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SLU7 Gene

protein-coding   GIFtS: 58
GCID: GC05M159762

SLU7 Splicing Factor Homolog (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SLU7 Splicing Factor Homolog (S. Cerevisiae)1 2     Pre-MRNA-Splicing Factor SLU72
Zinc Knuckle Motif Containing1 2     Splicing Factor2
hSlu72 3     Step II Splicing Factor SLU72
9G82     

External Ids:    HGNC: 169391   Entrez Gene: 105692   Ensembl: ENSG000001646097   OMIM: 6059745   UniProtKB: O953913   

Export aliases for SLU7 gene to outside databases

Previous GC identifers: GC05M159948 GC05M160339 GC05M159765 GC05M159811 GC05M154922


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLU7 Gene:
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a
splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing
process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing
factors and is involved in protein-nucleic acid and protein-protein interactions. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLU7 Gene:
SLU7 (SLU7 splicing factor homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with SLU7 include tonsillitis, and malaria. GO annotations related to this gene include pre-mRNA 3'-splice site binding and second spliceosomal transesterification activity.

UniProtKB/Swiss-Prot: SLU7_HUMAN, O95391
Function: Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I
attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1
properly in the spliceosome and for correct AG identification when more than one possible AG exists in
3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative
splicing regulation

Gene Wiki entry for SLU7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLU7 gene promoter:
         Nkx3-1   Elk-1   Sp1   Nkx3-1 v1   LCR-F1   Nkx3-1 v2   PPAR-gamma1   Nkx3-1 v3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLU7 promoter sequence
   Search Chromatin IP Primers for SLU7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLU7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3   Ensembl cytogenetic band:  5q33.3   HGNC cytogenetic band: 5q33.3

SLU7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLU7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M159762:  view genomic region     (about GC identifiers)

Start:
159,828,648 bp from pter      End:
159,848,718 bp from pter
Size:
20,071 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SLU7_HUMAN, O95391 (See protein sequence)
Recommended Name: Pre-mRNA-splicing factor SLU7  
Size: 586 amino acids; 68387 Da
Subunit: Component of late spliceosomal complexes. Associates with the spliceosome prior to recognition of the
3'-splice site for step II, probably during catalysis of step I
Secondary accessions: D3DQK2 Q3LUJ0 Q3LUJ1 Q6RXQ5 Q96FM9

Explore the universe of human proteins at neXtProt for SLU7: NX_O95391

Explore proteomics data for SLU7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys288, Lys355
  • Modification sites at PhosphoSitePlus

  • See SLU7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006416.3  
    ENSEMBL proteins: 
     ENSP00000297151   ENSP00000428943   ENSP00000429990   ENSP00000428362  

    SLU7 Human Recombinant Protein Products:

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    Novus Biologicals SLU7 Protein
    Novus Biologicals SLU7 Lysate
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    Cloud-Clone Corp. Proteins for SLU7

    SLU7 Antibody Products:

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    Cloud-Clone Corp. ELISAs for SLU7
    Cloud-Clone Corp. CLIAs for SLU7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021715 Slu7
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry O95391

    ProtoNet protein and cluster: O95391

    1 Blocks protein domain: IPB001878 C2HC-type zinc-finger signature

    UniProtKB/Swiss-Prot: SLU7_HUMAN, O95391
    Domain: The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle
    back to the cytoplasm via the CRM1 pathway
    Similarity: Belongs to the SLU7 family
    Similarity: Contains 1 CCHC-type zinc finger


    SLU7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLU7_HUMAN, O95391
    Function: Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I
    attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1
    properly in the spliceosome and for correct AG identification when more than one possible AG exists in
    3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative
    splicing regulation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000386second spliceosomal transesterification activity IDA10197984
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IDA15181151
    GO:0030628pre-mRNA 3'-splice site binding IDA15728250
         
    SLU7 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for SLU7:
     Cell division defect  Decreased influenza A virus in  Decreased viability of wild-ty  Increased G2M DNA content, inc 
     Increased gamma-H2AX phosphory  Increased number of mitotic ce  Metaphase cells  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLU7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLU7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLU7

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLU7:
    hsa-mir-124-3p (MIRT023059)

    Block miRNA regulation of human, mouse, rat SLU7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLU7 (see all 15):
    hsa-miR-577 hsa-miR-3163 hsa-miR-4303 hsa-miR-433 hsa-miR-1290 hsa-miR-653 hsa-miR-4251 hsa-miR-198
    SwitchGear 3'UTR luciferase reporter plasmidSLU7 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SLU7

