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Aliases for SMAD3 Gene

Aliases for SMAD3 Gene

  • SMAD Family Member 3 2 3 4
  • MADH3 3 4 6
  • Mothers Against DPP Homolog 3 3 4
  • MAD Homolog 3 3 4
  • JV15-2 3 4
  • HMAD-3 3 4
  • HSMAD3 3 4
  • MAD3 3 4
  • LDS3 3 6
  • MAD, Mothers Against Decapentaplegic Homolog 3 (Drosophila) 2
  • SMAD, Mothers Against DPP Homolog 3 (Drosophila) 2
  • MAD, Mothers Against Decapentaplegic Homolog 3 3
  • Mothers Against Decapentaplegic Homolog 3 3
  • SMAD, Mothers Against DPP Homolog 3 3
  • SMA- And MAD-Related Protein 3 3
  • Mad Protein Homolog 3
  • Mad Homolog JV15-2 3
  • HsT17436 3
  • HSPC193 3
  • SMAD 3 4
  • LDS1C 3
  • Smad3 4

External Ids for SMAD3 Gene

Previous HGNC Symbols for SMAD3 Gene

  • MADH3

Previous GeneCards Identifiers for SMAD3 Gene

  • GC15P065075
  • GC15P065145
  • GC15P067358
  • GC15P044193

Summaries for SMAD3 Gene

Entrez Gene Summary for SMAD3 Gene

  • The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]

GeneCards Summary for SMAD3 Gene

SMAD3 (SMAD Family Member 3) is a Protein Coding gene. Diseases associated with SMAD3 include loeys-dietz syndrome, type 3 and smad3-related loeys-dietz syndrome. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is SMAD1.

UniProtKB/Swiss-Prot for SMAD3 Gene

  • Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Gene Wiki entry for SMAD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMAD3 Gene

Genomics for SMAD3 Gene

Regulatory Elements for SMAD3 Gene

Genomic Location for SMAD3 Gene

Start:
67,063,763 bp from pter
End:
67,195,195 bp from pter
Size:
131,433 bases
Orientation:
Plus strand

Genomic View for SMAD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SMAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMAD3 Gene

Proteins for SMAD3 Gene

  • Protein details for SMAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84022-SMAD3_HUMAN
    Recommended name:
    Mothers against decapentaplegic homolog 3
    Protein Accession:
    P84022
    Secondary Accessions:
    • A8K4B6
    • B7Z4Z5
    • B7Z6M9
    • B7Z9Q2
    • F5H383
    • O09064
    • O09144
    • O14510
    • O35273
    • Q92940
    • Q93002
    • Q9GKR4

