Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLURP1 Gene

Aliases for SLURP1 Gene

  • Secreted LY6/PLAUR Domain Containing 1 2 3 5
  • Lymphocyte Antigen 6-Like Secreted 2 3
  • Anti-Neoplastic Urinary Protein 3 4
  • ARS(Component B)-81/S 3 4
  • ARS Component B 2 4
  • SLURP-1 3 4
  • ANUP 3 4
  • ARS 3 4
  • Secreted Ly6/UPAR Related Protein 1 3
  • LY6LS 3
  • ArsB 3
  • MDM 3

External Ids for SLURP1 Gene

Previous GeneCards Identifiers for SLURP1 Gene

  • GC08M143820
  • GC08M139075

Summaries for SLURP1 Gene

Entrez Gene Summary for SLURP1 Gene

  • The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLURP1 Gene

SLURP1 (Secreted LY6/PLAUR Domain Containing 1) is a Protein Coding gene. Diseases associated with SLURP1 include Meleda Disease and Al-Raqad Syndrome. GO annotations related to this gene include cytokine activity. An important paralog of this gene is LYPD2.

UniProtKB/Swiss-Prot for SLURP1 Gene

  • Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin.

Gene Wiki entry for SLURP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLURP1 Gene

Genomics for SLURP1 Gene

Regulatory Elements for SLURP1 Gene

Enhancers for SLURP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLURP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLURP1 Gene

142,740,944 bp from pter
142,742,411 bp from pter
1,468 bases
Minus strand

Genomic View for SLURP1 Gene

Genes around SLURP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLURP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLURP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLURP1 Gene

Proteins for SLURP1 Gene

  • Protein details for SLURP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secreted Ly-6/uPAR-related protein 1
    Protein Accession:
    Secondary Accessions:
    • Q53YJ6
    • Q6PUA6
    • Q92483

    Protein attributes for SLURP1 Gene

    103 amino acids
    Molecular mass:
    11186 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for SLURP1 Gene

neXtProt entry for SLURP1 Gene

Proteomics data for SLURP1 Gene at MOPED

Post-translational modifications for SLURP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLURP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for SLURP1

No data available for DME Specific Peptides for SLURP1 Gene

Domains & Families for SLURP1 Gene

Gene Families for SLURP1 Gene

Protein Domains for SLURP1 Gene


Suggested Antigen Peptide Sequences for SLURP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 UPAR/Ly6 domain.
  • Contains 1 UPAR/Ly6 domain.
genes like me logo Genes that share domains with SLURP1: view

Function for SLURP1 Gene

Molecular function for SLURP1 Gene

UniProtKB/Swiss-Prot Function:
Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin.
UniProtKB/Swiss-Prot Induction:
Regulated by retinoic acid, EGF and IFNG/IFN-gamma.
genes like me logo Genes that share phenotypes with SLURP1: view

Human Phenotype Ontology for SLURP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLURP1 Gene

MGI Knock Outs for SLURP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLURP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for SLURP1 Gene

Localization for SLURP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLURP1 Gene


Subcellular locations from

Jensen Localization Image for SLURP1 Gene COMPARTMENTS Subcellular localization image for SLURP1 gene
Compartment Confidence
extracellular 5
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SLURP1 Gene

Pathways & Interactions for SLURP1 Gene

SuperPathways for SLURP1 Gene

No Data Available

Interacting Proteins for SLURP1 Gene

Gene Ontology (GO) - Biological Process for SLURP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 14506129
GO:0050884 neuromuscular process controlling posture IEA --
genes like me logo Genes that share ontologies with SLURP1: view

No data available for Pathways by source and SIGNOR curated interactions for SLURP1 Gene

Drugs & Compounds for SLURP1 Gene

(2) Drugs for SLURP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for SLURP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLURP1: view

Transcripts for SLURP1 Gene

mRNA/cDNA for SLURP1 Gene

(1) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SLURP1 Gene

No ASD Table

Relevant External Links for SLURP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLURP1 Gene

mRNA expression in normal human tissues for SLURP1 Gene

mRNA differential expression in normal tissues according to GTEx for SLURP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x18.6), Skin - Sun Exposed (Lower leg) (x16.8), and Skin - Not Sun Exposed (Suprapubic) (x11.0).

