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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SMARCD2 Gene

protein-coding GIFtS: 61
GCID: GC17M061909

SWI/SNF related, matrix associated, actin dependent regulator...

Explore 6 diseases affiliated with
SMARCD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 2¹ ²		PRO2451¹
BAF60B¹ ² ³ ⁵		Chromatin Remodeling Complex BAF60B Subunit²
CRACD2¹ ²		Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60B²
Rsc6p¹ ²		SWI/SNF Complex 60 KDa Subunit B²
60 KDa BRG-1/Brm-Associated Factor Subunit B² ³		SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily D Member 2²
BRG1-Associated Factor 60B² ³		Swp73-Like Protein²

External Ids:	HGNC: 11107¹	Entrez Gene: 6603²	Ensembl: ENSG00000108604⁷	OMIM: 601736⁵	UniProtKB: Q92925³

Export aliases for SMARCD2 gene to outside databases

Previous GC identifers: GC17M061559 GC17M064335 GC17M062250 GC17M062382 GC17M059263 GC17M057277

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SMARCD2:

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and

ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure

around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and

has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different

isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SMRD2_HUMAN, Q92925

Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of

DNA-nucleosome topology)

Gene Wiki entry for SMARCD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SMARCD2 gene promoter:
Elk-1 RelA AP-4 NF-kappaB Max AREB6 NF-kappaB2 NF-kappaB1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SMARCD2 promoter sequence

Search SABiosciences Chromatin IP Primers for SMARCD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMARCD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23-q24 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23-q24

SMARCD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMARCD2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M061909: view genomic region (about GC identifiers)

Start:	61,909,441 bp from pter	End:	61,920,425 bp from pter
Size:	10,985 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SMRD2_HUMAN, Q92925 (See protein sequence)

Recommended Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

Size: 531 amino acids; 58921 Da

Subunit: Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2,

SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one

or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. May

interact with SMARCA4, the catalytic subunit of the SWI/SNF related nucleosome-remodeling complexes BRG1(I) and

BRG1(II). The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF

nucleosome-remodeling complexes is not fully known. Interacts with UNKL

Subcellular location: Nucleus

Sequence caution: Sequence=AAC50696.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAF20280.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: A5PLL5 A6NNQ7 B4DV56 B4E1R6 Q7L2I6 Q9UHZ1

Alternative splicing: 3 isoforms: Q92925-1 Q92925-2 Q92925-3 (Produced by aberrant splicing sites)

Explore the universe of human proteins at neXtProt for SMARCD2: NX_Q92925

Post-translational modifications:

Ubiquitinated through a signaling process involving RAC1 and the RING finger protein UNKL¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92925

SMARCD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001091896.1

ENSEMBL proteins:

ENSP00000392617 ENSP00000318451 ENSP00000225742 ENSP00000398946 ENSP00000464503

ENSP00000463793 ENSP00000462761

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	Uscn Proteins for SMARCD2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016514	SWI/SNF complex	IDA	8804307

SMARCD2 for ontologies About GeneDecksing

SMARCD2 Antibody Products:

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	Uscn ELISAs and CLIAs for SMARCD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SMARCD2 for domains About GeneDecksing

1 InterPro domain/family:

IPR003121 SWIB_MDM2_domain

Graphical View of Domain Structure for InterPro Entry Q92925

ProtoNet protein and cluster: Q92925

1 Blocks protein family: IPB003121 SWIB complex

UniProtKB/Swiss-Prot: SMRD2_HUMAN, Q92925

Similarity: Belongs to the SMARCD family

Similarity: Contains 1 SWIB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SMRD2_HUMAN, Q92925

Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of

DNA-nucleosome topology)

Genatlas biochemistry entry for SMARCD2:

general transcriptional activator S cerevisiae SWI/SNF related protein,matrix associated,actin-dependent regulator of

chromatin,subfamily D,member 2,component of the chromatin remodeling complex,preferentially expressed in muscle and

pancreas

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	NAS	8804307

SMARCD2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SMARCD2:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SMARCD2

miRNA Products:		miRTarBase miRNAs that target SMARCD2: hsa-mir-125b (MIRT004999)

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		hsa-miR-3607-3p hsa-miR-301a hsa-miR-30d hsa-miR-650 hsa-miR-9 hsa-miR-30a hsa-miR-3612 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: SMARCD2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCD2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_Ligand-dependent activation of the ESR1/AP-1 pathway

