SMAP2 Gene
protein-coding GIFtS: 49
GCID: GC01P040810
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small ArfGAP2(Previous names: stromal membrane-associated protein 1-like, stromal membrane-associated...) (Previous symbol: SMAP1L)
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Aliases for SMAP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Small ArfGAP21 2 | | RP1-228H13.32 | | SMAP1L1 2 3 | | Stromal Membrane-Associated Protein 22 | | Stromal Membrane-Associated GTPase-Activating Protein 21 2 | | SMOC25 | | Stromal Membrane-Associated Protein 1-Like1 3 | | |
Export aliases for SMAP2 gene to outside databasesPrevious GC identifers: GC01P040614 GC01P038958 |
Summaries for SMAP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: SMAP2_HUMAN, Q8WU79Function: GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role inclathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity)
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Genomic Views for SMAP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SMAP2 gene promoter: c-Fos AP-1 AML1a p53 FosB CREB FOXJ2 (long isoform) deltaCREB c-Jun FOXJ2 Other transcription factors
Search SABiosciences Chromatin IP Primers for SMAP2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMAP2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35.3-p34.1 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p35.3-p34.1SMAP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P040810: view genomic region
(about GC identifiers)
Start:
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40,810,522 bp from pter |
End:
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40,888,998 bp from pter |
Size:
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78,477 bases |
Orientation:
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plus strand |
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Proteins for SMAP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SMAP2_HUMAN, Q8WU79 (See
protein sequence)Recommended Name: Stromal membrane-associated protein 2 Size: 429 amino acids; 46786 Da
Subunit: Interacts with ARF1. Interacts with PICALM and clathrin heavy chains (By similarity)
Subcellular location: Cytoplasm. Note=Detected in multiple foci throughout the cytoplasm and in juxtanuclear structures(By similarity)
1 PDB 3D structure from and Proteopedia for SMAP2:2IQJ (3D)
 
Secondary accessions: B2R7T1 B7Z5B5 B7Z8V2 D3DPV2 Q5QPL2 Q96C93 Q9NST2 Q9UJL8Alternative splicing: 3 isoforms: Q8WU79-1 Q8WU79-2 Q8WU79-3 Explore the universe of human proteins at neXtProt for SMAP2: NX_Q8WU79
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WU79 SMAP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001185907.1 NP_001185908.1 NP_001185909.1 NP_073570.1 ENSEMBL proteins: ENSP00000389895 ENSP00000361803 ENSP00000361793 ENSP00000442835 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SMAP2 for ontologies About GeneDecksing
SMAP2 Antibody Products: Assay Products for SMAP2: |
Protein
Domains / Families for SMAP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SMAP2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WU79ProtoNet protein and cluster: Q8WU79 1 Blocks protein family: IPB001164 HIV Rev interacting protein signature
UniProtKB/Swiss-Prot: SMAP2_HUMAN, Q8WU79Similarity: Contains 1 Arf-GAP domain |
Function for SMAP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SMAP2_HUMAN, Q8WU79Function: GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role inclathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMAP2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMAP2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): SMAP2 (NM_001198979) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMAP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMAP2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAP2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008060 | ARF GTPase activator activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
SMAP2 for ontologies About GeneDecksing
|
Pathways & Interactions for SMAP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Endocytosis | |
Pathway sources See GeneCards unified pathways Show all pathways
1
Kegg Pathway (Kegg details for SMAP2):
SMAP2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMAP2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 2 Interacting proteins for SMAP2 (ENSP000003618034) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032312 | regulation of ARF GTPase activity |
IEA | -- |
SMAP2 for ontologies About GeneDecksing
|
Drugs & Compounds for SMAP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SMAP2 Search CenterWatch for drugs/clinical trials and news about SMAP2 
|
Transcripts for SMAP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SMAP2 gene (4 alternative transcripts): NM_001198978.1 NM_001198979.1 NM_001198980.1 NM_022733.2 Unigene Cluster for SMAP2: Small ArfGAP2 Hs.15200 [show with all ESTs]Unigene Representative Sequence: NM_0227335 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000435168 ENST00000372718(uc010ojh.2 uc001cfj.3) ENST00000372708(uc001cfk.3 uc021oma.1 uc010oji.2 uc010ojj.2) ENST00000487871 ENST00000539317
