Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLX1B Gene

protein-coding   GIFtS: 41
GCID: GC16P029481

SLX1 Structure-Specific Endonuclease Subunit Homolog B (S....

(Previous name: GIY-YIG domain containing 2)
(Previous symbol: GIYD2)
  Search for SLX1B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SLX1 Structure-Specific Endonuclease Subunit Homolog B (S.
Cerevisiae)1 2
     Structure-Specific Endonuclease Subunit SLX12
GIYD21 2 3     EC 3.6.1.-3
GIY-YIG Domain-Containing Protein 12 3     GIYD13
GIY-YIG Domain Containing 21     SLX13

External Ids:    HGNC: 287481   Entrez Gene: 790082   Ensembl: ENSG000001816257   UniProtKB: Q9BQ833   

Export aliases for SLX1B gene to outside databases

Previous GC identifer: GC16P029471


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLX1B Gene:
This gene encodes a protein that is an important regulator of genome stability. The protein represents the
catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures
that are formed during repair and recombination processes. Two identical copies of this gene are located on the p
arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative
splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and
the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. (provided by
RefSeq, Nov 2010)

GeneCards Summary for SLX1B Gene: 
SLX1B (SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is SLX1A.

UniProtKB/Swiss-Prot: SLX1_HUMAN, Q9BQ83
Function: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary
structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA
substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for
5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves
HJs by generating two pairs of ligatable, nicked duplex products




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SLX1B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLX1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLX1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SLX1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLX1B gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029481:  view genomic region     (about GC identifiers)

Start:
29,465,822 bp from pter      End:
29,469,545 bp from pter
Size:
3,724 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SLX1_HUMAN, Q9BQ83 (See protein sequence)
Recommended Name: Structure-specific endonuclease subunit SLX1  
Size: 275 amino acids; 30771 Da
Cofactor: Divalent cation
Subunit: Forms a heterodimer with SLX4
Subcellular location: Nucleus
Caution: Found in a segmental duplication on p arm of chromosome 16 giving rise to two identical copies of this
gene sharing exons with SULT1A3 and SULT1A4
Secondary accessions: B7ZME1 Q6NTG6
Alternative splicing: 2 isoforms:  Q9BQ83-1   Q9BQ83-2   

Explore the universe of human proteins at neXtProt for SLX1B: NX_Q9BQ83

Explore proteomics data for SLX1B at MOPED 

SLX1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SLX1B Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_076949.1  NP_835145.1  

ENSEMBL proteins: 
 ENSP00000328940   ENSP00000335316   ENSP00000456372  

Human Recombinant Protein Products for SLX1B: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for SLX1B
OriGene Custom MassSpec 
OriGene Custom Protein Services for SLX1B
GenScript Custom Purified and Recombinant Proteins Services for SLX1B
Novus Biologicals SLX1B Protein
Novus Biologicals SLX1B Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for SLX1B 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0033557Slx1-Slx4 complex ----

SLX1B for ontologies           About GeneDecksing



SLX1B Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for SLX1B
GenScript Custom Superior Antibodies Services for SLX1B
Novus Biologicals SLX1B Antibody
Abcam antibodies for SLX1B
Cloud-Clone Corp. Antibodies for SLX1B 
Search ThermoFisher Antibodies for SLX1B
Search LSBio for Antibodies for SLX1B 

Assay Products for SLX1B: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SLX1B
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SLX1B
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for SLX1B 
Cloud-Clone Corp. CLIAs for SLX1B


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR000305 GIY-YIG_SF
 IPR027299 GIY-YIG_dom
 IPR027520 Slx1

Graphical View of Domain Structure for InterPro Entry Q9BQ83

ProtoNet protein and cluster: Q9BQ83

UniProtKB/Swiss-Prot: SLX1_HUMAN, Q9BQ83
Similarity: Belongs to the SLX1 family
Similarity: Contains 1 GIY-YIG domain
Similarity: Contains 1 SLX1-type zinc finger


SLX1B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SLX1_HUMAN, Q9BQ83
Function: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary
structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA
substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for
5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves
HJs by generating two pairs of ligatable, nicked duplex products

     Enzyme Number (IUBMB): EC 3.6.1.-1

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0008821crossover junction endodeoxyribonuclease activity ----
GO:00171085'-flap endonuclease activity ----
GO:0046872metal ion binding ----
     
SLX1B for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for SLX1B 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLX1B

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLX1B 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLX1B 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLX1B
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLX1B
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for SLX1B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLX1B

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SLX1B
Sirion Biotech Customized adenovirus for overexpression of SLX1B

