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SMARCA4 Gene

protein-coding   GIFtS: 70
GCID: GC19P011071

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator...


(Previous symbol: SNF2L4)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of
Chromatin, Subfamily A, Member 41 2
     SNF2-beta2 3
SNF2L41 2 3     BRG1-Associated Factor 190A2 3
ATP-Dependent Helicase SMARCA41 2 3     MRD162 5
Mitotic Growth And Transcription Activator1 2 3     RTPS22 5
BRG12 3 5     BAF1902
Brahma Protein-Like 11 2     SNF22
BRM/SWI2-Related Gene 11 2     SNF2LB2
Global Transcription Activator Homologous Sequence1 2     SWI22
Homeotic Gene Regulator1 2     hSNF2b2
Nuclear Protein GRB11 2     Transcription Activator BRG12
SNF2-Like 41 2     EC 3.6.4.-3
Sucrose Nonfermenting-Like 41 2     SNF2B3
Protein Brahma Homolog 12 3     SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin
Subfamily A Member 43
Protein BRG-12 3     EC 3.6.18
BAF190A2 3     

External Ids:    HGNC: 111001   Entrez Gene: 65972   Ensembl: ENSG000001276167   OMIM: 6032545   UniProtKB: P515323   

Export aliases for SMARCA4 gene to outside databases

Previous GC identifers: GC19P011203 GC19P010916 GC19P010932 GC19P010649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SMARCA4 Gene:
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma
protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate
transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is
part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional
activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as
regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor
predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, May 2012)

GeneCards Summary for SMARCA4 Gene:
SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) is a protein-coding gene. Diseases associated with SMARCA4 include rhabdoid tumor predisposition syndrome 2, and mental retardation, autosomal dominant 16. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is SMARCA2.

UniProtKB/Swiss-Prot: SMCA4_HUMAN, P51532
Function: Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional
activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by
orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In
resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a
phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to
release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a
CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the
NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of
CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the
neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a
stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become
committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic
neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit
mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are
exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific
complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent
neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for
dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing
Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to
SHH-dependent differentiating cues (By similarity). Also involved in vitamin D-coupled transcription regulation
via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR),
which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Acts as a corepressor of
ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition
(EMT) by ZEB1

Gene Wiki entry for SMARCA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMARCA4 gene promoter:
         NF-1   NF-1/L   STAT1   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMARCA4 promoter sequence
   Search Chromatin IP Primers for SMARCA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMARCA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3

SMARCA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMARCA4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P011071:  view genomic region     (about GC identifiers)

Start:
11,071,598 bp from pter      End:
11,176,071 bp from pter
Size:
104,474 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SMCA4_HUMAN, P51532 (See protein sequence)
Recommended Name: Transcription activator BRG1  
Size: 1647 amino acids; 184646 Da
Subunit: Component of the CREST-BRG1 complex, at least composed of SMARCA4/BRG1/BAF190A, SS18L1/CREST, HDAC1, RB1
and SP1 (By similarity). Interacts with NR3C1, PGR, SMARD1, TOPBP1 and ZMIM2/ZIMP7. Component of the BAF complex,
which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53,
ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, IKFZ1, and one or more of
SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. Interacts directly with IKFZ1 in the BAF complex. In muscle
cells, the BAF complex also contains DPF3. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1,
SMARCA4/BRG1/BAF190A, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes.
Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1,
SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with (via the bromodomain) with TERT;
the interaction regulates Wnt-mediated signaling. Component of neural progenitors-specific chromatin remodeling
complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C,
SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170,
PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex)
composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B,
SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C,
ACTL6B/BAF53B and actin. Interacts with PHF10/BAF45A (By similarity). Interacts with MYOG (By similarity).
Interacts with ZEB1 (via N-terminus)
3 PDB 3D structures from and Proteopedia for SMARCA4:
2GRC (3D)        2H60 (3D)        3UVD (3D)    
Secondary accessions: B1A8Z4 B1A8Z5 B1A8Z6 B1A8Z7 E9PBR8 O95052 Q9HBD3
Alternative splicing: 5 isoforms:  P51532-1   P51532-2   P51532-3   P51532-4   P51532-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SMARCA4: NX_P51532

