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SMAP1 Gene

protein-coding   GIFtS: 57
GCID: GC06P071377

Small ArfGAP 1

(Previous names: stromal membrane-associated protein 1, stromal membrane-associated...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Small ArfGAP 11 2
Stromal Membrane-Associated GTPase-Activating Protein 11 2
Stromal Membrane-Associated Protein 11 2
SMAP-12

External Ids:    HGNC: 196511   Entrez Gene: 606822   Ensembl: ENSG000001123057   OMIM: 6113725   UniProtKB: Q8IYB53   

Export aliases for SMAP1 gene to outside databases

Previous GC identifers: GC06P071335 GC06P071373 GC06P071434 GC06P068575


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SMAP1 Gene:
The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity
suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic
stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding
different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for SMAP1 Gene:
SMAP1 (small ArfGAP 1) is a protein-coding gene. GO annotations related to this gene include ARF GTPase activator activity and clathrin binding. An important paralog of this gene is SMAP2.

UniProtKB/Swiss-Prot: SMAP1_HUMAN, Q8IYB5
Function: GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a
role in erythropoiesis (By similarity)

Gene Wiki entry for SMAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SMAP1 gene promoter:
         MEF-2A   PPAR-alpha   FOXF2   MEF-2   Chx10   aMEF-2   ITF-2   Tal-1beta   Pax-4a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSMAP1 promoter sequence
   Search Chromatin IP Primers for SMAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SMAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13   Ensembl cytogenetic band:  6q13   HGNC cytogenetic band: 6q12-q13

SMAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMAP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P071377:  view genomic region     (about GC identifiers)

Start:
71,377,479 bp from pter      End:
71,571,718 bp from pter
Size:
194,240 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SMAP1_HUMAN, Q8IYB5 (See protein sequence)
Recommended Name: Stromal membrane-associated protein 1  
Size: 467 amino acids; 50386 Da
Subunit: Interacts with ARF6. Interacts with clathrin heavy chains via the clathrin box-like motif (By similarity)
Sequence caution: Sequence=AAH08672.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
1 PDB 3D structure from and Proteopedia for SMAP1:
2CRR (3D)    
Secondary accessions: Q53H70 Q5SYQ2 Q6PK24 Q8NDH4 Q96L38 Q96L39 Q9H8X4
Alternative splicing: 3 isoforms:  Q8IYB5-1   Q8IYB5-2   Q8IYB5-3   

Explore the universe of human proteins at neXtProt for SMAP1: NX_Q8IYB5

Explore proteomics data for SMAP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23
  • Modification sites at PhosphoSitePlus

  • See SMAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001037770.1  NP_001268368.1  NP_001268369.1  NP_068759.2  

    ENSEMBL proteins: 
     ENSP00000359481   ENSP00000313382   ENSP00000359484   ENSP00000415426   ENSP00000398306  
     ENSP00000398541  

    SMAP1 Human Recombinant Protein Products:

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    Novus Biologicals SMAP1 Protein
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    1 InterPro protein domain:
     IPR001164 ArfGAP

    Graphical View of Domain Structure for InterPro Entry Q8IYB5

    ProtoNet protein and cluster: Q8IYB5

    1 Blocks protein domain: IPB001164 HIV Rev interacting protein signature

    UniProtKB/Swiss-Prot: SMAP1_HUMAN, Q8IYB5
    Similarity: Contains 1 Arf-GAP domain


    Find genes that share domains with SMAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMAP1_HUMAN, Q8IYB5
    Function: GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a
    role in erythropoiesis (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0030276clathrin binding IEA--
         
    Find genes that share ontologies with SMAP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SMAP1:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Smap1):
     behavior/neurological  cellular  hematopoietic system  immune system  liver/biliary system 
     tumorigenesis 

    Find genes that share phenotypes with SMAP1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMAP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SMAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SMAP1

    miRNA
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    miRTarBase miRNAs that target SMAP1:
    hsa-mir-25-3p (MIRT050219)

