SMAGP Gene
protein-coding GIFtS : 44
GCID: GC12 M051639
small cell adhesion glycoprotein
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Aliasesfor SMAGP gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Small Cell Adhesion Glycoprotein 1 2 MGC1494541 HSMAGP1 Small Cell Transmembrane And Glycosylated Protein2 Small Transmembrane And Glycosylated Protein2 3 Small Trans-Membrane And Glycosylated Protein2 MGC1494531
Export aliases for SMAGP gene to outside databases Previous GC identifers: GC12M049926 GC12M048672
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Summariesfor SMAGP gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: SMAGP_HUMAN, Q0VAQ4 Function : May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasisformation
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Genomic Viewsfor SMAGP gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SMAGP gene promoter: AP-1 FOXF2 Msx-1 FOXL1 Evi-1 Other transcription factors Search SABiosciences Chromatin IP Primers for SMAGP Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SMAGP
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13 SMAGP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M051639: view genomic region
(about GC identifiers )
Start:
51,639,133 bp from pter
End:
51,664,202 bp from pter
Size:
25,070 bases
Orientation:
minus strand
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Proteinsfor SMAGP gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SMAGP_HUMAN, Q0VAQ4 (See
protein sequence )Recommended Name: Small cell adhesion glycoprotein Size : 97 amino acids; 10679 Da
Subcellular location : Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle membrane; Single-passtype III membrane protein. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions. Detected on cytoplasmic membranes in undifferentiated tumors
Secondary accessions : A6NIL5Explore the universe of human proteins at neXtProt for SMAGP: NX_Q0VAQ4 Post-translational modifications:
O-glycosylated. The O-glycan is modified with sialic acid residues1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q0VAQ4 SMAGP Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001026798.1 NP_001029045.1 ENSEMBL proteins: ENSP00000369446 ENSP00000381471 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
SMAGP for ontologies About GeneDecksing SMAGP Antibody Products: Assay Products for SMAGP:
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Protein
Domains / Familiesfor SMAGP gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q0VAQ4
UniProtKB/Swiss-Prot: SMAGP_HUMAN, Q0VAQ4 Similarity : Belongs to the SMAGP family
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Functionfor SMAGP gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SMAGP_HUMAN, Q0VAQ4 Function : May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasisformation
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SMAGP (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SMAGP (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SMAGP (NM_001033873 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMAGP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMAGP
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAGP
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Pathways & Interactionsfor SMAGP gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMAGP STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for SMAGP (ENSP00000369446 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor SMAGP gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SMAGP Search CenterWatch for drugs/clinical trials and news about SMAGP
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Transcriptsfor SMAGP gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SMAGP gene (2 alternative transcripts): NM_001031628.1 NM_001033873.1 Unigene Cluster for SMAGP:
Small cell adhesion glycoprotein Hs.652389 [show with all ESTs ] Unigene Representative Sequence: BC045658 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000380103 (uc001rye.1 uc001ryf.1 ) ENST00000398453 (uc001ryd.1 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SMAGP (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SMAGP (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SMAGP (NM_001033873 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMAGP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMAGP
Additional cDNA sequence: AF091087.1 AK001839.1 BC001400.2 BC003379.1 BC008712.1 BC045658.1 BC120965.1 BC120966.1 CR456943.1
15 DOTS entries : DT.214646 DT.100777239
DT.100777242 DT.97842713 DT.100777240 DT.91753738 DT.100777244 DT.95361696 DT.100780451 DT.100696043 DT.100780452 DT.100009876 DT.205569 DT.205570 DT.305912 24/382 AceView cDNA sequences (see all 382 ):
AA227362 AI142906 BE385332 CA430247 CR597407 AA677695 BM990900 AV650596 BC008712 BI089401 AK001839 AI753013 CD367613 AL546104 AA333877 C05483 BM982348 AA488618 AI377053 BG678644 CR620025 BI061065 CB147881 AU129717 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SMAGP (see all 7 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e SP1 :   -   -   -   -   -     -     -   -             SP2 :         -   -     -     -   -             SP3 :         -   -     -     -   -             SP4 :               -     -   -             SP5 :                   -   -            
ECgene alternative splicing isoforms for SMAGP