    Protein attributes for SMAD3 Gene

    Size:
    425 amino acids
    Molecular mass:
    48081 Da
    Quaternary structure:
    • Monomer; in the absence of TGF-beta. Homooligomer; in the presence of TGF-beta. Heterotrimer; forms a heterotrimer in the presence of TGF-beta consisting of two molecules of C-terminally phosphorylated SMAD2 or SMAD3 and one of SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex. Interacts with TGFBR1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Interacts with AIP1, TGFB1I1, TTRAP, FOXL2, PML, PRDM16, HGS, WWP1 and SNW1. Interacts (via MH2 domain) with CITED2 (via C-terminus). Interacts with NEDD4L; the interaction requires TGF-beta stimulation. Interacts (via the MH2 domain) with ZFYVE9. Interacts with HDAC1, VDR, TGIF and TGIF2, RUNX3, CREBBP, SKOR1, SKOR2, SNON, ATF2, SMURF2 and TGFB1I1. Interacts with DACH1; the interaction inhibits the TGF-beta signaling. Forms a complex with SMAD2 and TRIM33 upon addition of TGF-beta. Found in a complex with SMAD3, RAN and XPO4. Interacts in the complex directly with XPO4. Interacts (via the MH2 domain) with LEMD3; the interaction represses SMAD3 transcriptional activity through preventing the formation of the heteromeric complex with SMAD4 and translocation to the nucleus. Interacts with RBPMS. Interacts (via MH2 domain) with MECOM. Interacts with WWTR1 (via its coiled-coil domain). Interacts (via the linker region) with EP300 (C-terminal); the interaction promotes SMAD3 acetylation and is enhanced by TGF-beta phosphorylation in the C-terminal of SMAD3. This interaction can be blocked by competitive binding of adenovirus oncoprotein E1A to the same C-terminal site on EP300, which then results in partially inhibited SMAD3/SMAD4 transcriptional activity. Interacts with SKI; the interaction represses SMAD3 transcriptional activity. Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. Interacts (via an N-terminal domain) with JUN (via its basic DNA binding and leucine zipper domains); this interaction is essential for DNA binding and cooperative transcriptional activity in response to TGF-beta. Interacts with PPM1A; the interaction dephosphorylates SMAD3 in the C-terminal SXS motif leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of TGF-beta signaling. Interacts (dephosphorylated form via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling. Interacts with MEN1. Interacts with IL1F7. Interaction with CSNK1G2. Interacts with PDPK1 (via PH domain). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation. Interacts with USP15. Interacts with PPP5C; the interaction decreases SMAD3 phosphorylation and protein levels. Interacts with LDLRAD4 (via the SMAD interaction motif). Interacts with PMEPA1.

    Three dimensional structures from OCA and Proteopedia for SMAD3 Gene

    Alternative splice isoforms for SMAD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMAD3 Gene

Proteomics data for SMAD3 Gene at MOPED

Post-translational modifications for SMAD3 Gene

  • Acetylation in the nucleus by EP300 in the MH2 domain regulates positively its transcriptional activity and is enhanced by TGF-beta.
  • Phosphorylated on serine and threonine residues. Enhanced phosphorylation in the linker region on Thr-179, Ser-204 and Ser-208 on EGF and TGF-beta treatment. Ser-208 is the main site of MAPK-mediated phosphorylation. CDK-mediated phosphorylation occurs in a cell-cycle dependent manner and inhibits both the transcriptional activity and antiproliferative functions of SMAD3. This phosphorylation is inhibited by flavopiridol. Maximum phosphorylation at the G(1)/S junction. Also phosphorylated on serine residues in the C-terminal SXS motif by TGFBR1 and ACVR1. TGFBR1-mediated phosphorylation at these C-terminal sites is required for interaction with SMAD4, nuclear location and transactivational activity, and appears to be a prerequisite for the TGF-beta mediated phosphorylation in the linker region. Dephosphorylated in the C-terminal SXS motif by PPM1A. This dephosphorylation disrupts the interaction with SMAD4, promotes nuclear export and terminates TGF-beta-mediated signaling. Phosphorylation at Ser-418 by CSNK1G2/CK1 promotes ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Phosphorylated by PDPK1.
  • Poly-ADP-ribosylated by PARP1 and PARP2. ADP-ribosylation negatively regulates SMAD3 transcriptional responses during the course of TGF-beta signaling.
  • Ubiquitinated. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes.
  • Ubiquitination at Lys33 and Lys81
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SMAD3 Gene

Domains for SMAD3 Gene

Gene Families for SMAD3 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

P84022

UniProtKB/Swiss-Prot:

SMAD3_HUMAN :
  • P84022
Domain:
  • The MH1 domain is required for DNA binding. Also binds zinc ions which are necessary for the DNA binding
  • The MH2 domain is required for both homomeric and heteromeric interactions and for transcriptional regulation. Sufficient for nuclear import
  • The linker region is required for the TGFbeta-mediated transcriptional activity and acts synergistically with the MH2 domain
  • Contains 1 MH1 (MAD homology 1) domain.
  • Contains 1 MH2 (MAD homology 2) domain.
Family:
  • Belongs to the dwarfin/SMAD family.
genes like me logo Genes that share domains with SMAD3: view

