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Aliases for SLURP1 Gene

Aliases for SLURP1 Gene

  • Secreted LY6/PLAUR Domain Containing 1 2 3
  • Lymphocyte Antigen 6-Like Secreted 2 3
  • Anti-Neoplastic Urinary Protein 3 4
  • ARS(Component B)-81/S 3 4
  • ARS Component B 2 4
  • SLURP-1 3 4
  • ANUP 3 4
  • MDM 3 6
  • ARS 3 4
  • Secreted Ly-6/UPAR-Related Protein 1 3
  • Secreted Ly6/UPAR Related Protein 1 3
  • LY6LS 3
  • ArsB 3

External Ids for SLURP1 Gene

Previous GeneCards Identifiers for SLURP1 Gene

  • GC08M143820
  • GC08M139075

Summaries for SLURP1 Gene

Entrez Gene Summary for SLURP1 Gene

  • The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLURP1 Gene

SLURP1 (Secreted LY6/PLAUR Domain Containing 1) is a Protein Coding gene. Diseases associated with SLURP1 include meleda disease and palmoplantar keratosis. GO annotations related to this gene include cytokine activity. An important paralog of this gene is LYPD2.

UniProtKB/Swiss-Prot for SLURP1 Gene

  • Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin

Gene Wiki entry for SLURP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLURP1 Gene

Genomics for SLURP1 Gene

Regulatory Elements for SLURP1 Gene

Genomic Location for SLURP1 Gene

Start:
142,740,944 bp from pter
End:
142,742,411 bp from pter
Size:
1,468 bases
Orientation:
Minus strand

Genomic View for SLURP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLURP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLURP1 Gene

Proteins for SLURP1 Gene

  • Protein details for SLURP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55000-SLUR1_HUMAN
    Recommended name:
    Secreted Ly-6/uPAR-related protein 1
    Protein Accession:
    P55000
    Secondary Accessions:
    • Q53YJ6
    • Q6PUA6
    • Q92483

    Protein attributes for SLURP1 Gene

    Size:
    103 amino acids
    Molecular mass:
    11186 Da
    Quaternary structure:
    • Homodimer

neXtProt entry for SLURP1 Gene

Proteomics data for SLURP1 Gene at MOPED

Post-translational modifications for SLURP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLURP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLURP1 Gene

Domains for SLURP1 Gene

Protein Domains for SLURP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLURP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55000

UniProtKB/Swiss-Prot:

SLUR1_HUMAN :
  • P55000
Domain:
  • Contains 1 UPAR/Ly6 domain.
genes like me logo Genes that share domains with SLURP1: view

No data available for Gene Families for SLURP1 Gene

Function for SLURP1 Gene

Molecular function for SLURP1 Gene

UniProtKB/Swiss-Prot Function: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin
UniProtKB/Swiss-Prot Induction: Regulated by retinoic acid, EGF and IFNG/IFN-gamma.

Gene Ontology (GO) - Molecular Function for SLURP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 8742060
genes like me logo Genes that share ontologies with SLURP1: view

Phenotypes for SLURP1 Gene

GenomeRNAi human phenotypes for SLURP1:
genes like me logo Genes that share phenotypes with SLURP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLURP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLURP1 Gene

Localization for SLURP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLURP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLURP1 Gene COMPARTMENTS Subcellular localization image for SLURP1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
chloroplast 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLURP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14721776
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SLURP1: view

Pathways for SLURP1 Gene

SuperPathways for SLURP1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLURP1 Gene

Gene Ontology (GO) - Biological Process for SLURP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001775 cell activation NAS 11285253
GO:0007155 cell adhesion TAS 14506129
GO:0007626 locomotory behavior IEA --
GO:0010839 negative regulation of keratinocyte proliferation IEA --
GO:0050884 neuromuscular process controlling posture IEA --
genes like me logo Genes that share ontologies with SLURP1: view

No data available for Pathways by source for SLURP1 Gene

Compounds for SLURP1 Gene

(7) Novoseek inferred chemical compound relationships for SLURP1 Gene

Compound -log(P) Hits PubMed IDs
anup 96.5 6
antimonite 83.2 1
arsenate 68.9 2
arsenite 67.5 4
norepinephrine 11.4 2
genes like me logo Genes that share compounds with SLURP1: view

Transcripts for SLURP1 Gene

mRNA/cDNA for SLURP1 Gene

(10) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLURP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLURP1 Gene

No ASD Table

Relevant External Links for SLURP1 Gene

GeneLoc Exon Structure for
SLURP1
ECgene alternative splicing isoforms for
SLURP1

