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Aliases for SLU7 Gene

Aliases for SLU7 Gene

  • SLU7 Splicing Factor Homolog (S. Cerevisiae) 2 3
  • Zinc Knuckle Motif Containing 2 3
  • HSlu7 3 4
  • Pre-MRNA-Splicing Factor SLU7 3
  • Step II Splicing Factor SLU7 3
  • Splicing Factor 3
  • 9G8 3

External Ids for SLU7 Gene

Previous GeneCards Identifiers for SLU7 Gene

  • GC05M159948
  • GC05M160339
  • GC05M159765
  • GC05M159811
  • GC05M159762
  • GC05M154922

Summaries for SLU7 Gene

Entrez Gene Summary for SLU7 Gene

  • Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLU7 Gene

SLU7 (SLU7 Splicing Factor Homolog (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Spliceosome. GO annotations related to this gene include pre-mRNA 3-splice site binding and second spliceosomal transesterification activity.

UniProtKB/Swiss-Prot for SLU7 Gene

  • Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

Gene Wiki entry for SLU7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLU7 Gene

Genomics for SLU7 Gene

Regulatory Elements for SLU7 Gene

Genomic Location for SLU7 Gene

Start:
160,401,641 bp from pter
End:
160,421,711 bp from pter
Size:
20,071 bases
Orientation:
Minus strand

Genomic View for SLU7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLU7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLU7 Gene

Proteins for SLU7 Gene

  • Protein details for SLU7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95391-SLU7_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor SLU7
    Protein Accession:
    O95391
    Secondary Accessions:
    • D3DQK2
    • Q3LUJ0
    • Q3LUJ1
    • Q6RXQ5
    • Q96FM9

    Protein attributes for SLU7 Gene

    Size:
    586 amino acids
    Molecular mass:
    68387 Da
    Quaternary structure:
    • Component of late spliceosomal complexes. Associates with the spliceosome prior to recognition of the 3-splice site for step II, probably during catalysis of step I

neXtProt entry for SLU7 Gene

Proteomics data for SLU7 Gene at MOPED

Post-translational modifications for SLU7 Gene

  • Ubiquitination at Lys288 and Lys355
  • Modification sites at PhosphoSitePlus

Other Protein References for SLU7 Gene

No data available for DME Specific Peptides for SLU7 Gene

Domains for SLU7 Gene

Protein Domains for SLU7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLU7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95391

UniProtKB/Swiss-Prot:

SLU7_HUMAN :
  • O95391
Domain:
  • The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.
Family:
  • Belongs to the SLU7 family.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with SLU7: view

No data available for Gene Families for SLU7 Gene

Function for SLU7 Gene

Molecular function for SLU7 Gene

UniProtKB/Swiss-Prot Function: Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

Gene Ontology (GO) - Molecular Function for SLU7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000386 second spliceosomal transesterification activity IDA 10197984
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IDA 15181151
GO:0030628 pre-mRNA 3-splice site binding IDA 15728250
genes like me logo Genes that share ontologies with SLU7: view
genes like me logo Genes that share phenotypes with SLU7: view

Animal Model Products

CRISPR Products

miRNA for SLU7 Gene

miRTarBase miRNAs that target SLU7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLU7 Gene

Localization for SLU7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLU7 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLU7 Gene COMPARTMENTS Subcellular localization image for SLU7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SLU7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21122810
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IDA 10197984
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with SLU7: view

Pathways for SLU7 Gene

SuperPathways for SLU7 Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with SLU7: view

Pathways by source for SLU7 Gene

1 KEGG pathway for SLU7 Gene

Gene Ontology (GO) - Biological Process for SLU7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions IDA 10197984
GO:0000380 alternative mRNA splicing, via spliceosome IDA 15728250
GO:0000389 mRNA 3-splice site recognition IDA 15728250
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006886 intracellular protein transport IDA 21122810
genes like me logo Genes that share ontologies with SLU7: view

Transcripts for SLU7 Gene

Unigene Clusters for SLU7 Gene

SLU7 splicing factor homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLU7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLU7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - -
SP2: - - - -
SP3:
SP4:
SP5: - - - - - - - -
SP6: - -
SP7: -
SP8: - - -
SP9: - - - - -
SP10: - -
SP11:
SP12: -

