SMARCD3 Gene
protein-coding GIFtS : 56
GCID: GC07 M150935
SWI/SNF related, matrix associated, actin dependent regulator...
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Aliasesfor SMARCD3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin,Subfamily D, Member 3 1 2 Chromatin Remodeling Complex BAF60C Subunit2 BAF60C1 2 3 5 Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60C2 CRACD31 2 SWI/SNF Complex 60 KDa Subunit C2 Rsc6p1 2 SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of ChromatinSubfamily D Member 32 60 KDa BRG-1/Brm-Associated Factor Subunit C2 3 Swp73-Like Protein2 BRG1-Associated Factor 60C2 3
Export aliases for SMARCD3 gene to outside databases Previous GC identifers: GC07M149182 GC07M150250 GC07M150327 GC07M150373 GC07M150566 GC07M144747
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Summariesfor SMARCD3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SMARCD3 : The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: SMRD3_HUMAN, Q6STE5 Function : Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclearreceptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity) Gene Wiki entry for SMARCD3
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Genomic Viewsfor SMARCD3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SMARCD3 gene promoter: PPAR-gamma1 PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for SMARCD3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SMARCD3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q35-q36 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q35-q36 SMARCD3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M150935: view genomic region
(about GC identifiers )
Start:
150,935,850 bp from pter
End:
150,974,982 bp from pter
Size:
39,133 bases
Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 150,265,596-150,303,777
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Proteinsfor SMARCD3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SMRD3_HUMAN, Q6STE5 (See
protein sequence )Recommended Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Size : 483 amino acids; 55016 Da
Subunit : Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2,SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Interacts with SMARCA4/BRG1/BAF190A, the catalytic subunit of the SWI/SNF related nucleosome-remodeling complexes BRG1(I) and BRG1(II). The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF nucleosome-remodeling complexes is not fully known. Also interacts with several nuclear receptors including PPARG/NR1C3, RXRA/NR1F1, ESR1, NR5A1, NR5A2/LRH1 and other transcriptional activators including the HLH protein SREBF1/SREBP1 and the homeobox protein PBX1. May allow recruitment of Swi/SNF containing complexes specifically to promoters where these factors are located. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity)
Subcellular location : Nucleus
Sequence caution : Sequence=AAC50697.1; Type=Frameshift; Positions=41, 65, 78;
Secondary accessions : D3DX10 Q2YD86 Q75MJ2 Q75MR8 Q92926 Q9BUH1Alternative splicing : 2 isoforms : Q6STE5-1 Q6STE5-2 Explore the universe of human proteins at neXtProt for SMARCD3: NX_Q6STE5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6STE5 SMARCD3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001003801.1 NP_001003802.1 NP_003069.2 ENSEMBL proteins: ENSP00000262188 ENSP00000376558 ENSP00000417908 ENSP00000417145 ENSP00000419886 ENSP00000349254 Reactome Protein details: Q6STE5 Human Recombinant Protein Products: Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7 ): About this table
SMARCD3 for ontologies About GeneDecksing SMARCD3 Antibody Products: Assay Products for SMARCD3:
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Protein
Domains / Familiesfor SMARCD3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SMARCD3 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6STE5 ProtoNet protein and cluster: Q6STE5
1 Blocks protein family : IPB003121 SWIB complex UniProtKB/Swiss-Prot: SMRD3_HUMAN, Q6STE5 Similarity : Belongs to the SMARCD familySimilarity : Contains 1 SWIB domain
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Functionfor SMARCD3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SMRD3_HUMAN, Q6STE5 Function : Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclearreceptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)
Genatlas biochemistry entry for SMARCD3 : general transcriptional activator S cerevisiae SWI/SNF related protein,matrix associated,actin-dependent regulator of chromatin,subfamily D,member 3,component of the chromatin remodeling complex,preferentially expressed in muscle and pancreas Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SMARCD3 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SMARCD3 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): SMARCD3 (NM_001003801 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMARCD3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMARCD3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCD3
