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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLTM Gene

protein-coding   GIFtS: 51
GCID: GC15M059171

SAFB-Like, Transcription Modulator

  Search for SLTM
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SAFB-Like, Transcription Modulator1 2
Modulator Of Estrogen-Induced Transcription2 3
Met2
SAFB-Like Transcription Modulator2
MET3

External Ids:    HGNC: 207091   Entrez Gene: 798112   Ensembl: ENSG000001377767   UniProtKB: Q9NWH93   

Export aliases for SLTM gene to outside databases

Previous GC identifers: GC15M056959 GC15M035994


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLTM Gene: 
SLTM (SAFB-like, transcription modulator) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SAFB2.

UniProtKB/Swiss-Prot: SLTM_HUMAN, Q9NWH9
Function: When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis (By
similarity)

summary for SLTM Gene:
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLTM gene promoter:
         NF-AT   GATA-1   Evi-1   AREB6   NF-AT4   NF-AT2   Sox9   NF-AT3   aMEF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLTM promoter sequence
   Search SABiosciences Chromatin IP Primers for SLTM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLTM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.1   Ensembl cytogenetic band:  15q22.1   HGNC cytogenetic band: 15q21.3

SLTM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLTM gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M059171:  view genomic region     (about GC identifiers)

Start:
59,171,244 bp from pter      End:
59,225,852 bp from pter
Size:
54,609 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SLTM_HUMAN, Q9NWH9 (See protein sequence)
Recommended Name: SAFB-like transcription modulator  
Size: 1034 amino acids; 117148 Da
Subcellular location: Nucleus (By similarity). Note=Detected in punctate structures (By similarity)
Sequence caution: Sequence=AAI08657.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAB14502.1; Type=Erroneous initiation; Sequence=BAB14971.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB14971.1; Type=Miscellaneous discrepancy; Note=Contaminating
sequence. Potential poly-A sequence;
Secondary accessions: B2RTX3 Q2VPK7 Q52MB3 Q658J7 Q6ZNF2 Q86TK6 Q9H7C3 Q9H8U9

Explore the universe of human proteins at neXtProt for SLTM: NX_Q9NWH9

Explore proteomics data for SLTM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NWH9

  • SLTM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLTM Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001013865.1  NP_079031.2  

    ENSEMBL proteins: 
     ENSP00000369887   ENSP00000411534   ENSP00000452805   ENSP00000453711   ENSP00000454000  
     ENSP00000453662   ENSP00000452945   ENSP00000249736   ENSP00000453371   ENSP00000453065  
     ENSP00000453179   ENSP00000453987   ENSP00000453775   ENSP00000439271  

    Human Recombinant Protein Products for SLTM: 
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    Novus Biologicals SLTM Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLTM 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    SLTM for ontologies           About GeneDecksing



    SLTM Antibody Products: 
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    Assay Products for SLTM: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLTM 
    Cloud-Clone Corp. CLIAs for SLTM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR003034 SAP_dom
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9NWH9

    ProtoNet protein and cluster: Q9NWH9

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB003034 DNA-binding SAP


    UniProtKB/Swiss-Prot: SLTM_HUMAN, Q9NWH9
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 SAP domain


    SLTM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLTM_HUMAN, Q9NWH9
    Function: When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    SLTM for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLTM:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLTM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLTM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLTM 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLTM 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLTM:
    hsa-mir-34b (MIRT004825), hsa-mir-1 (MIRT001357), hsa-mir-34c-5p (MIRT000757), hsa-mir-340 (MIRT005458), hsa-mir-30a (MIRT005167), hsa-mir-34b (MIRT000758), hsa-mir-206 (MIRT000185), hsa-mir-562 (MIRT005024), hsa-mir-199b-3p (MIRT004514), hsa-mir-34a (MIRT000759), hsa-mir-23b (MIRT004292)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLTM
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SLTM (see all 33):
    hsa-miR-411* hsa-miR-607 hsa-miR-379* hsa-miR-429 hsa-miR-3614-3p hsa-miR-132 hsa-miR-606 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSLTM 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLTM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLTM

