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SMAD6 Gene

protein-coding GIFtS: 60

GC15P064781

SMAD family member 6
(Previous names: MAD, mothers against decapentaplegic homolog 6 (Drosophila), SMAD, mothers against DPP homolog 6 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MADH7, MADH6)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
HsT17432 ^¹, ²
MADH6 ^², ³, ⁵
MADH7 ^²
Smad6 ^³
hSMAD6 ^³

Descriptions
MAD (mothers against decapentaplegic, Drosophila) homolog 6 ^²
MAD, mothers against decapentaplegic homolog 6 (Drosophila) ^¹
Mothers against DPP homolog 6 ^³
Mothers against decapentaplegic, drosophila, homolog of, 6 ^²
SMAD 6 ^³
SMAD family member 6 ^²
SMAD, mothers against DPP homolog 6 ^²
SMAD, mothers against DPP homolog 6 (Drosophila) ^¹

External Ids
HGNC: 6772¹
Entrez Gene: 4091²
UniProtKB: O43541³
Ensembl: ENSG00000137834⁷

Search outside databases for aliases for SMAD6 gene

Previous GC identifer: GC15P064681

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SMAD6:

The protein encoded by this gene belongs to the SMAD family of proteins, which are related to

Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are

signal transducers and transcriptional modulators that mediate multiple signaling pathways. This

protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple

transcript variants encoding different isoforms have been found for this gene.

UniProtKB/Swiss-Prot: SMAD6_HUMAN, O43541

Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor

superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins)

signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory

SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions

Gene Wiki entry for SMAD6 (Mothers_against_decapentaplegic_homolog_6)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SMAD6 gene

Entrez Gene cytogenetic band: 15q21-q22 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q21-q22

SMAD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P064781: (about GC identifiers)

Start:	64,781,688 bp from pter
End:	64,861,380 bp from pter
Size:	79,693 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SMAD6_HUMAN, O43541 (See protein sequence)

Recommended Name: Mothers against decapentaplegic homolog 6

Size: 496 amino acids; 53497 Da

Subunit: Interacts with NEDD4L (By similarity). Interacts with RNF111 and AXIN1. Interacts with

TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and

PRKX

Subcellular location: Nucleus

Secondary accessions: A9J6M5 O43654 Q15799 Q7Z7L4 Q96E31 Q9UKZ3

Alternative splicing: 4 isoforms: O43541-1 O43541-2 O43541-3 O43541-4

Post-translational modifications:

Phosphorylated by BMP type 1 receptor kinase and by PRKX¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001136333.1 NP_005576.3

ENSEMBL proteins:

ENSP00000345054 ENSP00000288840

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SMAD6)
	Human Recombinant Proteins from Abnova (SMAD6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005667	transcription factor complex	IEA	--
GO:0005737	cytoplasm	TAS	19018011
GO:0005829	cytosol	EXP	9436979

About this table

Antibodies for SMAD6:

	Invitrogen Antibodies for SMAD6
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SMAD6
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for SMAD6
	Antibodies from Abcam (SMAD6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SMAD6)
	Novus Biologicals Antibodies for SMAD6

Assays for SMAD6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O43541

ProtoNet protein and cluster: O43541

1 Blocks protein family: IPB001132 Dwarfin protein

UniProtKB/Swiss-Prot: SMAD6_HUMAN, O43541

Similarity: Belongs to the dwarfin/SMAD family

Similarity: Contains 1 MH1 (MAD homology 1) domain

Similarity: Contains 1 MH2 (MAD homology 2) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SMAD6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SMAD6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005585

Applied Biosystems Silencer® siRNAs for SMAD6

Sigma-Aldrich siRNA for SMAD6

Sigma-Aldrich shRNA for SMAD6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SMAD6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142861
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142861
untagged cDNA clones in CMV expression vector (see all 3): NM_001142861

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005585

UniProtKB/Swiss-Prot: SMAD6_HUMAN, O43541

Function: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor

superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins)

signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory

SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Smad6):

homeostasis/metabolism

lethality-postnatal

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	IDA	9256479
GO:0031625	ubiquitin protein ligase binding	IPI	11278251
GO:0034713	type I transforming growth factor beta receptor binding	IDA	9436979
GO:0042803	protein homodimerization activity	IPI	9436979

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for SMAD6 (Your Favorite Gene powered by Ingenuity) (see all 6 )

TGF-&beta
Human Embryonic Stem Cell Pluripotency
Cardiomyocyte Differentiation via BMP Receptors
RAR Activation
Molecular Mechanisms of Cancer