    Block miRNA regulation of human, mouse, rat SMAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMAP1 (see all 32):
    hsa-miR-30c hsa-miR-320a hsa-miR-892b hsa-miR-10b hsa-miR-202 hsa-miR-767-5p hsa-miR-485-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidSMAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SMAP1
    Predesigned siRNA for gene silencing in human, mouse, rat SMAP1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SMAP1 (NM_021940)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMAP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SMAP1_HUMAN, Q8IYB5: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with SMAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SMAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis


    Find genes that share SuperPaths with SMAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SMAP1):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SMAP1
    Interactions:

        Search GeneGlobe Interaction Network for SMAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SMAP1 (Q8IYB53 ENSP000003594844) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRF2Q9HAW03, ENSP000002206594I2D: score=1 STRING: ENSP00000220659
    PHLDA3Q9Y5J53, ENSP000003562784I2D: score=1 STRING: ENSP00000356278
    WRAP73Q9P2S53, ENSP000002707084I2D: score=1 STRING: ENSP00000270708
    SMURF2Q9HAU43, ENSP000002624354I2D: score=3 STRING: ENSP00000262435
    PTP4A3O753653I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032312regulation of ARF GTPase activity IEA--
    GO:0045648positive regulation of erythrocyte differentiation IEA--
    GO:2000369regulation of clathrin-mediated endocytosis IEA--

    Find genes that share ontologies with SMAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SMAP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SMAP1 gene (4 alternative transcripts): 
    NM_001044305.2  NM_001281439.1  NM_001281440.1  NM_021940.4  

    Unigene Cluster for SMAP1:

    Small ArfGAP 1
    Hs.485717  [show with all ESTs]
    Unigene Representative Sequence: NM_001044305
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370452 ENST00000316999 ENST00000370455(uc003pfr.3 uc003pfs.3 uc010kao.3 uc010kap.3)
    ENST00000445046 ENST00000439432 ENST00000422334(uc011dxy.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat SMAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SMAP1 (see all 32):
    hsa-miR-30c hsa-miR-320a hsa-miR-892b hsa-miR-10b hsa-miR-202 hsa-miR-767-5p hsa-miR-485-3p hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidSMAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SMAP1 (NM_021940)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMAP1
    Primer
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    OriGene qPCR primer pairs and template standards for SMAP1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SMAP1
      QuantiTect SYBR Green Assays in human, mouse, rat SMAP1
      QuantiFast Probe-based Assays in human, mouse, rat SMAP1

    Additional mRNA sequence: 

    AF442495.1 AK023221.1 AK074340.1 AK124239.1 AK222711.1 AK290448.1 AK303387.1 AK307807.1 
    AK315579.1 AL833906.1 AY055003.1 AY055004.1 BC008672.2 BC028074.1 BC036123.1 

    15 DOTS entries:

    DT.454075  DT.95310418  DT.91971398  DT.308112  DT.100784972  DT.92407740  DT.95310421  DT.121383526 
    DT.121383547  DT.454074  DT.91830795  DT.95310431  DT.100703908  DT.97788482  DT.97845909 

    Selected AceView cDNA sequences (see all 265):

    CR624449 CA442778 AI453440 NM_021940 AI859101 AI683335 BI964097 AI086160 
    AI932332 N69071 F02580 AI264383 AI125336 AI914038 AI218164 BU621724 
    BE219038 AF442495 AK124239 AA749368 AW368832 AW161581 CD676822 AY055004 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SMAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCCATAGA
    SMAP1 Expression
    About this image


    SMAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
    SMAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SMAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485717

    UniProtKB/Swiss-Prot: SMAP1_HUMAN, Q8IYB5
    Tissue specificity: Detected in bone marrow, adrenal gland, trachea, lymph node, spinal cord, peripheral blood
    leukocytes, thyroid and stomach

