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Aliases for SMC2 Gene

Aliases for SMC2 Gene

  • Structural Maintenance Of Chromosomes 2 2 3
  • CAPE 3 4 6
  • SMC2 (Structural Maintenance Of Chromosomes 2, Yeast)-Like 1 2 3
  • Chromosome-Associated Protein E 3 4
  • XCAP-E Homolog 3 4
  • SMC Protein 2 3 4
  • SMC2L1 3 4
  • SMC-2 3 4
  • Structural Maintenance Of Chromosomes (SMC) Family Member, Chromosome-Associated Protein E 3
  • SMC2 Structural Maintenance Of Chromosomes 2-Like 1 (Yeast) 2
  • Structural Maintenance Of Chromosomes Protein 2 3
  • HCAP-E 4
  • CAP-E 3

External Ids for SMC2 Gene

Previous HGNC Symbols for SMC2 Gene

  • SMC2L1

Previous GeneCards Identifiers for SMC2 Gene

  • GC09P105896
  • GC09P106856
  • GC09P076458

Summaries for SMC2 Gene

Entrez Gene Summary for SMC2 Gene

  • Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]

GeneCards Summary for SMC2 Gene

SMC2 (Structural Maintenance Of Chromosomes 2) is a Protein Coding gene. Diseases associated with SMC2 include smith-mccort dysplasia 2. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for SMC2 Gene

  • Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Wiki entry for SMC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMC2 Gene

Genomics for SMC2 Gene

Regulatory Elements for SMC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SMC2 Gene

Start:
104,094,260 bp from pter
End:
104,141,419 bp from pter
Size:
47,160 bases
Orientation:
Plus strand

Genomic View for SMC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMC2 Gene

Proteins for SMC2 Gene

  • Protein details for SMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95347-SMC2_HUMAN
    Recommended name:
    Structural maintenance of chromosomes protein 2
    Protein Accession:
    O95347
    Secondary Accessions:
    • Q6IEE0
    • Q9P1P2

    Protein attributes for SMC2 Gene

    Size:
    1197 amino acids
    Molecular mass:
    135656 Da
    Quaternary structure:
    • Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Interacts with BRD4 (isoform B), leading to insulate chromatin from DNA damage response pathway.
    SequenceCaution:
    • Sequence=AAC72360.1; Type=Frameshift; Positions=890, 908; Evidence={ECO:0000305}; Sequence=AAF29579.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SMC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMC2 Gene

Proteomics data for SMC2 Gene at MOPED

Post-translational modifications for SMC2 Gene

  • Ubiquitination at Lys12, Lys68, Lys114, Lys523, Lys580, Lys958, and Lys1178
  • Modification sites at PhosphoSitePlus

Other Protein References for SMC2 Gene

No data available for DME Specific Peptides for SMC2 Gene

Domains for SMC2 Gene

Gene Families for SMC2 Gene

HGNC:
  • SMC :Structural maintenance of chromosomes proteins

Protein Domains for SMC2 Gene

Suggested Antigen Peptide Sequences for SMC2 Gene

Graphical View of Domain Structure for InterPro Entry

O95347

UniProtKB/Swiss-Prot:

SMC2_HUMAN :
  • O95347
Domain:
  • The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.
Family:
  • Belongs to the SMC family. SMC2 subfamily.
genes like me logo Genes that share domains with SMC2: view

Function for SMC2 Gene

Molecular function for SMC2 Gene

UniProtKB/Swiss-Prot Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Ontology (GO) - Molecular Function for SMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12589063
GO:0005524 ATP binding IEA --
GO:0046982 protein heterodimerization activity IPI 9789013
genes like me logo Genes that share ontologies with SMC2: view

Phenotypes for SMC2 Gene

GenomeRNAi human phenotypes for SMC2:
genes like me logo Genes that share phenotypes with SMC2: view

Animal Model Products

CRISPR Products

miRNA for SMC2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SMC2 Gene

Localization for SMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMC2 Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensins association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMC2 Gene COMPARTMENTS Subcellular localization image for SMC2 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 10958694
GO:0000793 condensed chromosome IDA 12589063
GO:0000796 condensin complex IDA 10958694
GO:0005634 nucleus IDA 12589063
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SMC2: view

Pathways for SMC2 Gene

genes like me logo Genes that share pathways with SMC2: view

Pathways by source for SMC2 Gene

1 Qiagen pathway for SMC2 Gene
3 Cell Signaling Technology pathways for SMC2 Gene
2 BioSystems pathways for SMC2 Gene
1 GeneGo (Thomson Reuters) pathway for SMC2 Gene

Gene Ontology (GO) - Biological Process for SMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007076 mitotic chromosome condensation IDA 11136719
GO:0010032 meiotic chromosome condensation IEA --
GO:0045132 meiotic chromosome segregation IEA --
GO:0051276 chromosome organization --
genes like me logo Genes that share ontologies with SMC2: view