Development_Ligand-dependent activation of the ESR1/AP-1 pathway	1.00	Transcription Ligand-dependent activation of the ESR1/SP pathway	0.37
Development Ligand-dependent activation of the ESR1/AP-1 pathway	1.00	Chromatin Remodeling	0.30
Transcription_Ligand-dependent activation of the ESR1/SP pathway	0.37

BRCA1 Pathway

BRCA1 Pathway

1.00

AMPK Enzyme Complex Pathway

AMPK Enzyme Complex Pathway

1.00

PEDF Induced Signaling

Glucocorticoid Receptor Signaling

0.27

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for SMARCD2

	Development Ligand-dependent activation of the ESR1/AP-1 pathway
	Transcription Ligand-dependent activation of the ESR1/SP pathway

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SMARCD2

	AMPK Enzyme Complex Pathway
	BRCA1 Pathway
	Glucocorticoid Receptor Signaling
	Chromatin Remodeling

2 GeneGo (Thomson Reuters) Pathways for SMARCD2

	Transcription Ligand-dependent activation of the ESR1/SP pathway
	Development Ligand-dependent activation of the ESR1/AP-1 pathway

SMARCD2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SMARCD2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/36 Interacting proteins for SMARCD2 (Q92925^{2, 3} ENSP00000392617⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RELB	Q01201²^,³	MINT-49013 I2D: score=2
SMARCA4	P51532³, ENSP00000350720⁴	I2D: score=4 STRING: ENSP00000350720
XRN1	Q8IZH2³, ENSP00000264951⁴	I2D: score=4 STRING: ENSP00000264951
UNKL	Q9H9P5³, ENSP00000384850⁴	I2D: score=2 STRING: ENSP00000384850
BRCA1	P38398³, ENSP00000350283⁴	I2D: score=1 STRING: ENSP00000350283

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006337	nucleosome disassembly	IDA	8895581
GO:0006338	chromatin remodeling	IDA	11726552
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	NAS	8804307

SMARCD2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SMARCD2
Search CenterWatch for drugs/clinical trials and news about SMARCD2 / SMRD2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SMARCD2 gene (2 alternative transcripts):

NM_001098426.1 NM_003077.3

Unigene Cluster for SMARCD2:

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2

Hs.250581 [show with all ESTs]

Unigene Representative Sequence: NM_001098426

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000448276(uc010wpt.1 uc010dea.1 uc010deb.1) ENST00000323347

ENST00000225742 ENST00000450364 ENST00000584483 ENST00000584400 ENST00000578234

ENST00000581832 ENST00000580054 ENST00000577686 ENST00000577990

miRNA Products:		OriGene 3'-UTR Clone: SMARCD2 Browse OriGene MicroRNA Expression Plasmids
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		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SMARCD2 (see all 35):
		hsa-miR-3607-3p hsa-miR-301a hsa-miR-30d hsa-miR-650 hsa-miR-9 hsa-miR-30a hsa-miR-3612 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: SMARCD2 3' UTR sequence

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Additional cDNA sequence:

AF113019.1 AK025917.1 AK300939.1 AK303951.1 AK307944.1 BC018953.2 BC136322.1 BC142963.1

U66618.1

18 DOTS entries:

DT.100812531 DT.100048389 DT.100812532 DT.99955808 DT.414952 DT.121007119 DT.100812535 DT.100674436

DT.95191243 DT.121007439 DT.95313017 DT.121007306 DT.100059364 DT.121007381 DT.121007589 DT.95313011

DT.102845023 DT.91868540

7 AceView cDNA sequences:

BC018953 CR612124 CR593297 AF113019 NM_003077 AK025917 U66618

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SMARCD2 (see all 11) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14
SP1:																									-										-
SP2:																																			-
SP3:					-		-				-						-								-										-
SP4:					-						-						-								-
SP5:											-						-								-										-

ECgene alternative splicing isoforms for SMARCD2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SMARCD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAGGCCAG

About this image

SMARCD2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Limb

Limb Bud

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SMARCD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMARCD2