Function for SMAD3 Gene

Molecular function for SMAD3 Gene

UniProtKB/Swiss-Prot Function: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Gene Ontology (GO) - Molecular Function for SMAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 21947082
GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IDA 21947082
GO:0000987 core promoter proximal region sequence-specific DNA binding IDA 18832382
GO:0000988 contributes_to protein binding transcription factor activity IDA 18832382
GO:0001102 RNA polymerase II activating transcription factor binding IPI 17251190
genes like me logo Genes that share ontologies with SMAD3: view
genes like me logo Genes that share phenotypes with SMAD3: view

Animal Models for SMAD3 Gene

MGI Knock Outs for SMAD3:
Targeting motifs for SMAD3 Gene
HOMER Transcription Factor Regulatory Elements motif SMAD3
  • Consensus sequence: TWGTCTGV Submotif: canonical Cell Type: NPC GeoId: GSE36673

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for SMAD3 Gene

Localization for SMAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMAD3 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Co-localizes with LEMD3 at the nucleus inner membrane. MAPK-mediated phosphorylation appears to have no effect on nuclear import. PDPK1 prevents its nuclear translocation in response to TGF-beta.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SMAD3 Gene COMPARTMENTS Subcellular localization image for SMAD3 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3
cytoskeleton 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SMAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 21828274
GO:0005622 intracellular --
GO:0005634 nucleus IDA 12446380
GO:0005637 nuclear inner membrane IDA 15647271
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SMAD3: view

Pathways for SMAD3 Gene

genes like me logo Genes that share pathways with SMAD3: view

Gene Ontology (GO) - Biological Process for SMAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0001501 skeletal system development --
GO:0001649 osteoblast differentiation --
GO:0001657 ureteric bud development IEA --
GO:0001666 response to hypoxia IMP 12411310
genes like me logo Genes that share ontologies with SMAD3: view

Compounds for SMAD3 Gene

(40) Novoseek inferred chemical compound relationships for SMAD3 Gene

Compound -log(P) Hits PubMed IDs
tgf beta1 78.1 26
wp631 75.2 1
threonine 50.9 7
serine 47.6 20
rpa 2 44.4 2
genes like me logo Genes that share compounds with SMAD3: view

Transcripts for SMAD3 Gene

Unigene Clusters for SMAD3 Gene

SMAD family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SMAD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17
SP1: - - - - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - - - - - - - - - - - - - - -
SP9:
SP10:
SP11: - - -

Relevant External Links for SMAD3 Gene

GeneLoc Exon Structure for
SMAD3
ECgene alternative splicing isoforms for
SMAD3

Expression for SMAD3 Gene

mRNA expression in normal human tissues for SMAD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SMAD3 Gene

SOURCE GeneReport for Unigene cluster for SMAD3 Gene Hs.727986

genes like me logo Genes that share expressions with SMAD3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SMAD3 Gene

Orthologs for SMAD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMAD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMAD2 36
  • 100 (a)
OneToOne
SMAD3 35
  • 99.69 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SMAD3 35
  • 94.12 (n)
  • 99.76 (a)
SMAD3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMAD3 35
  • 94.2 (n)
  • 100 (a)
SMAD3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Smad3 35
  • 93.02 (n)
  • 100 (a)
Smad3 16
Smad3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SMAD3 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMAD3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Smad3 35
  • 92.31 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves SMAD3 35
  • 86.75 (n)
  • 99.06 (a)
SMAD3 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia madh3-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia smad3 35
  • 83.25 (n)
  • 95.99 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1591 35
zebrafish
(Danio rerio)
Actinopterygii madh3b 35
smad3a 36
  • 97 (a)
OneToMany
smad3b 35
  • 81 (n)
  • 93.82 (a)
smad3b 36
  • 94 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009777 35
  • 62.78 (n)
  • 68.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Smox 35
  • 67.22 (n)
  • 70.55 (a)
Smox 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sma-2 36
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
Species with no ortholog for SMAD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SMAD3 Gene

