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SLPI Gene

protein-coding   GIFtS: 55
GCID: GC20M043880

Secretory Leukocyte Peptidase Inhibitor

(Previous name: secretory leukocyte protease inhibitor (antileukoproteinase))
  See SLPI-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Secretory Leukocyte Peptidase Inhibitor1 2     MPI2 3
Secretory Leukocyte Protease Inhibitor (Antileukoproteinase)1 2     WAP42 3
antileukoproteinase1 2     WFDC42 3
Mucus Proteinase Inhibitor2 3     WAP Four-Disulfide Core Domain Protein 42 3
Protease Inhibitor WAP42 3     HUSI2 5
Seminal Proteinase Inhibitor2 3     ALK12
ALP2 3     HUSI-I2
BLPI2 3     Secretory Leukocyte Protease Inhibitor3
HUSI-12 3     

External Ids:    HGNC: 110921   Entrez Gene: 65902   Ensembl: ENSG000001241077   OMIM: 1072855   UniProtKB: P039733   

Export aliases for SLPI gene to outside databases

Previous GC identifers: GC20M043609 GC20M044519 GC20M044566 GC20M043314 GC20M040622


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLPI Gene:
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in
various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for
trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by
protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have
broad-spectrum anti-biotic activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLPI Gene:
SLPI (secretory leukocyte peptidase inhibitor) is a protein-coding gene. Diseases associated with SLPI include trichomoniasis, and urogenital tuberculosis. GO annotations related to this gene include endopeptidase inhibitor activity and enzyme binding.

UniProtKB/Swiss-Prot: SLPI_HUMAN, P03973
Function: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and
cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues

Gene Wiki entry for SLPI Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLPI gene promoter:
         TBP   C/EBPbeta   ISGF-3   USF1   Nkx2-2   Arnt   Roaz   C/EBPalpha   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLPI promoter sequence
   Search Chromatin IP Primers for SLPI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLPI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

SLPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLPI gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043880:  view genomic region     (about GC identifiers)

Start:
43,880,879 bp from pter      End:
43,883,206 bp from pter
Size:
2,328 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SLPI_HUMAN, P03973 (See protein sequence)
Recommended Name: Antileukoproteinase precursor  
Size: 132 amino acids; 14326 Da
Miscellaneous: The pathologies of several chronic and acute diseases of the respiratory tract involve an imbalance
between the proteases of cells involved in inflammatary responses and the inhibitors of these proteases. The
inflammation-mediated release of neutrophil elastase in the lungs of patients whose levels of active
alpha-1-antiprotease are compromised by genetic background, cigarette smoking, air pollutants, or a combination
of all three can result in severe lung damage and a decreased lifespan. The relatively small size of this
protein, its lack of glycosylation and its stability make this protein a candidate for use as a therapeutic agent
in diseases mediated by leukocyte elastase-antielastase imbalances
2 PDB 3D structures from and Proteopedia for SLPI:
2Z7F (3D)        4DOQ (3D)    
Secondary accessions: B2R5H8 P07757

Explore the universe of human proteins at neXtProt for SLPI: NX_P03973

Explore proteomics data for SLPI at MOPED


See SLPI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003055.1  
ENSEMBL proteins: 
 ENSP00000342082  

SLPI Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for SLPI

 
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SLPI Antibody Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
WFDC: WAP four-disulfide core domain containing

1 InterPro protein domain:
 IPR008197 WAP-type_4-diS_core

Graphical View of Domain Structure for InterPro Entry P03973

ProtoNet protein and cluster: P03973

1 Blocks protein domain: IPB008197 4-disulphide core signature

UniProtKB/Swiss-Prot: SLPI_HUMAN, P03973
Similarity: Contains 2 WAP domains


Find genes that share domains with SLPI           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SLPI_HUMAN, P03973
Function: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and
cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues

     Genatlas biochemistry entry for SLPI:
secretory leukoprotease inhibitor,involved in antineutrophil elastase protection at inflammatory sites

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004866endopeptidase inhibitor activity TAS3485543
GO:0004867serine-type endopeptidase inhibitor activity IEA--
GO:0005515protein binding IPI19333378
GO:0019899enzyme binding IPI19333378
GO:0030414peptidase inhibitor activity ----
     
Find genes that share ontologies with SLPI           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for SLPI:
 Big cells 

     4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slpi):
 hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

Find genes that share phenotypes with SLPI           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for SLPI: Slpitm1Nkw Slpitm1Ktak Slpitm1Smw

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLPI
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLPI

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLPI
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLPI

miRNA
Products:
    
miRTarBase miRNAs that target SLPI:
hsa-mir-146a-5p (MIRT021280), hsa-mir-335-5p (MIRT018178)

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Search for qRT-PCR Assays for microRNAs that regulate SLPI
SwitchGear 3'UTR luciferase reporter plasmidSLPI 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat SLPI

Gene Editing
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Sino Biological Human cDNA Clone for SLPI
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLPI
Addgene plasmids for SLPI 

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for SLPI 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLPI


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SLPI_HUMAN, P03973: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytosol2
nucleus2
cytoskeleton1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0031012colocalizes with extracellular matrix IDA--
GO:0070062extracellular vesicular exosome IDA19199708