GeneDecks SMAD6 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for SMAD6

5/57 Interacting proteins for SMAD6 (O43541^{1, 2} ENSP00000288840³) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMURF2	Q9HAU4², ENSP00000262435³	MINT-61796 STRING (score=.982)
RUNX2	Q13950¹, ENSP00000352514³	EBI-976374, EBI-976402 STRING (score=.98)
Runx2 Runx2 (xeno)	Q08775¹	EBI-976374, EBI-903354
SMURF1	ENSP00000354621³	STRING (score=.997)
BMP2	ENSP00000368104³	STRING (score=.996)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006955	immune response	IMP	16886151
GO:0007352	zygotic determination of dorsal/ventral axis	IMP	9436979
GO:0030514	negative regulation of BMP signaling pathway	IDA	9436979

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SMAD6
1 Novoseek chemical compound relationship for SMAD6 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	0.00	1	12397035 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SMAD6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SMAD6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005585

Sigma-Aldrich siRNA for SMAD6

Sigma-Aldrich shRNA for SMAD6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001142861 NM_005585

REFSEQ mRNAs for SMAD6 gene (2 alternative transcripts):

NM_001142861.2 NM_005585.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001142861 NM_005585

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142861
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142861
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001142861

Additional cDNA sequence:

AF035528.1 AF037469.1 AF043640.1 AM909653.1 BC012986.2 BC029288.1 U59914.1

4 DOTS entries:

DT.448546 DT.40197628 DT.101958886 DT.92016400

24/221 AceView cDNA sequences (see all 221 ):

AI074483 AW044343 BM704524 BU727453 BF594048 BE467124 AI246158 BF589206

AI193899 BF115451 BQ070275 AW015926 AI268197 AI453564 AI797117 AW182279

BG055424 AI377382 AI199866 AF037469 AI381905 BQ776596 AA007517 AI769301

highest scoring ESTs for SMAD6:

AF035528 AA007517 AA007518 AA045002 AA046567 AA131266 AA131352 AA136175 AA233107 AA243739

Unigene Cluster for SMAD6:

SMAD family member 6

Hs.153863 [show with all ESTs]

Unigene Representative Sequence: NM_005585

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000338426 ENST00000288840

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SMAD6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SMAD6

¹ / ² / ³

5 probe-sets matching SMAD6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1955_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF035528	1.00	1.00	1.00	1
207069_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005585	0.60	1.00	0.82	1
209886_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI628464	0.60	1.00	0.82	1
207069_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209886_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SMAD6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAGAAGAAG

SOURCE GeneReport for Unigene cluster: Hs.153863
Expression variation in blood from EXPOLDB for SMAD6
UniProtKB/Swiss-Prot: SMAD6_HUMAN, O43541
Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is
up-regulated in diseased heart tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SMAD6 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SMAD6¹	--	SMAD family member 6	94.89(n) 95.56(a)	487612 XM_544737.2 XP_544737.2
chimpanzee (Pan troglodytes)	SMAD6¹	--	SMAD family member 6	99.26(n) 99.4(a)	467711 XM_523105.2 XP_523105.2
cow (Bos taurus)	SMAD6¹	--	SMAD family member 6	95.36(n) 95.77(a)	511279 XM_864907.2 XP_870000.1
rat (Rattus norvegicus)	Smad6¹	--	SMAD family member 6	91.67(n) 94.72(a)	367100 XM_345947.3 XP_345948.2
mouse (Mus musculus)	Smad6^{1, 5}	9⁵	MAD homolog 6 (Drosophila)^{1, 5}	91.8(n)¹ 94.31(a)¹	17130¹ NM_008542.2¹ NP_032568.2¹ AB221689⁵ AF010133⁵ (see all 8)

About this table Species with no ortholog for SMAD6

ENSEMBL Gene Tree for SMAD6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SMAD6 gene

SMAD4² SMAD7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/498 NCBI SNPs in SMAD6 are shown (see all 498 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 204)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4776318^1,2	A,C,F,H	64861711(+)	`CCATGC/ACCCCC`	1	--	ng3¹		7		NA EU EA WA	542
	rs2278601^1,2	C,F,H	64781292(+)	`CGTCCG/AAGTCT`	1	--	ng5¹		5		EA EU WA	1900
--	rs8042578^1,2	A,C,F	64780018(+)	`ATCTCC/GAGGGA`	1	--	ng5¹		1		NA	65
--	rs4776822^1,2	A,C	64782377(+)	`TTGTTA/GAGCAG`	1	--	ut5¹		0	--	--	--	--
--	rs8041981^1,2	A	64779769(+)	`GTAATA/CCACAG`	1	--	ng5¹		0	--	--	--	--
--	rs45604646^1,2	F	64782084(+)	`GGGATG/AAAGGG`	1	--	ut5¹		1		NA	26
--	rs45615538^1,2	F	64861144(+)	`TGGTGT/CAATTC`	2	--	ut3¹		1		NA	44
--	rs45549936^1,2	F	64782332(+)	`TGGCGG/AAGCAG`	1	--	ut5¹		1		NA	24
--	rs45536731^1,2	F	64781839(+)	`GGGCGC/TGGGCT`	1	--	ut5¹		1		NA	40
	rs12591946^1,2	C,F,H	64860603(+)	`GGCTTC/TGGCAT`	2	F/F	syn¹ ese³		4		EU EA WA	418