ExUns: 17 ^ 18a · 18b ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SLU7 Gene

GeneLoc Exon Structure for
SLU7
ECgene alternative splicing isoforms for
SLU7

Expression for SLU7 Gene

mRNA expression in normal human tissues for SLU7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLU7 Gene

SOURCE GeneReport for Unigene cluster for SLU7 Gene Hs.435342

genes like me logo Genes that share expressions with SLU7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLU7 Gene

Orthologs for SLU7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLU7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLU7 35
  • 99.72 (n)
  • 99.66 (a)
SLU7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLU7 35
  • 92.78 (n)
  • 97.44 (a)
SLU7 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLU7 35
  • 94.71 (n)
  • 98.29 (a)
SLU7 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slu7 35
  • 87.01 (n)
  • 95.56 (a)
Slu7 16
Slu7 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLU7 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slu7 35
  • 86.78 (n)
  • 94.7 (a)
chicken
(Gallus gallus)
Aves SLU7 35
  • 79.14 (n)
  • 89.75 (a)
SLU7 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLU7 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22916 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slu7 35
  • 75.48 (n)
  • 83.36 (a)
Str.4427 35
zebrafish
(Danio rerio)
Actinopterygii slu7 35
  • 72.3 (n)
  • 80.94 (a)
slu7 36
  • 73 (a)
OneToOne
wufc94e11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004776 35
  • 57.61 (n)
  • 58.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Slu7 35
  • 61.22 (n)
  • 63.22 (a)
Slu7 36
  • 50 (a)
OneToOne
CG1420 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea K07C5.6 35
  • 58.41 (n)
  • 52.64 (a)
K07C5.6 36
  • 38 (a)
OneToOne
K07C5.6 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLU7 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3918 35
thale cress
(Arabidopsis thaliana)
eudicotyledons SMP1 35
  • 54.91 (n)
  • 50.78 (a)
rice
(Oryza sativa)
Liliopsida Os.12068 35
Os08g0127700 35
  • 55.08 (n)
  • 50.97 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15248 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5050 36
  • 55 (a)
OneToOne
Species with no ortholog for SLU7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLU7 Gene

ENSEMBL:
Gene Tree for SLU7 (if available)
TreeFam:
Gene Tree for SLU7 (if available)

Paralogs for SLU7 Gene

No data available for Paralogs for SLU7 Gene

Variants for SLU7 Gene

Sequence variations from dbSNP and Humsavar for SLU7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1579052 -- 160,412,508(+) TTCAA(A/T)GTTCG reference, synonymous-codon
rs1579053 -- 160,412,496(+) AGTTT(C/T)TGGGC synonymous-codon, reference
rs1579074 -- 160,412,310(+) CTGTA(C/T)ACAAA intron-variant
rs1862386 -- 160,406,522(-) CAGGA(A/G)CGGGC synonymous-codon, reference
rs1862387 -- 160,406,380(-) CCATT(G/T)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLU7 Gene

Variant ID Type Subtype PubMed ID
nsv5097 CNV Loss 18451855
nsv883072 CNV Loss 21882294
nsv527693 CNV Loss 19592680

Relevant External Links for SLU7 Gene

HapMap Linkage Disequilibrium report
SLU7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLU7 Gene

Disorders for SLU7 Gene

No disorders were found for SLU7 Gene.

No data available for UniProtKB/Swiss-Prot for SLU7 Gene

Publications for SLU7 Gene

  1. Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing. (PMID: 15728250) Shomron N. … Ast G. (J. Cell Sci. 2005) 2 3 4
  2. Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. (PMID: 10197984) Chua K. … Reed R. (Genes Dev. 1999) 2 3 4
  3. Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus. (PMID: 15181151) Shomron N. … Ast G. (Mol. Biol. Cell 2004) 3 4 23
  4. Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing. (PMID: 17804646) Alberstein M. … Ast G. (RNA 2007) 3 23
  5. The RNA splicing factor hSlu7 is required for correct 3' splice-site choice. (PMID: 10647016) Chua K. … Reed R. (Nature 1999) 3 4

Products for SLU7 Gene

Sources for SLU7 Gene

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