    Gene Editing
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    Sirion Biotech Validated adenovirus to knockdown SLTM (MET) in human, mouse 
                         Customized adenovirus for overexpression of SLTM

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SLTM (NM_024755)
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                         Customized lentivirus expression plasmids for stable overexpression of SLTM 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SLTM
    Search LifeMap BioReagents cell lines for SLTM
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLTM


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Tocris Bioscience Pathway for SLTM
        Akt Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLTM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for SLTM (Q9NWH92, 3 ENSP000003698874) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    NELL1Q928322, 3, ENSP000002989254MINT-8187739 I2D: score=1 STRING: ENSP00000298925
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IEA--

    SLTM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SLTM available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CrizotinibPotent c-MET/ALK inhibitor[877399-52-5]
    PF 04217903 mesylateHighly selective c-Met inhibitor[956906-93-7]
    PHA 665752Potent and selective MET inhibitor[477575-56-7]
    SU 11274Selective inhibitor of MET kinase activity[658084-23-2]

    Search CenterWatch for drugs/clinical trials and news about SLTM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLTM gene (3 alternative transcripts): 
    NM_017968.2  NM_001013843.1  NM_024755.2  

    Unigene Cluster for SLTM:

    SAFB-like, transcription modulator
    Hs.512932  [show with all ESTs]
    Unigene Representative Sequence: NM_024755
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000380516(uc002afn.3 uc002afo.3 uc002afp.3 uc002afq.3 uc010bgd.3)
    ENST00000432750 ENST00000560494 ENST00000492526 ENST00000493062 ENST00000557924
    ENST00000558052 ENST00000560695 ENST00000557791 ENST00000558734 ENST00000497088
    ENST00000558756 ENST00000249736 ENST00000473359 ENST00000559305 ENST00000480144(uc002afr.1)
    ENST00000559880 ENST00000558486
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLTM
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate SLTM (see all 33):
    hsa-miR-411* hsa-miR-607 hsa-miR-379* hsa-miR-429 hsa-miR-3614-3p hsa-miR-132 hsa-miR-606 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSLTM 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLTM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLTM
    Clone
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    OriGene clones in human, mouse for SLTM (see all 15)
    OriGene ORF clones in mouse, rat for SLTM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLTM (NM_024755)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLTM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLTM
    Sirion Biotech Customized lentivirus for stable overexpression of SLTM 
                         Customized lentivirus expression plasmids for stable overexpression of SLTM 
    Primer
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    OriGene qPCR primer pairs and template standards for SLTM
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLTM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLTM

    Additional mRNA sequence: 

    AK000867.1 AK023275.1 AK024710.1 AK055195.1 AK131242.1 AK291423.1 AL834297.1 BC014944.1 
    BC040120.1 BC046119.1 BC108656.1 BC140851.1 

    24/32 DOTS entries (see all 32):

    DT.91668337  DT.92441749  DT.100824151  DT.416645  DT.95226820  DT.121067727  DT.91748271  DT.92441742 
    DT.121067633  DT.100824149  DT.92441743  DT.100715676  DT.121067559  DT.40279242  DT.100724795  DT.100824150 
    DT.121067623  DT.121067625  DT.86752183  DT.92441744  DT.100657323  DT.100824147  DT.121067550  DT.121067698 

    24/328 AceView cDNA sequences (see all 328):

    AA281405 AA479225 BP336775 BF593573 AI082786 AI962572 BU521691 AL834297 
    BQ224039 AV704632 BQ009455 AA587698 AA779624 AA931237 NM_024755 AL535480 
    AK023275 CB134801 AI005007 AA491094 AU138111 BG756820 AA479070 BM983311 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for SLTM (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^
    SP1:                                      -     -     -                 -     -                                               -                                 
    SP2:                                      -     -     -                 -     -                                   -           -                                 
    SP3:                                                                    -     -                                   -           -                                 
    SP4:                                                                                                              -           -                                 
    SP5:                                      -     -     -                 -     -     -     -     -                 -           -                                 