Explore proteomics data for SMARCA4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys399, Lys405, Lys437, Lys471, Lys626, Lys997, Lys1081, Lys1386
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SMARCA4 (P51532) (see all 12)
     RAHRIGQ  TGTPLQN  LHKVLRP  DSDWNPH 


    See SMARCA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001122316.1  NP_001122317.1  NP_001122318.1  NP_001122319.1  NP_001122320.1  NP_001122321.1  NP_003063.2  

    ENSEMBL proteins: 
     ENSP00000343896   ENSP00000395654   ENSP00000445036   ENSP00000464778   ENSP00000392837  
     ENSP00000466963   ENSP00000467200   ENSP00000467796   ENSP00000350720   ENSP00000414727  
     ENSP00000397783  
    Reactome Protein details: P51532

    SMARCA4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SMARCA4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SMARCA4
    GenScript Custom Purified and Recombinant Proteins Services for SMARCA4
    Novus Biologicals SMARCA4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SMARCA4

    SMARCA4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SMARCA4
    R&D Systems Antibodies for SMARCA4 (Brg1)
    Cell Signaling Technology (CST) Antibodies for SMARCA4 
    OriGene Antibodies for SMARCA4
    OriGene Custom Antibody Services for SMARCA4
    Novus Biologicals SMARCA4 Antibodies
    Abcam antibodies for SMARCA4
    Cloud-Clone Corp. Antibodies for SMARCA4
    ThermoFisher Antibodies for SMARCA4
    LSBio Antibodies in human, mouse, rat for SMARCA4

    SMARCA4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SMARCA4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SMARCA4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SMARCA4
    Cloud-Clone Corp. CLIAs for SMARCA4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    Selected InterPro protein domains (see all 10):
     IPR013999 HAS_subgr
     IPR014012 Helicase/SANT-assoc_DNA-bd
     IPR000330 SNF2_N
     IPR014978 Gln-Leu-Gln_QLQ
     IPR006576 BRK_domain

    Graphical View of Domain Structure for InterPro Entry P51532

    ProtoNet protein and cluster: P51532

    4 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB001487 Bromodomain signature
    IPB006562 HSA
    IPB006576 Domain in transcription and CHROMO domain helicase


    UniProtKB/Swiss-Prot: SMCA4_HUMAN, P51532
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 HSA domain
    Similarity: Contains 1 QLQ domain


    SMARCA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMCA4_HUMAN, P51532
    Function: Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional
    activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by
    orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In
    resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a
    phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to
    release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a
    CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the
    NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of
    CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the
    neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a
    stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become
    committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic
    neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit
    mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are
    exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific
    complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent
    neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for
    dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing
    Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to
    SHH-dependent differentiating cues (By similarity). Also involved in vitamin D-coupled transcription regulation
    via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR),
    which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Acts as a corepressor of
    ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition
    (EMT) by ZEB1

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.-1

         Gene Ontology (GO): Selected molecular function terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0001105RNA polymerase II transcription coactivator activity IDA15774904
    GO:0002039p53 binding IPI11950834
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
         
    SMARCA4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SMARCA4:
     Increased cell number in G2M,  

         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Smarca4) (see all 16):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 
     mortality/aging  muscle  nervous system  renal/urinary system  respiratory system 

    SMARCA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Smarca4tm1Mag for SMARCA4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMARCA4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SMARCA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SMARCA4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SMARCA4

    miRNA
    Products:
        
    miRTarBase miRNAs that target SMARCA4:
    hsa-mir-16-5p (MIRT051309), hsa-mir-222-3p (MIRT046781), hsa-mir-98-5p (MIRT027823), hsa-mir-155-5p (MIRT020993), hsa-mir-342-5p (MIRT038217), hsa-let-7b-5p (MIRT032484), hsa-mir-34a-5p (MIRT025405), hsa-mir-615-3p (MIRT039649), hsa-mir-21-5p (MIRT006516)

