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SLN Gene

protein-coding   GIFtS: 50
GCID: GC11M107612

Sarcolipin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
sarcolipin1 2

External Ids:    HGNC: 110891   Entrez Gene: 65882   Ensembl: ENSG000001702907   OMIM: 6022035   UniProtKB: O006313   

Export aliases for SLN gene to outside databases

Previous GC identifers: GC11M109772 GC11M108934 GC11M107115 GC11M107083 GC11M103503


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLN Gene:
Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of
Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small
proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts
with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the
rate of ATP hydrolysis. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLN Gene:
SLN (sarcolipin) is a protein-coding gene. GO annotations related to this gene include enzyme inhibitor activity and ATPase binding.

UniProtKB/Swiss-Prot: SARCO_HUMAN, O00631
Function: Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity
of the ATPase for Ca(2+). Required for muscle-based, non-shivering thermogenesis (By similarity). Modulates
calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle

Gene Wiki entry for SLN (Sarcolipin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLN gene promoter:
         Nkx3-1   Nkx3-1 v4   MEF-2   Nkx3-1 v1   C/EBPalpha   MEF-2A   Nkx3-1 v2   Nkx3-1 v3   c-Myb   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLN promoter sequence
   Search Chromatin IP Primers for SLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22-q23

SLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLN gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M107612:  view genomic region     (about GC identifiers)

Start:
107,578,101 bp from pter      End:
107,590,419 bp from pter
Size:
12,319 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SARCO_HUMAN, O00631 (See protein sequence)
Recommended Name: Sarcolipin  
Size: 31 amino acids; 3762 Da
Subunit: Interacts with calcium ATPase ATP2A1/SERCA1
1 PDB 3D structure from and Proteopedia for SLN:
1JDM (3D)    
Secondary accessions: Q6ICV3

Explore the universe of human proteins at neXtProt for SLN: NX_O00631

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_003054.1  
    ENSEMBL proteins: 
     ENSP00000435380   ENSP00000434189   ENSP00000304707  

    SLN Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SLN

     
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    antibodies-online antibodies for SLN (16 products) 

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    Cloud-Clone Corp. ELISAs for SLN
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    antibodies-online kits for SLN (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008028 Sarcolipin

    Graphical View of Domain Structure for InterPro Entry O00631

    ProtoNet protein and cluster: O00631

    1 Blocks protein domain: IPB008028 Sarcolipin

    UniProtKB/Swiss-Prot: SARCO_HUMAN, O00631
    Similarity: Belongs to the sarcolipin family


    Find genes that share domains with SLN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SARCO_HUMAN, O00631
    Function: Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity
    of the ATPase for Ca(2+). Required for muscle-based, non-shivering thermogenesis (By similarity). Modulates
    calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle

         Genatlas biochemistry entry for SLN:
    sarcolipin,low molecular weight proteolipid associated with the fast-twitch skeletal muscle sarcoplasmic reticulum
    Ca++ ATPase (ATP2A1),phospholamban homolog

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity ISS12032137
    GO:0030234enzyme regulator activity ----
    GO:0051117ATPase binding ISS12032137
         
    Find genes that share ontologies with SLN           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sln):
     cardiovascular system  muscle 

    Find genes that share phenotypes with SLN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slntm1Peri for SLN

       genOway: Develop your customized and physiologically relevant rodent model for SLN

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate SLN:
    hsa-miR-617 hsa-miR-145 hsa-miR-590-3p hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidSLN 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SARCO_HUMAN, O00631: Sarcoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum
    membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS9367679
    GO:0016529sarcoplasmic reticulum IDA9575189
    GO:0033017sarcoplasmic reticulum membrane IEA--

    Find genes that share ontologies with SLN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLN
    Interactions:

        GeneGlobe Interaction Network for SLN

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SLN (O006313 ENSP000003047074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP2A1O149833, ENSP000003495954I2D: score=2 STRING: ENSP00000349595
    PLNP266783, ENSP000003501324I2D: score=2 STRING: ENSP00000350132
    ATP2A2P166153I2D: score=1 
    --ENSP000003248924STRING: ENSP00000324892
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport NAS9367679
    GO:0043086negative regulation of catalytic activity ISS12032137
    GO:0043242negative regulation of protein complex disassembly ISS12032137
    GO:0051924regulation of calcium ion transport ISS--
    GO:0070296sarcoplasmic reticulum calcium ion transport ISS--

    Find genes that share ontologies with SLN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLN (SARCO)

    1 HMDB Compound for SLN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for SLN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 47 30 9575189 (4), 17616528 (2), 16519897 (2), 18081313 (2) (see all 13)
    lipid 20.1 13 17586575 (3), 16953579 (3), 11781085 (2), 11772399 (1) (see all 6)



    Find genes that share compounds with SLN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLN gene: 
    NM_003063.2  

    Unigene Cluster for SLN:

