Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SMC1B Gene

protein-coding   GIFtS: 57
GCID: GC22M045739

Structural Maintenance Of Chromosomes 1B

(Previous names: SMC1 (structural maintenance of chromosomes 1, yeast)-like...)
(Previous symbol: SMC1L2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Structural Maintenance Of Chromosomes 1B1 2     SMC1BETA2
SMC1L21 2 3     bK268H52
SMC1 (Structural Maintenance Of Chromosomes 1, Yeast)-Like 11 2     bK268H5.52
SMC-1-beta2 3     Mitosis-Specific Chromosome Segregation Protein Like Protein Beta2
SMC-1B2 3     SMC1 Structural Maintenance Of Chromosomes 1-Like 22
SMC Protein 1B2 3     Structural Maintenance Of Chromosomes Protein 1B2
SMC1 Structural Maintenance Of Chromosomes 1-Like 2 (Yeast)1     

External Ids:    HGNC: 111121   Entrez Gene: 271272   Ensembl: ENSG000000779357   OMIM: 6086855   UniProtKB: Q8NDV33   

Export aliases for SMC1B gene to outside databases

Previous GC identifers: GC22M044118 GC22M028686


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SMC1B Gene:
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and
mitosis (3:Revenkova et al., 2001 (PubMed 11564881)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SMC1B Gene:
SMC1B (structural maintenance of chromosomes 1B) is a protein-coding gene. Diseases associated with SMC1B include azoospermia, and pneumonia. An important paralog of this gene is SMC1A.

UniProtKB/Swiss-Prot: SMC1B_HUMAN, Q8NDV3
Function: Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but
not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the
organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome
movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The
cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At
anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The
meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from
chromatin during prophase I (By similarity)

Gene Wiki entry for SMC1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMC1B gene promoter:
         Bach1   SREBP-1c   Nkx2-5   HNF-3beta   C/EBPalpha   SREBP-1b   PPAR-gamma1   SREBP-1a   c-Myb   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMC1B promoter sequence
   Search Chromatin IP Primers for SMC1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMC1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31   Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q13

SMC1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMC1B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M045739:  view genomic region     (about GC identifiers)

Start:
45,739,944 bp from pter      End:
45,809,500 bp from pter
Size:
69,557 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SMC1B_HUMAN, Q8NDV3 (See protein sequence)
Recommended Name: Structural maintenance of chromosomes protein 1B  
Size: 1235 amino acids; 143908 Da
Subunit: Forms a heterodimer with SMC3. Component of a meiosis-specific cohesin complex, probably composed of the
SMC1B and SMC3 heterodimer attached via their hinge domain, RAD21 (or its meiosis-specific related protein REC8),
which link them, and STAG3, which interacts with RAD21 or REC8 (By similarity)
Sequence caution: Sequence=BAC86266.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A0AV46 B0QY23 B0QY24 Q5TIC3 Q6ZUF9 Q9Y3G5
Alternative splicing: 3 isoforms:  Q8NDV3-1   Q8NDV3-2   Q8NDV3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMC1B: NX_Q8NDV3

Explore proteomics data for SMC1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys529
  • Modification sites at PhosphoSitePlus

  • See SMC1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_683515.3  
    ENSEMBL proteins: 
     ENSP00000350036   ENSP00000385902  
    Reactome Protein details: Q8NDV3

    SMC1B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SMC1B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SMC1B
    GenScript Custom Purified and Recombinant Proteins Services for SMC1B
    Novus Biologicals SMC1B Protein
    Novus Biologicals SMC1B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SMC1B

    SMC1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SMC1B
    OriGene Custom Antibody Services for SMC1B
    Novus Biologicals SMC1B Antibodies
    Abcam antibodies for SMC1B
    Cloud-Clone Corp. Antibodies for SMC1B
    ThermoFisher Antibody for SMC1B
    LSBio Antibodies in human, mouse, rat for SMC1B

