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Aliases for SLTM Gene

Aliases for SLTM Gene

  • SAFB-Like, Transcription Modulator 2 3
  • Modulator Of Estrogen-Induced Transcription 3 4
  • Met 3 4

External Ids for SLTM Gene

Previous GeneCards Identifiers for SLTM Gene

  • GC15M056959
  • GC15M059171
  • GC15M035994

Summaries for SLTM Gene

GeneCards Summary for SLTM Gene

SLTM (SAFB-Like, Transcription Modulator) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SAFB.

UniProtKB/Swiss-Prot for SLTM Gene

  • When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLTM Gene

Genomics for SLTM Gene

Regulatory Elements for SLTM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLTM Gene

Chromosome:
15
Start:
58,879,045 bp from pter
End:
58,934,313 bp from pter
Size:
55,269 bases
Orientation:
Minus strand

Genomic View for SLTM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLTM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLTM Gene

Proteins for SLTM Gene

  • Protein details for SLTM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWH9-SLTM_HUMAN
    Recommended name:
    SAFB-like transcription modulator
    Protein Accession:
    Q9NWH9
    Secondary Accessions:
    • A8K5V8
    • B2RTX3
    • Q2VPK7
    • Q52MB3
    • Q658J7
    • Q6ZNF2
    • Q86TK6
    • Q9H7C3
    • Q9H8U9

    Protein attributes for SLTM Gene

    Size:
    1034 amino acids
    Molecular mass:
    117148 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI08657.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14502.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14971.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14971.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLTM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLTM Gene

Proteomics data for SLTM Gene at MOPED

Post-translational modifications for SLTM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLTM Gene

Domains & Families for SLTM Gene

Gene Families for SLTM Gene

Suggested Antigen Peptide Sequences for SLTM Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWH9

UniProtKB/Swiss-Prot:

SLTM_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 SAP domain.
genes like me logo Genes that share domains with SLTM: view

Function for SLTM Gene

Molecular function for SLTM Gene

UniProtKB/Swiss-Prot Function:
When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.

Gene Ontology (GO) - Molecular Function for SLTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SLTM: view
genes like me logo Genes that share phenotypes with SLTM: view

Animal Model Products

miRNA for SLTM Gene

miRTarBase miRNAs that target SLTM

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLTM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLTM Gene

Localization for SLTM Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLTM Gene

Nucleus. Note=Detected in punctate structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLTM Gene COMPARTMENTS Subcellular localization image for SLTM gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SLTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SLTM: view

Pathways & Interactions for SLTM Gene

genes like me logo Genes that share pathways with SLTM: view

Interacting Proteins for SLTM Gene

Gene Ontology (GO) - Biological Process for SLTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with SLTM: view

No data available for SIGNOR curated interactions for SLTM Gene

Drugs & Compounds for SLTM Gene

No Compound Related Data Available

Transcripts for SLTM Gene

Unigene Clusters for SLTM Gene

SAFB-like, transcription modulator:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLTM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLTM Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - -
SP8: -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d · 17e ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - -
SP13:
SP14: - -
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for SLTM Gene

GeneLoc Exon Structure for
SLTM
ECgene alternative splicing isoforms for
SLTM

Expression for SLTM Gene

mRNA expression in normal human tissues for SLTM Gene

Protein differential expression in normal tissues from HIPED for SLTM Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6) and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SLTM Gene



SOURCE GeneReport for Unigene cluster for SLTM Gene Hs.512932

genes like me logo Genes that share expression patterns with SLTM: view

Protein tissue co-expression partners for SLTM Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLTM Gene

Orthologs for SLTM Gene

This gene was present in the common ancestor of animals.

Orthologs for SLTM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLTM 35
  • 94.46 (n)
  • 95.21 (a)
SLTM 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLTM 35
  • 94.45 (n)
  • 95.61 (a)
SLTM 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sltm 35
  • 89.46 (n)
  • 91.37 (a)
Sltm 16
Sltm 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLTM 35
  • 99.77 (n)
  • 100 (a)
SLTM 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLTM 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLTM 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLTM 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6513 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22945 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15690 35
sltm 35
  • 60.46 (n)
  • 59.89 (a)
sltm 36
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10016 35
fruit fly
(Drosophila melanogaster)
Insecta Saf-B 36
  • 21 (a)
OneToMany
Species with no ortholog for SLTM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLTM Gene

ENSEMBL:
Gene Tree for SLTM (if available)
TreeFam:
Gene Tree for SLTM (if available)

Paralogs for SLTM Gene

Paralogs for SLTM Gene

genes like me logo Genes that share paralogs with SLTM: view

Variants for SLTM Gene

Sequence variations from dbSNP and Humsavar for SLTM Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs953204 -- 58,910,206(-) CTGTT(A/T)ACTTT intron-variant
rs953205 -- 58,910,025(-) tctct(A/G)ttata intron-variant
rs954023 -- 58,909,839(-) TGCTG(C/T)tatag intron-variant
rs964285 -- 58,878,765(+) ATATA(A/G)AGGGA downstream-variant-500B
rs1079087 -- 58,893,557(+) TGATA(C/T)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLTM Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
esv34110 CNV Loss 18971310
nsv527307 CNV Gain 19592680
nsv904270 CNV Loss 21882294
nsv94675 CNV Loss 16902084

Variation tolerance for SLTM Gene

Residual Variation Intolerance Score: 3.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLTM Gene

HapMap Linkage Disequilibrium report
SLTM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLTM Gene

Disorders for SLTM Gene

Relevant External Links for SLTM

Genetic Association Database (GAD)
SLTM
Human Genome Epidemiology (HuGE) Navigator
SLTM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLTM
genes like me logo Genes that share disorders with SLTM: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLTM Gene

Publications for SLTM Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67
  3. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 67

Products for SLTM Gene

Sources for SLTM Gene

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