SMAD7 Gene
protein-coding GIFtS : 66 GCID: GC18 M046446
SMAD family member 7 MAD, mothers against decapentaplegic homolog 7 (Drosophila),... MADH8, MADH7 )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor SMAD7 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases SMAD Family Member 7 1 2 3 MAD (Mothers Against Decapentaplegic, Drosophila) Homolog 72 MADH71 2 3 5 Mothers Against Decapentaplegic Homolog 72 MADH81 2 3 Mothers Against Decapentaplegic, Drosophila, Homolog Of, 72 Mothers Against DPP Homolog 82 3 SMAD, Mothers Against DPP Homolog 72 HSMAD71 Smad73 MAD Homolog 82 3 MAD Homolog 73 CRCS32 5 Mothers Against Decapentaplegic Homolog 83 MAD, Mothers Against Decapentaplegic Homolog 7 (Drosophila)1 Mothers Against DPP Homolog 73 SMAD, Mothers Against DPP Homolog 7 (Drosophila)1 SMAD 73
Export aliases for SMAD7 gene to outside databases Previous GC identifers: GC18M044699 GC18M044700 GC18M043299
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor SMAD7 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SMAD7 : The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2010) UniProtKB/Swiss-Prot: SMAD7_HUMAN, O15105 Function : Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; hasbeen shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity) Gene Wiki entry for SMAD7 (Mothers against decapentaplegic homolog 7)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor SMAD7 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000018.9 NC_018929.1 NT_010966.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SMAD7 gene promoter:AhR STAT1 Pax-5 HFH-1 p300 MyoD HNF-4alpha1 Other transcription factors Search SABiosciences Chromatin IP Primers for SMAD7 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1 SMAD7 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 18 GeneLoc Exon Structure
GeneLoc location for GC18M046446: view genomic region
(about GC identifiers )
Start: 46,446,223 bp from pter End:
46,477,081 bp from pter
Size: 30,859 bases Orientation:
minus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor SMAD7 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SMAD7_HUMAN, O15105 See
protein sequence )Recommended Name: Size : 426 amino acids; 46426 DaSubunit : Interacts with WWP1 (By similarity). Interacts with COPS5. Interacts with NEDD4L. Interacts with STAMBP.Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts (via MH2 domain) with EP300. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation. Interacts with PDPK1 (via PH domain)
Subcellular location : Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 or induces translocation from thenucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta
6/7 PDB 3D structures from (see all 7 ):2DJY (3D) 2KXQ (3D) 2LTV (3D) 2LTW (3D) 2LTX (3D) 2LTY (3D) Secondary accessions : B7Z773 O14740 Q6DK23Alternative splicing : 2 isoforms : O15105-1 O15105-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SMAD7: NX_O15105 Post-translational modifications:
Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK11
Ubiquitinated by WWP1 (By similarity). Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation. In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation1
Acetylation prevents ubiquitination and degradation mediated by SMURF11 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O15105 SMAD7 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (4 alternative transcripts): NP_001177750.1 NP_001177751.1 NP_001177752.1 NP_005895.1 ENSEMBL proteins: ENSP00000262158 ENSP00000466902 ENSP00000467621 ENSP00000465590 Reactome Protein details: O15105 Human Recombinant Protein Products: Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing SMAD7 Antibody Products: Assay Products for SMAD7:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains /for SMAD7 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry O15105 ProtoNet protein and cluster: O15105
1 Blocks protein family : IPB001132 UniProtKB/Swiss-Prot: SMAD7_HUMAN, O15105 Similarity : Belongs to the dwarfin/SMAD familySimilarity : Contains 1 MH1 (MAD homology 1) domainSimilarity : Contains 1 MH2 (MAD homology 2) domain
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor SMAD7 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SMAD7_HUMAN, O15105 Function : Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; hasbeen shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity) Induction : By TGFB1
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): SMAD7 (NM_005904 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMAD7 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMAD7
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAD7
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing 1 GenomeRNAi human phenotype for SMAD7 :Animal Models: Smad7 tm1.1Shou Smad7 tm1Rheu Smad7 tm1.2Ink 11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Smad7) :About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor SMAD7 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/20 super-pathways (see all 20 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Immune response_IFN gamma signaling pathway 2 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 3 Development_TGF-beta receptor signaling 4 Generic Transcription Pathway 5 Signaling by BMP