Expression for SLURP1 Gene

mRNA expression in normal human tissues for SLURP1 Gene

mRNA differential expression in normal tissues according to GTEx for SLURP1 Gene

This gene is overexpressed in Esophagus - Mucosa (18.6), Skin - Sun Exposed (Lower leg) (16.8), and Skin - Not Sun Exposed (Suprapubic) (11.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLURP1 Gene

SOURCE GeneReport for Unigene cluster for SLURP1 Gene Hs.103505

mRNA Expression by UniProt/SwissProt for SLURP1 Gene

P55000-SLUR1_HUMAN
Tissue specificity: Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.
genes like me logo Genes that share expressions with SLURP1: view

In Situ Assay Products

Orthologs for SLURP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLURP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLURP1 35
  • 99.68 (n)
  • 100 (a)
SLURP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLURP1 35
  • 82.11 (n)
  • 70.73 (a)
SLURP1 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLURP1 35
  • 79.07 (n)
  • 68.6 (a)
SLURP1 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slurp1 35
  • 77.67 (n)
  • 67.96 (a)
Slurp1 16
Slurp1 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLURP1 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slurp1 35
  • 79.21 (n)
  • 71.29 (a)
chicken
(Gallus gallus)
Aves SLURP1 36
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLURP1 36
  • 34 (a)
OneToOne
Species with no ortholog for SLURP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLURP1 Gene

ENSEMBL:
Gene Tree for SLURP1 (if available)
TreeFam:
Gene Tree for SLURP1 (if available)

Paralogs for SLURP1 Gene

Paralogs for SLURP1 Gene

Selected SIMAP similar genes for SLURP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLURP1: view

Variants for SLURP1 Gene

Sequence variations from dbSNP and Humsavar for SLURP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2572914 -- 142,742,440(+) TTATA(C/G)CCAGG upstream-variant-2KB
rs3758081 -- 142,742,955(+) GTAGC(A/G)TGGGC upstream-variant-2KB
rs3758082 -- 142,743,065(+) TCTTG(A/G)TTTTA upstream-variant-2KB
rs3758083 -- 142,743,190(+) CATAC(C/T)GCTCA upstream-variant-2KB
rs4736321 -- 142,740,776(+) GGGCC(C/T)AGGAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLURP1 Gene

Variant ID Type Subtype PubMed ID
esv2661137 CNV Deletion 23128226
dgv7910n71 CNV Loss 21882294
dgv7915n71 CNV Loss 21882294
nsv831485 CNV Loss 17160897
nsv891638 CNV Loss 21882294
nsv831486 CNV Gain 17160897
nsv891639 CNV Gain 21882294
dgv7917n71 CNV Loss 21882294
esv2737925 CNV Deletion 23290073

Relevant External Links for SLURP1 Gene

HapMap Linkage Disequilibrium report
SLURP1
Human Gene Mutation Database (HGMD)
SLURP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLURP1 Gene

Disorders for SLURP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for SLURP1 Gene including...

Search for SLURP1 Gene in MalaCards »

(1) OMIM Diseases for SLURP1 Gene (606119)

UniProtKB/Swiss-Prot

SLUR1_HUMAN
  • Mal de Meleda (MDM) [MIM:248300]: A rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities. {ECO:0000269 PubMed:11285253, ECO:0000269 PubMed:12483299, ECO:0000269 PubMed:14756676, ECO:0000269 PubMed:17008884}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for SLURP1 Gene

(4) Novoseek inferred disease relationships for SLURP1 Gene

Disease -log(P) Hits PubMed IDs
mal de meleda 98.5 25
keratoderma palmoplantar 90.9 5
skin diseases 47.6 2
tumors 0 4

Relevant External Links for SLURP1

Human Genome Epidemiology (HuGE) Navigator
SLURP1
genes like me logo Genes that share disorders with SLURP1: view

Publications for SLURP1 Gene

  1. Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. (PMID: 10211827) Andermann K. … Nehls M. (Protein Sci. 1999) 2 3 4 23
  2. Mutations in the gene encoding SLURP-1 in Mal de Meleda. (PMID: 11285253) Fischer J. … Prud'homme J.-F. (Hum. Mol. Genet. 2001) 2 3 4 23
  3. Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes. (PMID: 8742060) Ridge R.J. … Sloane N.H. (Cytokine 1996) 3 4 23
  4. Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates. (PMID: 12483299) Eckl K.M. … Hennies H.C. (Hum. Genet. 2003) 3 4 23
  5. ARS component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda. (PMID: 14721776) Mastrangeli R. … Papoian R. (Eur. J. Dermatol. 2003) 3 4 23

Products for SLURP1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SLURP1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SLURP1
    • Block miRNA regulation of SLURP1 using miScript Target Protectors

    Sources for SLURP1 Gene

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