ENSEMBL:
Gene Tree for SMAD3 (if available)
TreeFam:
Gene Tree for SMAD3 (if available)

Paralogs for SMAD3 Gene

Paralogs for SMAD3 Gene

Pseudogenes.org Pseudogenes for SMAD3 Gene

genes like me logo Genes that share paralogs with SMAD3: view

Variants for SMAD3 Gene

Sequence variations from dbSNP and Humsavar for SMAD3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs718663 -- 67,120,258(+) CCCTG(A/G)GCTGC intron-variant
rs731874 -- 67,154,493(+) ACTGT(A/G)GTAGA intron-variant
rs744910 -- 67,154,447(+) TGTTG(A/G)GAACA intron-variant
rs745103 -- 67,142,737(-) TGTTA(C/T)TTAGC intron-variant
rs749772 -- 67,145,440(+) AAACA(A/C/T)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SMAD3 Gene

Variant ID Type Subtype PubMed ID
nsv904327 CNV Loss 21882294
nsv507785 CNV Insertion 20534489
nsv512399 CNV Loss 21212237
esv1009806 CNV Deletion 20482838
esv2749799 CNV Deletion 23290073
esv1476959 CNV Deletion 17803354
nsv94737 CNV Loss 16902084
dgv457e199 CNV Deletion 23128226
nsv457187 CNV Loss 19166990

Relevant External Links for SMAD3 Gene

HapMap Linkage Disequilibrium report
SMAD3
Human Gene Mutation Database (HGMD)
SMAD3
Locus Specific Mutation Databases (LSDB)
SMAD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMAD3 Gene

Disorders for SMAD3 Gene

(1) OMIM Diseases for SMAD3 Gene (603109)

UniProtKB/Swiss-Prot

SMAD3_HUMAN
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The disease may be caused by mutations affecting the gene represented in this entry.
  • Loeys-Dietz syndrome 3 (LDS3) [MIM:613795]: An aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by the triad of arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Patients with LDS3 also manifest early-onset osteoarthritis. They lack craniosynostosis and mental retardation. {ECO:0000269 PubMed:21217753, ECO:0000269 PubMed:21778426}. Note=The disease is caused by mutations affecting the gene represented in this entry. SMAD3 mutations have been reported to be also associated with thoracic aortic aneurysms and dissection (TAAD) (PubMed:21778426). This phenotype is distinguised from LDS3 by having aneurysms restricted to thoracic aorta. As individuals carrying these mutations also exhibit aneurysms of other arteries, including abdominal aorta, iliac, and/or intracranial arteries (PubMed:21778426), they have been classified as LDS3 by the OMIM resource. {ECO:0000269 PubMed:21778426}.

(3) University of Copenhagen DISEASES for SMAD3 Gene

(47) Novoseek inferred disease relationships for SMAD3 Gene

Disease -log(P) Hits PubMed IDs
keloid 55 10
renal fibrosis 47.9 1
liver fibrosis 45 1
sclerosis systemic 42.7 1
leukemogenesis 37.8 4

Relevant External Links for SMAD3

Genetic Association Database (GAD)
SMAD3
Human Genome Epidemiology (HuGE) Navigator
SMAD3
genes like me logo Genes that share disorders with SMAD3: view

Publications for SMAD3 Gene

  1. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. (PMID: 9311995) Nakao A. … ten Dijke P. (EMBO J. 1997) 3 4 23
  2. Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers. (PMID: 9464505) Arai T. … Yuasa Y. (Cancer Lett. 1998) 3 4 23
  3. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta- induced transcription. (PMID: 9732876) Zhang Y. … Derynck R. (Nature 1998) 3 4 23
  4. TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. (PMID: 9843571) Shen X. … Wang X.F. (Mol. Biol. Cell 1998) 3 4 23
  5. Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. (PMID: 12154125) Qin B.Y. … Lin K. (Genes Dev. 2002) 3 4 23

Products for SMAD3 Gene

  • Addgene plasmids for SMAD3

Sources for SMAD3 Gene

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