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMAP2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMAP2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): SMAP2 (NM_001198979) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMAP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMAP2  |
Additional cDNA sequence: AK294675.1 AK298702.1 AK303975.1 AK308280.1 AK313105.1 AK316218.1 AL133206.1 AL137764.1 BC014512.1 BC021133.1 22 DOTS entries: DT.95084422 DT.100788986 DT.100788985 DT.91871563 DT.95084424 DT.121455548 DT.121455570 DT.91709282 DT.91798780 DT.91928820 DT.95084426 DT.100743993 DT.75185348 DT.92429819 DT.95316147 DT.95362284 DT.100676060 DT.121455536 DT.75123591 DT.91654083 DT.95084427 DT.97854429 24/215 AceView cDNA sequences (see all 215): BF110646 AA303231 BM477933 AI433766 CB529519 AL137764 AW102984 BX282026 AI298661 NM_022733 BC021133 CA436192 BM977398 CA312506 BE465267 AA872328 AI288517 BC014512 AL133206 T34311 T30306 BQ772546 BE219478 AI874260 GeneLoc Exon Structure
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Expression for SMAP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SMAP2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGTGGGAACC
About this image See SMAP2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SMAP2
SOURCE GeneReport for Unigene cluster: Hs.15200 SABiosciences Custom PCR Arrays for SMAP2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMAP2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SMAP2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMAP2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMAP2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAP2 |
Orthologs for SMAP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SMAP2 gene from 7/28 species (see all 28) About this table
ENSEMBL Gene Tree for SMAP2 (if available) TreeFam Gene Tree for SMAP2 (if available)  |
Paralogs for SMAP2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SMAP2 gene
- SMAP12 ADAP12 ADAP22
2 SIMAP similar genes for SMAP2 using alignment to 1 protein entry: SMAP2_HUMAN:ARFGAP1 SMAP1
SMAP2 for paralogs About GeneDecksing
|
Genomic Variants for SMAP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for SMAP2 (40810522 - 40888998 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SMAP2: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMAP2 |
|
Disorders
/ Diseases for SMAP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SMAP2 for disorders About GeneDecksing
OMIM gene information: 607223
OMIM disorders: --
1 disease for SMAP2: About MalaCardsmalaria Human Genome Epidemiology (HuGE) Navigator: SMAP2 (5 documents) Export disorders for SMAP2 gene to outside databases
|
Publications for SMAP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SMAP2 gene, integrated from 9 sources (see all 18): (articles sorted by number of sources associating them with SMAP2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. (PubMed id 16571680)1, 3 Natsume W....Satake M. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- The carboxy-terminal region of SMAP2 directs subcellu lar localization as well as Arf protein specificity. (PubMed id 21147065)1 Sakakura I....Watanabe T. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Putative association of SMAPIL polymorphisms with ris k of aspirin intolerance in asthmatics. (PubMed id 20831471)1 Kim J.Y....Shin H.D. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
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External Searches for SMAP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing SMAP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SMAP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SMAP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SMAP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SMAP2 gene: Search GeneIP for patents involving SMAP2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SMAP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for SMAP2 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SMAP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SMAP2 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for SMAP2 | | OriGene 3'-UTR Clone for SMAP2 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SMAP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SMAP2 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for SMAP2 | | OriGene Custom Protein Services for SMAP2 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMAP2 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SMAP2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMAP2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SMAP2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SMAP2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SMAP2 |
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 | | SMAP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAP2 |
|  |  |  | | | Search ThermoFisher Antibodies for SMAP2 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMAP2 |
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