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Aliases for SMAGP Gene

Aliases for SMAGP Gene

  • Small Cell Adhesion Glycoprotein 2 3
  • Small Trans-Membrane And Glycosylated Protein 2 3
  • Small Transmembrane And Glycosylated Protein 3 4
  • Small Cell Transmembrane And Glycosylated Protein 3
  • HSMAGP 3

External Ids for SMAGP Gene

Previous GeneCards Identifiers for SMAGP Gene

  • GC12M049926
  • GC12M051639
  • GC12M048672

Summaries for SMAGP Gene

GeneCards Summary for SMAGP Gene

SMAGP (Small Cell Adhesion Glycoprotein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SMAGP Gene

  • May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMAGP Gene

Genomics for SMAGP Gene

Regulatory Elements for SMAGP Gene

Genomic Location for SMAGP Gene

Start:
51,244,558 bp from pter
End:
51,270,890 bp from pter
Size:
26,333 bases
Orientation:
Minus strand

Genomic View for SMAGP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMAGP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMAGP Gene

Proteins for SMAGP Gene

  • Protein details for SMAGP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VAQ4-SMAGP_HUMAN
    Recommended name:
    Small cell adhesion glycoprotein
    Protein Accession:
    Q0VAQ4
    Secondary Accessions:
    • A6NIL5

    Protein attributes for SMAGP Gene

    Size:
    97 amino acids
    Molecular mass:
    10679 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMAGP Gene

Proteomics data for SMAGP Gene at MOPED

Post-translational modifications for SMAGP Gene

  • O-glycosylated. The O-glycan is modified with sialic acid residues.
  • Glycosylation at Thr2, Ser3, Thr6, Thr7, Ser9, Thr16, Thr17, and Thr23
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SMAGP Gene

Domains for SMAGP Gene

Protein Domains for SMAGP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMAGP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0VAQ4

UniProtKB/Swiss-Prot:

SMAGP_HUMAN :
  • Q0VAQ4
Family:
  • Belongs to the SMAGP family.
genes like me logo Genes that share domains with SMAGP: view

No data available for Gene Families for SMAGP Gene

Function for SMAGP Gene

Molecular function for SMAGP Gene

UniProtKB/Swiss-Prot Function: May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.

Gene Ontology (GO) - Molecular Function for SMAGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SMAGP: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SMAGP Gene

Localization for SMAGP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMAGP Gene

Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle membrane; Single-pass type III membrane protein. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions. Detected on cytoplasmic membranes in undifferentiated tumors.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMAGP Gene COMPARTMENTS Subcellular localization image for SMAGP gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SMAGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with SMAGP: view

Pathways for SMAGP Gene

SuperPathways for SMAGP Gene

No Data Available

Interacting Proteins for SMAGP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369446%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000221566%0d%0a
Selected Interacting proteins: ENSP00000369446 Q0VAQ4-SMAGP_HUMAN for SMAGP Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SMAGP Gene

None

No data available for Pathways by source for SMAGP Gene

Transcripts for SMAGP Gene

Unigene Clusters for SMAGP Gene

Small cell adhesion glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMAGP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for SMAGP Gene

GeneLoc Exon Structure for
SMAGP
ECgene alternative splicing isoforms for
SMAGP

Expression for SMAGP Gene

mRNA expression in normal human tissues for SMAGP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMAGP Gene

This gene is overexpressed in Esophagus - Mucosa (11.7), Colon - Transverse (5.2), and Vagina (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMAGP Gene

SOURCE GeneReport for Unigene cluster for SMAGP Gene Hs.652389

mRNA Expression by UniProt/SwissProt for SMAGP Gene

Q0VAQ4-SMAGP_HUMAN
Tissue specificity: Detected in breast, endometrium, colon and biliary tract. Detected in polarized epithelial structures characterized by cell-cell adhesion (at protein level).
genes like me logo Genes that share expressions with SMAGP: view

Orthologs for SMAGP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMAGP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMAGP 35
  • 99.66 (n)
  • 98.97 (a)
SMAGP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SMAGP 35
  • 86.25 (n)
  • 82.47 (a)
SMAGP 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMAGP 35
  • 89.56 (n)
  • 89.16 (a)
SMAGP 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smagp 35
  • 86.11 (n)
  • 80.21 (a)
Smagp 16
Smagp 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMAGP 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smagp 35
  • 85.07 (n)
  • 80.21 (a)
lizard
(Anolis carolinensis)
Reptilia SMAGP 36
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18833 35
Species with no ortholog for SMAGP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMAGP Gene

ENSEMBL:
Gene Tree for SMAGP (if available)
TreeFam:
Gene Tree for SMAGP (if available)

Paralogs for SMAGP Gene

Selected SIMAP similar genes for SMAGP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SMAGP: view

No data available for Paralogs for SMAGP Gene

Variants for SMAGP Gene

Sequence variations from dbSNP and Humsavar for SMAGP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs814041 -- 51,267,752(-) gcact(C/T)tggga intron-variant
rs1298483 -- 51,248,994(-) caagc(A/G)attct intron-variant
rs1877260 -- 51,263,999(-) AAATA(A/T)TAAAA intron-variant
rs1877261 -- 51,263,852(-) ATAAA(A/G)GAAAT intron-variant
rs1975004 -- 51,267,730(+) gctca(A/G)tctgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMAGP Gene

Variant ID Type Subtype PubMed ID
esv34039 CNV Loss 18971310
nsv704 CNV Insertion 18451855
esv273161 CNV Insertion 20981092

Relevant External Links for SMAGP Gene

HapMap Linkage Disequilibrium report
SMAGP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMAGP Gene

Disorders for SMAGP Gene

No disorders were found for SMAGP Gene.

No data available for UniProtKB/Swiss-Prot for SMAGP Gene

Publications for SMAGP Gene

  1. SMAGP, a new small trans-membrane glycoprotein altered in cancer. (PMID: 15021913) Tarbe N.G. … Weidle U.H. (Oncogene 2004) 2 3 4
  2. Overexpression of the small transmembrane and glycosylated protein SMAGP supports metastasis formation of a rat pancreatic adenocarcinoma line. (PMID: 15986429) Tarbe N.G. … Zoeller M. (Int. J. Cancer 2005) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for SMAGP Gene

Sources for SMAGP Gene

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