SMARCC2 Gene
protein-coding GIFtS: 62
GCID: GC12M056555
|
|
SWI/SNF related, matrix associated, actin dependent regulator...
| |
Aliases
for SMARCC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin,Subfamily C, Member 21 2 | | SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of ChromatinSubfamily C Member 22 3 | | BAF1701 2 3 5 | | Chromatin Remodeling Complex BAF170 Subunit2 | | CRACC21 2 | | Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 1702 | | Rsc81 2 | | SWI/SNF Complex Subunit SMARCC22 | | BRG1-Associated Factor 1702 3 | | SWI3-Like Protein2 | | SWI/SNF Complex 170 KDa Subunit2 3 | | |
Export aliases for SMARCC2 gene to outside databasesPrevious GC identifers: GC12M056496 GC12P056713 GC12M056272 GC12M054843 GC12M053594 |
Summaries
for SMARCC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SMARCC2:
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase andATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structurearound those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI andcontains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SMRC2_HUMAN, Q8TAQ2Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration ofDNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May berequired for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved invitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complexrecruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of theCYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and theneuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitorto a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to theiradult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switchin subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate intoneurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternativeACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex isessential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex alongwith CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)
Gene Wiki entry for SMARCC2
|
Genomic Views
for SMARCC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SMARCC2 gene promoter:
c-Fos AP-1 p300 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for SMARCC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMARCC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.2 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.2SMARCC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M056555: view genomic region
(about GC identifiers)
Start:
|
56,555,636 bp from pter |
End:
|
56,583,351 bp from pter |
Size:
|
27,716 bases |
Orientation:
|
minus strand |
|
Proteins
for SMARCC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SMRC2_HUMAN, Q8TAQ2 (See
protein sequence)Recommended Name: SWI/SNF complex subunit SMARCC2 Size: 1214 amino acids; 132879 Da
Subunit: Component of 6 multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I),WINAC and Brg1(II). Each of the five complexes contains a catalytic subunit (either SMARCA4 or SMARCA2), and at leastSMARCE1, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCC1 and SMARCB1. Other subunits specific to each of the complexes mayalso be present. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2,SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and oneor more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Mayalso interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 andSMARCA4. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1,SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with SMARD1. Component of neuralprogenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A orARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47,SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specificchromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A,SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57,SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=BAD92243.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: F8VTJ5 Q59GV3 Q92923 Q96E12 Q96GY4Alternative splicing: 3 isoforms: Q8TAQ2-1 Q8TAQ2-2 Q8TAQ2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SMARCC2: NX_Q8TAQ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TAQ2
SMARCC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001123892.1 NP_003066.2 NP_620706.1
ENSEMBL proteins: ENSP00000377591 ENSP00000449396 ENSP00000302919 ENSP00000447680 ENSP00000267064 ENSP00000449429
Human Recombinant Protein Products for SMARCC2:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
SMARCC2 for ontologies About GeneDecksing
SMARCC2 Antibody Products:
Assay Products for SMARCC2: |
Protein
Domains /
Families
for SMARCC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SMARCC2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q8TAQ2ProtoNet protein and cluster: Q8TAQ2 4 Blocks protein families: IPB000953 Chromo domain IPB001005 Myb DNA-binding domain IPB001357 BRCT domain IPB007526 SWIRM
UniProtKB/Swiss-Prot: SMRC2_HUMAN, Q8TAQ2Similarity: Belongs to the SMARCC familySimilarity: Contains 1 SANT domainSimilarity: Contains 1 SWIRM domain |
Function