    ExUns: 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d · 17e ^ 18 ^ 19 ^ 20
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for SLTM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLTM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCAACTA
    SLTM Expression
    About this image


    See SLTM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLTM

    SOURCE GeneReport for Unigene cluster: Hs.512932
        SABiosciences Custom PCR Arrays for SLTM
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLTM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLTM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLTM gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sltm1 , 5 SAFB-like, transcription modulator1, 5 89.4(n)1
    91.21(a)1
      9 (39.53 cM)5
    666601  NM_026337.11  NP_080613.11 
     705429205 
    chicken
    (Gallus gallus)
    Aves SLTM1 SAFB-like, transcription modulator 80.22(n)
    81.62(a)
      415401  XM_413786.3  XP_413786.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLTM6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL343573.1(183307-197333)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.229452 Xenopus laevis transcribed sequence with weak similarity more 77.03(n)    BU914625.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.156902 Danio rerio cDNA clone MGC65985 IMAGE6792464, complete more 72.64(n)    BC056582.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Saf-B1 Scaffold attachment factor B 41.05(n)
    34.05(a)
      42958  NM_170169.2  NP_733041.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPG16
    eIF3a subunit of the core complex of translation i...
    4(a)
    1 → many
    II(395383-398277)


    ENSEMBL Gene Tree for SLTM (if available)
    TreeFam Gene Tree for SLTM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLTM gene
    SAFB22  SAFB2  
    2 SIMAP similar genes for SLTM using alignment to 13 protein entries:     SLTM_HUMAN (see all proteins):
    SAFB    SAFB2

    SLTM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1098 SNPs in SLTM are shown (see all 1098)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1435746501,2
    C--59170864(+) ACTCAG/TAAGTG 2 -- ds50010--------
    rs9642851,2
    C,F,H--59170964(+) ATATAA/GAGGGA 2 -- ds500133Minor allele frequency- N:0.00NS EA NA WA 3116
    rs1882565331,2
    --59170985(+) TTTTTG/TGAAAG 2 -- ds50010--------
    rs1467743071,2
    --59170988(+) TTTGAA/CAGAGC 2 -- ds50010--------
    rs1467365041,2
    C--59171427(+) TCCAT-/CAAA  
            
    CAAAC
    2 -- ut310--------
    rs1809136551,2
    --59171550(+) AACCTC/GAACAA 2 -- ut310--------
    rs1863984641,2
    --59171604(+) TTAAAA/CAGGTT 2 -- ut310--------
    rs1896393911,2
    --59171609(+) AAGGTC/TCTCAA 2 -- ut310--------
    rs1405000301,2
    --59171616(+) TCAACA/CCTTTA 2 -- ut310--------
    rs1815338041,2
    --59171692(+) GATGCA/TCTTAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SLTM (59171244 - 59225852 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLTM:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904270CNV Loss21882294
    esv34110CNV Loss18971310
    nsv94675CNV Loss16902084
    nsv527307CNV Gain19592680
    nsv904254CNV Gain21882294
    nsv7266OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLTM for disorders           About MalaCards

    SLTM for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLTM
    Human Genome Epidemiology (HuGE) Navigator: SLTM (1 document)

    Export disorders for SLTM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLTM gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SLTM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variants in several genomic regions associated with a sperger disorder. (PubMed id 21182207)1, 4 Salyakina D....Pericak-Vance M.A. (2010)
    2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79811 HGNC: 20709 AceView: FLJ13213 Ensembl:ENSG00000137776 euGenes: HUgn79811
    ECgene: SLTM H-InvDB: SLTM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLTM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLTM gene:
    Search GeneIP for patents involving SLTM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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