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Aliases for SLTM Gene

Aliases for SLTM Gene

  • SAFB Like Transcription Modulator 2 3 5
  • Modulator Of Estrogen-Induced Transcription 3 4
  • MET 3 4
  • SAFB-Like Transcription Modulator 3

External Ids for SLTM Gene

Previous GeneCards Identifiers for SLTM Gene

  • GC15M056959
  • GC15M059171
  • GC15M035994

Summaries for SLTM Gene

GeneCards Summary for SLTM Gene

SLTM (SAFB Like Transcription Modulator) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SAFB2.

UniProtKB/Swiss-Prot for SLTM Gene

  • When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLTM Gene

Genomics for SLTM Gene

Regulatory Elements for SLTM Gene

Enhancers for SLTM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G058864 1.6 FANTOM5 Ensembl ENCODE 13.3 +68.6 68567 3.3 PKNOX1 FOXA2 ATF1 ARNT ARID4B SIN3A DMAP1 BRCA1 ZNF48 DEK MINDY2 SLTM ENSG00000225798 LOC101928725 SNORD3P1 ENSG00000259353 RNF111 ADAM10 RPL21P14
GH15G058515 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +416.6 416621 4.5 HDAC1 PKNOX1 FOXA2 ATF1 WRNIP1 RAD21 RELB IKZF2 CREM USF2 ADAM10 SLTM LIPC ENSG00000225798 RNF111 AQP9 LOC101928668 LIPC-AS1
GH15G058833 1.2 Ensembl ENCODE 10.8 +100.5 100500 1.4 PKNOX1 ATF1 CREB3L1 ARNT TCF12 ELK1 GATA2 KLF13 NCOA1 REST LOC101928725 MINDY2 SNORD3P1 ENSG00000225798 SLTM ADAM10 LIPC ENSG00000259402 GC15P058860
GH15G058737 1.2 FANTOM5 Ensembl ENCODE 9.6 +195.9 195913 1.6 JUN ZNF10 CEBPB FOSL1 FOXM1 JUND NR2C1 ZBTB33 FOS MYC MINDY2 SNORD3P1 LOC101928725 ENSG00000225798 SLTM RNF111 ADAM10 ENSG00000278513
GH15G058731 1.1 FANTOM5 Ensembl ENCODE 9.6 +202.0 202027 2.2 JUND JUN CEBPB NFE2L1 NFE2 FOS NFE2L2 MINDY2 SNORD3P1 LOC101928725 ENSG00000225798 SLTM ADAM10 RNF111 ENSG00000278513
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLTM on UCSC Golden Path with GeneCards custom track

Promoters for SLTM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000077273 1213 3001 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for SLTM Gene

Chromosome:
15
Start:
58,879,045 bp from pter
End:
58,934,313 bp from pter
Size:
55,269 bases
Orientation:
Minus strand

Genomic View for SLTM Gene

Genes around SLTM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLTM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLTM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLTM Gene

Proteins for SLTM Gene

  • Protein details for SLTM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWH9-SLTM_HUMAN
    Recommended name:
    SAFB-like transcription modulator
    Protein Accession:
    Q9NWH9
    Secondary Accessions:
    • A8K5V8
    • B2RTX3
    • Q2VPK7
    • Q52MB3
    • Q658J7
    • Q6ZNF2
    • Q86TK6
    • Q9H7C3
    • Q9H8U9

    Protein attributes for SLTM Gene

    Size:
    1034 amino acids
    Molecular mass:
    117148 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI08657.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14502.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14971.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14971.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLTM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLTM Gene

Post-translational modifications for SLTM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLTM Gene

Domains & Families for SLTM Gene

Gene Families for SLTM Gene

Suggested Antigen Peptide Sequences for SLTM Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SLTM: view

No data available for UniProtKB/Swiss-Prot for SLTM Gene

Function for SLTM Gene

Molecular function for SLTM Gene

UniProtKB/Swiss-Prot Function:
When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.

