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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMC1B Gene

protein-coding   GIFtS: 54
GCID: GC22M045739

structural maintenance of chromosomes 1B

(Previous names: SMC1 (structural maintenance of chromosomes 1, yeast)-like...)
(Previous symbol: SMC1L2)
 Explore 4 diseases affiliated with
SMC1B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SMC1B    

Aliases
for SMC1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Structural Maintenance Of Chromosomes 1B1 2     SMC1 Structural Maintenance Of Chromosomes 1-Like 2 (Yeast)1
SMC1L21 2 3     SMC1BETA2
BK268H51     BK268H5.51
SMC1 (Structural Maintenance Of Chromosomes 1, Yeast)-Like 11 2     Mitosis-Specific Chromosome Segregation Protein Like Protein Beta2
SMC-1-Beta1     SMC1 Structural Maintenance Of Chromosomes 1-Like 22
SMC-1B2 3     Structural Maintenance Of Chromosomes Protein 1B2
SMC Protein 1B2 3     

External Ids:    HGNC: 111121   Entrez Gene: 271272   Ensembl: ENSG000000779357   OMIM: 6086855   UniProtKB: Q8NDV33   

Export aliases for SMC1B gene to outside databases

Previous GC identifers: GC22M044118 GC22M028686


Summaries
for SMC1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SMC1B:
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis
(3:Revenkova et al., 2001 (PubMed 11564881)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SMC1B_HUMAN, Q8NDV3
Function: Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or
only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of
chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin
complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms
a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and
dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably
replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity)

Gene Wiki entry for SMC1B


Genomic Views
for SMC1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SMC1B gene promoter:
         Bach1   SREBP-1c   Nkx2-5   HNF-3beta   C/EBPalpha   SREBP-1b   PPAR-gamma1   SREBP-1a   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SMC1B promoter sequence
   Search SABiosciences Chromatin IP Primers for SMC1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMC1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q13

SMC1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMC1B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M045739:  view genomic region     (about GC identifiers)

Start:
 45,739,944 bp from pter      End:
 45,809,500 bp from pter
Size:
 69,557 bases      Orientation:
 minus strand

Proteins
for SMC1B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SMC1B_HUMAN, Q8NDV3 (See protein sequence)
Recommended Name: Structural maintenance of chromosomes protein 1B  
Size: 1235 amino acids; 143908 Da
Subunit: Forms a heterodimer with SMC3. Component of a meiosis-specific cohesin complex, probably composed of the SMC1B
and SMC3 heterodimer attached via their hinge domain, RAD21 (or its meiosis-specific related protein REC8), which link
them, and STAG3, which interacts with RAD21 or REC8 (By similarity)
Subcellular location: Nucleus. Chromosome (By similarity). Chromosome, centromere (By similarity). Note=Associates with
chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In
late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation
by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to
metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity)
Sequence caution: Sequence=BAC86266.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A0AV46 B0QY23 B0QY24 Q5TIC3 Q6ZUF9 Q9Y3G5
Alternative splicing: 3 isoforms:  Q8NDV3-1   Q8NDV3-2   Q8NDV3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMC1B: NX_Q8NDV3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NDV3

    • SMC1B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_683515.3  
    ENSEMBL proteins: 
     ENSP00000350036   ENSP00000385902  
    Reactome Protein details: Q8NDV3
    Human Recombinant Protein Products: 
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    Novus Biologicals SMC1B Protein
    Novus Biologicals SMC1B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SMC1B

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000795synaptonemal complex ----
    GO:0000800lateral element IEA--
    GO:0005634nucleus ----
    GO:0030893meiotic cohesin complex IDA--


    SMC1B for ontologies           About GeneDecksing



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    ThermoFisher Antibody for SMC1B

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    Uscn ELISAs and CLIAs for SMC1B

    Protein Domains /
    Families
    for SMC1B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SMC1B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003395 RecF/RecN/SMC
     IPR024704 SMC
     IPR010935 SMC_hinge