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for SLX1B (see all 11)
OriGene ORF clones in mouse, rat for SLX1B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): SLX1B (NM_024044)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLX1B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLX1B
Sirion Biotech Customized lentivirus for stable overexpression of SLX1B 
                     Customized lentivirus expression plasmids for stable overexpression of SLX1B 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SLX1B
Search LifeMap BioReagents cell lines for SLX1B
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLX1B


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for SLX1B About                                                                                                See pathways by source

SuperPathContained pathways About
1Fanconi anemia pathway
Fanconi anemia pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1         Kegg Pathway  (Kegg details for SLX1B):
    Fanconi anemia pathway


SLX1B for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLX1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/60 Interacting proteins for SLX1B (Q9BQ831, 3 ENSP000003289404) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
InteractantInteraction Details
GeneCardExternal ID(s)
SLX4Q8IY921, 3, ENSP000002940084EBI-2370858,EBI-2370740 I2D: score=3 STRING: ENSP00000294008
CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
CALM2P621583I2D: score=2 
CALM3P621583I2D: score=2 
SMN1Q166373, ENSP000003700834I2D: score=2 STRING: ENSP00000370083
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000724double-strand break repair via homologous recombination ----
GO:0006281DNA repair ----
GO:0010792DNA double-strand break processing involved in repair via single-strand annealing ----

SLX1B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLX1B (SLX1)

Search CenterWatch for drugs/clinical trials and news about SLX1B / SLX1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLX1B gene (2 alternative transcripts): 
NM_024044.3  NM_178044.2  

Unigene Cluster for SLX1B:

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
Hs.728161  [show with all ESTs]
Unigene Representative Sequence: BM559384
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000330181(uc002dsx.3 uc002dsy.3) ENST00000565219 ENST00000351581
ENST00000567248 ENST00000566424
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLX1B
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLX1B
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for SLX1B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLX1B
Clone
Products:
     
OriGene clones in human, mouse for SLX1B (see all 11)
OriGene ORF clones in mouse, rat for SLX1B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): SLX1B (NM_024044)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLX1B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLX1B
Sirion Biotech Customized lentivirus for stable overexpression of SLX1B 
                     Customized lentivirus expression plasmids for stable overexpression of SLX1B 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SLX1B
OriGene qSTAR qPCR primer pairs in human, mouse for SLX1B
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SLX1B
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLX1B
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLX1B

Additional mRNA sequence: 

AK027092.1 AK225436.1 BC000754.2 BC000803.1 BC015990.2 BC019306.1 BC069007.1 BC130545.1 
BC130547.1 

23 DOTS entries:

DT.447160  DT.100671063  DT.95160992  DT.97862591  DT.91773177  DT.101983748  DT.87015527  DT.100671064 
DT.100671066  DT.314327  DT.100640541  DT.100671068  DT.91750581  DT.100671059  DT.100685794  DT.100868004 
DT.91773187  DT.100702850  DT.100768237  DT.120696666  DT.120696711  DT.417735  DT.91750579 

24/341 AceView cDNA sequences (see all 341):

AA280914 CB128930 L25275 AA443614 BP368379 CR608222 CR606532 AA904903 
NM_177552 AK097386 AI333520 CA424210 BC019306 CR597573 AA346672 BM856557 
CA488232 NM_003166 CR592426 CR617039 AW249842 CA424865 AA962685 NM_024044 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLX1B expression in normal human tissues (normalized intensities)      SLX1B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGATCTGCCT
SLX1B Expression
About this image


SLX1B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Heart (Cardiovascular System)
         Atrioventricular Node Cells Atrioventricular Node

See SLX1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLX1B

SOURCE GeneReport for Unigene cluster: Hs.728161
    SABiosciences Custom PCR Arrays for SLX1B
Primer
Products:
OriGene qPCR primer pairs and template standards for SLX1B
OriGene qSTAR qPCR primer pairs in human, mouse for SLX1B
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SLX1B
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLX1B
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLX1B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLX1B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLX1B gene from 8/18 species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slx1b1 , 5 SLX1 structure-specific endonuclease subunit homolog more1, 5 77.4(n)1
78.28(a)1
  7 (69.25 cM)5
757641  NM_029420.41  NP_083696.21 
 1266894685 
chicken
(Gallus gallus)
Aves --
--
31(a)
1 → many
8(28728161-28734974)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
51(a)
1 → many
GL343279.1(450819-455485)
African clawed frog
(Xenopus laevis)
Amphibia Xl.144412 Xenopus laevis transcribed sequence with weak similarity more 75.48(n)    BJ041980.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1000018451 structure-specific endonuclease subunit slx1-like 55.87(n)
53.2(a)
  100001845  XM_001337088.3  XP_001337124.1 
fruit fly
(Drosophila melanogaster)
Insecta slx11 nuclease slx1 52.54(n)
46.61(a)
  40578  NM_141227.2  NP_649484.3 
worm
(Caenorhabditis elegans)
Secernentea slx-11 Protein SLX-1 48.44(n)
42.22(a)
  172157  NM_059140.3  NP_491541.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLX16
Subunit of a complex, with Slx4p, that hydrolyzes ...
23(a)
1 → many
II(675313-676227)