Pathway sources See GeneCards unified pathways Show all pathways 3 1 3 5/9 (see all 9 ) 5/12 (see all 12 )2 (Kegg details for SMAD7) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SMAD7 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/125 Interacting proteins for SMAD7 (O15105 1 , 2 , 3 ENSP00000262158 4 via UniProtKB, MINT, STRING , and/or I2D (see all 125 )About this table Gene Ontology (GO): 5/38 biological process terms (GO ID links to tree view) (see all 38 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000122 negative regulation of transcription from RNA polymerase II promoter
IDA 17438144 GO:0001657 ureteric bud development
IEA -- GO:0006351 transcription, DNA-dependent
TAS -- GO:0006367 transcription initiation from RNA polymerase II promoter
TAS -- GO:0007179 transforming growth factor beta receptor signaling pathway
TAS --
About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor SMAD7 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for SMAD7 10/18 Novoseek chemical compound relationships for SMAD7 gene (see all 18 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tgf beta1
71.9
6
17469181 (2), 16871886 (1), 17763417 (1), 20196115 (1) (see all 5 )
sb 203580
40.9
2
15905080 (1)
hydroxyproline
24.6
3
18430418 (2), 18992195 (1)
matrigel
17.9
2
16407850 (1), 16007121 (1)
bleomycin
16.4
9
10393693 (5), 16187293 (1), 12761881 (1)
oligonucleotide
10.8
3
19079231 (1), 12464953 (1), 14586410 (1)
pd 98,059
7.52
1
12615364 (1)
cycloheximide
4.21
2
10896788 (1)
glucose
2.78
4
12753288 (2), 19674192 (1)
vegf
1.85
5
16902401 (2), 15492278 (1), 19450457 (1), 20006606 (1)
SMAD7
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor SMAD7 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SMAD7 gene (4 alternative transcripts): NM_001190821.1 NM_001190822.1 NM_001190823.1 NM_005904.3 Unigene Cluster for SMAD7:
SMAD family member 7 Hs.465087 [show with all ESTs ] Unigene Representative Sequence: AF010193 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000262158 (uc002ldg.3 uc021ujr.1 ) ENST00000545051 (uc002ldf.3 uc010xde.2 )ENST00000591805 ENST00000589634 ENST00000587336 ENST00000585986 ENST00000586093 ENST00000588190 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): SMAD7 (NM_005904 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SMAD7 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMAD7
Additional cDNA sequence: AF010193.1 AF015261.1 AK131394.1 AK301535.1 BC074818.2 BC074819.2
6 DOTS entries : DT.313061 DT.99955302
DT.100745695 DT.121083990 DT.40212194 DT.121083988 24/69 AceView cDNA sequences (see all 69 ):
AF015261 AI635141 BQ189164 AA347448 AW170511 CD671921 BC074818 AA347449 AW614916 AI215892 AW339682 AA683504 CD679259 BU731315 CK903955 AA347306 BC074819 AK131394 BX111807 BE046204 BM479978 BM052739 AA347307 AI807690 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SMAD7 (see all 6 ) About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e SP1 : - - SP2 : - - - - SP3 : - - - - SP4 : - - SP5 : -
ECgene alternative splicing isoforms for SMAD7
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for SMAD7 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SMAD7 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTTAGACTTT
About this image SMAD7 expression in embryonic tissues and stem cells About this table See SMAD7 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SMAD7 SOURCE GeneReport for Unigene cluster: Hs.465087 UniProtKB/Swiss-Prot: SMAD7_HUMAN, O15105 Tissue specificity : Ubiquitous with higher expression in the lung and vascular endotheliumSABiosciences Expression via Pathway-Focused PCR Arrays including SMAD7 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAD7
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor SMAD7 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for SMAD7 gene from 5/18 species (see all 18 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves SMAD76
Uncharacterized protein
89(a)
1 ↔ 1
Z(1122718-1131903)
lizard Reptilia SMAD76
--
95(a)
1 ↔ 1
2(518218-571058)
African clawed frog Amphibia madh72
MAD, mothers against decapentaplegic homolog 7 (Drosophila)
81.46(n)
BC059286.1
zebrafish Actinopterygii madh72
MAD, mothers against decapentaplegic homolog 7 (Drosophila)
81.68(n)
326282 AY134491.1
fruit fly Insecta Dad6
Daughters against dpp
19(a)
1 → many
3R(12879729-12896135)
