Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLPI Gene

Aliases for SLPI Gene

  • Secretory Leukocyte Peptidase Inhibitor 2 3
  • Secretory Leukocyte Protease Inhibitor (Antileukoproteinase) 2 3
  • WAP Four-Disulfide Core Domain Protein 4 3 4
  • Seminal Proteinase Inhibitor 3 4
  • Mucus Proteinase Inhibitor 3 4
  • Protease Inhibitor WAP4 3 4
  • Antileukoproteinase 2 3
  • HUSI-1 3 4
  • WFDC4 3 4
  • HUSI 3 6
  • BLPI 3 4
  • WAP4 3 4
  • ALP 3 4
  • MPI 3 4
  • Secretory Leukocyte Protease Inhibitor 4
  • HUSI-I 3
  • ALK1 3

External Ids for SLPI Gene

Previous GeneCards Identifiers for SLPI Gene

  • GC20M043609
  • GC20M044519
  • GC20M044566
  • GC20M043314
  • GC20M043880
  • GC20M040622

Summaries for SLPI Gene

Entrez Gene Summary for SLPI Gene

  • This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]

GeneCards Summary for SLPI Gene

SLPI (Secretory Leukocyte Peptidase Inhibitor) is a Protein Coding gene. Diseases associated with SLPI include trichomoniasis and urogenital tuberculosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include enzyme binding and endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SLPI Gene

  • Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues

Gene Wiki entry for SLPI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLPI Gene

Genomics for SLPI Gene

Regulatory Elements for SLPI Gene

Genomic Location for SLPI Gene

Start:
45,252,239 bp from pter
End:
45,254,564 bp from pter
Size:
2,326 bases
Orientation:
Minus strand

Genomic View for SLPI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLPI Gene

Proteins for SLPI Gene

  • Protein details for SLPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P03973-SLPI_HUMAN
    Recommended name:
    Antileukoproteinase
    Protein Accession:
    P03973
    Secondary Accessions:
    • B2R5H8
    • P07757

    Protein attributes for SLPI Gene

    Size:
    132 amino acids
    Molecular mass:
    14326 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The pathologies of several chronic and acute diseases of the respiratory tract involve an imbalance between the proteases of cells involved in inflammatary responses and the inhibitors of these proteases. The inflammation-mediated release of neutrophil elastase in the lungs of patients whose levels of active alpha-1-antiprotease are compromised by genetic background, cigarette smoking, air pollutants, or a combination of all three can result in severe lung damage and a decreased lifespan. The relatively small size of this protein, its lack of glycosylation and its stability make this protein a candidate for use as a therapeutic agent in diseases mediated by leukocyte elastase-antielastase imbalances

    Three dimensional structures from OCA and Proteopedia for SLPI Gene

neXtProt entry for SLPI Gene

Proteomics data for SLPI Gene at MOPED

Post-translational modifications for SLPI Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLPI Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

No data available for DME Specific Peptides for SLPI Gene

Domains for SLPI Gene

Gene Families for SLPI Gene

HGNC:
  • WFDC :WAP four-disulfide core domain containing

Protein Domains for SLPI Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLPI Gene

Graphical View of Domain Structure for InterPro Entry

P03973

UniProtKB/Swiss-Prot:

SLPI_HUMAN :
  • P03973
Domain:
  • Contains 2 WAP domains.
genes like me logo Genes that share domains with SLPI: view

Function for SLPI Gene

Molecular function for SLPI Gene

GENATLAS Biochemistry: secretory leukoprotease inhibitor,involved in antineutrophil elastase protection at inflammatory sites
UniProtKB/Swiss-Prot Function: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues

Gene Ontology (GO) - Molecular Function for SLPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 3485543
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding IPI 19333378
GO:0019899 enzyme binding IPI 19333378
GO:0030414 peptidase inhibitor activity --
genes like me logo Genes that share ontologies with SLPI: view

Phenotypes for SLPI Gene

genes like me logo Genes that share phenotypes with SLPI: view

Animal Models for SLPI Gene

MGI Knock Outs for SLPI:

Animal Model Products

CRISPR Products

miRNA for SLPI Gene

miRTarBase miRNAs that target SLPI

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLPI

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLPI Gene

Localization for SLPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLPI Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLPI Gene COMPARTMENTS Subcellular localization image for SLPI gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SLPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with SLPI: view

Pathways for SLPI Gene

genes like me logo Genes that share pathways with SLPI: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • HIV Host Response in human,mouse,rat

Gene Ontology (GO) - Biological Process for SLPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0032091 negative regulation of protein binding IDA 19333378
GO:0045071 negative regulation of viral genome replication IDA 19333378
genes like me logo Genes that share ontologies with SLPI: view

