SMARCD1 Gene
protein-coding GIFtS: 59
GCID: GC12P050478
|
|
SWI/SNF related, matrix associated, actin dependent regulator...
| |
Aliases
for SMARCD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin,Subfamily D, Member 11 2 | | Chromatin Remodeling Complex BAF60A Subunit2 | | BAF60A1 2 3 5 | | Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60A2 | | CRACD11 2 | | SWI/SNF Complex 60 KDa Subunit A2 | | Rsc6p1 2 | | SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of ChromatinSubfamily D Member 12 | | 60 KDa BRG-1/Brm-Associated Factor Subunit A2 3 | | Swp73-Like Protein2 | | BRG1-Associated Factor 60A2 3 | | SWI/SNF Complex 60 KDa Subunit3 |
Export aliases for SMARCD1 gene to outside databasesPrevious GC identifers: GC12P050773 GC12P050535 GC12P050195 GC12P048766 GC12P048767 GC12P048768 GC12P047511 |
Summaries
for SMARCD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SMARCD1:
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase andATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structurearound those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI andhas sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have beenfound for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SMRD1_HUMAN, Q96GM5Function: Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development aswitch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycleand become committed to their adult state. The transition from proliferating neural stem/progenitor cells topost-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitorsexit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, areexchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specificcomplexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neuralstem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendritegrowth (By similarity). Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancerVitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and thevitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via itsassociation with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which isrequired for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene
Gene Wiki entry for SMARCD1
|
Genomic Views
for SMARCD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SMARCD1 gene promoter:
E2F-4 E2F-3a STAT1 E2F-5 E2F-2 YY1 E2F-1 E2F HSF2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for SMARCD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMARCD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13-q14 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13-q14SMARCD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P050478: view genomic region
(about GC identifiers)
Start:
|
50,478,755 bp from pter |
End:
|
50,494,495 bp from pter |
Size:
|
15,741 bases |
Orientation:
|
plus strand |
|
Proteins
for SMARCD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMRD1_HUMAN, Q96GM5 (See
protein sequence)Recommended Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Size: 515 amino acids; 58233 Da
Subunit: Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2,SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1,and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also containsDPF3. Specifically interacts with the VDR heterodimer complex. Component of the WINAC complex, at least composed ofSMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B.Interacts with ESR1, NR3C1, NR1H4, PGR, SMARCA4, SMARCC1 and SMARCC2. Component of neural progenitors-specificchromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A,SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57,SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAFcomplex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B,SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C,ACTL6B/BAF53B and actin (By similarity)
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC50695.1; Type=Frameshift; Positions=30; Sequence=AAD23390.1; Type=Erroneous initiation;Sequence=AAH09368.3; Type=Erroneous initiation;
Secondary accessions: A6NN27 Q92924 Q9Y635Alternative splicing: 2 isoforms: Q96GM5-1 Q96GM5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SMARCD1: NX_Q96GM5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96GM5
SMARCD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_003067.3 NP_620710.2
ENSEMBL proteins: ENSP00000378414 ENSP00000370924 ENSP00000447386 ENSP00000448030 ENSP00000449825 ENSP00000448627 ENSP00000447909
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SMARCD1 for ontologies About GeneDecksing
SMARCD1 Antibody Products:
Assay Products for SMARCD1: |
Protein
Domains /
Families
for SMARCD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SMARCD1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96GM5ProtoNet protein and cluster: Q96GM5 1 Blocks protein family: IPB003121 SWIB complex
UniProtKB/Swiss-Prot: SMRD1_HUMAN, Q96GM5Similarity: Belongs to the SMARCD familySimilarity: Contains 1 SWIB domain |
Function
for SMARCD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SMRD1_HUMAN, Q96GM5Function: Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development aswitch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycleand become committed to their adult state. The transition from proliferating neural stem/progenitor cells topost-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitorsexit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, areexchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specificcomplexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neuralstem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendritegrowth (By similarity). Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancerVitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and thevitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via itsassociation with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which isrequired for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene Genatlas biochemistry entry for SMARCD1:general transcriptional activator S cerevisiae SWI/SNF related protein,matrix associated,actin-dependent regulator ofchromatin,subfamily D,member 1,component of the chromatin remodeling complex,ubiquitously expressed
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMARCD1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMARCD1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SMARCD1 (NM_003076) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMARCD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMARCD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCD1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SMARCD1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SMARCD1:
|
Pathways & Interactions
for SMARCD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_Ligand-dependent activation of the ESR1/AP-1 pathway | | | 2 | BRCA1 Pathway | | | 3 | AMPK Enzyme Complex Pathway | | | 4 | Glucocorticoid receptor regulatory network | | | 5 | PEDF Induced Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for SMARCD1
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SMARCD1
2  GeneGo (Thomson Reuters) Pathways for SMARCD1
1  BioSystems Pathway for SMARCD1