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Expression for SMAGP gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SMAGP expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTTACGTGAT
About this image SMAGP expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Primitive gut tube-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See SMAGP Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SMAGP SOURCE GeneReport for Unigene cluster: Hs.652389 UniProtKB/Swiss-Prot: SMAGP_HUMAN, Q0VAQ4 Tissue specificity : Detected in breast, endometrium, colon and biliary tract. Detected in polarized epithelialstructures characterized by cell-cell adhesion (at protein level) SABiosciences Custom PCR Arrays for SMAGP Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SMAGPBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SMAGP QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SMAGP QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SMAGP In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAGP
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Orthologsfor SMAGP gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for SMAGP gene from 3/8 species (see all 8 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Smagp1 , 5
small cell adhesion glycoprotein1, 5
86.11(n) 1 80.21(a) 1
 
15 (56.37 cM) 5 207818 1 NM_001033872.1 1 NP_001029044.1 1 100621342 5
lizard (Anolis carolinensis)
Reptilia
SMAGP6
--
47(a)
1 ↔ 1
2(67600328-67602952)
African clawed frog (Xenopus laevis)
Amphibia
Xl.188332
Xenopus laevis transcribed sequences
87.05(n)
 
BG347115.1
ENSEMBL Gene Tree for SMAGP (if available)TreeFam Gene Tree for SMAGP (if available)
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Paralogsfor SMAGP gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor SMAGP gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SMAGP (51639133 - 51664202 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for SMAGP 1 CNV : 47982
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SMAGP
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Disorders
/ Diseasesfor SMAGP gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SMAGP for disorders About GeneDecksing 3 diseases for SMAGP : About MalaCards endocarditis adenocarcinoma pancreatitis Export disorders for SMAGP gene to outside databases
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Publicationsfor SMAGP gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SMAGP gene integrated from 9 sources : (articles sorted by number of sources associating them with SMAGP) Utopia : connect your pdf to the dynamic world of online information
SMAGP, a new small trans-membrane glycoprotein altered in cancer. (PubMed id 15021913) 1 , 2 , 3 Tarbe N.G.... Weidle U.H. (2004) Overexpression of the small transmembrane and glycosylated protein SMAGP supports metastasis formation of a rat pancreatic adenocarcinoma line. (PubMed id 15986429) 1 , 2 Tarbe N.G.... Zoeller M. (2005) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) The finished DNA sequence of human chromosome 12. (PubMed id 16541075) 2 Scherer S.E.... Gibbs R.A. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SMAGP gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SMAGP gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SMAGP gene
(According to HUGE )
About This Section --
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Specialized Databases showing SMAGP gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SMAGP Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SMAGP gene: Search GeneIP for patents involving SMAGP GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SMAGP gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SMAGP OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SMAGP OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SMAGP OriGene Protein Over-expression Lysate for SMAGP Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SMAGP Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SMAGP OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SMAGP Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SMAGP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SMAGP OriGene Custom Protein Services for SMAGP OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMAGP QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SMAGP QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat SMAGP QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SMAGP QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SMAGP QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SMAGP
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SMAGP Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAGP
ThermoFisher Antibody for SMAGP
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMAGP
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Aliases for SMAGP
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Disorders / Diseases for SMAGP
Domains / Families for SMAGP
Drugs / Compounds for SMAGP
Expression for SMAGP
Function for SMAGP
Genomic Views for SMAGP
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Orthologs for SMAGP
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Pathways / Interactions for SMAGP
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Proteins for SMAGP
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Summaries for SMAGP
Transcripts for SMAGP
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