ENSEMBL Gene Tree for SLX1B (if available)
TreeFam Gene Tree for SLX1B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SLX1B gene
SLX1A1 2  
2 SIMAP similar genes for SLX1B using alignment to 2 protein entries:     SLX1_HUMAN (see all proteins):
SLX1A    SLX1

SLX1B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
Structural Variations
     Database of Genomic Variants (DGV) 10/17 variations for SLX1B (see all 17):    About this table     
Variant IDTypeSubtypePubMed ID
esv2714183CNV Deletion23290073
nsv471388CNV Duplication19718026
nsv471387CNV Duplication19718026
nsv821543CNV Duplication20802225
nsv471389CNV Duplication19718026
nsv820959CNV Duplication20802225
nsv905723CNV Loss21882294
nsv498862CNV Loss21111241
nsv905720CNV Loss21882294
nsv9426CNV Gain18304495

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing SLX1B
DNA2.0 Custom Variant and Variant Library Synthesis for SLX1B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SLX1B gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLX1B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. (PubMed id 19595721)1, 2, 3 Munoz I.M.... Rouse J. (2009)
  2. Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies. (PubMed id 15358107)1, 2, 3 Hildebrandt M.A....Weinshilboum R.M. (2004)
  3. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PubMed id 19596235)1, 2 Svendsen J.M.... Harper J.W. (2009)
  4. Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases. (PubMed id 19596236)1, 2 Fekairi S.... Gaillard P.-H.L. (2009)
  5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
  6. Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination. (PubMed id 19595722)1 Andersen S.L....Sekelsky J. (2009)
  7. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 79008 HGNC: 28748 AceView: SULT1A3 Ensembl:ENSG00000181625 euGenes: HUgn79008
ECgene: SLX1B Kegg: 79008 H-InvDB: SLX1B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SLX1B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SLX1B gene:
Search GeneIP for patents involving SLX1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLX1B  
 OriGene qPCR primer pairs and template standards for SLX1B   OriGene Protein Over-expression Lysate for SLX1B  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for SLX1B  
 OriGene qSTAR qPCR primer pairs in human, mouse for SLX1B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for SLX1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SLX1B   OriGene Custom Protein Services for SLX1B  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLX1B
 QIAGEN SeqTarget long-range PCR primers for resequencing SLX1B
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLX1B
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLX1B
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLX1B
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLX1B
 GenScript Custom Purified and Recombinant Proteins Services for SLX1B GenScript cDNA clones with any tag delivered in your preferred vector for SLX1B
 GenScript Custom Assay Services for SLX1B GenScript Custom Superior Antibodies Services for SLX1B
 GenScript Custom overexpressing Cell Line Services for SLX1B CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Search Regulatory tfbs for SLX1B
 Search Chromatin IP Primers for SLX1B
 RT2 qPCR Primer Assay in human, mouse / rat SLX1B
 Search GNC Networks for SLX1B
 SABiosciences Custom PCR Arrays for SLX1B
 Search Tocris compounds for SLX1B (SLX1)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 SLX1B antibodies
 SLX1B proteins
 SLX1B lysates
 Antibodies for SLX1B
 See all of Abcam's Antibodies, Kits and Proteins for SLX1B
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Proteins for SLX1B
 Antibodies for SLX1B
 ELISAs for SLX1B
 CLIAs for SLX1B
 Search LifeMap BioReagents cell lines for SLX1B
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLX1B
 Browse SwitchGear 3'UTR luciferase reporter plasmids for SLX1B
 Browse SwitchGear Promoter luciferase reporter plasmids for SLX1B
 Search ThermoFisher Antibodies for SLX1B
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLX1B
 inGenious Targeting Laboratory - Custom generated mouse model solutions for SLX1B
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLX1B
Customized:
 lentivirus for stable overexpression of SLX1B
 lentivirus expression plasmids for stable overexpression of SLX1B
 adenovirus for overexpression of SLX1B
 Search LSBio for Antibodies for SLX1B
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      SLX1B gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4