ENSEMBL Gene Tree for SMAD7 (if available)TreeFam Gene Tree for SMAD7 (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor SMAD7 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SMAD7 gene SMAD2 2 SMAD3 2 SMAD1 2 SMAD5 2 SMAD6 2 SMAD9 2 SMAD4 2 4 SIMAP similar genes for SMAD7 using alignment to 3 protein entries: SMAD7_HUMAN (see all proteins ):SMAD3 SMAD4 SMAD6 SMAD1 About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor SMAD7 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 18 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for SMAD7 (46446223 - 46477081 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SMAD7: -- Human Gene Mutation Database (HGMD) : SMAD7 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor SMAD7 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 602932 OMIM disorders : 612229 UniProtKB/Swiss-Prot: SMAD7_HUMAN, O15105 Genetic variations in SMAD7 influence susceptibility to colorectal cancer type 3 (CRCS3) [MIM:612229]. Colorectal cancer consists of tumors or cancer of either the colon or rectum or both. Cancers of the large intestine are the second most common form of cancer found in males and females. Symptoms include rectal bleeding, occult blood in stools, bowel obstruction and weight loss. Treatment is based largely on the extent of cancer penetration into the intestinal wall. Surgical cures are possible if the malignancy is confined to the intestine. Risk can be reduced when following a diet which is low in fat and high in fiber 20/54 (see all 54 ): About MalaCards colorectal cancer fibrodysplasia ossificans progressiva lichen planus oral lichen planus localized scleroderma inflammatory bowel disease ureteral obstruction esophageal squamous cell carcinoma squamous cell carcinoma pancreatic ductal adenocarcinoma adult t-cell leukemia chronic lymphocytic leukemia keloids lymphocytic leukemia leukemia/lymphoma scleroderma familial colorectal cancer malignant glioma fibrosis leiomyoma 1 disease from the University of Copenhagen DISEASES database for SMAD7 :Ureteral obstruction 10/38 Novoseek disease relationships for SMAD7 gene (see all 38 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
renal fibrosis
51.5
2
18508563 (1), 15193216 (1)
keloid
46.9
7
17144456 (4), 19781253 (2), 16156269 (1)
pancreatic cancer
46.2
19
15150118 (4), 10498890 (3), 16714330 (3), 15811853 (2) (see all 7 )
scars hypertrophic
45.6
1
18616749 (1)
pulmonary fibrosis
38.8
7
10393693 (3)
liver fibrosis
35.5
3
19878580 (2), 19861282 (1)
diabetic nephropathies
27.2
2
19959709 (1), 12397035 (1)
aggressiveness
21.4
1
12952364 (1)
pancreatic carcinoma
21.3
2
12140283 (1), 9892110 (1)
colon adenocarcinoma
21
2
15922743 (1), 18781153 (1)
Genetic Association Database (GAD): SMAD7 Human Genome Epidemiology (HuGE) Navigator: SMAD7 (32 documents) Export disorders for SMAD7 gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor SMAD7 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SMAD7 gene, integrated from 9 sources (see all 411 ):(articles sorted by number of sources associating them with SMAD7) Utopia : connect your pdf to the dynamic
Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. (PubMed id 9256479) 1 , 2 , 3, 9(1997) Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. (PubMed id 9335507) 1 , 2 , 9(1997) Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. (PubMed id 11278251) 1 , 2 , 9(2001) Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation. (PubMed id 11163210) 1 , 2 , 9(2000) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. (PubMed id 16601693) 1 , 2 , 9(2006) Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation. (PubMed id 14993265) 1 , 2 , 9(2004) GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. (PubMed id 14718519) 1 , 2 , 9(2004) Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7. (PubMed id 14657019) 1 , 2 , 9(2003) The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. (PubMed id 9215638) 1 , 2 , 9(1997) An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. (PubMed id 16641086) 1 , 2 , 9(2006)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for SMAD7 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing SMAD7 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing SMAD7 gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing SMAD7 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for SMAD7 gene: SMAD7 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor SMAD7 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for SMAD7 OriGene shRNA RFP for SMAD7 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for SMAD7 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SMAD7 OriGene 3'-UTR Clone for SMAD7 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for SMAD7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SMAD7 OriGene Custom Protein Services for SMAD7 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SMAD7 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for SMAD7
SMAD7 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMAD7
ThermoFisher Antibodies for SMAD7
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SMAD7
Jump to Section...
Aliases for SMAD7
Databases for SMAD7
Disorders / Diseases for SMAD7
Domains / Families for SMAD7
Drugs / Compounds for SMAD7
Expression for SMAD7
Function for SMAD7
Genomic Views for SMAD7
Intellectual Property for SMAD7
Orthologs for SMAD7
Paralogs for SMAD7
Pathways / Interactions for SMAD7
Products for SMAD7
Proteins for SMAD7
Publications for SMAD7
Search Box for SMAD7
Summaries for SMAD7
Transcripts for SMAD7
Variants for SMAD7
TOP
BOTTOM
and Proteopedia 
for SMAD7 (
Kegg Pathways 
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
In-situ hybridization
