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Aliases for SMARCD2 Gene

Aliases for SMARCD2 Gene

  • SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 2 2 3 5
  • Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60B 2 3
  • 60 KDa BRG-1/Brm-Associated Factor Subunit B 3 4
  • Chromatin Remodeling Complex BAF60B Subunit 2 3
  • SWI/SNF Complex 60 KDa Subunit B 2 3
  • BRG1-Associated Factor 60B 3 4
  • Swp73-Like Protein 2 3
  • BAF60B 3 4
  • PRO2451 3
  • CRACD2 3
  • Rsc6p 3

External Ids for SMARCD2 Gene

Previous GeneCards Identifiers for SMARCD2 Gene

  • GC17M061559
  • GC17M064335
  • GC17M062250
  • GC17M062382
  • GC17M059263
  • GC17M061909
  • GC17M057277

Summaries for SMARCD2 Gene

Entrez Gene Summary for SMARCD2 Gene

  • The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SMARCD2 Gene

SMARCD2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 2) is a Protein Coding gene. Among its related pathways are Prostate Cancer and BRCA1 Pathway. GO annotations related to this gene include transcription coactivator activity and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is SMARCD1.

UniProtKB/Swiss-Prot for SMARCD2 Gene

  • Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).

Gene Wiki entry for SMARCD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMARCD2 Gene

Genomics for SMARCD2 Gene

Regulatory Elements for SMARCD2 Gene

Enhancers for SMARCD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SMARCD2 on UCSC Golden Path with GeneCards custom track

Promoters for SMARCD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SMARCD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SMARCD2 Gene

Chromosome:
17
Start:
63,832,081 bp from pter
End:
63,843,065 bp from pter
Size:
10,985 bases
Orientation:
Minus strand

Genomic View for SMARCD2 Gene

Genes around SMARCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMARCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMARCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMARCD2 Gene

Proteins for SMARCD2 Gene

  • Protein details for SMARCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92925-SMRD2_HUMAN
    Recommended name:
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
    Protein Accession:
    Q92925
    Secondary Accessions:
    • A5PLL5
    • A6NNQ7
    • B4DV56
    • B4E1R6
    • Q7L2I6
    • Q9UHZ1

    Protein attributes for SMARCD2 Gene

    Size:
    531 amino acids
    Molecular mass:
    58921 Da
    Quaternary structure:
    • Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. May interact with SMARCA4, the catalytic subunit of the SWI/SNF related nucleosome-remodeling complexes BRG1(I) and BRG1(II). The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF nucleosome-remodeling complexes is not fully known. Interacts with UNKL.
    SequenceCaution:
    • Sequence=AAC50696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF20280.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SMARCD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMARCD2 Gene

Proteomics data for SMARCD2 Gene at MOPED

Post-translational modifications for SMARCD2 Gene

  • Ubiquitinated through a signaling process involving RAC1 and the RING finger protein UNKL.
  • Ubiquitination at Lys 168, Lys 226, Lys 262, Lys 289, Lys 451, Lys 480, and Lys 514
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SMARCD2 Gene

Domains & Families for SMARCD2 Gene

Protein Domains for SMARCD2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SMARCD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92925

UniProtKB/Swiss-Prot:

SMRD2_HUMAN :
  • Contains 1 SWIB domain.
  • Belongs to the SMARCD family.
Domain:
  • Contains 1 SWIB domain.
Family:
  • Belongs to the SMARCD family.
genes like me logo Genes that share domains with SMARCD2: view

No data available for Gene Families for SMARCD2 Gene

Function for SMARCD2 Gene

Molecular function for SMARCD2 Gene

GENATLAS Biochemistry:
general transcriptional activator S cerevisiae SWI/SNF related protein,matrix associated,actin-dependent regulator of chromatin,subfamily D,member 2,component of the chromatin remodeling complex,preferentially expressed in muscle and pancreas
UniProtKB/Swiss-Prot Function:
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).

