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Aliases for SLX4IP Gene

Aliases for SLX4IP Gene

  • SLX4 Interacting Protein 2 3
  • SLX4-Interacting Protein 3 4
  • C20orf94 3 4
  • Chromosome 20 Open Reading Frame 94 2
  • UPF0492 Protein C20orf94 3
  • Protein SLX4IP 3
  • DJ1099D15.3 3
  • BA204H22.1 3
  • BA254M13.1 3

External Ids for SLX4IP Gene

Previous Symbols for SLX4IP Gene

  • C20orf94

Summaries for SLX4IP Gene

GeneCards Summary for SLX4IP Gene

SLX4IP (SLX4 Interacting Protein) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLX4IP Gene

Genomics for SLX4IP Gene

Genomic Location for SLX4IP Gene

Start:
10,435,303 bp from pter
End:
10,636,829 bp from pter
Size:
201,527 bases
Orientation:
Plus strand

Genomic View for SLX4IP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLX4IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLX4IP Gene

No data available for Regulatory Elements for SLX4IP Gene

Proteins for SLX4IP Gene

  • Protein details for SLX4IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYV7-SLX4I_HUMAN
    Recommended name:
    Protein SLX4IP
    Protein Accession:
    Q5VYV7
    Secondary Accessions:
    • Q05CG2
    • Q05CT9

    Protein attributes for SLX4IP Gene

    Size:
    408 amino acids
    Molecular mass:
    45552 Da
    Quaternary structure:
    • Interacts with SLX4/BTBD12; subunit of different structure-specific endonucleases.
    SequenceCaution:
    • Sequence=AAH20787.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH26094.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for SLX4IP Gene

Proteomics data for SLX4IP Gene at MOPED

Post-translational modifications for SLX4IP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLX4IP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLX4IP Gene

Domains for SLX4IP Gene

Protein Domains for SLX4IP Gene

ProtoNet:

UniProtKB/Swiss-Prot:

SLX4I_HUMAN
Family:
  • Belongs to the SLX4IP family.:
    • Q5VYV7
genes like me logo Genes that share domains with SLX4IP: view

No data available for Gene Families for SLX4IP Gene

Function for SLX4IP Gene

Gene Ontology (GO) - Molecular Function for SLX4IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19596235
genes like me logo Genes that share ontologies with SLX4IP: view

Phenotypes for SLX4IP Gene

GenomeRNAi human phenotypes for SLX4IP:
genes like me logo Genes that share phenotypes with SLX4IP: view

miRNA for SLX4IP Gene

miRTarBase miRNAs that target SLX4IP

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLX4IP Gene

Localization for SLX4IP Gene

No data available for Gene Ontology (GO) - Cellular Components for SLX4IP Gene

Pathways for SLX4IP Gene

SuperPathways for SLX4IP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLX4IP Gene

None

No data available for Pathways by source for SLX4IP Gene

Transcripts for SLX4IP Gene

mRNA/cDNA for SLX4IP Gene

Unigene Clusters for SLX4IP Gene

SLX4 interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLX4IP Gene

No ASD Table

Relevant External Links for SLX4IP Gene

GeneLoc Exon Structure for
SLX4IP
ECgene alternative splicing isoforms for
SLX4IP

Expression for SLX4IP Gene

mRNA expression in normal human tissues for SLX4IP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLX4IP Gene

SOURCE GeneReport for Unigene cluster for SLX4IP Gene Hs.668782

genes like me logo Genes that share expressions with SLX4IP: view

Orthologs for SLX4IP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLX4IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLX4IP 36
  • 99.35 (n)
  • 98.77 (a)
SLX4IP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLX4IP 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLX4IP 36
  • 89.11 (n)
  • 82.67 (a)
SLX4IP 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slx4ip 36
  • 82.18 (n)
  • 70.79 (a)
Slx4ip 16
Slx4ip 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 74 (a)
OneToMany
-- 37
  • 51 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slx4ip 36
  • 82.42 (n)
  • 71.14 (a)
chicken
(Gallus gallus)
Aves C3H20ORF94 36
  • 60.84 (n)
  • 45.5 (a)
C3H20ORF94 37
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLX4IP 37
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slx4ip 36
  • 55.4 (n)
  • 44.25 (a)
zebrafish
(Danio rerio)
Actinopterygii slx4ip 37
  • 21 (a)
OneToOne
Species with no ortholog for SLX4IP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLX4IP Gene

ENSEMBL:
Gene Tree for SLX4IP (if available)
TreeFam:
Gene Tree for SLX4IP (if available)

Paralogs for SLX4IP Gene

No data available for Paralogs for SLX4IP Gene

Variants for SLX4IP Gene

Sequence variations from dbSNP and Humsavar for SLX4IP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs225138 -- 10,470,152(+) AGTCG(A/G)GTCTG intron-variant
rs225139 -- 10,470,436(+) TCTAG(C/T)AGTAG intron-variant
rs225140 -- 10,470,838(+) TGATA(A/G)CACTT intron-variant
rs225141 -- 10,470,925(+) TGAAT(G/T)CATGT intron-variant
rs225143 -- 10,471,243(+) TTTTC(A/G)TATGT intron-variant

Relevant External Links for SLX4IP Gene

HapMap Linkage Disequilibrium report
SLX4IP

No data available for Structural Variations from Database of Genomic Variants (DGV) for SLX4IP Gene

Disorders for SLX4IP Gene

UniProtKB/Swiss-Prot

SLX4I_HUMAN
  • Note=Chromosomal aberrations involving SLX4IP are found in acute lymphoblastic leukemia. A site-specific deletion within the 5 region of SLX4IP is found in 30% of childhood acute lymphoblastic leukemia in general and more than 60% of ETV6/RUNX1-rearranged acute lymphoblastic leukemia. Breakpoints within SLX4IP reveal junctions with typical characteristics of illegitimate V(D)J mediated recombination. SLX4IP deletions are significantly associated with male gender and ETV6/RUNX1-rearranged acute lymphoblastic leukemia. {ECO:0000269 PubMed:24045615}.

No disorders were found for SLX4IP Gene.

Publications for SLX4IP Gene

  1. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PMID: 19596235) Svendsen J.M. … Harper J.W. (Cell 2009) 2 3 4
  2. Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia. (PMID: 24045615) Meissner B. … Stanulla M. (Hum. Mol. Genet. 2014) 3 4
  3. Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing. (PMID: 24412650) Laguette N. … Benkirane M. (Cell 2014) 3
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SLX4IP Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SLX4IP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SLX4IP
    • Block miRNA regulation of SLX4IP using miScript Target Protectors

    Sources for SLX4IP Gene

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