    Sarcolipin
    Hs.334629  [show with all ESTs]
    Unigene Representative Sequence: BF694738
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531293(uc001pjp.3) ENST00000525934 ENST00000305991
    miRNA
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    hsa-miR-617 hsa-miR-145 hsa-miR-590-3p hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidSLN 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SLN
      QuantiTect SYBR Green Assays in human, mouse, rat SLN
      QuantiFast Probe-based Assays in human, mouse, rat SLN

    Additional mRNA sequence: 

    AK312097.1 BC005261.1 BC094685.1 BC104150.2 BC104185.2 BC113930.1 BC113987.1 U96094.1 

    3 DOTS entries:

    DT.215889  DT.92432410  DT.92432404 

    Selected AceView cDNA sequences (see all 153):

    AI126997 BF222001 AI421504 F18591 BU737006 F18810 AJ572341 F34806 
    AW051121 CR450290 F34683 BG204330 AJ572800 F22314 AA196050 F26159 
    F32532 BG207478 F31795 AA112042 W67459 BM668976 AW450261 AJ346720 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAATAAAGT
    SLN Expression
    About this image


    SLN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Hepatocyte-like cells
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    SLN Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.334629
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SLN gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sln5 sarcolipin   --   9 (29.24 cM) 53850251 


    ENSEMBL Gene Tree for SLN (if available)
    TreeFam Gene Tree for SLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLN (see all 142)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498723371,2
    C--107577649(+) ATAAC-/AATAATCA 1 -- ds50010--------
    rs1445204651,2
    --107577663(+) AATAGA/TCTATG 1 -- ds50010--------
    rs1845373511,2
    --107577671(+) ATGCTA/CCTCTT 1 -- ds50010--------
    rs112123361,2
    H--107577678(+) TCTTAG/AGGACA 1 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs1893640371,2
    --107577680(+) TTAGGA/GACATG 1 -- ds50010--------
    rs1485490671,2
    --107577758(+) TTATAA/CGATAG 1 -- ds50010--------
    rs71053971,2
    C,F,A,H--107577778(+) TTCTTG/CTGGAT 1 -- ds500111Minor allele frequency- C:0.21NS EA NA WA CSA 785
    rs127872351,2
    H--107577785(+) GGATTC/ATAAAG 1 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs127870731,2
    H--107577788(+) TTCTAA/GAGATA 1 -- ds50014Minor allele frequency- G:0.00NS EA 412
    rs127870951,2
    H--107577831(+) TAGCCA/CGCAAT 1 -- ds50014Minor allele frequency- C:0.00NS EA 420

    HapMap Linkage Disequilibrium report for SLN (107578101 - 107590419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750979CNV Gain17911159
    nsv898378CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLN
    DNA2.0 Custom Variant and Variant Library Synthesis for SLN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602203    OMIM disorders: --


    Find genes that share disorders with SLN           About GenesLikeMe

    1 Novoseek inferred disease relationship for SLN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atrial fibrillation 10.9 4 17010328 (3), 15530144 (1)

    Genetic Association Database (GAD): SLN
    Human Genome Epidemiology (HuGE) Navigator: SLN (5 documents)

    Export disorders for SLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLN gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with SLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the gene encoding human sarcolipin (SLN), a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody disease. (PubMed id 9367679)1, 2, 3, 9 Odermatt A.... Maclennan D.H. (Genomics 1997)
    2. Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase. (PubMed id 9575189)1, 2, 9 Odermatt A....MacLennan D.H. (J. Biol. Chem. 1998)
    3. Structure and orientation of sarcolipin in lipid environments. (PubMed id 11781085)1, 2, 9 Mascioni A.... Veglia G. (Biochemistry 2002)
    4. The variation of the sarcolipin gene (SLN) in atrial fibrillation, long QT syndrome and sudden arrhythmic death syndrome. (PubMed id 17010328)1, 4, 9 Nyberg M.T....Christiansen M. ( international journal of clinical chemistry 2007)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Sarcolipin uncouples hydrolysis of ATP from accumulation of Ca2+ by the Ca2+-ATPase of skeletal-muscle sarcoplasmic reticulum. (PubMed id 11772399)1, 9 Smith W.S....Lee A.G. (Biochem. J. 2002)
    7. Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban. (PubMed id 12692302)1, 9 Asahi M....MacLennan D.H. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    8. SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defects. (PubMed id 17515962)1, 9 Vittorini S....Clerico A. (Mol. Med. 2007)
    9. Sarco(endo)plasmic reticulum calcium ATPase (SERCA) inhibition by sarcolipin is encoded in its luminal tail. (PubMed id 23362265)1 Gorski P.A....Young H.S. (J. Biol. Chem. 2013)
    10. Decreased sarcolipin protein expression and enhanced sarco(endo)plasmic reticulum Ca2+ uptake in human atrial fibrillation. (PubMed id 21640081)1 Shanmugam M....Babu G.J. (Biochem. Biophys. Res. Commun. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6588 HGNC: 11089 AceView: SLN Ensembl:ENSG00000170290 euGenes: HUgn6588
    ECgene: SLN H-InvDB: SLN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLN gene:
    Search GeneIP for patents involving SLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse Small Molecules at EMD Millipore
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