Gene Ontology (GO) - Molecular Function for SMARCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031492 contributes_to nucleosomal DNA binding IDA 16217013
genes like me logo Genes that share ontologies with SMARCD2: view
genes like me logo Genes that share phenotypes with SMARCD2: view

Animal Models for SMARCD2 Gene

MGI Knock Outs for SMARCD2:

Animal Model Products

CRISPR Products

miRNA for SMARCD2 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SMARCD2 Gene

Localization for SMARCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMARCD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMARCD2 Gene COMPARTMENTS Subcellular localization image for SMARCD2 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SMARCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA 16217013
genes like me logo Genes that share ontologies with SMARCD2: view

Pathways & Interactions for SMARCD2 Gene

genes like me logo Genes that share pathways with SMARCD2: view

Gene Ontology (GO) - Biological Process for SMARCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043044 ATP-dependent chromatin remodeling IEA,IDA 16217013
genes like me logo Genes that share ontologies with SMARCD2: view

No data available for SIGNOR curated interactions for SMARCD2 Gene

Drugs & Compounds for SMARCD2 Gene

No Compound Related Data Available

Transcripts for SMARCD2 Gene

mRNA/cDNA for SMARCD2 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMARCD2 Gene

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMARCD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - -
SP2: -
SP3: - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: -
SP10: - - -
SP11:

Relevant External Links for SMARCD2 Gene

GeneLoc Exon Structure for
SMARCD2
ECgene alternative splicing isoforms for
SMARCD2

Expression for SMARCD2 Gene

mRNA expression in normal human tissues for SMARCD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SMARCD2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (37.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMARCD2 Gene



SOURCE GeneReport for Unigene cluster for SMARCD2 Gene Hs.250581

mRNA Expression by UniProt/SwissProt for SMARCD2 Gene

Q92925-SMRD2_HUMAN
Tissue specificity: Isoform 2 is expressed in the pancreas.
genes like me logo Genes that share expression patterns with SMARCD2: view

Protein tissue co-expression partners for SMARCD2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SMARCD2 Gene

Orthologs for SMARCD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SMARCD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SMARCD2 35
  • 93.35 (n)
  • 99.25 (a)
SMARCD2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMARCD2 35
  • 93.85 (n)
  • 99.25 (a)
SMARCD2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smarcd2 35
  • 90.96 (n)
  • 98.12 (a)
Smarcd2 16
Smarcd2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SMARCD2 35
  • 99.69 (n)
  • 99.81 (a)
SMARCD2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smarcd2 35
  • 91.4 (n)
  • 97.93 (a)
oppossum
(Monodelphis domestica)
Mammalia SMARCD2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves SMARCD2 35
  • 80.95 (n)
  • 90.85 (a)
SMARCD2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMARCD2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia smarcd2 35
  • 75.15 (n)
  • 83.19 (a)
Str.1281 35
zebrafish
(Danio rerio)
Actinopterygii smarcd2 35
  • 73.73 (n)
  • 81.24 (a)
smarcd2 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Bap60 37
  • 67 (a)
Bap60 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18E3.2 37
  • 47 (a)
ZK1128.5 37
  • 49 (a)
ham-3 36
  • 51 (a)
ManyToMany
swsn-2.2 36
  • 48 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSC6 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
Species with no ortholog for SMARCD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMARCD2 Gene

ENSEMBL:
Gene Tree for SMARCD2 (if available)
TreeFam:
Gene Tree for SMARCD2 (if available)

Paralogs for SMARCD2 Gene

Paralogs for SMARCD2 Gene

(2) SIMAP similar genes for SMARCD2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SMARCD2: view

Variants for SMARCD2 Gene

Sequence variations from dbSNP and Humsavar for SMARCD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1130100 -- 63,834,719(-) CTGAC(A/G)ATCAC reference, missense
rs1130101 -- 63,834,718(-) TGACA(A/G)TCACC reference, missense
rs1130102 -- 63,834,572(-) AGTGG(C/T)ACCGG reference, missense
rs1130103 -- 63,834,570(-) TGGCA(C/T)CGGAT reference, synonymous-codon
rs1130104 -- 63,834,569(-) GGCAC(C/T)GGATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SMARCD2 Gene

Variant ID Type Subtype PubMed ID
nsv833510 CNV Loss 17160897
nsv510720 CNV Loss 20534489
nsv517272 CNV Gain+Loss 19592680

Variation tolerance for SMARCD2 Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SMARCD2 Gene

Disorders for SMARCD2 Gene

Relevant External Links for SMARCD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SMARCD2

No disorders were found for SMARCD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMARCD2 Gene

Publications for SMARCD2 Gene

  1. Diversity and specialization of mammalian SWI/SNF complexes. (PMID: 8804307) Wang W. … Crabtree G.R. (Genes Dev. 1996) 2 3 4 67
  2. Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. (PMID: 9693044) Ring H.Z. … Francke U. (Genomics 1998) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SMARCD2 Gene

Sources for SMARCD2 Gene

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