurora B signaling

5/6 Reactome Pathways for SMC2 (see all 6)

	Mitotic Prometaphase
	Cell Cycle
	Condensation of Prometaphase Chromosomes
	M Phase
	Mitotic M-M/G1 phases

SMC2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SMC2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/895 Interacting proteins for SMC2 (O95347^{2, 3} ENSP00000286398⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 895)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMC4	Q9NTJ3²^,³, ENSP00000341382⁴	MINT-7945693 MINT-4330025 MINT-4329866 MINT-7947479 I2D: score=9 STRING: ENSP00000341382
NCAPD2	Q15021²^,³, ENSP00000325017⁴	MINT-4330014 MINT-7945693 MINT-7947479 I2D: score=7 STRING: ENSP00000325017
SMC3	Q9UQE7²^,³, ENSP00000354720⁴	MINT-7945693 MINT-7947479 MINT-8395092 I2D: score=4 STRING: ENSP00000354720
NCAPH2	Q6IBW4²^,³, ENSP00000410088⁴	MINT-4330039 MINT-4330003 I2D: score=1 STRING: ENSP00000410088
NDC80	O14777²^,³	MINT-7945693 MINT-7947479 I2D: score=3

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006281	DNA repair	IEA	--
GO:0006310	DNA recombination	IEA	--
GO:0007062	sister chromatid cohesion	IEA	--
GO:0007076	mitotic chromosome condensation	IDA	11136719
GO:0010032	meiotic chromosome condensation	IEA	--

SMC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SMC2
Search CenterWatch for drugs/clinical trials and news about SMC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SMC2 gene (4 alternative transcripts):

NM_001042550.1 NM_001042551.1 NM_001265602.1 NM_006444.2

Unigene Cluster for SMC2:

Structural maintenance of chromosomes 2

Hs.119023 [show with all ESTs]

Unigene Representative Sequence: NM_001042550

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000440179 ENST00000374793(uc004bbx.3 uc004bby.3) ENST00000374787

ENST00000493955 ENST00000286398(uc010mtg.1 uc010mth.1 uc004bbu.1 uc004bbv.3 uc004bbw.3 uc011lvl.2)

ENST00000303219

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SMC2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMC2
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SMC2 (see all 11):
		hsa-miR-3163 hsa-miR-7-2* hsa-miR-211 hsa-miR-570 hsa-miR-204 hsa-miR-7-1* hsa-miR-3151 hsa-miR-3143

		SwitchGear 3'UTR luciferase reporter plasmid: SMC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMC2 (see all 7) OriGene shRNA RFP: SMC2 OriGene siRNA: SMC2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMC2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SMC2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMC2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMC2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SMC2 (NM_001204453)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMC2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMC2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SMC2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMC2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMC2

Additional cDNA sequence:

AF092563.1 AJ420415.1 AJ420453.1 AK000955.1 AK001485.1 AK124957.1 AK292599.1 AK307752.1

AL833191.1 AY739716.1 BC003396.1 BC017845.1 BC032705.1 BC055081.1 BC061906.1 BC071750.1

BC107891.1 BC130385.1 BC144163.1 U46075.1

12 DOTS entries:

DT.91769211 DT.40123755 DT.91769208 DT.97858951 DT.121188688 DT.100786034 DT.99958410 DT.100786041

DT.100655211 DT.100725608 DT.95233620 DT.95374504

24/206 AceView cDNA sequences (see all 206):

AI242240 AI831542 BG428946 AA135965 BU663246 AI056829 BQ921497 CB158802

CD108447 AI864957 BE881875 AF113673 BQ227522 AL833191 Z44045 AU133674

AU133083 CB139943 AI065097 AI753216 AW504314 BM453914 AK000955 AA430089

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for SMC2 (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14	^
SP1:
SP2:
SP3:
SP4:													-		-		-
SP5:

ExUns:	15a	·	15b	^	16	^	17	^	18	^	19a	·	19b	·	19c	^	20a	·	20b	^	21	^	22a	·	22b	^	23	^	24a	·	24b	^	25a	·	25b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SMC2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SMC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SMC2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Prechondrocytic Mesenchymal Cells

Bone, Cartilage

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Hypothalamus

Brain

Neural Tube

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Spinal Cord

Spinal Dorsal Columns

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SMC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMC2

