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Aliases for SMAP2 Gene

Aliases for SMAP2 Gene

  • Small ArfGAP2 2 3 5
  • Stromal Membrane-Associated GTPase-Activating Protein 2 2 3
  • Stromal Membrane-Associated Protein 1-Like 2 4
  • SMAP1L 3 4
  • Stromal Membrane-Associated Protein 2 3

External Ids for SMAP2 Gene

Previous HGNC Symbols for SMAP2 Gene

  • SMAP1L

Previous GeneCards Identifiers for SMAP2 Gene

  • GC01P040614
  • GC01P040810
  • GC01P038958

Summaries for SMAP2 Gene

GeneCards Summary for SMAP2 Gene

SMAP2 (Small ArfGAP2) is a Protein Coding gene. Among its related pathways are Endocytosis. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is SMAP1.

UniProtKB/Swiss-Prot for SMAP2 Gene

  • GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMAP2 Gene

Genomics for SMAP2 Gene

Regulatory Elements for SMAP2 Gene

Enhancers for SMAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F040379 1.9 FANTOM5 Ensembl ENCODE 49.5 +47.6 47635 26.7 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D SSRP1 SMAP2 RLF PPIEL ENSG00000231296 ZMPSTE24 LOC101929901 EXO5 LOC105378672 LOC101929516 ENSG00000259943
GH01F040372 1.5 FANTOM5 ENCODE 39.6 +31.0 31009 5.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 SMAP2 PPIEL LOC105378674 ENSG00000229528 ENSG00000213987 LOC101929516 EXO5 SNORA55 PABPC4 LOC105378672
GH01F040413 0.7 ENCODE 21.6 +69.4 69427 1.7 SOX13 BCOR ZNF644 RARA ZNF366 RERE NR2F6 PRDM10 CREM SOX5 SMAP2 ZFP69B COL9A2 EXO5 LOC105378672 ZMPSTE24 ENSG00000231296 ZFP69 RLF HEYL
GH01F040421 1.3 Ensembl ENCODE 11 +77.7 77748 2.5 ATF1 MLX ARID4B FEZF1 DMAP1 ZNF48 YY1 ZNF263 NFYC MXD4 EXO5 ZFP69B SMAP2 ZFP69 ENSG00000227278 ENSG00000238186 LOC105378672 GC01P040432 GC01M040364
GH01F040241 1.3 Ensembl ENCODE 10 -102.3 -102291 2.9 HDGF PKNOX1 ATF1 CREB3L1 SIN3A ARID4B YY1 SLC30A9 ZNF143 ZNF548 PPT1 ENSG00000231296 EXO5 COL9A2 RLF SMAP2 LOC101929516 GC01P040244 GC01M040241
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SMAP2 on UCSC Golden Path with GeneCards custom track

Promoters for SMAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SMAP2 Gene

40,344,844 bp from pter
40,423,326 bp from pter
78,483 bases
Plus strand

Genomic View for SMAP2 Gene

Genes around SMAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMAP2 Gene

Proteins for SMAP2 Gene

  • Protein details for SMAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Stromal membrane-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R7T1
    • B7Z5B5
    • B7Z8V2
    • D3DPV2
    • Q5QPL2
    • Q96C93
    • Q9NST2
    • Q9UJL8

    Protein attributes for SMAP2 Gene

    429 amino acids
    Molecular mass:
    46786 Da
    Quaternary structure:
    • Interacts with ARF1. Interacts with PICALM and clathrin heavy chains (By similarity).

    Three dimensional structures from OCA and Proteopedia for SMAP2 Gene

    Alternative splice isoforms for SMAP2 Gene


neXtProt entry for SMAP2 Gene

Post-translational modifications for SMAP2 Gene

  • Ubiquitination at Lys 66
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SMAP2 Gene

Domains & Families for SMAP2 Gene

Gene Families for SMAP2 Gene

Protein Domains for SMAP2 Gene

Suggested Antigen Peptide Sequences for SMAP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Arf-GAP domain.
  • Contains 1 Arf-GAP domain.
genes like me logo Genes that share domains with SMAP2: view

Function for SMAP2 Gene

Molecular function for SMAP2 Gene

UniProtKB/Swiss-Prot Function:
GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity).