    Graphical View of Domain Structure for InterPro Entry Q8NDV3

    ProtoNet protein and cluster: Q8NDV3

    1 Blocks protein family: IPB010935 SMCs flexible hinge

    UniProtKB/Swiss-Prot: SMC1B_HUMAN, Q8NDV3
    Domain: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic
    interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer
    are then connected by different ends of the cleavable RAD21 or REC8 protein, forming a ring structure (By similarity)
    Similarity: Belongs to the SMC family. SMC1 subfamily


    Function
    for SMC1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SMC1B_HUMAN, Q8NDV3
    Function: Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or
    only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of
    chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin
    complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms
    a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and
    dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably
    replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SMC1B
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SMC1B:
    hsa-miR-31
    SwitchGear 3'UTR luciferase reporter plasmid: SMC1B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMC1B (see all 7)
    OriGene shRNA RFP: SMC1B
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMC1B (see all 3)
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--


    SMC1B for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for SMC1B: Smc1btm1Jess Smc1btm2.2Jess
         4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Smc1b):
     cellular  endocrine/exocrine gland  normal  reproductive system 

    SMC1B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SMC1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiotic Synapsis1.00
    		Meiosis0.70
    		Telomere clustering at the nuclear membrane0.82
    		Chromosome Maintenance0.56
    2Synapsis
    		Synapsis1.00
    		Formation of Axial/Lateral Elements of Synaptonemal Complex0.56
    3Meiosis
    		Meiosis1.00
    4Oocyte meiosis
    		Oocyte meiosis1.00
    5Cell Cycle
    		Cell Cycle1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SMC1B
        Meiosis


    5/7        Reactome Pathways for SMC1B (see all 7)
        Synapsis
    Meiotic Synapsis
    Cell Cycle
    Meiosis
    Chromosome Maintenance


    2         Kegg Pathways  (Kegg details for SMC1B):
        Cell cycle
    Oocyte meiosis


    SMC1B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMC1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for SMC1B (Q8NDV33 ENSP000003500364) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE73, ENSP000003547204I2D: score=2 STRING: ENSP00000354720
    REC8O950723, ENSP000003086994I2D: score=1 STRING: ENSP00000308699
    CHPT1Q8WUD63I2D: score=1 
    BRCA1ENSP000003502834STRING: ENSP00000350283
    SGOL1ENSP000002637534STRING: ENSP00000263753
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0007062sister chromatid cohesion IEA--
    GO:0007126meiosis IEA--
    GO:0030261chromosome condensation IEA--


    SMC1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for SMC1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SMC1B
    Search CenterWatch for drugs/clinical trials and news about SMC1B 

    Transcripts
    for SMC1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SMC1B gene: 
    NM_148674.3  

    Unigene Cluster for SMC1B:

    Structural maintenance of chromosomes 1B
    Hs.334176  [show with all ESTs]
    Unigene Representative Sequence: NM_148674
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357450(uc003bgc.3 uc003bgd.3) ENST00000404354(uc003bge.1)


    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SMC1B:
    hsa-miR-31
    SwitchGear 3'UTR luciferase reporter plasmid: SMC1B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMC1B (see all 7)
    OriGene shRNA RFP: SMC1B
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMC1B
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMC1B

    Additional cDNA sequence: 

    AJ504806.2 AK125736.1 BC126208.1 

    5 DOTS entries:

    DT.40273013  DT.207836  DT.91746237  DT.91864298  DT.92416027 

    24/31 AceView cDNA sequences (see all 31):

    AL704843 H55708 AJ504806 NM_148674 BG194018 BX282082 BF888585 BG187600 
    AA641962 AA207011 AK125736 AA641909 BG208448 AA204664 BU585031 BG181498 
    BG210019 BG186119 BG201132 BG221580 BE082988 BG191403 H55194 BF377342 

    GeneLoc Exon Structure


    Expression
    for SMC1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMC1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SMC1B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesPrimary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Epiblast-like cells (Reconstitution of mo...)
    Primordial germ cell-like cells (Reconstitution of mo...)

