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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SMAGP Gene

protein-coding   GIFtS: 44
GCID: GC12M051639

small cell adhesion glycoprotein

 Explore 3 diseases affiliated with
SMAGP via our new
 Human Malady Compendium 
Biological research products
for SMAGP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Small Cell Adhesion Glycoprotein1 2     MGC1494541
HSMAGP1     Small Cell Transmembrane And Glycosylated Protein2
Small Transmembrane And Glycosylated Protein2 3     Small Trans-Membrane And Glycosylated Protein2
MGC1494531     

External Ids:    HGNC: 269181   Entrez Gene: 572282   Ensembl: ENSG000001705457   UniProtKB: Q0VAQ43   

Export aliases for SMAGP gene to outside databases

Previous GC identifers: GC12M049926 GC12M048672


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SMAGP_HUMAN, Q0VAQ4
Function: May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis
formation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SMAGP gene promoter:
         AP-1   FOXF2   Msx-1   FOXL1   Evi-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SMAGP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SMAGP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

SMAGP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SMAGP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M051639:  view genomic region     (about GC identifiers)

Start:
51,639,133 bp from pter      End:
51,664,202 bp from pter
Size:
25,070 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SMAGP_HUMAN, Q0VAQ4 (See protein sequence)
Recommended Name: Small cell adhesion glycoprotein  
Size: 97 amino acids; 10679 Da
Subcellular location: Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle membrane; Single-pass
type III membrane protein. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions.
Detected on cytoplasmic membranes in undifferentiated tumors
Secondary accessions: A6NIL5

Explore the universe of human proteins at neXtProt for SMAGP: NX_Q0VAQ4

Post-translational modifications:

  • O-glycosylated. The O-glycan is modified with sialic acid residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q0VAQ4

  • SMAGP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001026798.1  NP_001029045.1  

    ENSEMBL proteins: 
     ENSP00000369446   ENSP00000381471  

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    Uscn Proteins for SMAGP

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005886plasma membrane IDA--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IDA--


    SMAGP for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q0VAQ4

    UniProtKB/Swiss-Prot: SMAGP_HUMAN, Q0VAQ4
    Similarity: Belongs to the SMAGP family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SMAGP_HUMAN, Q0VAQ4
    Function: May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis
    formation

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SMAGP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SMAGP (ENSP000003694464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SMAGP
    Search CenterWatch for drugs/clinical trials and news about SMAGP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SMAGP gene (2 alternative transcripts): 
    NM_001031628.1  NM_001033873.1  

    Unigene Cluster for SMAGP:

    Small cell adhesion glycoprotein
    Hs.652389  [show with all ESTs]
    Unigene Representative Sequence: BC045658
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380103(uc001rye.1 uc001ryf.1) ENST00000398453(uc001ryd.1)


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    hsa-miR-2110 hsa-miR-4330 hsa-miR-3176 hsa-miR-24 hsa-miR-4276 hsa-miR-3922-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Clone
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    Additional cDNA sequence: 

    AF091087.1 AK001839.1 BC001400.2 BC003379.1 BC008712.1 BC045658.1 BC120965.1 BC120966.1 
    CR456943.1 

    15 DOTS entries:

    DT.214646  DT.100777239  DT.100777242  DT.97842713  DT.100777240  DT.91753738  DT.100777244  DT.95361696 
    DT.100780451  DT.100696043  DT.100780452  DT.100009876  DT.205569  DT.205570  DT.305912 

    24/382 AceView cDNA sequences (see all 382):

    AA227362 AI142906 BE385332 CA430247 CR597407 AA677695 BM990900 AV650596 
    BC008712 BI089401 AK001839 AI753013 CD367613 AL546104 AA333877 C05483 
    BM982348 AA488618 AI377053 BG678644 CR620025 BI061065 CB147881 AU129717 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SMAGP (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
    SP1:        -     -     -     -     -           -           -     -                                 
    SP2:                          -     -           -           -     -                                 
    SP3:                          -     -           -           -     -                                 
    SP4:                                            -           -     -                                 
    SP5:                                                        -     -                                 


    ECgene alternative splicing isoforms for SMAGP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SMAGP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTACGTGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SMAGP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SMAGP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SMAGP

    SOURCE GeneReport for Unigene cluster: Hs.652389

    UniProtKB/Swiss-Prot: SMAGP_HUMAN, Q0VAQ4
    Tissue specificity: Detected in breast, endometrium, colon and biliary tract. Detected in polarized epithelial
    structures characterized by cell-cell adhesion (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAGP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SMAGP gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Smagp1 , 5 small cell adhesion glycoprotein1, 5 86.11(n)1
    80.21(a)1
      15 (56.37 cM)5
    2078181  NM_001033872.11  NP_001029044.11 
     1006213425 
    lizard
    (Anolis carolinensis)
    Reptilia SMAGP6
    --
    47(a)
    1 ↔ 1
    2(67600328-67602952)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.188332 Xenopus laevis transcribed sequences 87.05(n)    BG347115.1 


    ENSEMBL Gene Tree for SMAGP (if available)
    TreeFam Gene Tree for SMAGP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/439 NCBI SNPs in SMAGP are shown (see all 439    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113315421,2
    C,F,--51641036(+) TTTACA/-ATAAG 2 -- int13Minor allele frequency- -:0.50NA CSA 6
    rs1898638911,2
    --51641060(+) GTTGTA/GTGTGT 2 -- int10--------
    rs1460472451,2
    C,--51641134(+) CATTA-/TTTTTA 2 -- int10--------
    rs1482802401,2
    --51641145(+) TAACAA/TAATGA 2 -- int10--------
    rs761563711,2
    F,--51641239(+) TCCTCT/CACCCT 2 -- int11Minor allele frequency- C:0.02EA 120
    rs1831761541,2
    --51641475(+) TGGCTA/GATCCT 2 -- int10--------
    rs1172087861,2
    F,--51641539(+) ACTCAC/GCCACT 2 -- int11Minor allele frequency- G:0.12EA 120
    rs1411414691,2
    --51641628(+) CACTGC/TACCCC 2 -- int10--------
    rs1878596391,2
    --51641645(+) TGCACA/GGTGAG 2 -- int10--------
    rs1168530861,2
    --51641696(+) GGCCTG/CATCTA 2 -- int11Minor allele frequency- C:0.01NA 120

    HapMap Linkage Disequilibrium report for SMAGP (51639133 - 51664202 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SMAGP
         1 CNV: 47982

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SMAGP for disorders           About GeneDecksing

    3 diseases for SMAGP:    About MalaCards
    endocarditis    adenocarcinoma    pancreatitis


    Export disorders for SMAGP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SMAGP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SMAGP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SMAGP, a new small trans-membrane glycoprotein altered in cancer. (PubMed id 15021913)1, 2, 3 Tarbe N.G.... Weidle U.H. (2004)
    2. Overexpression of the small transmembrane and glycosylated protein SMAGP supports metastasis formation of a rat pancreatic adenocarcinoma line. (PubMed id 15986429)1, 2 Tarbe N.G.... Zoeller M. (2005)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57228 HGNC: 26918 AceView: TFCP2 Ensembl:ENSG00000170545 euGenes: HUgn57228
    ECgene: SMAGP H-InvDB: SMAGP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SMAGP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SMAGP gene:
    Search GeneIP for patents involving SMAGP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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