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SLURP1 Gene

protein-coding   GIFtS: 51
GCID: GC08M143820

Secreted LY6/PLAUR Domain Containing 1

  See SLURP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secreted LY6/PLAUR Domain Containing 11 2     ARS(Component B)-81/S2 3
ARS Component B1 3     MDM2 5
Lymphocyte Antigen 6-Like Secreted1 2     ArsB2
Anti-Neoplastic Urinary Protein2 3     LY6LS2
ANUP2 3     Secreted Ly-6/UPAR-Related Protein 12
ARS2 3     Secreted Ly6/UPAR Related Protein 12
SLURP-12 3     

External Ids:    HGNC: 187461   Entrez Gene: 571522   Ensembl: ENSG000001262337   OMIM: 6061195   UniProtKB: P550003   

Export aliases for SLURP1 gene to outside databases

Previous GC identifer: GC08M139075


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLURP1 Gene:
The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It
is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated
with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as
several members of the Ly6/uPAR family of glycoprotein receptors. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLURP1 Gene:
SLURP1 (secreted LY6/PLAUR domain containing 1) is a protein-coding gene. Diseases associated with SLURP1 include meleda disease, and palmoplantar keratosis. GO annotations related to this gene include cytokine activity. An important paralog of this gene is LYPD2.

UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000
Function: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in
maintaining the physiological and structural integrity of the keratinocyte layers of the skin

Gene Wiki entry for SLURP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLURP1 gene promoter:
         GR   p53   GR-beta   Nkx2-5   Tal-1beta   AP-2gamma   C/EBPalpha   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLURP1 promoter sequence
   Search Chromatin IP Primers for SLURP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLURP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

SLURP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLURP1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M143820:  view genomic region     (about GC identifiers)

Start:
143,822,362 bp from pter      End:
143,823,829 bp from pter
Size:
1,468 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000 (See protein sequence)
Recommended Name: Secreted Ly-6/uPAR-related protein 1 precursor  
Size: 103 amino acids; 11186 Da
Subunit: Homodimer
Caution: It is not certain that ARS and ANUP are identical proteins
Secondary accessions: Q53YJ6 Q6PUA6 Q92483

Explore the universe of human proteins at neXtProt for SLURP1: NX_P55000

Explore proteomics data for SLURP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLURP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065160.1  
    ENSEMBL proteins: 
     ENSP00000246515  

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    antibodies-online proteins for SLURP1 (7 products) 

     
    antibodies-online peptides for SLURP1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027103 SLURP1
     IPR016054 LY6_UPA_recep-like
     IPR001526 LY6_UPAR

    Graphical View of Domain Structure for InterPro Entry P55000

    ProtoNet protein and cluster: P55000

    1 Blocks protein domain: IPB001526 CD59 antigen

    UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000
    Similarity: Contains 1 UPAR/Ly6 domain


    Find genes that share domains with SLURP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLUR1_HUMAN, P55000
    Function: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in
    maintaining the physiological and structural integrity of the keratinocyte layers of the skin
    Induction: Regulated by retinoic acid, EGF and IFNG/IFN-gamma

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity NAS8742060
         
    Find genes that share ontologies with SLURP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLURP1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLURP1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLUR1_HUMAN, P55000: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    chloroplast1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14721776
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with SLURP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SLURP1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLURP1

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001775cell activation NAS11285253
    GO:0007155cell adhesion TAS14506129

    Find genes that share ontologies with SLURP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLURP1 (SLUR1)

    7 Novoseek inferred chemical compound relationships for SLURP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anup 96.5 9 8742060 (3), 9920854 (1), 11227487 (1), 15165708 (1)
    antimonite 83.2 1 9271073 (1)
    arsenate 68.9 2 11931390 (1), 9271073 (1)
    arsenite 67.5 4 11931390 (2), 17061211 (1), 9271073 (1)
    norepinephrine 11.4 3 2154750 (1), 10779380 (1)
    steroid 6.98 1 16707768 (1)
    testosterone 0 1 16707768 (1)



    Find genes that share compounds with SLURP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLURP1 gene: 
    NM_020427.2  

    Unigene Cluster for SLURP1:

    Secreted LY6/PLAUR domain containing 1
    Hs.103505  [show with all ESTs]
    Unigene Representative Sequence: BQ027886
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000246515(uc003ywy.3)
    miRNA
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    Additional mRNA sequence: 

    BC105133.1 BC105135.1 

    1 DOTS entry:

    DT.97805489 

    10 AceView cDNA sequences:

    BX107730 BC069292 NM_020427 AY579080 BQ027921 BQ188001 BQ027886 AI092857 
    AY579079 CA433583 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLURP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLURP1 Expression
    About this image


    SLURP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
             corneal epithelial basal cells   
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
             corneal epithelial basal cells   
     
     Esophagus (Gastrointestinal Tract)
    SLURP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLURP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.103505

    UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000
    Tissue specificity: Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin,
    notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine

        Pathway & Disease-focused RT2 Profiler PCR Array including SLURP1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLURP1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slurp11 , 5 secreted Ly6/Plaur domain containing 11, 5 77.67(n)1
    67.96(a)1
      15 (34.26 cM)5
    572771  NM_020519.11  NP_065265.11 
     747266445 
    chicken
    (Gallus gallus)
    Aves SLURP16
    secreted LY6/PLAUR domain containing 1
    31(a)
    1 ↔ 1
    2(147883994-147890790)
    lizard
    (Anolis carolinensis)
    Reptilia SLURP16
    secreted LY6/PLAUR domain containing 1
    34(a)
    1 ↔ 1
    GL343222.1(2349367-2350271)