Find genes that share ontologies with SLPI           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Arrays including SLPI: 
          HIV Host Response in human mouse rat
          Antibacterial Response in human mouse rat

Interactions:

    GeneGlobe Interaction Network for SLPI

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for SLPI (P039733 ENSP000003420824) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
CTSBP078583, ENSP000003420704I2D: score=2 STRING: ENSP00000342070
CTSSP257743, ENSP000003579814I2D: score=2 STRING: ENSP00000357981
ELANEP082463, ENSP000002636214I2D: score=2 STRING: ENSP00000263621
CTSLP077113, ENSP000003453444I2D: score=2 STRING: ENSP00000345344
GRNP287993, ENSP000000538674I2D: score=4 STRING: ENSP00000053867
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0010951negative regulation of endopeptidase activity TAS3485543
GO:0032091negative regulation of protein binding IDA19333378
GO:0045071negative regulation of viral genome replication IDA19333378

Find genes that share ontologies with SLPI           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLPI

Selected Novoseek inferred chemical compound relationships for SLPI gene (see all 123)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
deoxypyridinoline 70.1 49 11488735 (5), 15988811 (5), 8822322 (2), 16532321 (2) (see all 22)
edelfosine 65.8 21 1600412 (4), 1581895 (4), 7763020 (1), 7707324 (1) (see all 5)
iopentol 65.2 1 1594886 (1)
nylestriol 65 1 8344086 (1)
alendronate 64.8 18 10388477 (4), 19690798 (2), 15231011 (1), 16737141 (1) (see all 12)
pyridinoline 62.6 22 8822322 (2), 8971958 (1), 10219502 (1), 10806731 (1) (see all 12)
serine 61.3 101 17964057 (3), 19103172 (3), 20007580 (3), 8890201 (2) (see all 73)
procollagen 54.3 11 9102853 (1), 16816926 (1), 15255284 (1), 19338427 (1) (see all 9)
isopropyl palmitate 52.3 2 9329628 (1), 7768003 (1)
creatinine 52.1 62 16299682 (3), 11229247 (3), 19361280 (3), 7912862 (2) (see all 49)



Find genes that share compounds with SLPI           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SLPI gene: 
NM_003064.3  

Unigene Cluster for SLPI:

Secretory leukocyte peptidase inhibitor
Hs.517070  [show with all ESTs]
Unigene Representative Sequence: BG483345
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000338380(uc002xnm.1)
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidSLPI 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat SLPI
Clone
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OriGene clones in human, mouse for SLPI (see all 7)
OriGene ORF clones in mouse, rat for SLPI
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SLPI (NM_003064)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLPI
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLPI
Addgene plasmids for SLPI 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for SLPI
OriGene qSTAR qPCR primer pairs in human, mouse for SLPI
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLPI
  QuantiTect SYBR Green Assays in human, mouse, rat SLPI
  QuantiFast Probe-based Assays in human, mouse, rat SLPI

Additional mRNA sequence: 

AF114471.1 AK312192.1 BC020708.1 X04470.1 X04503.1 

4 DOTS entries:

DT.75167096  DT.86841070  DT.120795814  DT.95271447 

Selected AceView cDNA sequences (see all 224):

AI399779 CA946422 AA026497 BM694343 BM694113 BM708085 BQ027533 BM842052 
AA165296 CK430164 CD723292 AA401179 AA683520 NM_003064 AI201558 AA165295 
X04470 CD108133 BE612494 T68469 AF114471 BI819626 AI276322 BC020708 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLPI expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTGGGAAAT
SLPI Expression
About this image


SLPI expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 15) fully expand
 
 Adipose (Muscoskeletal System)    fully expand to see all 3 entries
         Visceral White Adipocytes Visceral White Adipose
         Visceral White Adipose
         HyStem+BMP4-induced SM30 cells
 
 Bone (Muscoskeletal System)    fully expand to see all 3 entries
         Bone Marrow
         HyStem+TGFbeta3+GDF5-induced E15 cells
 
 Liver (Hepatobiliary System)    fully expand to see all 2 entries
         Mature Mesothelial Cells Hepatic Mesenchyme
         Liver Lobule
 
 Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
         HyStem+TGFbeta3+GDF5-induced E15 cells
 
 Lung (Respiratory System)
         Alveolar type II cells
SLPI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLPI Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.517070

UniProtKB/Swiss-Prot: SLPI_HUMAN, P03973
Tissue specificity: Mucous fluids

    Pathway & Disease-focused RT2 Profiler PCR Arrays including SLPI: 
          HIV Host Response in human mouse rat
          Antibacterial Response in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for SLPI
OriGene qSTAR qPCR primer pairs in human, mouse for SLPI
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLPI
QuantiTect SYBR Green Assays in human, mouse, rat SLPI
QuantiFast Probe-based Assays in human, mouse, rat SLPI
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLPI

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SLPI gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slpi1 , 5 secretory leukocyte peptidase inhibitor1, 5 69.23(n)1
59.23(a)1
  2 (85.16 cM)5
205681  NM_011414.31  NP_035544.11 
 1643540705 
lizard
(Anolis carolinensis)
Reptilia SLPI6
secretory leukocyte peptidase inhibitor
48(a)
1 ↔ 1
4(143152331-143169982)


ENSEMBL Gene Tree for SLPI (if available)
TreeFam Gene Tree for SLPI (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLPI gene
2 SIMAP similar genes for SLPI using alignment to 2 protein entries:     SLPI_HUMAN (see all proteins):
WFDC12    WFDC5

Find genes that share paralogs with SLPI           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLPI (see all 146)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs769871181,2
F--43850922(+) GTTGGT/CTGGAT 1 -- ds50011Minor allele frequency- C:0.01EA 120
rs1908897191,2
C--43850981(+) ATATCA/GTAACA 1 -- ds50010--------
rs1830227841,2
--43851128(+) GTTGAA/CAATCC 1 -- ds50010--------
rs81264011,2
C,F,H--43851239(+) GAGTCA/GGCACT 1 -- ds500115Minor allele frequency- G:0.03NS EA NA WA CSA 1346
rs747692431,2
C,F--43851392(+) AGGATG/ATGCAA 1 -- ut311Minor allele frequency- A:0.03EA 120
rs82821,2
C,F,A,H--43851411(-) TAAACG/AAGCCT 1 -- ut31 ese316Minor allele frequency- A:0.06NS EA NA WA 1930
rs1870244901,2
C--43851532(+) CACACA/GGAGCA 1 -- ut310--------
rs26645501,2
C,H--43851546(+) CTCCAG/AAGCCT 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 414
rs1428073471,2
C--43851606(+) CAGCAG/TAGAAA 1 -- int10--------
rs1917603591,2
C--43851622(+) CAAATA/CATATC 1 -- int10--------

HapMap Linkage Disequilibrium report for SLPI (43880879 - 43883206 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SLPI: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SLPI
DNA2.0 Custom Variant and Variant Library Synthesis for SLPI

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 107285    OMIM disorders: --

12 diseases for SLPI:    
About MalaCards
trichomoniasis    urogenital tuberculosis    farmer's lung    pasteurellosis
end stage renal failure    hypophosphatasia    embryonal sarcoma    oral candidiasis
gastroschisis    histiocytic sarcoma    osteoporosis    cystic fibrosis

3 diseases from the University of Copenhagen DISEASES database for SLPI:
Bacterial vaginosis     Lung disease     Cystic fibrosis

Find genes that share disorders with SLPI           About GenesLikeMe

Selected Novoseek inferred disease relationships for SLPI gene (see all 96)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
renal osteodystrophy 72.5 2 9127327 (1), 10710245 (1)
osteoporosis 62.9 11 12477579 (1), 16737141 (1), 8741491 (1), 10388477 (1) (see all 10)
bone loss 58.3 6 15936304 (2), 8822322 (1), 16758145 (1), 15207772 (1) (see all 5)
hyperparathyroidism secondary 56 4 15207772 (2), 1947853 (1), 8595712 (1)
hypophosphatasia 51.9 1 7720239 (1)
hyperparathyroidism 48.8 2 8363875 (1), 2109488 (1)
inflammation 46.3 44 10498899 (2), 19212204 (2), 8569039 (2), 8811480 (2) (see all 34)
pustular psoriasis 44.8 2 7604637 (2)
osteopenia 44.6 5 1424153 (1), 18342460 (1)
renal failure chronic 44.1 6 9329628 (1), 1947853 (1), 7768003 (1), 1700741 (1) (see all 6)


Export disorders for SLPI gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLPI gene, integrated from 10 sources (see all 786):
(articles sorted by number of sources associating them with SLPI)
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  1. Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases. (PubMed id 3640338)1, 2, 3 Stetler G.... Thompson R.C. (Nucleic Acids Res. 1986)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 3 Clauss A.... Lundwall A. (Biochem. J. 2002)
  4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
  5. Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor. (PubMed id 2039600)1, 2 Sallenave J.-M. and Ryle A.P. (Biol. Chem. Hoppe-Seyler 1991)
  6. The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin. (PubMed id 3366116)1, 2 Gruetter M.G.... Bode W. (EMBO J. 1988)
  7. The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red sea turtle proteinase inhibitor. (PubMed id 3485543)1, 2 Seemueller U.... Lottspeich F. (FEBS Lett. 1986)
  8. Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus. (PubMed id 3533531)1, 2 Heinzel R.... Steffens G. (Eur. J. Biochem. 1986)
  9. Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. (PubMed id 3462719)1, 2 Thompson R.C. and Ohlsson K. (Proc. Natl. Acad. Sci. U.S.A. 1986)
  10. Secretory leukocyte protease inhibitor antagonizes paclitaxel in ovarian cancer cells. (PubMed id 20068074)1, 9 Rasool N....Kohn E.C. (Clin. Cancer Res. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6590 HGNC: 11092 AceView: SLPI Ensembl:ENSG00000124107 euGenes: HUgn6590
ECgene: SLPI H-InvDB: SLPI

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLPI Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLPI gene:
Search GeneIP for patents involving SLPI

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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