    SMC1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SMC1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SMC1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SMC1B
    Cloud-Clone Corp. CLIAs for SMC1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SMC: Structural maintenance of chromosomes proteins

    5 InterPro protein domains:
     IPR003395 RecF/RecN/SMC_N
     IPR027417 P-loop_NTPase
     IPR024704 SMC
     IPR028468 Smc1
     IPR010935 SMC_hinge

    Graphical View of Domain Structure for InterPro Entry Q8NDV3

    ProtoNet protein and cluster: Q8NDV3

    1 Blocks protein domain: IPB010935 SMCs flexible hinge

    UniProtKB/Swiss-Prot: SMC1B_HUMAN, Q8NDV3
    Domain: The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the
    heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of
    the heterodimer are then connected by different ends of the cleavable RAD21 or REC8 protein, forming a ring
    structure (By similarity)
    Similarity: Belongs to the SMC family. SMC1 subfamily


    SMC1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMC1B_HUMAN, Q8NDV3
    Function: Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but
    not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the
    organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome
    movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The
    cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At
    anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The
    meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from
    chromatin during prophase I (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0046982protein heterodimerization activity ----
         
    SMC1B for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Smc1b):
     cellular  endocrine/exocrine gland  normal  reproductive system 

    SMC1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SMC1B: Smc1btm1Jess Smc1btm2.2Jess

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMC1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SMC1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SMC1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SMC1B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SMC1B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SMC1B:
    hsa-miR-31
    SwitchGear 3'UTR luciferase reporter plasmidSMC1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SMC1B
    Predesigned siRNA for gene silencing in human, mouse, rat SMC1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SMC1B

    Clone
    Products:
         
    OriGene clones in human, mouse for SMC1B (see all 6)
    OriGene ORF clones in mouse, rat for SMC1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SMC1B (NM_148674)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMC1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC1B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SMC1B
    Browse ESI BIO Cell Lines and PureStem Progenitors for SMC1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SMC1B_HUMAN, Q8NDV3: Nucleus. Chromosome (By similarity). Chromosome, centromere (By similarity). Note=Associates
    with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In
    late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of
    phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at
    the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes
    segregation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000795synaptonemal complex ----
    GO:0000800lateral element IEA--
    GO:0005694chromosome ----
    GO:0016020membrane ----

    SMC1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SMC1B About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    2Cell Cycle, Mitotic
    Cell Cycle0.90
    3Meiosis (REACTOME)
    Meiosis0.74
    4Cell cycle
    Cell cycle0.59
    5Oocyte meiosis
    Oocyte meiosis0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SMC1B
        Mitotic Roles of Polo Like Kinases

    1 Reactome Pathway for SMC1B
        Meiotic synapsis


    2 Kegg Pathways  (Kegg details for SMC1B):
        Cell cycle
    Oocyte meiosis


    SMC1B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMC1B
    Interactions:

        Search GeneGlobe Interaction Network for SMC1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SMC1B (Q8NDV33 ENSP000003500364) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE73, ENSP000003547204I2D: score=2 STRING: ENSP00000354720
    REC8O950723, ENSP000003086994I2D: score=1 STRING: ENSP00000308699
    CHPT1Q8WUD63I2D: score=1 
    BRCA1ENSP000003502834STRING: ENSP00000350283
    RAD21ENSP000002973384STRING: ENSP00000297338
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0007062sister chromatid cohesion IEA--
    GO:0007064mitotic sister chromatid cohesion ----
    GO:0007126meiotic nuclear division IEA--

    SMC1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMC1B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SMC1B gene: 
    NM_148674.3  

    Unigene Cluster for SMC1B:

    Structural maintenance of chromosomes 1B
    Hs.334176  [show with all ESTs]
    Unigene Representative Sequence: NM_148674
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357450(uc003bgc.3 uc003bgd.3) ENST00000404354(uc003bge.1)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SMC1B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SMC1B:
    hsa-miR-31
    SwitchGear 3'UTR luciferase reporter plasmidSMC1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SMC1B
    Predesigned siRNA for gene silencing in human, mouse, rat SMC1B
    Clone
    Products:
         