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SMAP1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smap11 , 5 stromal membrane-associated protein 15
    small ArfGAP 11
    89.88(n)1
    91.55(a)1
      1 (9.79 cM)5
    983661  NM_028534.21  NP_082810.11 
     238448465 
    chicken
    (Gallus gallus)
    Aves SMAP11 small ArfGAP 1 78.62(n)
    79.7(a)
      100858913  XM_003641020.2  XP_003641068.2 
    lizard
    (Anolis carolinensis)
    Reptilia SMAP16
    small ArfGAP 1
    69(a)
    1 ↔ 1
    1(167706875-167809696)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU906067.12   -- 77.94(n)    BU906067.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI839489.12   -- 79.79(n)    BI839489.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82433 ARF GTPase activator 34(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea W09D10.13 RNA recognition motif. (aka RRM, RBD,
    or RNP domain)
    31(a)   III(10808899-10811426)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AGE26
    ADP-ribosylation factor (ARF) GTPase activating pr...
    33(a)
    1 → many
    IX(272950-273846) YIL044C
    soybean
    (Glycine max)
    eudicotyledons Gma.65132 Transcribed sequence with weak similarity to protein more 68.62(n)  
    rice
    (Oryza sativa)
    Liliopsida CF320273.12   -- 90.36(n)    CF320273.1 


    ENSEMBL Gene Tree for SMAP1 (if available)
    TreeFam Gene Tree for SMAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SMAP1 gene
    SMAP22  ADAP22  ADAP12  
    11 SIMAP similar genes for SMAP1 using alignment to 5 protein entries:     SMAP1_HUMAN (see all proteins):
    AGAP1    AGAP8    ARFGAP1    ARFGAP3    AGAP3    ARFGAP2
    SMAP2    ADAP1    ASAP1    GIT1    ADAP2

    Find genes that share paralogs with SMAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SMAP1 (see all 3445)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105721781,2
    C--68590051(+) ACAGA-/T/TTT/TTTTTTTT/TTTTTTTTT/TTTTTT
    TTTT
    /TTTTTTTTTTT/TTTTTTTTTTTTTTTTT
    ttttt
    6 -- int1 cds11NA 2
    rs58772591,2
    C--68626698(+) atctc-/A/AA  
            
    aaaaa
    2 -- int1 trp30--------
    rs7819801,2
    C,H--71375494(+) GACATC/TGCTGT 2 -- us2k117Minor allele frequency- T:0.00NS EA NA WA CSA 787
    rs349006011,2
    C--71375717(+) TTTTT-/G/TGGGGG 2 -- us2k10--------
    rs3710398821,2
    C--71375718(+) TTTTT-/GGGGGG 2 -- us2k10--------
    rs721831731,2
    C--71375727(+) GGGGG-/GTGGGT 2 -- us2k10--------
    rs1819511401,2
    --71375892(+) TTTGTA/GTTATC 2 -- us2k10--------
    rs2020300221,2
    --71375896(+) TATTA-/TCAGTA 2 -- us2k10--------
    rs1444804161,2
    --71375915(+) GTTTCC/TCCATG 2 -- us2k10--------
    rs7819811,2
    C,F,A,H--71375961(+) GATCCG/ACCTGC 2 -- us2k14Minor allele frequency- A:0.50NA WA 8

    HapMap Linkage Disequilibrium report for SMAP1 (71377479 - 71571718 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SMAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819061CNV Loss19587683
    nsv482946CNV Gain15286789
    nsv886147CNV Gain21882294
    nsv524328CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611372    OMIM disorders: --


    Find genes that share disorders with SMAP1           About GenesLikeMe

    Genetic Association Database (GAD): SMAP1

    Export disorders for SMAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SMAP1 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SMAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, characterization and chromosome mapping of the human SMAP1 gene. (PubMed id 12119110)1, 2, 3 Marcos I....Antinolo G. (Gene 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. (PubMed id 9644265)1, 3 Sato Y....Obinata M. (J. Biochem. 1998)
    6. Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa. (PubMed id 16273301)1, 9 Barragan I....AntiA+olo G. (Int. J. Mol. Med. 2005)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 60682 HGNC: 19651 AceView: SMAP1 Ensembl:ENSG00000112305 euGenes: HUgn60682
    ECgene: SMAP1 Kegg: 60682 H-InvDB: SMAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SMAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SMAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SMAP1 gene:
    Search GeneIP for patents involving SMAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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