SOURCE GeneReport for Unigene cluster: Hs.250581

UniProtKB/Swiss-Prot: SMRD2_HUMAN, Q92925

Tissue specificity: Isoform 2 is expressed in the pancreas

SABiosciences Custom PCR Arrays for SMARCD2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMARCD2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCD2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMARCD2 gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SMARCD2¹	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 less	78.91(n) 88.32(a)		428275 XM_425835.3 XP_425835.3
lizard (Anolis carolinensis)	Reptilia	SMARCD2⁶	--	89(a)	1 ↔ 1	6(71614275-71628254)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.1281²	Transcribed sequence with moderate similarity to protein refNP_114084.1 (M.musculus) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 [Mus musculus] less	79.03(n)		141998452
zebrafish (Danio rerio)	Actinopterygii	smarcd2¹	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 less	71.74(n) 78.19(a)		564317 XM_687657.5 XP_692749.2
fruit fly (Drosophila melanogaster)	Insecta	Bap60³	general RNA polymerase II transcription factor less	67(a)		11E1 --
worm (Caenorhabditis elegans)	Secernentea	ZK1128.5³	D15Kz1 protein homolog	49(a) (best of 2)		III(10192443-10194381) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G01890⁶ CHC1⁶	SWI/SNF complex component SNF12-like protein	31(a) 26(a)	many ↔ many many ↔ many	3(310015-311976) 5(4568509-4570947)
rice (Oryza sativa)	Liliopsida	--	SWIB/MDM2 domain containing protein, expressed	32(a)	1 → many	4(18563504-18566100)

ENSEMBL Gene Tree for SMARCD2 (if available)
TreeFam Gene Tree for SMARCD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SMARCD2 gene

SMARCD3² SMARCD1²

2 SIMAP similar genes for SMARCD2 using alignment to 7 protein entries: SMRD2_HUMAN (see all proteins):

SMARCD3 SMARCD1

SMARCD2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186163088^1,2		--	61909959(+)	`ACCCTC/TGCCCC`	1	--	ut3¹		0	--	--	--	--
rs79978746^1,2	F	--	61909967(+)	`CCCAGG/CGGGAG`	1	--	ut3¹		1		WA	118
rs2584622^1,2	C,F,H	--	61910167(-)	`TTAGTT/CTTATA`	1	--	ut3¹ ese³		31		NA NS EA WA CSA	2585
rs138256675^1,2		--	61910206(+)	`ACTCCC/TCACCC`	1	--	ut3¹		0	--	--	--	--
rs142746247^1,2		--	61910226(+)	`TGTCTA/GCGGCC`	1	--	ut3¹		0	--	--	--	--
rs144299027^1,2		--	61910227(+)	`GTCTGC/TGGCCC`	1	--	ut3¹		0	--	--	--	--
rs74421455^1,2	C,F	--	61910287(+)	`AAAGAT/CCCCTG`	1	--	ut3¹		1		WA	118
rs191015799^1,2		--	61910308(+)	`TCAGGC/TGAATT`	2	H R	mis¹		0	--	--	--	--
rs79899871^1,2	F	--	61910342(+)	`CCTTCG/ACTGCT`	2	/R /*	stg¹		1		NA	4
rs181910740^1,2	C	--	61910349(+)	`TGCTGC/TACCTG`	2	V	syn¹		1		EU	497

HapMap Linkage Disequilibrium report for SMARCD2 (61909441 - 61920425 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SMARCD2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SMARCD2 for disorders           About GeneDecksing

OMIM gene information: 601736    OMIM disorders: --

6 diseases for SMARCD2:    About MalaCards

triple-a syndrome fanconi's anemia anemia breast cancer

thyroiditis leukemia

1 disease from the University of Copenhagen DISEASES database for SMARCD2:

triple-A syndrome

Export disorders for SMARCD2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SMARCD2 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with SMARCD2)

Utopia: connect your pdf to the dynamic
world of online information

Diversity and specialization of mammalian SWI/SNF complexes. (PubMed id 8804307)^{1, 2, 3} Wang W.... Crabtree G.R. (1996)
The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. (PubMed id 20148946)^{1, 2} LorA"s P....Gacon G. (2010)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. (PubMed id 9693044)^{1, 3} Ring H.Z....Francke U. (1998)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6603	HGNC: 11107	AceView: SMARCD2	Ensembl:ENSG00000108604	euGenes: HUgn6603
ECgene: SMARCD2	H-InvDB: SMARCD2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SMARCD2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SMARCD2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SMARCD2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SMARCD2 gene:
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GeneCards and IP:
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