    Block miRNA regulation of human, mouse, rat SMARCA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMARCA4 (see all 28):
    hsa-miR-3673 hsa-miR-631 hsa-miR-139-5p hsa-miR-1278 hsa-miR-3661 hsa-miR-888* hsa-miR-144 hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSMARCA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SMARCA4
    Predesigned siRNA for gene silencing in human, mouse, rat SMARCA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SMARCA4

    Clone
    Products:
         
    OriGene clones in human, mouse for SMARCA4 (see all 37)
    OriGene ORF clones in mouse, rat for SMARCA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): SMARCA4 (NM_003072)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMARCA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMARCA4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SMARCA4
    Browse ESI BIO Cell Lines and PureStem Progenitors for SMARCA4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SMCA4_HUMAN, P51532: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IDA12065415
    GO:0000792heterochromatin IEA--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA--
    GO:0005719nuclear euchromatin IEA--

    SMARCA4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SMARCA4 About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Transcription Ligand dependent activation of the ESR1 SP pathway
    Transcription Ligand dependent activation of the ESR1 SP pathway0.37
    Development Ligand dependent activation of the ESR1 AP 1 pathway0.37
    2AMPK Enzyme Complex Pathway
    Chromatin Remodeling0.00
    AMPK Enzyme Complex Pathway
    3PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43
    4Prostate Cancer
    Prostate Cancer0.32
    5Cell Cycle / Checkpoint Control
    DNA Damage0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SMARCA4 (see all 6)
        AHR Pathway
    AMPK Enzyme Complex Pathway
    BRCA1 Pathway
    Glucocorticoid Receptor Signaling
    Chromatin Remodeling

    3 Cell Signaling Technology (CST) Pathways for SMARCA4
        Chromatin Regulation / Acetylation
    Translational Control
    DNA Damage

    2 GeneGo (Thomson Reuters) Pathways for SMARCA4
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development Ligand-dependent activation of the ESR1/AP-1 pathway

    Selected BioSystems Pathways for SMARCA4 (see all 7)
        Integrated Breast Cancer Pathway
    TNF-alpha/NF-kB Signaling Pathway
    Prostate Cancer
    Direct p53 effectors
    Glucocorticoid receptor regulatory network

    1 Reactome Pathway for SMARCA4
        formation of the beta-catenin:TCF transactivating complex



    SMARCA4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SMARCA4: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SMARCA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SMARCA4 (P515321, 2, 3 ENSP000003507204) via UniProtKB, MINT, STRING, and/or I2D (see all 636)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-7914854 I2D: score=3 STRING: ENSP00000352980
    HIST1H4CP628052, 3, ENSP000003670344MINT-7914854 I2D: score=3 STRING: ENSP00000367034
    HIST1H4DP628052, 3, ENSP000003432824MINT-7914854 I2D: score=3 STRING: ENSP00000343282
    HIST1H4EP628052, 3, ENSP000003536244MINT-7914854 I2D: score=3 STRING: ENSP00000353624
    HIST1H4HP628052, 3, ENSP000002893524MINT-7914854 I2D: score=3 STRING: ENSP00000289352
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 41):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS17938176
    GO:0000902cell morphogenesis IEA--
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development ----
    GO:0001832blastocyst growth IEA--

    SMARCA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMARCA4 (SMCA4)

    Selected Novoseek inferred chemical compound relationships for SMARCA4 gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tpmp 62.6 1 15319865 (1)
    vancomycin 37.1 11 16323119 (2), 16813981 (1), 16464892 (1), 11959587 (1) (see all 7)
    trypsinogen 32.8 2 15506908 (1), 17033333 (1)
    androstane 28.8 1 18056193 (1)
    histidine 16.8 3 17479344 (1), 19239646 (1)
    atp 16.8 6 11435432 (3), 10733587 (1), 19556365 (1)
    dihydrofolate 14.7 3 16735515 (2)
    steroid 7.85 5 20526952 (1), 19184727 (1), 18842620 (1)
    estrogen 7.38 16 11003650 (4), 12775722 (1), 11336882 (1), 14729568 (1)
    zinc 7.19 4 15939400 (1), 12620226 (1), 9436984 (1), 18524893 (1)