    See SMC1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMC1B

    SOURCE GeneReport for Unigene cluster: Hs.334176
        SABiosciences Custom PCR Arrays for SMC1B
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    In Situ
    Assay Products:     
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    Orthologs
    for SMC1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMC1B gene from 6/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SMC1B1 structural maintenance of chromosomes 1B 70.74(n)
    65.34(a)    		   418243  XM_416467.3  XP_416467.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 71(a)
    64(a)
    		 1 ↔ many
    1 ↔ many
    		 5(84304940-84314875)
    5(84260163-84297391)
    zebrafish
    (Danio rerio)    		 Actinopterygii smc1b1 structural maintenance of chromosomes 1B 58.11(n)
    53.52(a)    		   797354  XM_001334221.1  XP_001334257.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SMC16
    		 SMC1
    		 40(a)
    		 1 → many
    		 3R(19884024-19888538)
    worm
    (Caenorhabditis elegans)    		 Secernentea him-16
    		 High Incidence of Males (increased X chromosome lo...
    		 37(a)
    		 1 → many
    		 I(4951335-4957670)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SMC16
    		 structural maintenance of chromosomes 1
    		 31(a)
    		 1 → many
    		 3(20235483-20243960)


    ENSEMBL Gene Tree for SMC1B (if available)
    TreeFam Gene Tree for SMC1B (if available) 

    Paralogs
    for SMC1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SMC1B gene
    SMC1A2  
    2 SIMAP similar genes for SMC1B using alignment to 1 protein entry:     SMC1B_HUMAN:
    SMC1A    DKFZp686L19178

    SMC1B for paralogs           About GeneDecksing



    Genomic Variants
    for SMC1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1084 NCBI SNPs in SMC1B are shown (see all 1084)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1838424661,2
    		--45739473(+) GCACAG/TTGGCG 1 -- ds50010--------
    rs1125865681,2
    		C,--45739497(+) CTGCAG/ACCTCC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1379341081,2
    		--45739565(+) GTGCAC/TCCCAT 1 -- ds50010--------
    rs96146451,2
    		C,--45739599(+) TTTAGG/TAGAGA 1 -- ds50013Minor allele frequency- T:0.17NA 6
    rs766083191,2
    		F,--45739618(-) CCAACG/ATGGCA 1 -- ds50012Minor allele frequency- A:0.50NA 6
    rs96144581,2
    		C,F,--45739658(+) GTGATA/CCACCC 1 -- ds50014Minor allele frequency- C:0.25NA 8
    rs1885542291,2
    		--45739725(+) GTCTTG/TTTCCA 1 -- ds50010--------
    rs21790581,2
    		C,F,O,A,H,--45739732(+) TCCATT/CTTGAA 1 -- ds500113Minor allele frequency- C:0.34EA NS NA 688
    rs134336771,2
    		C,F,H,--45739747(+) AAATGA/GAGTGG 1 -- ds50015Minor allele frequency- G:0.03NS EA WA 536
    rs1813183411,2
    		--45739781(+) AATAAC/TGTTTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SMC1B (45739944 - 45809500 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for SMC1B
         9 CNVs: 50878 31097 50877 8906 4132 50879 50876 3244 50875
    Human Gene Mutation Database (HGMD): SMC1B

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SMC1B

    Disorders / Diseases
    for SMC1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SMC1B for disorders           About GeneDecksing

    OMIM gene information: 608685    OMIM disorders: --

    4 diseases for SMC1B:    About MalaCards
    pneumonia    tuberculosis    malaria    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: SMC1B (2 documents)

    Export disorders for SMC1B gene to outside databases

    Publications
    for SMC1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMC1B gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SMC1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. The evolution of SMC proteins: phylogenetic analysis and structural implications. (PubMed id 14660695)1, 2 Cobbe N. and Heck M.M.S. (2004)
    3. Novel meiosis-specific isoform of mammalian SMC1. (PubMed id 11564881)1, 3 Revenkova E....Jessberger R. (2001)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Epigenetic displacement of HP1 from heterochromatin b y HIV-1 Vpr causes premature sister chromatid separation. (PubMed id 21875947)1 Shimura M....Ishizaka Y. (2011)
    6. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (2010)
    7. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1 Zhang X....Wu X. (2010)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for SMC1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SMC1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27127 HGNC: 11112 AceView: SMC1L2 Ensembl:ENSG00000077935 euGenes: HUgn27127
    ECgene: SMC1B Kegg: 27127 H-InvDB: SMC1B

    Other Databases showing SMC1B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SMC1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMC1B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SMC1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SMC1B gene:
    Search GeneIP for patents involving SMC1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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