Aliases for SLU7 Gene
External Ids for SLU7 Gene
Previous GeneCards Identifiers for SLU7 Gene
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLU7 Gene
SLU7 (SLU7 Homolog, Splicing Factor) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and RNA Polymerase II Transcription Termination. GO annotations related to this gene include nucleic acid binding and pre-mRNA 3-splice site binding.
UniProtKB/Swiss-Prot for SLU7 Gene
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.