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
SMARCD3 for ontologies About GeneDecksing
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Pathways & Interactionsfor SMARCD3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Development_Ligand-dependent activation of the ESR1/AP-1 pathway 2 Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 3 Metabolism 4 AMPK Enzyme Complex Pathway 5 LKB1 signaling events
Pathway sources See GeneCards unified pathways Show all pathways 2 EMD Millipore Pathways for SMARCD3 3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SMARCD3 2 GeneGo (Thomson Reuters) Pathways for SMARCD3 1 BioSystems Pathway for SMARCD3 4
Reactome Pathways for SMARCD3
SMARCD3 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMARCD3 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/143 Interacting proteins for SMARCD3 (Q6STE5 1 , 3 ENSP00000262188 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 143 )About this table Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14 ): About this table
SMARCD3 for ontologies About GeneDecksing
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Drugs & Compoundsfor SMARCD3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SMARCD3 Search CenterWatch for drugs/clinical trials and news about SMARCD3 / SMRD3
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Transcriptsfor SMARCD3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SMARCD3 gene (3 alternative transcripts): NM_001003801.1 NM_001003802.1 NM_003078.3 Unigene Cluster for SMARCD3:
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Hs.647067 [show with all ESTs ] Unigene Representative Sequence: BX648385 15 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000496530 ENST00000262188 (uc003wjs.3 ) ENST00000392811 (uc003wju.3 )ENST00000469154 (uc011kvh.1 ) ENST00000472789 ENST00000470588 ENST00000485592 ENST00000472988 ENST00000485610 (uc010lqa.1 ) ENST00000472103 ENST00000489503 ENST00000477169 ENST00000460431 ENST00000491651 ENST00000356800 (uc003wjt.3 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SMARCD3 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SMARCD3 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): SMARCD3 (NM_001003801 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMARCD3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMARCD3
Additional cDNA sequence: AK127595.1 AK297876.1 AK309500.1 AK316173.1 AY450430.1 AY450431.1 BC002628.2 BC110350.1 BX648385.1 U66619.1
14 DOTS entries : DT.100823978 DT.97806919
DT.95162257 DT.95162264 DT.100040559 DT.92444404 DT.100032588 DT.97835958 DT.100823987 DT.100831629 DT.92444405 DT.100735825 DT.100761446 DT.100823983 24/226 AceView cDNA sequences (see all 226 ):
CR620870 AI377853 F30206 BM552001 AL537989 AY450430 AA077344 BM783536 BU521158 NM_001003801 AA291613 BQ670467 CR602391 CB045063 Z38748 BG825152 AK127595 AA402202 BM755770 BF435073 BM547645 CD671355 AW050894 BM979567 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SMARCD3 (see all 9 ) About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 SP1 :     -     -   -           -         -       -           SP2 :         -   -           -         -       -           SP3 :           -           -         -       -           SP4 :         -   -   -   -               -       -           SP5 :                             -                
ECgene alternative splicing isoforms for SMARCD3
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Expression for SMARCD3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SMARCD3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTAAGCTTCT
About this image SMARCD3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Limb Limb Bud Limb Bud Mesenchyme Cells Mesoderm Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category Primitive streak-like cells (Generation of endode... )
See SMARCD3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SMARCD3 SOURCE GeneReport for Unigene cluster: Hs.647067 UniProtKB/Swiss-Prot: SMRD3_HUMAN, Q6STE5 Tissue specificity : Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland,spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue SABiosciences Expression via Pathway-Focused PCR Arrays including SMARCD3 : Polycomb & Trithorax Complexes in human mouse rat Epigenetic Chromatin Remodeling Factors in human mouse rat PPAR Targets in human mouse rat
Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SMARCD3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SMARCD3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SMARCD3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SMARCD3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCD3
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Orthologsfor SMARCD3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for SMARCD3 gene from 6/25 species (see all 25 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
