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Aliases for SLX4IP Gene

Aliases for SLX4IP Gene

  • SLX4 Interacting Protein 2 3 5
  • SLX4-Interacting Protein 3 4
  • C20orf94 3 4
  • Chromosome 20 Open Reading Frame 94 2
  • Protein SLX4IP 3
  • DJ1099D15.3 3
  • BA204H22.1 3
  • BA254M13.1 3

External Ids for SLX4IP Gene

Previous HGNC Symbols for SLX4IP Gene

  • C20orf94

Summaries for SLX4IP Gene

GeneCards Summary for SLX4IP Gene

SLX4IP (SLX4 Interacting Protein) is a Protein Coding gene. Diseases associated with SLX4IP include Lymphoblastic Leukemia.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLX4IP Gene

Genomics for SLX4IP Gene

Regulatory Elements for SLX4IP Gene

Enhancers for SLX4IP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLX4IP on UCSC Golden Path with GeneCards custom track

Promoters for SLX4IP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLX4IP on UCSC Golden Path with GeneCards custom track

Genomic Location for SLX4IP Gene

10,434,547 bp from pter
10,638,546 bp from pter
204,000 bases
Plus strand

Genomic View for SLX4IP Gene

Genes around SLX4IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLX4IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLX4IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLX4IP Gene

Proteins for SLX4IP Gene

  • Protein details for SLX4IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SLX4IP
    Protein Accession:
    Secondary Accessions:
    • Q05CG2
    • Q05CT9

    Protein attributes for SLX4IP Gene

    408 amino acids
    Molecular mass:
    45552 Da
    Quaternary structure:
    • Interacts with SLX4/BTBD12; subunit of different structure-specific endonucleases.
    • Sequence=AAH20787.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH26094.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for SLX4IP Gene

Post-translational modifications for SLX4IP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLX4IP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLX4IP Gene

Domains & Families for SLX4IP Gene

Protein Domains for SLX4IP Gene


Suggested Antigen Peptide Sequences for SLX4IP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLX4IP family.
  • Belongs to the SLX4IP family.
genes like me logo Genes that share domains with SLX4IP: view

No data available for Gene Families for SLX4IP Gene

Function for SLX4IP Gene

Gene Ontology (GO) - Molecular Function for SLX4IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19596235
genes like me logo Genes that share ontologies with SLX4IP: view

Phenotypes for SLX4IP Gene

genes like me logo Genes that share phenotypes with SLX4IP: view

Animal Models for SLX4IP Gene

MGI Knock Outs for SLX4IP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLX4IP Gene

Localization for SLX4IP Gene

Subcellular locations from

Jensen Localization Image for SLX4IP Gene COMPARTMENTS Subcellular localization image for SLX4IP gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SLX4IP Gene

Pathways & Interactions for SLX4IP Gene

SuperPathways for SLX4IP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLX4IP Gene


No data available for Pathways by source and SIGNOR curated interactions for SLX4IP Gene

Drugs & Compounds for SLX4IP Gene

No Compound Related Data Available

Transcripts for SLX4IP Gene

mRNA/cDNA for SLX4IP Gene

Unigene Clusters for SLX4IP Gene

SLX4 interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLX4IP Gene

No ASD Table

Relevant External Links for SLX4IP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLX4IP Gene

mRNA expression in normal human tissues for SLX4IP Gene

Protein differential expression in normal tissues from HIPED for SLX4IP Gene

This gene is overexpressed in Kidney (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLX4IP Gene

NURSA nuclear receptor signaling pathways regulating expression of SLX4IP Gene:


SOURCE GeneReport for Unigene cluster for SLX4IP Gene:

genes like me logo Genes that share expression patterns with SLX4IP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLX4IP Gene

Orthologs for SLX4IP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLX4IP Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SLX4IP 34
  • 89.11 (n)
  • 82.67 (a)
  • 82 (a)
(Mus musculus)
Mammalia Slx4ip 34
  • 82.18 (n)
  • 70.79 (a)
Slx4ip 16
Slx4ip 35
  • 68 (a)
(Rattus norvegicus)
Mammalia Slx4ip 34
  • 82.42 (n)
  • 71.14 (a)
(Bos Taurus)
Mammalia SLX4IP 35
  • 70 (a)
(Pan troglodytes)
Mammalia SLX4IP 35
  • 99 (a)
  • 99.35 (n)
  • 98.77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
-- 35
  • 51 (a)
(Gallus gallus)
Aves C3H20ORF94 34
  • 60.84 (n)
  • 45.5 (a)
C3H20ORF94 35
  • 40 (a)
(Anolis carolinensis)
Reptilia SLX4IP 35
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slx4ip 34
  • 55.4 (n)
  • 44.25 (a)
(Danio rerio)
Actinopterygii slx4ip 35
  • 21 (a)
Species where no ortholog for SLX4IP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLX4IP Gene

Gene Tree for SLX4IP (if available)
Gene Tree for SLX4IP (if available)

Paralogs for SLX4IP Gene

No data available for Paralogs for SLX4IP Gene

Variants for SLX4IP Gene

Sequence variations from dbSNP and Humsavar for SLX4IP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs928351 -- 10,528,152(+) CAGTT(A/T)ATTAA intron-variant
rs587240 -- 10,489,177(-) GTGAA(A/C)GTTTG intron-variant
rs587246 -- 10,489,183(-) ACTTA(C/T)GTGAA intron-variant
rs587708 -- 10,489,273(-) TACAA(C/T)GTCTT intron-variant
rs589905 -- 10,505,595(-) AAACA(C/T)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLX4IP Gene

Variant ID Type Subtype PubMed ID
nsv1136506 CNV deletion 24896259
nsv507904 OTHER sequence alteration 20534489
nsv507905 OTHER sequence alteration 20534489
nsv522874 CNV loss 19592680
nsv833920 CNV gain 17160897
nsv962556 CNV duplication 23825009

Variation tolerance for SLX4IP Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.07; 68.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLX4IP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLX4IP Gene

Disorders for SLX4IP Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLX4IP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphoblastic leukemia
  • acute lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards


  • Note=Chromosomal aberrations involving SLX4IP are found in acute lymphoblastic leukemia. A site-specific deletion within the 5 region of SLX4IP is found in 30% of childhood acute lymphoblastic leukemia in general and more than 60% of ETV6/RUNX1-rearranged acute lymphoblastic leukemia. Breakpoints within SLX4IP reveal junctions with typical characteristics of illegitimate V(D)J mediated recombination. SLX4IP deletions are significantly associated with male gender and ETV6/RUNX1-rearranged acute lymphoblastic leukemia. {ECO:0000269 PubMed:24045615}.

Relevant External Links for SLX4IP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLX4IP: view

No data available for Genatlas for SLX4IP Gene

Publications for SLX4IP Gene

  1. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PMID: 19596235) Svendsen J.M. … Harper J.W. (Cell 2009) 2 3 4 65
  2. Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia. (PMID: 24045615) Meissner B. … Stanulla M. (Hum. Mol. Genet. 2014) 3 4 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance. (PMID: 25533185) Ouyang J. … Zou L. (Mol. Cell 2015) 3 65
  5. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 65

Products for SLX4IP Gene

Sources for SLX4IP Gene