Compounds for SLPI Gene

(123) Novoseek inferred chemical compound relationships for SLPI Gene

Compound -log(P) Hits PubMed IDs
deoxypyridinoline 70.1 33
edelfosine 65.8 11
iopentol 65.2 1
nylestriol 65 1
alendronate 64.8 16
genes like me logo Genes that share compounds with SLPI: view

Transcripts for SLPI Gene

mRNA/cDNA for SLPI Gene

(224) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLPI Gene

Secretory leukocyte peptidase inhibitor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLPI

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLPI Gene

No ASD Table

Relevant External Links for SLPI Gene

GeneLoc Exon Structure for
SLPI
ECgene alternative splicing isoforms for
SLPI

Expression for SLPI Gene

mRNA expression in normal human tissues for SLPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLPI Gene

This gene is overexpressed in Minor Salivary Gland (21.6) and Cervix - Endocervix (8.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLPI Gene

SOURCE GeneReport for Unigene cluster for SLPI Gene Hs.517070

mRNA Expression by UniProt/SwissProt for SLPI Gene

P03973-SLPI_HUMAN
Tissue specificity: Mucous fluids
genes like me logo Genes that share expressions with SLPI: view

In Situ Assay Products

Orthologs for SLPI Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLPI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLPI 35
  • 99.24 (n)
  • 99.24 (a)
SLPI 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MATN4 36
  • 63 (a)
OneToOne
SLPI 35
  • 76.84 (n)
  • 63.36 (a)
dog
(Canis familiaris)
Mammalia CKPI 36
  • 63 (a)
OneToOne
SLPI 35
  • 76.04 (n)
  • 64.84 (a)
mouse
(Mus musculus)
Mammalia Slpi 35
  • 69.23 (n)
  • 59.23 (a)
Slpi 16
Slpi 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SLPI 36
  • 48 (a)
OneToOne
Species with no ortholog for SLPI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLPI Gene

ENSEMBL:
Gene Tree for SLPI (if available)
TreeFam:
Gene Tree for SLPI (if available)

Paralogs for SLPI Gene

Selected SIMAP similar genes for SLPI Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLPI: view

No data available for Paralogs for SLPI Gene

Variants for SLPI Gene

Sequence variations from dbSNP and Humsavar for SLPI Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs8282 -- 45,252,257(-) TAAAC(A/G)AGCCT utr-variant-3-prime
rs1057432 -- 45,252,357(-) TTTCC(A/C)CCCTG utr-variant-3-prime
rs1061188 -- 45,252,339(-) GCTCC(A/C)CCACT utr-variant-3-prime
rs2206888 -- 45,253,365(+) CAGCC(A/G)CCCAG intron-variant
rs2664550 -- 45,252,392(+) CTCCA(A/G)AGCCT utr-variant-3-prime

Relevant External Links for SLPI Gene

HapMap Linkage Disequilibrium report
SLPI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLPI Gene

Disorders for SLPI Gene

MalaCards: The human disease database

MalaCards: The human disease database. (12) Diseases for SLPI Gene including...

Search for SLPI Gene in MalaCards »

(3) University of Copenhagen DISEASES for SLPI Gene

(96) Novoseek inferred disease relationships for SLPI Gene

Disease -log(P) Hits PubMed IDs
renal osteodystrophy 72.5 2
osteoporosis 62.9 10
bone loss 58.3 6
hyperparathyroidism secondary 56 4
hypophosphatasia 51.9 1
genes like me logo Genes that share disorders with SLPI: view

No data available for UniProtKB/Swiss-Prot for SLPI Gene

Publications for SLPI Gene

  1. Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases. (PMID: 3640338) Stetler G. … Thompson R.C. (Nucleic Acids Res. 1986) 2 3 4
  2. Alteration of secretory leukocyte protease inhibitor in human myometrium during labor. (PMID: 19254589) Li A. … Goodwin T.M. (Am. J. Obstet. Gynecol. 2009) 3 23
  3. Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor. (PMID: 2039600) Sallenave J.-M. … Ryle A.P. (Biol. Chem. Hoppe-Seyler 1991) 3 4
  4. The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin. (PMID: 3366116) Gruetter M.G. … Bode W. (EMBO J. 1988) 3 4
  5. Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. (PMID: 3462719) Thompson R.C. … Ohlsson K. (Proc. Natl. Acad. Sci. U.S.A. 1986) 3 4

Products for SLPI Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • HIV Host Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SLPI
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SLPI
    • Block miRNA regulation of SLPI using miScript Target Protectors
    • Addgene plasmids for SLPI

    Sources for SLPI Gene

    Back to Top

    Content