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HapMap Linkage Disequilibrium images for SMAD6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602931

5 Novoseek disease relationships for SMAD6 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic cancer	17.44	1	11135319 (1)
renal disease	0.00	1	12397035 (1)
tumors	0.00	2	10942134 (1), 14633701 (1)
hepatocellular carcinoma	0.00	1	11408948 (1)
carcinoma squamous cell	0.00	2	15736400 (1), 14633701 (1)

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Human Genome Epidemiology Navigator: SMAD6 (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/128 PubMed articles for SMAD6 gene (see all 128 ):

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. (PubMed id 9256479)^{1, 2, 3} Topper J.N.... Falb D. (1997)
Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads. (PubMed id 11483516)^{1, 3, 4} Itoh F.... Itoh S. (2001)
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members. (PubMed id 9712726)^{1, 3, 4} Afrakhte M.... ten Dijke P. (1998)
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. (PubMed id 16601693)^{3, 4} Liu W.... Lin S.-C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7. (PubMed id 14657019)^{3, 4} Koinuma D.... Miyazono K. (2003)
TGF-beta signaling by Smad proteins. (PubMed id 10708949)^{3, 4} Miyazono K. (2000)
The Smad pathway. (PubMed id 10708948)^{3, 4} Wrana J.L. and Attisano L. (2000)
Smad6 as a transcriptional corepressor. (PubMed id 10722652)^{3, 4} Bai S.... Cao X. (2000)
Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells. (PubMed id 10647776)^{3, 4} Verschueren K. and Huylebroeck D. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4091	HGNC: 6772	AceView: SMAD6	Ensembl:ENSG00000137834	euGenes: HUgn4091
ECgene: SMAD6	H-InvDB: SMAD6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for SMAD6	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SMAD6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SMAD6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SMAD6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SMAD6		Antibodies for SMAD6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SMAD6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SMAD6)
	Antibodies (SMAD6)
	Chimera RNAi (SMAD6)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for SMAD6

	Recombinant Proteins (SMAD6)
	Antibodies (SMAD6)

Search OriGene for SMAD6

Search Tocris compounds for SMAD6

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SMAD6

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SMAD6 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for SMAD6

Summaries
for SMAD6

Genomic Location
for SMAD6

Proteins
for SMAD6

Protein Domains/
Families
for SMAD6

Gene Function
for SMAD6

Pathways & Interactions
for SMAD6

Drugs & Compounds
for SMAD6

Transcripts
for SMAD6

Expression
for SMAD6

Orthologs
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Medical News
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Services
for SMAD6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SMAD6 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor SMAD6

Summariesfor SMAD6

Genomic Locationfor SMAD6

Proteinsfor SMAD6

Protein Domains/Familiesfor SMAD6

Gene Functionfor SMAD6

Pathways & Interactionsfor SMAD6

Drugs & Compoundsfor SMAD6

Transcriptsfor SMAD6

Expression for SMAD6

Orthologsfor SMAD6

Paralogsfor SMAD6

SNPs/Variantsfor SMAD6

Disorders & Mutationsfor SMAD6

Medical Newsfor SMAD6

Publicationsfor SMAD6

Search for SMAD6

Genome Databases showing SMAD6

Other Databases showing SMAD6

Specialized Databases showing SMAD6

Licensable Technologiesfor SMAD6

Servicesfor SMAD6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SMAD6

Summaries
for SMAD6

Genomic Location
for SMAD6

Proteins
for SMAD6

Protein Domains/
Families
for SMAD6

Gene Function
for SMAD6

Pathways & Interactions
for SMAD6

Drugs & Compounds
for SMAD6

Transcripts
for SMAD6

Expression
for SMAD6

Orthologs
for SMAD6

Paralogs
for SMAD6

SNPs/Variants
for SMAD6

Disorders & Mutations
for SMAD6

Medical News
for SMAD6

Publications
for SMAD6

Licensable Technologies
for SMAD6

Services
for SMAD6