Transcripts for SMC2 Gene

Unigene Clusters for SMC2 Gene

Structural maintenance of chromosomes 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SMC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SMC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMC2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1:
SP2:
SP3:
SP4: - - -
SP5:
SP6: - - - - - -
SP7: - - - - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - -
SP14:
SP15:
SP16: -

ExUns: 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12: -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for SMC2 Gene

GeneLoc Exon Structure for
SMC2
ECgene alternative splicing isoforms for
SMC2

Expression for SMC2 Gene

mRNA expression in normal human tissues for SMC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMC2 Gene

SOURCE GeneReport for Unigene cluster for SMC2 Gene Hs.119023

genes like me logo Genes that share expressions with SMC2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMC2 Gene

Orthologs for SMC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMC2 35
  • 99.69 (n)
  • 99.83 (a)
SMC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SMC2 35
  • 91.86 (n)
  • 93.03 (a)
SMC2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMC2 35
  • 93 (n)
  • 95.89 (a)
SMC2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smc2 35
  • 88.82 (n)
  • 92.18 (a)
Smc2 16
Smc2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SMC2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMC2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smc2 35
  • 88.8 (n)
  • 93.28 (a)
chicken
(Gallus gallus)
Aves SMC2 35
  • 71.27 (n)
  • 67.6 (a)
SMC2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMC2 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XCAP-E 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486893 35
  • 76.12 (n)
  • 82.49 (a)
Str.234 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13481 35
zebrafish
(Danio rerio)
Actinopterygii hmzeh1628 35
smc2 35
  • 69 (n)
  • 75.08 (a)
smc2 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011425 35
  • 51.44 (n)
  • 48.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta SMC2 35
  • 51.12 (n)
  • 41.32 (a)
SMC2 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mix-1 36
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR236W 35
  • 47.49 (n)
  • 39.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMC2 35
  • 48.75 (n)
  • 38.17 (a)
SMC2 36
  • 36 (a)
OneToOne
SMC2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16005g 35
  • 48.95 (n)
  • 38.02 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SMC2 35
  • 54.63 (n)
  • 46.29 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4594 35
corn
(Zea mays)
Liliopsida Zm.10261 35
rice
(Oryza sativa)
Liliopsida Os01g0904400 35
  • 54.57 (n)
  • 47.71 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.20443 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07679 35
  • 48.36 (n)
  • 41.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut14 35
  • 48.64 (n)
  • 37.69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2681 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3109 36
  • 51 (a)
OneToOne
Species with no ortholog for SMC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SMC2 Gene

ENSEMBL:
Gene Tree for SMC2 (if available)
TreeFam:
Gene Tree for SMC2 (if available)

Paralogs for SMC2 Gene

Selected SIMAP similar genes for SMC2 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SMC2: view

No data available for Paralogs for SMC2 Gene

Variants for SMC2 Gene

Sequence variations from dbSNP and Humsavar for SMC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs15532 -- 104,139,596(+) ACCCG(A/C)TTCTA utr-variant-3-prime
rs483377 -- 104,140,018(-) ATACT(C/T)ACACA utr-variant-3-prime
rs965966 -- 104,108,879(-) tctgg(A/G)gtata intron-variant
rs980249 -- 104,126,236(-) cccca(A/G)ccttt intron-variant
rs999312 -- 104,114,958(+) AAACT(A/C)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMC2 Gene

Variant ID Type Subtype PubMed ID
nsv831676 CNV Gain 17160897
nsv893668 CNV Gain 21882294
esv26670 CNV Loss 19812545
esv2738869 CNV Deletion 23290073

Relevant External Links for SMC2 Gene

HapMap Linkage Disequilibrium report
SMC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMC2 Gene

Disorders for SMC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SMC2 Gene including...

Search for SMC2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SMC2 Gene

Relevant External Links for SMC2

Genetic Association Database (GAD)
SMC2
genes like me logo Genes that share disorders with SMC2: view

No data available for UniProtKB/Swiss-Prot for SMC2 Gene

Publications for SMC2 Gene

  1. A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation. (PMID: 10958694) Schmiesing J.A. … Yokomori K. (Mol. Cell. Biol. 2000) 3 4 23
  2. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics. (PMID: 9789013) Schmiesing J.A. … Yokomori K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  3. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PMID: 11136719) Kimura K. … Hirano T. (J. Biol. Chem. 2001) 3 4
  4. In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex. (PMID: 12589063) Przewloka M.R. … Cary R.B. (Mol. Biol. Cell 2003) 3 23
  5. Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma. (PMID: 17488335) Ham M.F. … Aozasa K. (Cancer Sci. 2007) 3 23

Products for SMC2 Gene

Sources for SMC2 Gene

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