SMARCD1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SMARCD1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/863 Interacting proteins for SMARCD1 (Q96GM51, 2, 3 ENSP000003784144) via UniProtKB, MINT, STRING, and/or I2D (see all 863)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SMARCB1 | Q128242, 3, ENSP000002631214 | MINT-7945693 MINT-7947479 I2D:
score=7 STRING: ENSP00000263121 | | ARID1A | O144972, 3, ENSP000003204854 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000320485 | | SMARCA4 | P515321, 3, ENSP000003507204 | EBI-1965109,EBI-302489 I2D:
score=9 STRING: ENSP00000350720 | | KRT15 | P190122, 3, ENSP000002540434 | MINT-66111 I2D:
score=5 STRING: ENSP00000254043 | | LDOC1 | O957512, 3, ENSP000003595574 | MINT-67863 I2D:
score=5 STRING: ENSP00000359557 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SMARCD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SMARCD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SMARCD1
Search CenterWatch for drugs/clinical trials and news about SMARCD1 / SMRD1
|
Transcripts
for SMARCD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SMARCD1 gene (2 alternative transcripts): NM_003076.4 NM_139071.2 Unigene Cluster for SMARCD1: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 Hs.79335 [show with all ESTs]Unigene Representative Sequence: NM_00307612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394963(uc001rvx.4 uc001rvy.4 uc009zlp.3) ENST00000381513
ENST00000551966 ENST00000550477 ENST00000547247(uc010smo.1) ENST00000547637
ENST00000551497 ENST00000548573 ENST00000549274 ENST00000550280 ENST00000551352
ENST00000549526
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMARCD1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMARCD1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SMARCD1 (NM_003076) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMARCD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMARCD1 |
Additional cDNA sequence: AF109733.1 AK130517.1 AK292700.1 AK293932.1 BC000063.2 BC009368.2 U66617.1 15 DOTS entries: DT.86855136 DT.100685679 DT.100794327 DT.95310816 DT.100037423 DT.95147184 DT.121127795 DT.121127798 DT.100794328 DT.100794329 DT.100794331 DT.121127794 DT.95310765 DT.99941756 DT.121127817 24/273 AceView cDNA sequences (see all 273): BQ218828 BU509684 BQ949766 BQ957208 BE740488 BX280691 BQ933801 BU931457 BM740007 CF272236 AA580866 BQ225880 AI287806 BC000063 CA397586 BQ010066 BC009368 BQ929257 BU160528 AW237284 BQ061434 CA441703 NM_003076 BQ073233
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SMARCD1 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SMARCD1
|
Expression
for SMARCD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMARCD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCAAACTT
About this image
See SMARCD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMARCD1
SOURCE GeneReport for Unigene cluster: Hs.79335
UniProtKB/Swiss-Prot: SMRD1_HUMAN, Q96GM5Tissue specificity: Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas andplacenta
SABiosciences Custom PCR Arrays for SMARCD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMARCD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMARCD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMARCD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMARCD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCD1 |
Orthologs
for SMARCD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SMARCD1 gene from 9/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Smarcd11 , 5 |
SWI/SNF related, matrix associated, actin dependent more1, 5 |
93.2(n)1
99.42(a)1 |
|
15 (56.13 cM)5
837971 NM_031842.21 NP_114030.21
997022875 |
chicken
(Gallus gallus) |
Aves |
SMARCD11 |
SWI/SNF related, matrix associated, actin dependent more |
82.29(n)
95.9(a) |
|
426882 XM_424488.3 XP_424488.3 |
lizard
(Anolis carolinensis) |
Reptilia |
SMARCD16 |
-- |
98(a) |
1 ↔ 1 |
2(91665244-91675936) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.54922 |
Xenopus laevis, similar to SWI/SNF related, clone IMAGE5542448, more |
80.2(n) |
|
BC045009.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
smarcd12 |
SWI/SNF related, matrix associated, actin dependent more |
77.95(n) |
|
323115 BC049347.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Bap603 |
general RNA polymerase II transcription
factor |
78(a) |
|
11E1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C18E3.23 |
-- |
53(a)
(best of 2) |
|
I(4210999-4212514) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CHC11 |
SWI/SNF complex component SNF12-like protein |
46.84(n)
36.53(a) |
|
831267 NM_121421.3 NP_196921.1 |
rice
(Oryza sativa) |
Liliopsida |
Os04g03821001 |
hypothetical protein |
50.42(n)
39.62(a) |
|
4335638 NM_001059140.1 NP_001052605.1 |
ENSEMBL Gene Tree for SMARCD1 (if available)
TreeFam Gene Tree for SMARCD1 (if available) |
Paralogs
for SMARCD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SMARCD1 gene
- SMARCD32 SMARCD22
2 SIMAP similar genes for SMARCD1 using alignment to 7 protein entries: SMRD1_HUMAN (see all proteins):SMARCD3 SMARCD2
SMARCD1 for paralogs About GeneDecksing
|
Genomic Variants
for SMARCD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SMARCD1 (50478755 - 50494495 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SMARCD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMARCD1 |
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Disorders
/ Diseases
for SMARCD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SMARCD1 for disorders About GeneDecksing
OMIM gene information: 601735
OMIM disorders: --
6  diseases for SMARCD1: About MalaCardstriple-a syndrome fanconi's anemia williams syndrome anemia
leukemia neuronitis
1 disease from the University of Copenhagen DISEASES database for SMARCD1:triple-A syndrome Export disorders for SMARCD1 gene to outside databases
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Publications
for SMARCD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMARCD1 gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with SMARCD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. (PubMed id 12917342)1, 2, 3, 9 Hsiao P.W.... Archer T.K. (2003)
- Diversity and specialization of mammalian SWI/SNF complexes. (PubMed id 8804307)1, 2, 3 Wang W.... Crabtree G.R. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. (PubMed id 9693044)1, 3 Ring H.Z....Francke U. (1998)
- Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. (PubMed id 8895581)1, 2 Wang W....Crabtree G.R. (1996)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex b y blocking CHFR mediated ubiquitination and degradation of its major components. (PubMed id 22285184)1 Jung I....Seong R.H. (2012)
- Double plant homeodomain (PHD) finger proteins DPF3a a nd -3b are required as transcriptional co-activators in SWI/SNF complex-dependen t activation of NF-kB RelA/p50 heterodimer. (PubMed id 22334708)1 Ishizaka A....Iba H. (2012)
|
External Searches for SMARCD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing SMARCD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing SMARCD1 gene
(According to HUGE)
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| -- |
Specialized Databases showing SMARCD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SMARCD1 gene:
Search GeneIP for patents involving SMARCD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SMARCD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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