SLPI Gene

Aliases
for SLPI gene

Previous GC identifers: GC20M043609 GC20M044519 GC20M044566 GC20M043314 GC20M040622

Summaries
for SLPI gene

Genomic Views
for SLPI gene

RefSeq DNA sequence:

NC_000020.10  NC_018931.1  NT_011362.10  

SwitchGear Promoter luciferase reporter plasmid: SLPI promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLPI

SLPI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043880:  view genomic region     (about GC identifiers)

Proteins
for SLPI gene

1 PDB 3D structure from and Proteopedia for SLPI:

2Z7F (3D)    

Explore the universe of human proteins at neXtProt for SLPI: NX_P03973

SLPI Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SLPI
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SLPI OriGene Protein Over-expression Lysate: SLPI OriGene Custom Protein Services for SLPI
	GenScript Custom Purified and Recombinant Proteins Services for SLPI
	Novus Biologicals SLPI Proteins Novus Biologicals SLPI Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SLPI
	Uscn Proteins for SLPI

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SLPI
	OriGene Antibodies: SLPI OriGene Custom Antibody Services for SLPI
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	Novus Biologicals SLPI Antibodies
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	Uscn Antibodies for SLPI
	ThermoFisher Antibodies for SLPI

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for SLPI
	GenScript Custom Assay Services for SLPI
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLPI

Protein Domains /
Families
for SLPI gene

ProtoNet protein and cluster: P03973

Function
for SLPI gene

miRNA Products:		OriGene 3'-UTR Clone: SLPI Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLPI
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLPI
		SwitchGear 3'UTR luciferase reporter plasmid: SLPI 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLPI (see all 7) OriGene shRNA RFP: SLPI OriGene siRNA: SLPI
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLPI

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SLPI

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLPI (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLPI OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLPI (NM_003064)
		Sino Biological Human cDNA Clone for SLPI
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLPI
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLPI

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLPI
		Search LifeMap BioReagents cell lines for SLPI

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLPI

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Slpi)

Pathways & Interactions
for SLPI gene

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SLPI gene

Transcripts
for SLPI gene

Expression
for SLPI gene

SLPI expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGGGAAAT

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeVisceral White AdiposeVisceral White Adipocytes			Adipose
	AdiposeVisceral White Adipose			Adipose
	LiverLiver Lobule			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	Embryoid bodies (Two-step protocol fo...)
	Alveolar type II cells (Derivation of mature...)			Lung
	HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)			Adipose, Bone, Cartilage

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLPI Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLPI
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLPI
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLPI

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLPI

Orthologs
for SLPI gene

Paralogs
for SLPI gene

Paralogs for SLPI gene

WFDC3²  WFDC2²  WFDC5²  

2 SIMAP similar genes for SLPI using alignment to 2 protein entries:     SLPI_HUMAN (see all proteins):

WFDC12    WFDC5

SLPI for paralogs           About GeneDecksing

Genomic Variants
for SLPI gene

10/119 NCBI SNPs in SLPI are shown (see all 119)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs769871181,2		--	43880409(+)	GTTGGT/CTGGAT	1	--	ds5001		1		EA	120
rs1908897191,2		--	43880468(+)	ATATCA/GTAACA	1	--	ds5001		0	--	--	--	--
rs1830227841,2		--	43880615(+)	GTTGAA/CAATCC	1	--	ds5001		0	--	--	--	--
rs81264011,2	C,F,H,	--	43880726(+)	GAGTCA/GGCACT	1	--	ds5001		15		NS EA NA WA CSA	1346
rs747692431,2	C,F,	--	43880879(+)	AGGATG/ATGCAA	1	--	ut31		1		EA	120
rs82821,2	C,F,A,H,	--	43880898(-)	TAAACG/AAGCCT	1	--	ut31 ese3		16		NS EA NA WA	1930
rs1870244901,2	C,	--	43881019(+)	CACACA/GGAGCA	1	--	ut31		0	--	--	--	--
rs26645501,2	C,H	--	43881033(+)	CTCCAG/AAGCCT	1	--	ut31 ese3		4		NS EA	414
rs1428073471,2	C,	--	43881093(+)	CAGCAG/TAGAAA	1	--	int1		0	--	--	--	--
rs1917603591,2	C,	--	43881109(+)	CAAATA/CATATC	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLPI (43880879 - 43883206 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SLPI: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLPI

DNA2.0 Custom Variant and Variant Library Synthesis for SLPI

Disorders / Diseases
for SLPI gene

20/161 diseases for SLPI

10/96 Novoseek disease relationships for SLPI gene (see all 96)    About this table

Publications
for SLPI gene

PubMed articles for SLPI gene, integrated from 9 sources (see all 784): (articles sorted by number of sources associating them with SLPI)

Utopia: connect your pdf to the dynamic world of online information

1. Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases. (PubMed id 3640338)^{1, 2, 3} Stetler G.... Thompson R.C. (1986)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)^{1, 3} Clauss A.... Lundwall A. (2002)
4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
5. Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor. (PubMed id 2039600)^{1, 2} Sallenave J.-M. and Ryle A.P. (1991)
6. The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin. (PubMed id 3366116)^{1, 2} Gruetter M.G.... Bode W. (1988)
7. The acid-stable proteinase inhibitor of human mucous secretions (HUSI-I, antileukoprotease). Complete amino acid sequence as revealed by protein and cDNA sequencing and structural homology to whey proteins and Red sea turtle proteinase inhibitor. (PubMed id 3485543)^{1, 2} Seemueller U.... Lottspeich F. (1986)
8. Molecular cloning and expression of cDNA for human antileukoprotease from cervix uterus. (PubMed id 3533531)^{1, 2} Heinzel R.... Steffens G. (1986)
9. Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. (PubMed id 3462719)^{1, 2} Thompson R.C. and Ohlsson K. (1986)
10. Secretory leukocyte protease inhibitor antagonizes pa clitaxel in ovarian cancer cells. (PubMed id 20068074)^{1, 9} Rasool N....Kohn E.C. (2010)

External Searches for SLPI gene

Genome Databases showing SLPI gene

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Specialized Databases showing SLPI gene

Products
for SLPI gene