for SMARCC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SMRC2_HUMAN, Q8TAQ2Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration ofDNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May berequired for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved invitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complexrecruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of theCYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and theneuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitorto a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to theiradult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switchin subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate intoneurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternativeACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex isessential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex alongwith CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity) Genatlas biochemistry entry for SMARCC2:general transcriptional activator S cerevisiae SWI/SNF related protein,matrix associated,actin-dependent regulator ofchromatin,subfamily C,member 2,component of the chromatin remodeling complex,ubiquitously expressed
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SMARCC2 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for SMARCC2:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMARCC2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMARCC2 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): SMARCC2 (NM_003075) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMARCC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMARCC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCC2 |
|
Pathways & Interactions
for SMARCC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_Ligand-dependent activation of the ESR1/AP-1 pathway | | | 2 | BRCA1 Pathway | | | 3 | AMPK Enzyme Complex Pathway | | | 4 | TNF-alpha/NF-kB Signaling Pathway | | | 5 | Glucocorticoid receptor regulatory network | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for SMARCC2
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SMARCC2
1 
Cell Signaling Technology (CST) Pathway for SMARCC2
2  GeneGo (Thomson Reuters) Pathways for SMARCC2
2  BioSystems Pathways for SMARCC2
SMARCC2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SMARCC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/843 Interacting proteins for SMARCC2 (Q8TAQ22, 3 ENSP000002670644) via UniProtKB, MINT, STRING, and/or I2D (see all 843)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SMARCB1 | Q128242, 3, ENSP000002631214 | MINT-7945693 MINT-6614004 MINT-7947479 I2D:
score=6 STRING: ENSP00000263121 | | ARID1A | O144972, 3, ENSP000003204854 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000320485 | | HDAC1 | Q135472, 3, ENSP000003626494 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000362649 | | HDAC2 | Q927692, 3, ENSP000003813314 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000381331 | | RCOR1 | Q9UKL02, 3, ENSP000002622414 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000262241 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
SMARCC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SMARCC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SMARCC2
Search CenterWatch for drugs/clinical trials and news about SMARCC2 / SMRC2
|
Transcripts
for SMARCC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SMARCC2 gene (3 alternative transcripts): NM_001130420.1 NM_003075.3 NM_139067.2 Unigene Cluster for SMARCC2: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 Hs.236030 [show with all ESTs]Unigene Representative Sequence: NM_00307515 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394023(uc001skd.3 uc001ska.3 uc001skb.3 uc001skc.3 uc010sqf.2)
ENST00000550164 ENST00000347471 ENST00000552674 ENST00000267064 ENST00000549209
ENST00000548130 ENST00000552931 ENST00000552566 ENST00000549757 ENST00000550859
ENST00000550519 ENST00000550150 ENST00000552627 ENST00000547356
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMARCC2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMARCC2 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SMARCC2 (NM_003075) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMARCC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMARCC2 |
Additional cDNA sequence: AB209006.1 AB209293.1 AK025128.1 AK293896.1 AK315153.1 BC009067.1 BC013045.1 BC026222.2 BC128599.1 BT009924.1 U66616.1 24/32 DOTS entries (see all 32): DT.95329800 DT.95147655 DT.100825006 DT.91697062 DT.100825010 DT.121141352 DT.100825009 DT.92449194 DT.100825011 DT.121141059 DT.121141032 DT.92449199 DT.95367585 DT.95367593 DT.121141224 DT.101981170 DT.95367587 DT.92449195 DT.121141399 DT.121141579 DT.97805383 DT.99951373 DT.95367595 DT.97783975 24/512 AceView cDNA sequences (see all 512): CD365740 BM708157 BM888051 BQ023892 BQ917727 AW404379 AA683164 AI342737 BQ677507 AK025128 BQ645836 BU662086 BU686028 BM561395 BM983546 AA838609 BU539423 AW293121 CA848370 BQ433125 BG576320 BM423624 BU186524 BU786265
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SMARCC2 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | |
| ExUns: | 16c | · | 16d | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 | ^ | 30 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP4: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SMARCC2
|
Expression
for SMARCC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMARCC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTTTTATA
About this image
See SMARCC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SMARCC2