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SLU7 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: SLU7 (NM_006425)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLU7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLU7

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLU7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLU7_HUMAN, O95391: Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the
    cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the
    protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat
    shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may
    represent stress granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IDA10197984
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck IDA15728250

    SLU7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLU7 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SLU7):
        Spliceosome


    SLU7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLU7
    Interactions:

        GeneGlobe Interaction Network for SLU7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLU7 (O953911, 2, 3 ENSP000002971514) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF8Q6P2Q91, 2, ENSP000003043504EBI-750559,EBI-538479 MINT-8331833 MINT-8336001 STRING: ENSP00000304350
    CCDC85BQ158342, 3, ENSP000003116954MINT-67840 I2D: score=5 STRING: ENSP00000311695
    PPIL3Q9H2H82, 3, ENSP000002861754MINT-8337717 I2D: score=4 STRING: ENSP00000286175
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000375RNA splicing, via transesterification reactions IDA10197984
    GO:0000380alternative mRNA splicing, via spliceosome IDA15728250
    GO:0000389mRNA 3'-splice site recognition IDA15728250
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006886intracellular protein transport IDA--

    SLU7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLU7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLU7 gene: 
    NM_006425.4  

    Unigene Cluster for SLU7:

    SLU7 splicing factor homolog (S. cerevisiae)
    Hs.435342  [show with all ESTs]
    Unigene Representative Sequence: NM_006425
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297151(uc003lyg.3) ENST00000521320 ENST00000520841 ENST00000523219
    ENST00000521826 ENST00000521190 ENST00000519349(uc003lyh.1) ENST00000518268(uc003lyi.1)
    ENST00000520664
    miRNA
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    Block miRNA regulation of human, mouse, rat SLU7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLU7 (see all 15):
    hsa-miR-577 hsa-miR-3163 hsa-miR-4303 hsa-miR-433 hsa-miR-1290 hsa-miR-653 hsa-miR-4251 hsa-miR-198
    SwitchGear 3'UTR luciferase reporter plasmidSLU7 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SLU7
    Predesigned siRNA for gene silencing in human, mouse, rat SLU7
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLU7 (NM_006425)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLU7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLU7
    Primer
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    OriGene qPCR primer pairs and template standards for SLU7
    OriGene qSTAR qPCR primer pairs in human, mouse for SLU7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLU7
      QuantiTect SYBR Green Assays in human, mouse, rat SLU7
      QuantiFast Probe-based Assays in human, mouse, rat SLU7

    Additional mRNA sequence: 

    AF101074.1 AK000813.1 AK024875.1 AK314564.1 AY486334.1 BC010634.1 DQ174516.1 DQ174517.1 

    18 DOTS entries:

    DT.75138888  DT.100815957  DT.113421  DT.120874973  DT.120874953  DT.120874950  DT.97763942  DT.100810915 
    DT.100815956  DT.87016768  DT.92436670  DT.95075893  DT.95077191  DT.120875012  DT.120875027  DT.120875036 
    DT.95077192  DT.95077193 

    Selected AceView cDNA sequences (see all 264):

    CB129729 AA988874 AW103907 AF101074 BQ440015 AI669695 NM_006425 CB160479 
    BG538809 AI955199 BG392062 BU684616 BG623100 BI760642 BM480113 AA315479 
    AW157325 BM725270 BF726926 BM468455 AY486334 CR615944 AI432994 BU160436 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLU7 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                                                              -                 -                                                                           
    SP2:                    -     -                                   -                 -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                    -     -                             -     -     -     -     -     -                                                                     

    ExUns: 17 ^ 18a · 18b ^ 19
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SLU7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLU7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCTGCATC
    SLU7 Expression
    About this image