Gene Ontology (GO) - Molecular Function for SMAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SMAP2: view
genes like me logo Genes that share phenotypes with SMAP2: view

Animal Models for SMAP2 Gene

MGI Knock Outs for SMAP2:

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SMAP2 Gene

Localization for SMAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMAP2 Gene

Cytoplasm. Note=Detected in multiple foci throughout the cytoplasm and in juxtanuclear structures. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMAP2 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for SMAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SMAP2: view

Pathways & Interactions for SMAP2 Gene

SuperPathways for SMAP2 Gene

SuperPathway Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with SMAP2: view

Pathways by source for SMAP2 Gene

1 KEGG pathway for SMAP2 Gene

Gene Ontology (GO) - Biological Process for SMAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with SMAP2: view

No data available for SIGNOR curated interactions for SMAP2 Gene

Transcripts for SMAP2 Gene

Unigene Clusters for SMAP2 Gene

Small ArfGAP2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMAP2 Gene

No ASD Table

Relevant External Links for SMAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMAP2 Gene

This gene is overexpressed in Whole Blood (x22.1).

Protein differential expression in normal tissues from HIPED for SMAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.7) and Lymph node (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SMAP2 Gene

Protein tissue co-expression partners for SMAP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMAP2 Gene:


SOURCE GeneReport for Unigene cluster for SMAP2 Gene:

genes like me logo Genes that share expression patterns with SMAP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SMAP2 Gene

Orthologs for SMAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SMAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMAP2 34 35
  • 99.61 (n)
(Canis familiaris)
Mammalia SMAP2 34 35
  • 93.07 (n)
(Bos Taurus)
Mammalia SMAP2 34 35
  • 92.31 (n)
(Mus musculus)
Mammalia Smap2 34 16 35
  • 91.04 (n)
(Rattus norvegicus)
Mammalia Smap2 34
  • 90.65 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 86 (a)
-- 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia SMAP2 35
  • 83 (a)
(Gallus gallus)
Aves SMAP2 34 35
  • 76.84 (n)
(Anolis carolinensis)
Reptilia SMAP2 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia smap2 34
  • 70.71 (n)
(Danio rerio)
Actinopterygii smap2 34 35
  • 62.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8243 34 35
  • 48.83 (n)
(Caenorhabditis elegans)
Secernentea W09D10.1 35
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE2 35 37
  • 31 (a)
(Zea mays)
Liliopsida Zm.933 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9042 35
  • 34 (a)
Species where no ortholog for SMAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMAP2 Gene

Gene Tree for SMAP2 (if available)
Gene Tree for SMAP2 (if available)

Paralogs for SMAP2 Gene

Paralogs for SMAP2 Gene

(2) SIMAP similar genes for SMAP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SMAP2: view

Variants for SMAP2 Gene

Sequence variations from dbSNP and Humsavar for SMAP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1003710 -- 40,374,681(+) CGGAA(A/G)GGAAA intron-variant, utr-variant-5-prime
rs1004138 -- 40,386,669(-) CACAA(A/G)ACAGA intron-variant
rs1004139 -- 40,386,668(-) ACAAG(A/T)CAGAA intron-variant
rs1004140 -- 40,386,665(-) AGACA(C/G)AAAAC intron-variant
rs1007263 -- 40,416,168(-) TAGGG(C/T)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMAP2 Gene

Variant ID Type Subtype PubMed ID
nsv950697 CNV duplication 24416366
esv3585803 CNV loss 21293372

Variation tolerance for SMAP2 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SMAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMAP2 Gene

Disorders for SMAP2 Gene

Relevant External Links for SMAP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SMAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMAP2 Gene

Publications for SMAP2 Gene

  1. Putative association of SMAPIL polymorphisms with risk of aspirin intolerance in asthmatics. (PMID: 20831471) Kim J.Y. … Shin H.D. (J Asthma 2010) 3 46 64
  2. SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. (PMID: 16571680) Natsume W. … Satake M. (Mol. Biol. Cell 2006) 2 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SMAP2 Gene

Sources for SMAP2 Gene

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