    SMARCA4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for SMARCA4 gene (7 alternative transcripts): 
    NM_001128844.1  NM_001128845.1  NM_001128846.1  NM_001128847.1  NM_001128848.1  NM_001128849.1  NM_003072.3  

    Unigene Cluster for SMARCA4:

    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
    Hs.327527  [show with all ESTs]
    Unigene Representative Sequence: NM_001128844
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000344626(uc002mqg.1) ENST00000429416(uc002mqe.2 uc010dxp.3 uc002mqf.4 uc010dxq.3 uc010dxr.3 uc002mqj.4 uc010dxs.3 uc002mqh.4)
    ENST00000541122 ENST00000589677 ENST00000444061(uc010dxt.1 uc002mqi.1)
    ENST00000590574 ENST00000591545 ENST00000592604 ENST00000586122 ENST00000587988
    ENST00000591595 ENST00000585799 ENST00000592158 ENST00000586892 ENST00000538456
    ENST00000586985 ENST00000586921 ENST00000358026(uc010dxo.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SMARCA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMARCA4 (see all 28):
    hsa-miR-3673 hsa-miR-631 hsa-miR-139-5p hsa-miR-1278 hsa-miR-3661 hsa-miR-888* hsa-miR-144 hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSMARCA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SMARCA4
    Predesigned siRNA for gene silencing in human, mouse, rat SMARCA4
    Clone
    Products:
         
    OriGene clones in human, mouse for SMARCA4 (see all 37)
    OriGene ORF clones in mouse, rat for SMARCA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): SMARCA4 (NM_003072)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMARCA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMARCA4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SMARCA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SMARCA4
      QuantiTect SYBR Green Assays in human, mouse, rat SMARCA4
      QuantiFast Probe-based Assays in human, mouse, rat SMARCA4

    Additional mRNA sequence: 

    AK026573.1 AK290033.1 AK299761.1 AK303352.1 AK308763.1 BC007302.1 BC033232.1 BC035916.1 
    BC139917.1 BC139924.1 BC150298.1 D26156.1 EU430756.1 EU430757.1 EU430758.1 EU430759.1 
    U29175.1 

    Selected DOTS entries (see all 33):

    DT.450147  DT.97797205  DT.97863067  DT.100044658  DT.92459331  DT.95278969  DT.95261723  DT.419850 
    DT.100641871  DT.121416303  DT.86999107  DT.85104775  DT.95261718  DT.121416575  DT.97772615  DT.86846751 
    DT.95261707  DT.95261729  DT.100734005  DT.100847963  DT.100861490  DT.101957292  DT.102836808  DT.121416154 

    Selected AceView cDNA sequences (see all 896):

    BQ182922 BU957286 AU134434 BQ676402 AW575077 BQ679802 BI260084 BU176729 
    BF796633 BQ277639 AA788842 AK055168 BX342302 BM926971 BQ064057 D26156 
    CR612486 BM797524 BQ684692 AW504911 N99416 AI660360 BE901358 BE252756 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SMARCA4 (see all 27)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b · 23c ^ 24a · 24b ^ 25 ^ 26 ^
    SP1:  -                                                                                                                                                         
    SP2:  -                                                                                                                                                         
    SP3:  -                                                                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for SMARCA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SMARCA4 expression in normal human tissues (normalized intensities)      SMARCA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGTCACCG
    SMARCA4 Expression
    About this image


    SMARCA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    SMARCA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMARCA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.327527

    UniProtKB/Swiss-Prot: SMCA4_HUMAN, P51532
    Tissue specificity: Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of
    normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at
    protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SMARCA4: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SMARCA4
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    QuantiFast Probe-based Assays in human, mouse, rat SMARCA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMARCA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SMARCA4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smarca41 , 5 SWI/SNF related, matrix associated, actin dependent more1, 5 89.24(n)1
    99.13(a)1
      9 (7.84 cM)5
    205861  NM_001174078.11  NP_001167549.11 
     216161695 
    chicken
    (Gallus gallus)
    Aves SMARCA41 SWI/SNF related, matrix associated, actin dependent more 86.03(n)
    95.95(a)
      395932  NM_205059.1  NP_990390.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.34452 Xenopus laevis transcribed sequence with moderate similarity more 80.28(n)    BU913051.1 
    zebrafish
    (Danio rerio)
    Actinopterygii smarca42 SWI/SNF related, matrix associated, actin dependent more 79.59(n)   353295  AY205256.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta brm3 positive regulation of transcription by
    homeotic more
    61(a)   3 72C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea C52B9.83 helicase 53(a)   X(4333379-4338468)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STH16
    ATPase component of the RSC chromatin remodeling c...
    34(a)
    1 → many
    IX(117992-122071) YIL126W