    SLU7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    SLU7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLU7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435342
        Custom PCR Arrays for SLU7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLU7
    OriGene qSTAR qPCR primer pairs in human, mouse for SLU7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLU7
    QuantiTect SYBR Green Assays in human, mouse, rat SLU7
    QuantiFast Probe-based Assays in human, mouse, rat SLU7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLU7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLU7 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slu71 , 5 SLU7 splicing factor homolog (S. cerevisiae)1, 5 87.01(n)1
    95.56(a)1
      11 (25.68 cM)5
    1931161  NM_198936.11  NP_945174.11 
     434337445 
    chicken
    (Gallus gallus)
    Aves SLU71 SLU7 splicing factor homolog (S. cerevisiae) 79.14(n)
    89.75(a)
      416157  NM_001006146.1  NP_001006146.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLU76
    SLU7 splicing factor homolog (S. cerevisiae)
    84(a)
    1 ↔ 1
    GL343286.1(1215386-1235574)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.229162 Xenopus laevis transcribed sequence with moderate similarity more 79.65(n)    CD302284.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc94e112 Transcribed sequence with moderate similarity to protein more 74.93(n)    BI888407.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG14203
    Slu71
    mRNA splicing pre-mRNA splicing factor3
    Slu71
    58(a)3
    61.22(n)1
    63.22(a)1
      434271  NM_143402.31  NP_651659.21 
    worm
    (Caenorhabditis elegans)
    Secernentea K07C5.61 , 3 Zinc finger, CCHC class3
    K07C5.61
    47(a)3
    58.41(n)1
    52.64(a)1
      V(10356264-10358404)3
    1794431  NM_073260.41  NP_505661.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SMP11 SMP1 54.91(n)
    50.78(a)
      842877  NM_105239.5  NP_564859.2 
    rice
    (Oryza sativa)
    Liliopsida Os.120682 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.32(n)    AK099242.1 


    ENSEMBL Gene Tree for SLU7 (if available)
    TreeFam Gene Tree for SLU7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLU7 (see all 440)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs133610521,2
    C,F,H--159829089(+) TCCCTA/GGAAGC 1 -- ut315Minor allele frequency- G:0.02NS EA WA 506
    rs1399908001,2
    C--159829117(+) CAATAA/GACCAA 1 -- ut310--------
    rs745329931,2
    C--159829235(+) TAGGGA/GCAATC 1 -- ut310--------
    rs745748151,2
    C,F--159829272(+) CCATAT/ACCTCT 1 -- ut311Minor allele frequency- A:0.03NA 120
    rs1843159941,2
    --159829282(+) TATGAC/TAAAGG 1 -- ut310--------
    rs1882802411,2
    --159829340(+) CTACTG/TATCAG 1 -- ut310--------
    rs1154276641,2
    C,F--159829440(+) CGCTTG/AAGCCC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs1394966081,2
    C--159829588(+) CCCTG-/TTTTTT 1 -- ut310--------
    rs31110001,2
    C,H--159829672(+) AAATAT/CAGAGA 1 -- ut3113Minor allele frequency- C:0.26NA WA CSA EA 375
    rs1925624741,2
    --159829795(+) TGAGGC/TGGGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLU7 (159828648 - 159848718 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLU7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527693CNV Loss19592680
    nsv883072CNV Loss21882294
    nsv5097CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLU7
    DNA2.0 Custom Variant and Variant Library Synthesis for SLU7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605974    OMIM disorders: --

    5 diseases for SLU7:    
    About MalaCards
    tonsillitis    malaria    cerebritis    thyroiditis
    endotheliitis


    SLU7 for disorders           About GeneDecksing


    Export disorders for SLU7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLU7 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SLU7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing. (PubMed id 15728250)1, 2, 3 Shomron N.... Ast G. (J. Cell Sci. 2005)
    2. Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. (PubMed id 10197984)1, 2, 3 Chua K. and Reed R. (Genes Dev. 1999)
    3. Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus. (PubMed id 15181151)1, 2, 9 Shomron N.... Ast G. (Mol. Biol. Cell 2004)
    4. Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7. (PubMed id 21122810)1, 2 Janowicz A.... Krebs J. (Biochim. Biophys. Acta 2011)
    5. The RNA splicing factor hSlu7 is required for correct 3' splice-site choice. (PubMed id 10647016)1, 2 Chua K. and Reed R. (Nature 1999)
    6. Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing. (PubMed id 17804646)1, 9 Alberstein M....Ast G. (RNA 2007)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly. (PubMed id 23754748)1 Banerjee S....Vijayraghavan U. (Mol. Cell. Biol. 2013)
    9. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10569 HGNC: 16939 AceView: SLU7 Ensembl:ENSG00000164609 euGenes: HUgn10569
    ECgene: SLU7 Kegg: 10569 H-InvDB: SLU7

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLU7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLU7 gene:
    Search GeneIP for patents involving SLU7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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