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Aliases for SLPI Gene

Aliases for SLPI Gene

  • Secretory Leukocyte Peptidase Inhibitor 2 3 5
  • Secretory Leukocyte Protease Inhibitor (Antileukoproteinase) 2 3
  • WAP Four-Disulfide Core Domain Protein 4 3 4
  • Seminal Proteinase Inhibitor 3 4
  • Mucus Proteinase Inhibitor 3 4
  • Protease Inhibitor WAP4 3 4
  • Antileukoproteinase 2 3
  • HUSI-1 3 4
  • WFDC4 3 4
  • BLPI 3 4
  • WAP4 3 4
  • ALP 3 4
  • MPI 3 4
  • Secretory Leukocyte Protease Inhibitor 4
  • HUSI-I 3
  • ALK1 3
  • HUSI 3

External Ids for SLPI Gene

Previous GeneCards Identifiers for SLPI Gene

  • GC20M043609
  • GC20M044519
  • GC20M044566
  • GC20M043314
  • GC20M043880
  • GC20M040622

Summaries for SLPI Gene

Entrez Gene Summary for SLPI Gene

  • This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]

GeneCards Summary for SLPI Gene

SLPI (Secretory Leukocyte Peptidase Inhibitor) is a Protein Coding gene. Diseases associated with SLPI include Lung Disease and Bronchitis. Among its related pathways are Immune System. GO annotations related to this gene include enzyme binding and endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SLPI Gene

  • Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879).

Gene Wiki entry for SLPI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLPI Gene

Genomics for SLPI Gene

Regulatory Elements for SLPI Gene

Enhancers for SLPI Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F045252 1.1 Ensembl ENCODE 16.4 +0.3 302 2.9 TBP PLRG1 BRCA1 RFX5 YY1 GTF3C2 SCRT2 SMARCC2 RCOR1 SMARCC1 NCOA5 SLPI ZNF335 KCNK15 PCIF1 ENSG00000271984 LOC105372630
GH20F045293 1.2 Ensembl ENCODE 14.6 -39.2 -39162 1.5 TBP CREB3L1 SIN3A RAD21 SCRT2 ZNF143 RCOR1 CREM SMARCC1 SMARCB1 SLPI WFDC5 RNU6ATAC38P WFDC12 RBPJL
GH20F045290 1.1 Ensembl ENCODE 14.6 -36.5 -36520 0.6 ELF3 RAD21 RFX5 ZNF366 ZNF143 FOS MIXL1 ZNF654 CEBPB MIER2 SLPI PIGT RBPJL
GH20F045173 0.8 ENCODE 13.2 +79.7 79678 2.6 GTF2F1 TBP TAF1 JUN MAX RAD21 ZNF7 TEAD3 POLR2A SMC3 SLPI NCOA5 LOC101929866 PI3
GH20F045138 0.8 ENCODE 13.1 +115.9 115864 1.3 CTCF TFAP4 CBX3 PKNOX1 ZNF175 ZBTB40 RAD21 SMC3 ZNF143 NR2F6 SLPI WFDC5 LOC101929863 WFDC12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLPI on UCSC Golden Path with GeneCards custom track

Genomic Location for SLPI Gene

Chromosome:
20
Start:
45,252,239 bp from pter
End:
45,254,564 bp from pter
Size:
2,326 bases
Orientation:
Minus strand

Genomic View for SLPI Gene

Genes around SLPI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLPI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLPI Gene

Proteins for SLPI Gene

  • Protein details for SLPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P03973-SLPI_HUMAN
    Recommended name:
    Antileukoproteinase
    Protein Accession:
    P03973
    Secondary Accessions:
    • B2R5H8
    • P07757

    Protein attributes for SLPI Gene

    Size:
    132 amino acids
    Molecular mass:
    14326 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The pathologies of several chronic and acute diseases of the respiratory tract involve an imbalance between the proteases of cells involved in inflammatary responses and the inhibitors of these proteases. The inflammation-mediated release of neutrophil elastase in the lungs of patients whose levels of active alpha-1-antiprotease are compromised by genetic background, cigarette smoking, air pollutants, or a combination of all three can result in severe lung damage and a decreased lifespan. The relatively small size of this protein, its lack of glycosylation and its stability make this protein a candidate for use as a therapeutic agent in diseases mediated by leukocyte elastase-antielastase imbalances.

    Three dimensional structures from OCA and Proteopedia for SLPI Gene

neXtProt entry for SLPI Gene

Post-translational modifications for SLPI Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLPI Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SLPI

No data available for DME Specific Peptides for SLPI Gene

Domains & Families for SLPI Gene

Gene Families for SLPI Gene

Protein Domains for SLPI Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLPI Gene

Graphical View of Domain Structure for InterPro Entry

P03973

UniProtKB/Swiss-Prot:

SLPI_HUMAN :
  • Contains 2 WAP domains.
Domain:
  • Contains 2 WAP domains.
genes like me logo Genes that share domains with SLPI: view

Function for SLPI Gene

Molecular function for SLPI Gene

GENATLAS Biochemistry:
secretory leukoprotease inhibitor,involved in antineutrophil elastase protection at inflammatory sites
UniProtKB/Swiss-Prot Function:
Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563, PubMed:10702419, PubMed:24121345). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879).
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to low ELANE activity. Up-regulated by ELANE treatment in bone marrow cells.

