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Aliases for SLU7 Gene

Aliases for SLU7 Gene

  • SLU7 Homolog, Splicing Factor 2 3 5
  • Zinc Knuckle Motif Containing 2 3
  • HSlu7 3 4
  • SLU7 Splicing Factor Homolog (S. Cerevisiae) 2
  • Pre-MRNA-Splicing Factor SLU7 3
  • SLU7 Splicing Factor Homolog 3
  • Step II Splicing Factor SLU7 3
  • Splicing Factor 3
  • 9G8 3

External Ids for SLU7 Gene

Previous GeneCards Identifiers for SLU7 Gene

  • GC05M159948
  • GC05M160339
  • GC05M159765
  • GC05M159811
  • GC05M159762
  • GC05M154922

Summaries for SLU7 Gene

Entrez Gene Summary for SLU7 Gene

  • Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLU7 Gene

SLU7 (SLU7 Homolog, Splicing Factor) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and RNA Polymerase II Transcription Termination. GO annotations related to this gene include nucleic acid binding and pre-mRNA 3-splice site binding.

UniProtKB/Swiss-Prot for SLU7 Gene

  • Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

Gene Wiki entry for SLU7 Gene

Additional gene information for SLU7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLU7 Gene

Genomics for SLU7 Gene

Regulatory Elements for SLU7 Gene

Enhancers for SLU7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H160417 1 ENCODE 11.5 +2.5 2529 2 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 PTTG1 SLU7 ZBED8
GH05H160421 1 ENCODE 11.4 -0.8 -790 2 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF143 FOS RUNX3 SP3 SP5 PTTG1 SLU7 GC05M160425
GH05H160438 1.4 Ensembl ENCODE dbSUPER 6.5 -17.3 -17332 1 HDGF PKNOX1 SIN3A ARID4B ZNF2 ZNF143 ZNF207 ATF7 RUNX3 KAT8 SLU7 ZBED8 GC05P160436 GC05P160447
GH05H160293 1.2 FANTOM5 Ensembl ENCODE 6.5 +127.4 127404 1 RFX1 POLR2A NR2F1 IKZF1 MAX BMI1 EBF1 CCNJL SLU7 PWWP2A GC05P160291 SNRPEP1
GH05H160433 1.4 FANTOM5 Ensembl ENCODE 4.8 -12.2 -12224 0 HDGF ZNF76 BMI1 FEZF1 ZNF2 ZNF366 ZNF143 RUNX3 IKZF2 EGR2 MIR146A PTTG1 SLU7 FABP6 PWWP2A GC05P160436 GC05M160425
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLU7 on UCSC Golden Path with GeneCards custom track

Promoters for SLU7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000189980 -289 1201 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF143 RUNX3 SP3 SP5 MXD4

Genomic Location for SLU7 Gene

Chromosome:
5
Start:
160,401,641 bp from pter
End:
160,421,711 bp from pter
Size:
20,071 bases
Orientation:
Minus strand

Genomic View for SLU7 Gene

Genes around SLU7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLU7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLU7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLU7 Gene

Proteins for SLU7 Gene

  • Protein details for SLU7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95391-SLU7_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor SLU7
    Protein Accession:
    O95391
    Secondary Accessions:
    • D3DQK2
    • Q3LUJ0
    • Q3LUJ1
    • Q6RXQ5
    • Q96FM9

    Protein attributes for SLU7 Gene

    Size:
    586 amino acids
    Molecular mass:
    68387 Da
    Quaternary structure:
    • Component of late spliceosomal complexes. Associates with the spliceosome prior to recognition of the 3-splice site for step II, probably during catalysis of step I.

neXtProt entry for SLU7 Gene

Post-translational modifications for SLU7 Gene

  • Ubiquitination at isoforms=288 and isoforms=355
  • Modification sites at PhosphoSitePlus

Other Protein References for SLU7 Gene

No data available for DME Specific Peptides for SLU7 Gene

Domains & Families for SLU7 Gene

Gene Families for SLU7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLU7 Gene

Suggested Antigen Peptide Sequences for SLU7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95391

UniProtKB/Swiss-Prot:

SLU7_HUMAN :
  • The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.
  • Belongs to the SLU7 family.
Domain:
  • The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.
Family:
  • Belongs to the SLU7 family.
genes like me logo Genes that share domains with SLU7: view

Function for SLU7 Gene

Molecular function for SLU7 Gene

UniProtKB/Swiss-Prot Function:
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

Phenotypes From GWAS Catalog for SLU7 Gene

Gene Ontology (GO) - Molecular Function for SLU7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000386 second spliceosomal transesterification activity IDA 10197984
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IDA 15181151
GO:0030628 pre-mRNA 3-splice site binding IDA 15728250
genes like me logo Genes that share ontologies with SLU7: view
genes like me logo Genes that share phenotypes with SLU7: view

Animal Models for SLU7 Gene

MGI Knock Outs for SLU7:
  • Slu7 tm1a(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLU7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLU7 Gene