Gene Ontology (GO) - Molecular Function for SLTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003690 double-stranded DNA binding IBA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with SLTM: view
genes like me logo Genes that share phenotypes with SLTM: view

Animal Model Products

CRISPR Products

miRNA for SLTM Gene

miRTarBase miRNAs that target SLTM

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLTM Gene

Localization for SLTM Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLTM Gene

Nucleus. Note=Detected in punctate structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLTM gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SLTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with SLTM: view

Pathways & Interactions for SLTM Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006915 apoptotic process IEA --
GO:0050684 regulation of mRNA processing IBA --
genes like me logo Genes that share ontologies with SLTM: view

No data available for Pathways by source and SIGNOR curated interactions for SLTM Gene

Drugs & Compounds for SLTM Gene

No Compound Related Data Available

Transcripts for SLTM Gene

Unigene Clusters for SLTM Gene

SAFB-like, transcription modulator:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLTM Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - -
SP8: -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d · 17e ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - -
SP13:
SP14: - -
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for SLTM Gene

GeneLoc Exon Structure for
SLTM
ECgene alternative splicing isoforms for
SLTM

Expression for SLTM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLTM Gene

Protein differential expression in normal tissues from HIPED for SLTM Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6) and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLTM Gene



Protein tissue co-expression partners for SLTM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLTM Gene:

SLTM

SOURCE GeneReport for Unigene cluster for SLTM Gene:

Hs.512932

Evidence on tissue expression from TISSUES for SLTM Gene

  • Nervous system(4.6)
  • Intestine(4.3)
  • Liver(4.3)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with SLTM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLTM Gene

Orthologs for SLTM Gene

This gene was present in the common ancestor of animals.

Orthologs for SLTM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLTM 35 34
  • 99.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLTM 34 35
  • 94.46 (n)
dog
(Canis familiaris)
Mammalia SLTM 34 35
  • 94.45 (n)
mouse
(Mus musculus)
Mammalia Sltm 16 35 34
  • 89.46 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 84 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLTM 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLTM 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLTM 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6513 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22945 34
zebrafish
(Danio rerio)
Actinopterygii sltm 34 35
  • 60.46 (n)
Dr.15690 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10016 34
fruit fly
(Drosophila melanogaster)
Insecta Saf-B 35
  • 21 (a)
OneToMany
Species where no ortholog for SLTM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLTM Gene

ENSEMBL:
Gene Tree for SLTM (if available)
TreeFam:
Gene Tree for SLTM (if available)

Paralogs for SLTM Gene

Paralogs for SLTM Gene

genes like me logo Genes that share paralogs with SLTM: view

Variants for SLTM Gene

Sequence variations from dbSNP and Humsavar for SLTM Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000406541 -- 58,901,578(+) TTCTT(C/T)CTCAT intron-variant
rs1000495887 -- 58,913,428(+) AACTA(C/G)AAAAA intron-variant
rs1000827465 -- 58,923,379(+) AAATA(A/G)TCTCT intron-variant
rs1000910711 -- 58,917,956(+) ACCAC(A/G)TTGGC intron-variant
rs1000914761 -- 58,934,011(+) CGTGC(C/G)CGCGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLTM Gene

Variant ID Type Subtype PubMed ID
esv34110 CNV loss 18971310
nsv1035640 CNV gain 25217958
nsv527307 CNV gain 19592680
nsv7266 OTHER inversion 18451855
nsv94675 CNV deletion 16902084

Variation tolerance for SLTM Gene

Residual Variation Intolerance Score: 3.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLTM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLTM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLTM Gene

Disorders for SLTM Gene

Relevant External Links for SLTM

Genetic Association Database (GAD)
SLTM
Human Genome Epidemiology (HuGE) Navigator
SLTM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLTM

No disorders were found for SLTM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLTM Gene

Publications for SLTM Gene

  1. Variants in several genomic regions associated with asperger disorder. (PMID: 21182207) Salyakina D. … Pericak-Vance M.A. (Autism Res 2010) 3 46 64
  2. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64

Products for SLTM Gene

Sources for SLTM Gene

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