Gene Ontology (GO) - Molecular Function for SLPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity IEA,TAS 3485543
GO:0004867 serine-type endopeptidase inhibitor activity IEA,IDA 3462719
GO:0005515 protein binding IPI 19333378
GO:0019899 enzyme binding IPI 19333378
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SLPI: view
genes like me logo Genes that share phenotypes with SLPI: view

Animal Models for SLPI Gene

MGI Knock Outs for SLPI:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SLPI

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLPI Gene

Localization for SLPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLPI Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLPI gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IDA 3462719
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SLPI: view

Pathways & Interactions for SLPI Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with SLPI: view

Pathways by source for SLPI Gene

2 Reactome pathways for SLPI Gene

Gene Ontology (GO) - Biological Process for SLPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response ISS --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0019731 antibacterial humoral response ISS --
GO:0032091 negative regulation of protein binding IDA 19333378
genes like me logo Genes that share ontologies with SLPI: view

No data available for SIGNOR curated interactions for SLPI Gene

Drugs & Compounds for SLPI Gene

(68) Drugs for SLPI Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(55) Additional Compounds for SLPI Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLPI: view

Transcripts for SLPI Gene

mRNA/cDNA for SLPI Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(224) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLPI Gene

Secretory leukocyte peptidase inhibitor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SLPI

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLPI Gene

No ASD Table

Relevant External Links for SLPI Gene

GeneLoc Exon Structure for
SLPI
ECgene alternative splicing isoforms for
SLPI

Expression for SLPI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLPI Gene

This gene is overexpressed in Minor Salivary Gland (x21.6) and Cervix - Endocervix (x8.1).

Protein differential expression in normal tissues from HIPED for SLPI Gene

This gene is overexpressed in Cervix (30.1) and Pancreatic juice (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLPI Gene



NURSA nuclear receptor signaling pathways regulating expression of SLPI Gene:

SLPI

SOURCE GeneReport for Unigene cluster for SLPI Gene:

Hs.517070

mRNA Expression by UniProt/SwissProt for SLPI Gene:

P03973-SLPI_HUMAN
Tissue specificity: Detected in blood plasma (PubMed:24352879). Detected in bone marrow myeloid cells (PubMed:24352879). Detected in airway sputum (PubMed:2039600). Detected in parotid gland secretions (PubMed:3462719). Detected in seminal plasma (at protein level) (PubMed:3485543). Detected in uterus cervix (PubMed:3533531).
genes like me logo Genes that share expression patterns with SLPI: view

No data available for Protein tissue co-expression partners for SLPI Gene

Orthologs for SLPI Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLPI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLPI 34 35
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia SLPI 34
  • 76.84 (n)
MATN4 35
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLPI 34
  • 76.04 (n)
CKPI 35
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slpi 34 16 35
  • 69.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
OneToMany
-- 35
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SLPI 35
  • 48 (a)
OneToOne
Species where no ortholog for SLPI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLPI Gene

ENSEMBL:
Gene Tree for SLPI (if available)
TreeFam:
Gene Tree for SLPI (if available)

Paralogs for SLPI Gene

(2) SIMAP similar genes for SLPI Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLPI: view

No data available for Paralogs for SLPI Gene

Variants for SLPI Gene

Sequence variations from dbSNP and Humsavar for SLPI Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1057432 -- 45,252,357(-) TTTCC(A/C)CCCTG intron-variant, utr-variant-3-prime
rs1061188 -- 45,252,339(-) GCTCC(A/C)CCACT intron-variant, utr-variant-3-prime
rs111623361 -- 45,253,574(+) GCTTA(C/G/T)TTGGG intron-variant, splice-donor-variant
rs111974616 -- 45,256,012(+) GTAGC(A/G)ATGGC intron-variant, upstream-variant-2KB
rs112145744 -- 45,253,302(+) GCGGC(C/G)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLPI Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958

Variation tolerance for SLPI Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLPI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLPI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLPI Gene

Disorders for SLPI Gene

MalaCards: The human disease database

(13) MalaCards diseases for SLPI Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung disease
  • lung diseases
bronchitis
  • acute bronchitis
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
mastitis
  • breast inflammation
trichomoniasis
  • trichomonas infection
- elite association - COSMIC cancer census association via MalaCards
Search SLPI in MalaCards View complete list of genes associated with diseases

Relevant External Links for SLPI

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLPI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLPI
genes like me logo Genes that share disorders with SLPI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLPI Gene

Publications for SLPI Gene

  1. Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases. (PMID: 3640338) Stetler G. … Thompson R.C. (Nucleic Acids Res. 1986) 2 3 4 64
  2. A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. (PMID: 24352879) Klimenkova O. … Skokowa J. (Blood 2014) 3 4 64
  3. Secretory leukocyte protease inhibitor antagonizes paclitaxel in ovarian cancer cells. (PMID: 20068074) Rasool N. … Kohn E.C. (Clin. Cancer Res. 2010) 3 22 64
  4. The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane. (PMID: 19333378) Py B. … Benichou S. (PLoS ONE 2009) 3 22 64
  5. Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles. (PMID: 19900269) Sharma S.M. … Rosenbaum J.T. (Arthritis Res. Ther. 2009) 3 22 64

Products for SLPI Gene

Sources for SLPI Gene

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