SOURCE GeneReport for Unigene cluster: Hs.236030
UniProtKB/Swiss-Prot: SMRC2_HUMAN, Q8TAQ2Tissue specificity: Ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including SMARCC2: | Polycomb & Trithorax Complexes in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMARCC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMARCC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMARCC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMARCC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCC2 |
Orthologs
for SMARCC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SMARCC2 gene from 9/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Smarcc21 , 5 |
SWI/SNF related, matrix associated, actin dependent more1, 5 |
90.53(n)1
96.81(a)1 |
|
10 (76.59 cM)5
680941 NM_001114096.11 NP_001107568.11
1284592365 |
lizard
(Anolis carolinensis) |
Reptilia |
SMARCC26 |
-- |
84(a) |
1 ↔ 1 |
2(93774966-93801442) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BC060337.12 |
-- |
79.72(n) |
|
BC060337.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
smarcc21 |
SWI/SNF related, matrix associated, actin dependent more |
71.35(n)
79.05(a) |
|
567476 XM_690772.3 XP_695864.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mor1 , 3 |
chromatin modeling general RNA polymerase II
transcription more3
moira1 |
48(a)3
54.4(n)1
50.23(a)1 |
|
3 89A113
419421 NM_001202301.11 NP_001189230.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
swsn-11 |
Protein SWSN-1 |
49.6(n)
43.51(a) |
|
180324 NM_075505.3 NP_507906.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SWI3(YJL176C)4
SWI31 |
Subunit of the SWI/SNF chromatin remodeling complex, more4
Swi3p1 |
44.46(n)1
33.21(a)1 |
|
10(94530-92053)4
8532641, 4 NP_012359.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATSWI3B6ATSWI3A6(see all 4) |
SWI/SNF complex subunit SWI3A(see all 4) |
25(a)21(a)(see all 4) |
many ↔ manymany ↔ many(see all 4) |
2(14228972-14231309) 2(19531947-19534401) |
rice
(Oryza sativa) |
Liliopsida |
----(see all 6) |
SWIRM domain containing protein, expressed(see all 6) |
24(a)21(a)(see all 6) |
many ↔ manymany ↔ many(see all 6) |
2(5238179-5242113) 4(23836259-23841065) |
ENSEMBL Gene Tree for SMARCC2 (if available)
TreeFam Gene Tree for SMARCC2 (if available) |
Paralogs
for SMARCC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SMARCC2 gene
- SMARCC12
2 SIMAP similar genes for SMARCC2 using alignment to 3 protein entries: SMRC2_HUMAN (see all proteins):DKFZp313D0632 SMARCC1
SMARCC2 for paralogs About GeneDecksing
|
Genomic Variants
for SMARCC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SMARCC2 (56555636 - 56583351 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SMARCC2
1 CNV: 0164
Human Gene Mutation Database (HGMD): SMARCC2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMARCC2 |
|
Disorders
/ Diseases
for SMARCC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SMARCC2 for disorders About GeneDecksing
OMIM gene information: 601734
OMIM disorders: --
10  diseases for SMARCC2: About MalaCardstriple-a syndrome fanconi's anemia williams syndrome anemia
hematopoiesis lung cancer breast cancer ataxia
leukemia neuronitis
Export disorders for SMARCC2 gene to outside databases
|
Publications
for SMARCC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMARCC2 gene, integrated from 9 sources (see all 103):
(articles sorted by number of sources associating them with SMARCC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Diversity and specialization of mammalian SWI/SNF complexes. (PubMed id 8804307)1, 2, 3 Wang W.... Crabtree G.R. (1996)
- BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. (PubMed id 12917342)1, 2, 9 Hsiao P.W.... Archer T.K. (2003)
- REST repression of neuronal genes requires components of the hSWI.SNF complex. (PubMed id 12192000)1, 2, 9 Battaglioli E.... Mandel G. (2002)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. (PubMed id 11238380)1, 2 Sif S.... Kingston R.E. (2001)
- Functional selectivity of recombinant mammalian SWI/SNF subunits. (PubMed id 11018012)1, 2 Kadam S....Emerson B.M. (2000)
- Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. (PubMed id 10078207)1, 2 Phelan M.L.... Kingston R.E. (1999)
- Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. (PubMed id 9693044)1, 3 Ring H.Z....Francke U. (1998)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for SMARCC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SMARCC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SMARCC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SMARCC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SMARCC2 gene:
Search GeneIP for patents involving SMARCC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SMARCC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SMARCC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMARCC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMARCC2 | | | OriGene Protein Over-expression Lysate for SMARCC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SMARCC2 | | OriGene 3'-UTR Clone for SMARCC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMARCC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMARCC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SMARCC2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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