Protein differential expression in normal tissues from HIPED for SLURP1 Gene

This gene is overexpressed in Cervix (34.0) and Urine (33.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLURP1 Gene

SOURCE GeneReport for Unigene cluster for SLURP1 Gene Hs.103505

mRNA Expression by UniProt/SwissProt for SLURP1 Gene

Tissue specificity: Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.
genes like me logo Genes that share expression patterns with SLURP1: view

Protein tissue co-expression partners for SLURP1 Gene

- Elite partner

Primer Products

Orthologs for SLURP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLURP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLURP1 35
  • 82.11 (n)
  • 70.73 (a)
  • 52 (a)
(Canis familiaris)
Mammalia SLURP1 35
  • 79.07 (n)
  • 68.6 (a)
  • 67 (a)
(Mus musculus)
Mammalia Slurp1 35
  • 77.67 (n)
  • 67.96 (a)
Slurp1 16
Slurp1 36
  • 64 (a)
(Pan troglodytes)
Mammalia SLURP1 35
  • 99.68 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Slurp1 35
  • 79.21 (n)
  • 71.29 (a)
(Monodelphis domestica)
Mammalia SLURP1 36
  • 52 (a)
(Gallus gallus)
Aves SLURP1 36
  • 31 (a)
(Anolis carolinensis)
Reptilia SLURP1 36
  • 34 (a)
Species with no ortholog for SLURP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLURP1 Gene

Gene Tree for SLURP1 (if available)
Gene Tree for SLURP1 (if available)

Paralogs for SLURP1 Gene

Paralogs for SLURP1 Gene

(1) SIMAP similar genes for SLURP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLURP1: view

Variants for SLURP1 Gene

Sequence variations from dbSNP and Humsavar for SLURP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_032871 Mal de Meleda (MDM)
VAR_032872 Mal de Meleda (MDM)
VAR_032873 Mal de Meleda (MDM)
rs28937888 Mal de Meleda (MDM) 142,741,199(-) GCATC(A/C/G)GGGCC reference, missense
VAR_032875 Mal de Meleda (MDM)

Structural Variations from Database of Genomic Variants (DGV) for SLURP1 Gene

Variant ID Type Subtype PubMed ID
esv2661137 CNV Deletion 23128226
dgv7910n71 CNV Loss 21882294
dgv7915n71 CNV Loss 21882294
nsv831485 CNV Loss 17160897
nsv891638 CNV Loss 21882294
nsv831486 CNV Gain 17160897
nsv891639 CNV Gain 21882294
dgv7917n71 CNV Loss 21882294
esv2737925 CNV Deletion 23290073

Variation tolerance for SLURP1 Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLURP1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLURP1 Gene

Disorders for SLURP1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for SLURP1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
meleda disease
  • keratosis palmoplantaris transgradiens of siemens
al-raqad syndrome
  • ars
palmoplantar keratosis
  • keratosis palmaris et plantaris
prostate carcinoma in situ
  • carcinoma in situ of prostate
  • actinic keratosis
- elite association - COSMIC cancer census association via MalaCards


  • Mal de Meleda (MDM) [MIM:248300]: A rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities. {ECO:0000269 PubMed:11285253, ECO:0000269 PubMed:12483299, ECO:0000269 PubMed:14756676, ECO:0000269 PubMed:17008884}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLURP1

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLURP1: view

No data available for Genatlas for SLURP1 Gene

Publications for SLURP1 Gene

  1. Mutations in the gene encoding SLURP-1 in Mal de Meleda. (PMID: 11285253) Fischer J. … Prud'homme J.-F. (Hum. Mol. Genet. 2001) 2 3 4 23 67
  2. Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. (PMID: 10211827) Andermann K. … Nehls M. (Protein Sci. 1999) 2 3 23
  3. Mutations in the SLURP-1 gene underlie Mal de Meleda in three Pakistani families. (PMID: 19692209) Wajid M. … Christiano A.M. (J. Dermatol. Sci. 2009) 3 23
  4. Mal de Meleda in a taiwanese. (PMID: 15909066) Chao S.C. … Lee J.Y. (J. Formos. Med. Assoc. 2005) 3 23
  5. Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates. (PMID: 12483299) Eckl K.M. … Hennies H.C. (Hum. Genet. 2003) 3 23

Products for SLURP1 Gene

Sources for SLURP1 Gene