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Aliases for SLTM Gene

Aliases for SLTM Gene

  • SAFB-Like, Transcription Modulator 2 3
  • Modulator Of Estrogen-Induced Transcription 3 4
  • Met 3 4
  • SAFB-Like Transcription Modulator 3

External Ids for SLTM Gene

Summaries for SLTM Gene

GeneCards Summary for SLTM Gene

SLTM (SAFB-Like, Transcription Modulator) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SAFB.

UniProtKB/Swiss-Prot for SLTM Gene

  • When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLTM Gene

Genomics for SLTM Gene

Genomic Location for SLTM Gene

Start:
58,879,045 bp from pter
End:
58,934,124 bp from pter
Size:
55,080 bases
Orientation:
Minus strand

Genomic View for SLTM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLTM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLTM Gene

Regulatory Elements for SLTM Gene

Proteins for SLTM Gene

  • Protein details for SLTM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWH9-SLTM_HUMAN
    Recommended name:
    SAFB-like transcription modulator
    Protein Accession:
    Q9NWH9
    Secondary Accessions:
    • A8K5V8
    • B2RTX3
    • Q2VPK7
    • Q52MB3
    • Q658J7
    • Q6ZNF2
    • Q86TK6
    • Q9H7C3
    • Q9H8U9

    Protein attributes for SLTM Gene

    Size:
    1034 amino acids
    Molecular mass:
    117148 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI08657.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14502.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14971.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14971.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLTM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLTM Gene

Proteomics data for SLTM Gene at MOPED

Post-translational modifications for SLTM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLTM Gene

Domains for SLTM Gene

Gene Families for SLTM Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

SLTM_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q9NWH9
  • Contains 1 SAP domain.:
    • Q9NWH9
genes like me logo Genes that share domains with SLTM: view

Function for SLTM Gene

Molecular function for SLTM Gene

UniProtKB/Swiss-Prot Function: When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.

Gene Ontology (GO) - Molecular Function for SLTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SLTM: view

Phenotypes for SLTM Gene

GenomeRNAi human phenotypes for SLTM:
genes like me logo Genes that share phenotypes with SLTM: view

miRNA for SLTM Gene

miRTarBase miRNAs that target SLTM

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLTM Gene

Localization for SLTM Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLTM Gene

Nucleus. Note=Detected in punctate structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLTM Gene COMPARTMENTS Subcellular localization image for SLTM gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SLTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SLTM: view

Pathways for SLTM Gene

genes like me logo Genes that share pathways with SLTM: view

Interacting Proteins for SLTM Gene

Gene Ontology (GO) - Biological Process for SLTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with SLTM: view

Transcripts for SLTM Gene

Unigene Clusters for SLTM Gene

SAFB-like, transcription modulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLTM Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - -
SP8: -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d · 17e ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - -
SP13:
SP14: - -
SP15: -
SP16:
SP17:
SP18:

Relevant External Links for SLTM Gene

GeneLoc Exon Structure for
SLTM
ECgene alternative splicing isoforms for
SLTM

Expression for SLTM Gene

mRNA expression in normal human tissues for SLTM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLTM Gene

SOURCE GeneReport for Unigene cluster for SLTM Gene Hs.512932

genes like me logo Genes that share expressions with SLTM: view

Orthologs for SLTM Gene

This gene was present in the common ancestor of animals.

Orthologs for SLTM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLTM 36
  • 99.77 (n)
  • 100 (a)
SLTM 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLTM 36
  • 94.46 (n)
  • 95.21 (a)
SLTM 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLTM 36
  • 94.45 (n)
  • 95.61 (a)
SLTM 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sltm 36
  • 89.46 (n)
  • 91.37 (a)
Sltm 16
Sltm 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 84 (a)
OneToMany
-- 37
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLTM 37
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLTM 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLTM 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22945 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6513 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10016 36
zebrafish
(Danio rerio)
Actinopterygii Dr.15690 36
sltm 36
  • 60.46 (n)
  • 59.89 (a)
sltm 37
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Saf-B 37
  • 21 (a)
OneToMany
Species with no ortholog for SLTM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLTM Gene

ENSEMBL:
Gene Tree for SLTM (if available)
TreeFam:
Gene Tree for SLTM (if available)

Paralogs for SLTM Gene

Paralogs for SLTM Gene

genes like me logo Genes that share paralogs with SLTM: view

Variants for SLTM Gene

Sequence variations from dbSNP and Humsavar for SLTM Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3145 -- 58,919,912(-) TCTGA(C/T)AGCAC intron-variant
rs953204 -- 58,910,206(-) CTGTT(A/T)ACTTT intron-variant
rs953205 -- 58,910,025(-) tctct(A/G)ttata intron-variant
rs954023 -- 58,909,839(-) TGCTG(C/T)tatag intron-variant
rs964285 -- 58,878,765(+) ATATA(A/G)AGGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLTM Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
esv34110 CNV Loss 18971310
nsv527307 CNV Gain 19592680
nsv904270 CNV Loss 21882294
nsv94675 CNV Loss 16902084

Relevant External Links for SLTM Gene

HapMap Linkage Disequilibrium report
SLTM

Disorders for SLTM Gene

Relevant External Links for SLTM

Genetic Association Database (GAD)
SLTM
Human Genome Epidemiology (HuGE) Navigator
SLTM
genes like me logo Genes that share disorders with SLTM: view

No data available for UniProtKB/Swiss-Prot for SLTM Gene

Publications for SLTM Gene

  1. Variants in several genomic regions associated with asperger disorder. (PMID: 21182207) Salyakina D. … Pericak-Vance M.A. (Autism Res 2010) 3 49
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 49
  4. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3
  5. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PMID: 20811636) Giannone R.J. … Liu Y. (PLoS ONE 2010) 3

Products for SLTM Gene

Sources for SLTM Gene

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