Localization for SLU7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLU7 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLU7 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLU7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 21122810
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 10197984
GO:0005737 cytoplasm IEA,IDA 21122810
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SLU7: view

Pathways & Interactions for SLU7 Gene

genes like me logo Genes that share pathways with SLU7: view

Pathways by source for SLU7 Gene

Gene Ontology (GO) - Biological Process for SLU7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions IDA 10197984
GO:0000380 alternative mRNA splicing, via spliceosome IDA 15728250
GO:0000389 mRNA 3-splice site recognition IDA 15728250
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
genes like me logo Genes that share ontologies with SLU7: view

No data available for SIGNOR curated interactions for SLU7 Gene

Drugs & Compounds for SLU7 Gene

No Compound Related Data Available

Transcripts for SLU7 Gene

Unigene Clusters for SLU7 Gene

SLU7 splicing factor homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLU7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLU7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - -
SP2: - - - -
SP3:
SP4:
SP5: - - - - - - - -
SP6: - -
SP7: -
SP8: - - -
SP9: - - - - -
SP10: - -
SP11:
SP12: -

ExUns: 17 ^ 18a · 18b ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SLU7 Gene

GeneLoc Exon Structure for
SLU7
ECgene alternative splicing isoforms for
SLU7

Expression for SLU7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLU7 Gene

Protein differential expression in normal tissues from HIPED for SLU7 Gene

This gene is overexpressed in Bone (21.2), Peripheral blood mononuclear cells (14.4), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLU7 Gene



Protein tissue co-expression partners for SLU7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLU7 Gene:

SLU7

SOURCE GeneReport for Unigene cluster for SLU7 Gene:

Hs.435342

Evidence on tissue expression from TISSUES for SLU7 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Eye(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLU7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLU7 Gene

Orthologs for SLU7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLU7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLU7 33 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia SLU7 33 34
  • 94.71 (n)
cow
(Bos Taurus)
Mammalia SLU7 33 34
  • 92.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slu7 33 16 34
  • 87.01 (n)
oppossum
(Monodelphis domestica)
Mammalia SLU7 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slu7 33
  • 86.78 (n)
chicken
(Gallus gallus)
Aves SLU7 33 34
  • 79.14 (n)
lizard
(Anolis carolinensis)
Reptilia SLU7 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slu7 33
  • 75.48 (n)
Str.4427 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.22916 33
zebrafish
(Danio rerio)
Actinopterygii slu7 33 34
  • 72.3 (n)
wufc94e11 33
fruit fly
(Drosophila melanogaster)
Insecta Slu7 33 34
  • 61.22 (n)
CG1420 35
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004776 33
  • 57.61 (n)
worm
(Caenorhabditis elegans)
Secernentea K07C5.6 35 33 34
  • 58.41 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLU7 36
thale cress
(Arabidopsis thaliana)
eudicotyledons SMP1 33
  • 54.91 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3918 33
rice
(Oryza sativa)
Liliopsida Os08g0127700 33
  • 55.08 (n)
Os.12068 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5050 34
  • 55 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15248 33
Species where no ortholog for SLU7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLU7 Gene

ENSEMBL:
Gene Tree for SLU7 (if available)
TreeFam:
Gene Tree for SLU7 (if available)

Paralogs for SLU7 Gene

No data available for Paralogs for SLU7 Gene

Variants for SLU7 Gene

Sequence variations from dbSNP and Humsavar for SLU7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000199380 -- 160,404,955(+) GAAAC(A/T)TGAGA intron-variant
rs1000234097 -- 160,401,617(+) CAAAT(A/G)TTAGA downstream-variant-500B, upstream-variant-2KB
rs1000419052 -- 160,406,810(+) TCTCA(A/G)TTGCT intron-variant
rs1000465140 -- 160,402,005(+) CACTG(A/T)TTCTA upstream-variant-2KB, utr-variant-3-prime
rs1000652121 -- 160,415,346(+) AGTAG(A/G)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLU7 Gene

Variant ID Type Subtype PubMed ID
esv3607367 CNV gain 21293372
esv3607370 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv5097 CNV deletion 18451855
nsv527693 CNV loss 19592680

Variation tolerance for SLU7 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLU7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLU7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLU7 Gene

Disorders for SLU7 Gene

Relevant External Links for SLU7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLU7

No disorders were found for SLU7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLU7 Gene

Publications for SLU7 Gene

  1. Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing. (PMID: 15728250) Shomron N … Ast G (Journal of cell science 2005) 2 3 4 60
  2. Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus. (PMID: 15181151) Shomron N … Ast G (Molecular biology of the cell 2004) 3 4 22 60
  3. Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. (PMID: 10197984) Chua K … Reed R (Genes & development 1999) 2 3 4 60
  4. Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7. (PMID: 21122810) Janowicz A … Krebs J (Biochimica et biophysica acta 2011) 3 4 60
  5. Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing. (PMID: 17804646) Alberstein M … Ast G (RNA (New York, N.Y.) 2007) 3 22 60

Products for SLU7 Gene

Sources for SLU7 Gene

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