SMARCD31
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 less
78.12(n) 89.93(a)
 
430336 XM_427895.3 XP_427895.3
zebrafish (Danio rerio)
Actinopterygii
smarcd3b1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b less
78.01(n) 89.5(a)
 
562140 NM_001127306.1 NP_001120778.1
fruit fly (Drosophila melanogaster)
Insecta
Bap601 , 3
general RNA polymerase II transcription factor less 3 Brahma associated protein 60kD1
70(a) 3 66.74(n) 1 65.65(a) 1
 
11E13 32268 1 NM_078588.3 1 NP_511143.2 1
worm (Caenorhabditis elegans)
Secernentea
ZK1128.53 swsn-2.11
D15Kz1 protein homolog3 Protein SWSN-2.11
51(a) (best of 2)3 54.67(n) 1 56.31(a) 1
 
III(10192443-10194381)3 176426 1 NM_066849.3 1 NP_499250.1 1
thale cress (Arabidopsis thaliana)
eudicotyledons
AT3G018906 CHC16
SWI/SNF complex component SNF12-like protein
31(a) 26(a)
many ↔ manymany ↔ many
3(310015-311976) 5(4568509-4570947)
rice (Oryza sativa)
Liliopsida
--
SWIB/MDM2 domain containing protein, expressed
32(a)
1 → many
4(18563504-18566100)
ENSEMBL Gene Tree for SMARCD3 (if available)TreeFam Gene Tree for SMARCD3 (if available)
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Paralogsfor SMARCD3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SMARCD3 gene SMARCD2 2 SMARCD1 2 2 SIMAP similar genes for SMARCD3 using alignment to 4 protein entries: SMRD3_HUMAN (see all proteins ):SMARCD1 SMARCD2
SMARCD3 for paralogs About GeneDecksing
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Genomic Variantsfor SMARCD3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
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Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SMARCD3 (150935850 - 150974982 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SMARCD3: --
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor SMARCD3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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SMARCD3 for disorders About GeneDecksing
OMIM gene information: 601737
OMIM disorders : --8 diseases for SMARCD3 : About MalaCards triple-a syndrome fanconi's anemia anemia breast carcinoma thyroiditis carcinoma prostatitis neuronitis Export disorders for SMARCD3 gene to outside databases
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Publicationsfor SMARCD3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SMARCD3 gene, integrated from 9 sources (see all 24 ): (articles sorted by number of sources associating them with SMARCD3) Utopia : connect your pdf to the dynamic world of online information
Diversity and specialization of mammalian SWI/SNF complexes. (PubMed id 8804307) 1 , 2 , 3 Wang W.... Crabtree G.R. (1996) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. (PubMed id 14701856) 1 , 2 Debril M.-B....Auwerx J. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence of human chromosome 7. (PubMed id 12853948) 1 , 2 Hillier L.W.... Wilson R.K. (2003) Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. (PubMed id 9693044) 1 , 3 Ring H.Z....Francke U. (1998) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Signal-dependent incorporation of MyoD-BAF60c into Brg 1-based SWI/SNF chromatin-remodelling complex. (PubMed id 22068056) 1 Forcales S.V....Puri P.L. (2012) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011)
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External Searches for SMARCD3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SMARCD3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing SMARCD3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SMARCD3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SMARCD3 gene: Search GeneIP for patents involving SMARCD3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SMARCD3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SMARCD3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SMARCD3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SMARCD3 OriGene Protein Over-expression Lysate for SMARCD3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SMARCD3 OriGene 3'-UTR Clone for SMARCD3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SMARCD3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SMARCD3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SMARCD3 OriGene Custom Protein Services for SMARCD3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMARCD3 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMARCD3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SMARCD3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SMARCD3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SMARCD3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SMARCD3
Search Tocris compounds for SMARCD3
SMARCD3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCD3
Search ThermoFisher Antibodies for SMARCD3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMARCD3
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