SOURCE GeneReport for Unigene cluster: Hs.119023

SABiosciences Custom PCR Arrays for SMC2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMC2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SMC2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMC2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMC2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMC2 gene from 9/41 species (see all 41) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SMC2¹	structural maintenance of chromosomes 2	70.97(n) 67.09(a)		396156 NM_205230.1 NP_990561.1
lizard (Anolis carolinensis)	Reptilia	SMC2⁶	--	81(a)	1 ↔ 1	GL343476.1(357861-392466)
African clawed frog (Xenopus laevis)	Amphibia	XCAP-E²	(XCAP-E)	77.92(n)		U13674.1
zebrafish (Danio rerio)	Actinopterygii	hmzeh1628²	hmzeh1628	75.45(n)		321452 BC044141.1
fruit fly (Drosophila melanogaster)	Insecta	SMC2¹	CG10212-PA	50.9(n) 41.13(a)		36653 NM_137151.2 NP_610995.1
worm (Caenorhabditis elegans)	Secernentea	mix-1⁶	Mitotic chromosome and X-chromosome-associated pro...	31(a)	1 ↔ 1	II(10824236-10841763)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SMC2(YFR031C)⁴ SMC2¹	Subunit of the condensin complex; essential SMC chromosomal more⁴ Smc2p¹	48.47(n)¹ 37.05(a)¹		6(220106-216594)⁴ 850589^{1, 4} NP_116687.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	ATSMC2¹	structural maintenance of chromosomes protein 2-2	55.51(n) 46.07(a)		823900 NM_114614.3 NP_190330.1
rice (Oryza sativa)	Liliopsida	CA763560.1²	--	70.9(n)		CA763560.1

ENSEMBL Gene Tree for SMC2 (if available)
TreeFam Gene Tree for SMC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10512326^1,2	C,F,A,H	--	106854545(-)	`TCTAAC/TTACTC`	3	--	us2k¹		29		NS EA NA CSA WA	2864
rs10991103^1,2	C,F,A,H	--	106854593(+)	`AACAAC/TAGTGC`	3	--	us2k¹		28		NS EA NA CSA WA	3174
rs10991104^1,2	C,F,H	--	106854605(+)	`CTTGTG/ATATGT`	3	--	us2k¹		23		NS EA NA WA	2732
rs113226687^1,2		--	106854705(+)	`CACTTT/CATTTC`	3	--	us2k¹		2		CSA WA	120
rs1360176^1,2	C,F,A,H	--	106854716(-)	`TGTCAA/CGTTGT`	3	--	us2k¹ tfbs³		30		MN NS EA NA WA CSA	3642
rs142907852^1,2		--	106854779(+)	`TAAAAC/GGAAGG`	3	--	us2k¹		0	--	--	--	--
rs116123985^1,2	F	--	106854940(+)	`GTGGAT/GAAGCA`	4	--	us2k¹		1		WA	118
rs1411103^1,2	C,F,O,A,H	--	106854958(-)	`CCTTTA/GTTTAC`	4	--	us2k¹		28		EA NA MN NS WA CSA	4087
rs76461259^1,2	C	--	106855005(+)	`TTACTA/CCCTTA`	4	--	us2k¹		0	--	--	--	--
rs145167125^1,2		--	106855042(+)	`CCATTC/TCTGGT`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SMC2 (106856541 - 106903700 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SMC2
1 Indel: 65479

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SMC2 for disorders           About GeneDecksing

OMIM gene information: 605576    OMIM disorders: --

7 diseases for SMC2:    About MalaCards

cornelia de lange syndrome pleural empyema pneumonia schizophrenia

tuberculosis malaria mycobacterium tuberculosis

1 disease from the University of Copenhagen DISEASES database for SMC2:

Cornelia de Lange syndrome

Export disorders for SMC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SMC2 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with SMC2)

Utopia: connect your pdf to the dynamic
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Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. (PubMed id 9789013)^{1, 2, 3} Schmiesing J.A....Yokomori K. (1998)
A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. (PubMed id 10958694)^{1, 2, 9} Schmiesing J.A.... Yokomori K. (2000)
The evolution of SMC proteins: phylogenetic analysis and structural implications. (PubMed id 14660695)^{1, 2} Cobbe N. and Heck M.M.S. (2004)
Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PubMed id 11136719)^{1, 2} Kimura K....Hirano T. (2001)
Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma. (PubMed id 17488335)^{1, 9} Ham M.F....Aozasa K. (2007)
In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex. (PubMed id 12589063)^{1, 9} Przewloka M.R....Cary R.B. (2003)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
A cohesin-RAD21 interactome. (PubMed id 22145905)¹ Panigrahi A.K....Pati D. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10592	HGNC: 14011	AceView: SMC2L1	Ensembl:ENSG00000136824	euGenes: HUgn10592
ECgene: SMC2	H-InvDB: SMC2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SMC2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SMC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SMC2 gene:
Search GeneIP for patents involving SMC2

GeneCards and IP:
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structural maintenance of chromosomes 2

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structural maintenance of chromosomes 2

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