    ENSEMBL Gene Tree for SMARCA4 (if available)
    TreeFam Gene Tree for SMARCA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMARCA4 gene
    SMARCA22  
    8 SIMAP similar genes for SMARCA4 using alignment to 7 protein entries:     SMCA4_HUMAN (see all proteins):
    CHD5    CHD2    SMARCA2    SMARCA5    ATRX    CHD1L
    HELLS    SMARCA1

    SMARCA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMARCA4 (see all 2430)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730113621,2
    C,F--11006777(+) CTATTT/AGGGAG 3 -- us2k16Minor allele frequency- A:0.37NA CSA WA EA 363
    rs1461271121,2
    --11006917(+) CCAGGG/TGAGGT 3 -- us2k10--------
    rs1487803841,2
    --11006930(+) CTCACG/TCCTGT 3 -- us2k10--------
    rs1425531571,2
    C--11006998(+) ACCAGA/CCTGGC 3 -- us2k10--------
    rs560274081,2
    C--11007053(+) CGGGCA/GTGGTG 3 -- us2k10--------
    rs1394588861,2
    C--11007061(+) GTGGCA/GGACGC 3 -- us2k10--------
    rs561885181,2
    C,F--11007161(+) CACTCC/TAGCCT 3 -- us2k12Minor allele frequency- T:0.07NA 122
    rs1412798761,2
    C--11007193(+) TCTCA-/AAAC  
            
    AAACA
    3 -- us2k10--------
    rs1424122801,2
    C--11007193(+) TCTCA-/AAA   
       CAAAC
    AAACA
    3 -- us2k10--------
    rs711641371,2
    C--11007226(-) TTGTG-/TGTT  
            
    TGTTT
    1 -- us2k11Minor allele frequency- TGTT:0.00NA 2

    HapMap Linkage Disequilibrium report for SMARCA4 (11071598 - 11176071 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SMARCA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667341CNV Deletion23128226
    nsv833751CNV Loss17160897
    nsv911050CNV Loss21882294
    dgv3728n71CNV Loss21882294
    nsv833750CNV Loss17160897
    nsv833749CNV Loss17160897
    nsv470126CNV Loss18288195
    esv275095CNV Gain+Loss21479260
    nsv7305OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): SMARCA4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SMARCA4
    DNA2.0 Custom Variant and Variant Library Synthesis for SMARCA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603254   
    OMIM disorders: 613325  614609  
    UniProtKB/Swiss-Prot: SMCA4_HUMAN, P51532
  • Rhabdoid tumor predisposition syndrome 2 (RTPS2) [MIM:613325]: A familial cancer syndrome predisposing to
    renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including
    choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors. Rhabdoid tumors are the
    most aggressive and lethal malignancies occurring in early childhood. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Mental retardation, autosomal dominant 16 (MRD16) [MIM:614609]: A disease characterized by multiple
    congenital anomalies and mental retardation. Mental retardation is defined by significantly below average general
    intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental
    period. MRD16 patients manifest developmental delay, absent or hypoplastic fifth fingernails or toenails, thick
    eyebrows and long eyelashes, hirsutism. Additional findings include hypotonia, microcephaly, seizures, a
    Dandy-Walker malformation, and vision and hearing problems. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • Selected diseases for SMARCA4 (see all 82):    About MalaCards
    rhabdoid tumor predisposition syndrome 2    mental retardation, autosomal dominant 16    smarca4-related coffin-siris syndrome    tumor predisposition syndrome
    rhabdoid tumors, somatic    rhabdoid tumor    coffin-siris syndrome    enamel erosion
    kabuki syndrome    peutz-jeghers syndrome    choroid plexus carcinoma    oculopharyngeal muscular dystrophy
    bacteremia    stargardt disease    lymphosarcoma    primary pigmented nodular adrenocortical disease
    glucocorticoid resistance    myxoid liposarcoma    ovarian cyst    alpha thalassemia