    ENSEMBL Gene Tree for SLURP1 (if available)
    TreeFam Gene Tree for SLURP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLURP1 gene
    LYPD22  
    1 SIMAP similar gene for SLURP1 using alignment to 1 protein entry:     SLUR1_HUMAN:
    LYPD2

    Find genes that share paralogs with SLURP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLURP1 (see all 114)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289378881,2,,4
    CMal de Meleda (MDM)4 untested1144096802(-) GCATCA/C/GGGGCC 3 R G mis10--------
    VAR_0328714
    Mal de Meleda (MDM)4--see VAR_0328712 W R mis40--------
    VAR_0328724
    Mal de Meleda (MDM)4--see VAR_0328722 R H mis40--------
    VAR_0328734
    Mal de Meleda (MDM)4--see VAR_0328732 C R mis40--------
    VAR_0328754
    Mal de Meleda (MDM)4--see VAR_0328752 C Y mis40--------
    rs289378891,2
    Cpathogenic1144097988(-) GAGCAA/CTGGCC 2 M L mis10--------
    rs1436484651,2
    --144096072(+) CCTCCA/GCTAAT 1 -- ds50010--------
    rs349564121,2
    C,F,H--144096213(+) GTATCC/TACCCT 1 -- ds500120Minor allele frequency- T:0.22NS EA NA CSA WA 2344
    rs1823280361,2
    --144096231(+) AAGTGA/GATGCC 1 -- ds50010--------
    rs47363211,2
    C,F,A--144096379(+) GGGCCC/TAGGAG 1 -- ds500111Minor allele frequency- T:0.26NA CSA WA EA 508

    HapMap Linkage Disequilibrium report for SLURP1 (143822362 - 143823829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SLURP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661137CNV Deletion23128226
    esv2737925CNV Deletion23290073
    nsv891638CNV Loss21882294
    dgv7917n71CNV Loss21882294
    dgv7910n71CNV Loss21882294
    dgv7915n71CNV Loss21882294
    nsv831485CNV Loss17160897
    nsv891639CNV Gain21882294
    nsv831486CNV Gain17160897

    Human Gene Mutation Database (HGMD): SLURP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLURP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLURP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606119   
    OMIM disorders: 248300  
    UniProtKB/Swiss-Prot: SLUR1_HUMAN, P55000
  • Mal de Meleda (MDM) [MIM:248300]: A rare autosomal recessive skin disorder, characterized by diffuse
    transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet
    (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on
    the knees and the elbows, and nail abnormalities. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 4 diseases for SLURP1:    
    About MalaCards
    meleda disease    palmoplantar keratosis    hydranencephaly    bacteremia

    2 diseases from the University of Copenhagen DISEASES database for SLURP1:
    Palmoplantar keratosis     Hydranencephaly

    Find genes that share disorders with SLURP1           About GenesLikeMe

    4 Novoseek inferred disease relationships for SLURP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mal de meleda 98.5 26 12535203 (3), 12950349 (3), 11872406 (2), 14506129 (2) (see all 16)
    keratoderma palmoplantar 90.9 5 19396877 (1), 12603845 (1), 16865292 (1), 17008884 (1) (see all 5)
    skin diseases 47.6 2 19396877 (1), 14506129 (1)
    tumors 0 4 10233778 (1), 19396877 (1), 15909066 (1), 9920854 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLURP1 (1 document)

    Export disorders for SLURP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLURP1 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with SLURP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the gene encoding SLURP-1 in Mal de Meleda. (PubMed id 11285253)1, 2, 3, 9 Fischer J.... Prud'homme J.-F. (Hum. Mol. Genet. 2001)
    2. Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. (PubMed id 10211827)1, 2, 3, 9 Andermann K.... Nehls M. (Protein Sci. 1999)
    3. Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes. (PubMed id 8742060)1, 2, 9 Ridge R.J. and Sloane N.H. (Cytokine 1996)
    4. ARS component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda. (PubMed id 14721776)1, 2, 9 Mastrangeli R.... Papoian R. (Eur. J. Dermatol. 2003)
    5. Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates. (PubMed id 12483299)1, 2, 9 Eckl K.M.... Hennies H.C. (Hum. Genet. 2003)
    6. Biological effects of SLURP-1 on human keratinocytes. (PubMed id 16354194)1, 2 Arredondo J.... Grando S.A. (J. Invest. Dermatol. 2005)
    7. Heterozygous manifestations in female carriers of Mal de Meleda. (PubMed id 14756676)1, 2 Mokni M.... Abdelhak S. (Clin. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda. (PubMed id 17008884)2, 9 Favre B.... Hohl D. (J. Invest. Dermatol. 2007)
    10. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. (PubMed id 14506129)1, 9 Chimienti F....Hohl D. (Hum. Mol. Genet. 2003)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57152 HGNC: 18746 AceView: ARS Ensembl:ENSG00000126233 euGenes: HUgn57152
    ECgene: SLURP1 H-InvDB: SLURP1

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLURP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLURP1 Genetics and Cytogenetics in Oncology and Haematology

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