Aliases for SLX1B Gene
- SLX1 Homolog B, Structure-Specific Endonuclease Subunit 2 3 5
- GIY-YIG Domain-Containing Protein 1 3 4
- GIYD2 3 4
- SLX1 Structure-Specific Endonuclease Subunit Homolog B (S. Cerevisiae) 2
- SLX1 Structure-Specific Endonuclease Subunit Homolog B 3
- Structure-Specific Endonuclease Subunit SLX1 3
- GIY-YIG Domain Containing 2 2
External Ids for SLX1B Gene
Previous HGNC Symbols for SLX1B Gene
Previous GeneCards Identifiers for SLX1B Gene
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for SLX1B Gene
SLX1B (SLX1 Homolog B, Structure-Specific Endonuclease Subunit) is a Protein Coding gene. Diseases associated with SLX1B include Congenital Hypoplastic Anemia and Fanconi Anemia, Complementation Group A. Among its related pathways are Fanconi anemia pathway and Homologous DNA Pairing and Strand Exchange. GO annotations related to this gene include crossover junction endodeoxyribonuclease activity and 5-flap endonuclease activity. An important paralog of this gene is SLX1A.
UniProtKB/Swiss-Prot for SLX1B Gene
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.