    OriGene clones in human, mouse for SMC1B (see all 6)
    OriGene ORF clones in mouse, rat for SMC1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SMC1B (NM_148674)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMC1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC1B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SMC1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SMC1B
      QuantiTect SYBR Green Assays in human, mouse, rat SMC1B
      QuantiFast Probe-based Assays in human, mouse, rat SMC1B

    Additional mRNA sequence: 

    AJ504806.2 AK125736.1 BC126208.1 

    5 DOTS entries:

    DT.40273013  DT.207836  DT.91746237  DT.91864298  DT.92416027 

    Selected AceView cDNA sequences (see all 31):

    NM_148674 H55708 AL704843 AJ504806 BG187600 AA207011 BG194018 BX282082 
    AK125736 AA641909 BF888585 AA641962 BG208448 BG210019 BG186119 AA204664 
    BG181498 BU585031 H55194 BG201132 BF377342 BG221580 BE082988 BG191403 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SMC1B expression in normal human tissues (normalized intensities)      SMC1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SMC1B Expression
    About this image


    SMC1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
             Primordial germ cell-like cells
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    SMC1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMC1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334176
        Custom PCR Arrays for SMC1B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SMC1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SMC1B
    QuantiTect SYBR Green Assays in human, mouse, rat SMC1B
    QuantiFast Probe-based Assays in human, mouse, rat SMC1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SMC1B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smc1b1 , 5 structural maintenance of chromosomes 1B1, 5 85.76(n)1
    83.31(a)1
      15 (40.25 cM)5
    1405571  NM_080470.11  NP_536718.11 
     850646915 
    chicken
    (Gallus gallus)
    Aves SMC1B1 structural maintenance of chromosomes 1B 70.74(n)
    65.34(a)
      418243  XM_416467.4  XP_416467.2 
    lizard
    (Anolis carolinensis)
    Reptilia SMC1B6
    structural maintenance of chromosomes 1B
    65(a)
    1 ↔ 1
    5(84260163-84315585)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia smc1b1 structural maintenance of chromosomes 1B 64.18(n)
    61.1(a)
      100145425  NM_001278349.1  NP_001265278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii smc1b1 structural maintenance of chromosomes 1B 58.58(n)
    54.46(a)
      797354  XM_001334221.2  XP_001334257.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta SMC16
    SMC1
    40(a)
    1 → many
    3R(19884024-19888538)
    worm
    (Caenorhabditis elegans)
    Secernentea him-16
    C44C10.46
    (see all 3)
    Protein C44C10.4 (C44C10.4) mRNA, complete cds
    (see all 3)
    37(a)
    26(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    I(4951334-4957667) WBGene00001860
    X(11693466-11695750) WBGene00008085
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SMC16
    Subunit of the multiprotein cohesin complex, essen...
    26(a)
    1 → many
    VI(119429-123106) YFL008W


    ENSEMBL Gene Tree for SMC1B (if available)
    TreeFam Gene Tree for SMC1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SMC1B gene
    SMC1A2  
    2 SIMAP similar genes for SMC1B using alignment to 1 protein entry:     SMC1B_HUMAN:
    SMC1A    DKFZp686L19178