    4 diseases from the University of Copenhagen DISEASES database for SMARCA4:
    Dental caries     Gingivitis     Alpha thalassemia     Intellectual disability

    SMARCA4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for SMARCA4 gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 43.3 7 14729964 (2), 15378006 (1), 15240517 (1), 16452305 (1) (see all 6)
    tumors 37 61 11085541 (5), 11850839 (3), 15586241 (3), 14673169 (3) (see all 33)
    cancer 35.9 29 15586241 (2), 17075831 (2), 15287030 (2), 16824695 (2) (see all 21)
    cystic fibrosis 30.4 12 9463322 (1), 10627945 (1), 11768555 (1), 15506908 (1) (see all 11)
    peutz-jeghers syndrome 25 1 15756273 (1)
    bacteremia 23.1 3 16323119 (2), 15319865 (1)
    nsclc 13.6 6 12566296 (2), 15240517 (1), 18386774 (1)
    pancreatic carcinoma 10.8 2 11414763 (1), 11147808 (1)
    oral cancer 9.68 5 15586241 (3), 16824695 (2)
    prostate cancer 4.97 10 12684665 (4), 17075831 (3), 18336616 (1)

    Genetic Association Database (GAD): SMARCA4
    Human Genome Epidemiology (HuGE) Navigator: SMARCA4 (6 documents)
    Tumor Gene Database (TGDB): SMARCA4

    Export disorders for SMARCA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SMARCA4 gene, integrated from 10 sources (see all 450):
    (articles sorted by number of sources associating them with SMARCA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor. (PubMed id 8208605)1, 2, 3 Chiba H.... Kato H. (Nucleic Acids Res. 1994)
    2. BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. (PubMed id 11085541)1, 2, 9 Wong A.K.C.... Lees E. (Cancer Res. 2000)
    3. Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails. (PubMed id 17274598)1, 2, 9 Shen W....Shi Y. (Biochemistry 2007)
    4. Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex. (PubMed id 17582821)1, 2, 9 Singh M.... Holak T.A. (ChemBioChem 2007)
    5. Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines. (PubMed id 18386774)1, 2, 9 Medina P.P....Sanchez-Cespedes M. (Hum. Mutat. 2008)
    6. BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. (PubMed id 8232556)1, 2, 9 Khavari P.A.... Crabtree G.R. (Nature 1993)
    7. BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. (PubMed id 12917342)1, 2, 9 Hsiao P.W.... Archer T.K. (Mol. Cell. Biol. 2003)
    8. Mutations affecting components of the SWI/SNF complex cause Coffin- Siris syndrome. (PubMed id 22426308)1, 2 Tsurusaki Y....Matsumoto N. (Nat. Genet. 2012)
    9. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (Nat. Genet. 2011)
    10. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)1, 4 Lettre G....Boerwinkle E. (PLoS Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6597 HGNC: 11100 AceView: SMARCA4 Ensembl:ENSG00000127616 euGenes: HUgn6597
    ECgene: SMARCA4 H-InvDB: SMARCA4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMARCA4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SMARCA4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SMARCA4 gene:
    Search GeneIP for patents involving SMARCA4

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     EMD Millipore Mono- and Polyclonal Antibodies for the study of SMARCA4
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     OriGene Antibodies for SMARCA4   OriGene RNAi products in human, mouse, rat for SMARCA4  
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     Block miRNA regulation of human, mouse, rat SMARCA4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SMARCA4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMARCA4 Predesigned siRNA for gene silencing in human, mouse, rat SMARCA4
     QuantiFast Probe-based Assays in human, mouse, rat SMARCA4 QuantiTect SYBR Green Assays in human, mouse, rat SMARCA4
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     Search Tocris compounds for SMARCA4 (SMCA4)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     ThermoFisher Antibodies for SMARCA4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMARCA4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMARCA4
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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