SLURP1 Gene
protein-coding GIFtS: 49
GCID: GC08M143820
|
|
secreted LY6/PLAUR domain containing 1
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Aliases
for SLURP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Secreted LY6/PLAUR Domain Containing 11 2 | | SLURP-12 3 | | ANUP1 2 3 | | ARS(Component B)-81/S2 3 | | ARS1 2 3 | | Lymphocyte Antigen 6-Like Secreted2 | | MDM1 2 5 | | Secreted Ly-6/UPAR-Related Protein 12 | | ArsB1 2 | | Secreted Ly6/UPAR Related Protein 12 | | LY6LS1 2 | | ARS Component B3 | | Anti-Neoplastic Urinary Protein2 3 | | |
Export aliases for SLURP1 gene to outside databasesPrevious GC identifer: GC08M139075 |
Summaries
for SLURP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLURP1:
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It isthought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Malde Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several membersof the Ly6/uPAR family of glycoprotein receptors. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000Function: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated inmaintaining the physiological and structural integrity of the keratinocyte layers of the skin
Gene Wiki entry for SLURP1
|
Genomic Views
for SLURP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLURP1 gene promoter:
GR p53 GR-beta Nkx2-5 Tal-1beta AP-2gamma C/EBPalpha GR-alpha ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLURP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLURP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3SLURP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M143820: view genomic region
(about GC identifiers)
Start:
|
143,822,362 bp from pter |
End:
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143,823,829 bp from pter |
Size:
|
1,468 bases |
Orientation:
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minus strand |
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Proteins
for SLURP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000 (See
protein sequence)Recommended Name: Secreted Ly-6/uPAR-related protein 1 precursor Size: 103 amino acids; 11186 Da
Subunit: Homodimer
Subcellular location: Secreted
Caution: It is not certain that ARS and ANUP are identical proteins
Secondary accessions: Q53YJ6 Q6PUA6 Q92483Explore the universe of human proteins at neXtProt for SLURP1: NX_P55000
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P55000
SLURP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065160.1
ENSEMBL proteins: ENSP00000246515
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SLURP1 for ontologies About GeneDecksing
SLURP1 Antibody Products:
Assay Products for SLURP1: |
Protein
Domains /
Families
for SLURP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLURP1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P55000ProtoNet protein and cluster: P55000 1 Blocks protein family: IPB001526 CD59 antigen
UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000Similarity: Contains 1 UPAR/Ly6 domain |
Function
for SLURP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000Function: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated inmaintaining the physiological and structural integrity of the keratinocyte layers of the skinInduction: Regulated by retinoic acid, EGF and IFNG/IFN-gamma
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLURP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
SLURP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLURP1:
|
Pathways & Interactions
for SLURP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLURP1
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SLURP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLURP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SLURP1 for compounds About GeneDecksing
 Browse Tocris compounds for SLURP1
7 Novoseek chemical compound relationships for SLURP1 gene About this table
Search CenterWatch for drugs/clinical trials and news about SLURP1 / SLUR1
|
Transcripts
for SLURP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLURP1 gene: NM_020427.2 Unigene Clusters for SLURP1: Secreted LY6/PLAUR domain containing 1 Hs.103505 [show with all ESTs], Hs.676358 Unigene Representative Sequences: BQ027886, NM_0204271 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000246515(uc003ywy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLURP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLURP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLURP1 (NM_020427) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLURP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLURP1 |
Additional cDNA sequence: AY579079.1 AY579080.1 BC069292.1 1 DOTS entry: DT.97805489 10 AceView cDNA sequences: AY579080 BX107730 NM_020427 BC069292 BQ027886 BQ188001 BQ027921 AI092857 AY579079 CA433583
GeneLoc Exon Structure
|
Expression
for SLURP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLURP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SLURP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLURP1
SOURCE GeneReport for Unigene clusters: Hs.103505 Hs.676358
UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000Tissue specificity: Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably theacrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine
SABiosciences Expression via Pathway-Focused PCR Array including SLURP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLURP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLURP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLURP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLURP1 |
Orthologs
for SLURP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SLURP1 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
SLURP16 |
-- |
34(a) |
1 ↔ 1 |
GL343222.1(2349367-2350271) |
ENSEMBL Gene Tree for SLURP1 (if available)
TreeFam Gene Tree for SLURP1 (if available) |
Paralogs
for SLURP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLURP1 gene
- LYPD22
1 SIMAP similar gene for SLURP1 using alignment to 1 protein entry: SLUR1_HUMAN:LYPD2
SLURP1 for paralogs About GeneDecksing
|
Genomic Variants
for SLURP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLURP1 (143822362 - 143823829 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SLURP1
3 CNVs: 82815 95749 4791
Human Gene Mutation Database (HGMD): SLURP1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLURP1 |
|
Disorders
/ Diseases
for SLURP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLURP1 for disorders About GeneDecksing
OMIM gene information: 606119
OMIM disorders: 248300
UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000
Defects in SLURP1 are a cause of Mal de Meleda (MDM) [MIM:248300]; also known as keratosis palmoplantaristransgradiens of Siemens. MDM is a rare autosomal recessive skin disorder, characterized by diffuse transgressivepalmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens).Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and theelbows, and nail abnormalities
17  diseases for SLURP1: About MalaCardspalmoplantar keratosis meleda disease keratoderma hydranencephaly
keratosis congenital cataracts skin disease kaposi's sarcoma
prostate carcinoma in situ cataract hepatitis b sarcoma
colon cancer prostate carcinoma hepatitis prostatitis
carcinoma
1 disease from the University of Copenhagen DISEASES database for SLURP1:Palmoplantar keratosis 4 Novoseek disease relationships for SLURP1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mal de meleda |
98.5 |
26 |
12535203 (3), 12950349 (3), 11872406 (2), 14506129 (2) (see all 16) |
| keratoderma palmoplantar |
90.9 |
5 |
19396877 (1), 12603845 (1), 16865292 (1), 17008884 (1) (see all 5) |
| skin diseases |
47.6 |
2 |
19396877 (1), 14506129 (1) |
| tumors |
0 |
4 |
10233778 (1), 19396877 (1), 15909066 (1), 9920854 (1) |
Human Genome Epidemiology (HuGE) Navigator: SLURP1 (1 document)
Export disorders for SLURP1 gene to outside databases
|
Publications
for SLURP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLURP1 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with SLURP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in the gene encoding SLURP-1 in Mal de Meleda. (PubMed id 11285253)1, 2, 3, 9 Fischer J.... Prud'homme J.-F. (2001)
- Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. (PubMed id 10211827)1, 2, 3, 9 Andermann K.... Nehls M. (1999)
- Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes. (PubMed id 8742060)1, 2, 9 Ridge R.J. and Sloane N.H. (1996)
- ARS component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda. (PubMed id 14721776)1, 2, 9 Mastrangeli R.... Papoian R. (2003)
- Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates. (PubMed id 12483299)1, 2, 9 Eckl K.M.... Hennies H.C. (2003)
- Biological effects of SLURP-1 on human keratinocytes. (PubMed id 16354194)1, 2 Arredondo J.... Grando S.A. (2005)
- Heterozygous manifestations in female carriers of Mal de Meleda. (PubMed id 14756676)1, 2 Mokni M.... Abdelhak S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda. (PubMed id 17008884)2, 9 Favre B.... Hohl D. (2007)
- Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. (PubMed id 14506129)1, 9 Chimienti F....Hohl D. (2003)
|
External Searches for SLURP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLURP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLURP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLURP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SLURP1 gene:
Search GeneIP for patents involving SLURP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLURP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLURP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLURP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLURP1 | | | OriGene Protein Over-expression Lysate for SLURP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLURP1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLURP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLURP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SLURP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLURP1 | | OriGene Custom Protein Services for SLURP1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLURP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLURP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLURP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLURP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLURP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLURP1 |
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