    SMC1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SMC1B (see all 1344)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838424661,2
    --45739473(+) GCACAG/TTGGCG 1 -- ds50010--------
    rs1125865681,2
    C,F--45739497(+) CTGCAG/ACCTCC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1379341081,2
    --45739565(+) GTGCAC/TCCCAT 1 -- ds50010--------
    rs96146451,2
    C--45739599(+) TTTAGG/TAGAGA 1 -- ds50013Minor allele frequency- T:0.17NA 6
    rs766083191,2
    F--45739618(-) CCAACG/ATGGCA 1 -- ds50012Minor allele frequency- A:0.50NA 6
    rs96144581,2
    C,F--45739658(+) GTGATA/CCACCC 1 -- ds50014Minor allele frequency- C:0.25NA 8
    rs1885542291,2
    --45739725(+) GTCTTG/TTTCCA 1 -- ds50010--------
    rs21790581,2
    C,F,O,A,H--45739732(+) TCCATT/CTTGAA 1 -- ds500113Minor allele frequency- C:0.34EA NS NA 688
    rs134336771,2
    C,F,H--45739747(+) AAATGA/GAGTGG 1 -- ds50015Minor allele frequency- G:0.03NS EA WA 536
    rs1813183411,2
    --45739781(+) AATAAC/TGTTTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SMC1B (45739944 - 45809500 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SMC1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3651CNV Insertion18451855
    nsv834221CNV Loss17160897
    nsv471210CNV Gain18288195
    esv34218CNV Gain17911159
    nsv515690CNV Gain+Loss19592680
    nsv9921CNV Gain+Loss18304495
    dgv1411e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SMC1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SMC1B
    DNA2.0 Custom Variant and Variant Library Synthesis for SMC1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608685    OMIM disorders: --

    6 diseases for SMC1B:    About MalaCards
    azoospermia    pneumonia    type 1 diabetes    tuberculosis
    neuroblastoma    hiv-1


    SMC1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): SMC1B
    Human Genome Epidemiology (HuGE) Navigator: SMC1B (2 documents)

    Export disorders for SMC1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SMC1B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with SMC1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    3. The evolution of SMC proteins: phylogenetic analysis and structural implications. (PubMed id 14660695)1, 2 Cobbe N. and Heck M.M.S. (Mol. Biol. Evol. 2004)
    4. Novel meiosis-specific isoform of mammalian SMC1. (PubMed id 11564881)1, 3 Revenkova E....Jessberger R. (Mol. Cell. Biol. 2001)
    5. Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation. (PubMed id 21875947)1 Shimura M....Ishizaka Y. (J. Cell Biol. 2011)
    6. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (BMB Rep 2010)
    7. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (Diabetes 2010)
    8. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27127 HGNC: 11112 AceView: SMC1L2 Ensembl:ENSG00000077935 euGenes: HUgn27127
    ECgene: SMC1B Kegg: 27127 H-InvDB: SMC1B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SMC1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SMC1B gene:
    Search GeneIP for patents involving SMC1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SMC1B   OriGene RNAi products in human, mouse, rat for SMC1B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SMC1B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SMC1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for SMC1B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SMC1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SMC1B   OriGene Custom Protein Services for SMC1B  

     
     
     Block miRNA regulation of human, mouse, rat SMC1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SMC1B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMC1B Predesigned siRNA for gene silencing in human, mouse, rat SMC1B
     QuantiFast Probe-based Assays in human, mouse, rat SMC1B QuantiTect SYBR Green Assays in human, mouse, rat SMC1B
     Custom PCR Arrays for SMC1B Search Chromatin IP Primers for SMC1B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SMC1B  Search GeneGlobe Interaction Network for SMC1B
     Regulatory tfbs in SMC1B promoter
     GenScript Custom Purified and Recombinant Proteins Services for SMC1B GenScript cDNA clones with any tag delivered in your preferred vector for SMC1B
     GenScript Custom Assay Services for SMC1B GenScript Custom overexpressing Cell Line Services for SMC1B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SMC1B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SMC1B antibodies
     SMC1B proteins
     SMC1B lysates
     Antibodies for SMC1B
     See all of Abcam's Antibodies, Kits and Proteins for SMC1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SMC1B
     Antibodies for SMC1B
     ELISAs for SMC1B
     CLIAs for SMC1B



     Browse ESI BIO Cell Lines and PureStem Progenitors for SMC1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMC1B
     SwitchGear 3'UTR luciferase reporter plasmids for SMC1B
     SwitchGear Promoter luciferase reporter plasmids for SMC1B
     ThermoFisher Antibody for SMC1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMC1B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMC1B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SMC1B
     LSBio Antibodies in human, mouse, rat for SMC1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SMC1B gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4