SLMO2 Gene
protein-coding GIFtS: 45
GCID: GC20M057608
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|
slowmo homolog 2 (Drosophila)(Previous name: chromosome 20 open reading frame 45 )
(Previous symbol: C20orf45)
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Aliases
for SLMO2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Slowmo Homolog 2 (Drosophila)1 2 | | C20orf451 2 3 | | PRELID3B1 2 | | DJ543J19.51 | | Chromosome 20 Open Reading Frame 451 | | Protein Slowmo Homolog 22 |
Export aliases for SLMO2 gene to outside databasesPrevious GC identifers: GC20M057042 GC20M054395 |
Summaries
for SLMO2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLMO2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLMO2 gene promoter:
GR AML1a p53 GR-beta LCR-F1 YY1 GATA-1 STAT3 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLMO2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLMO2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.32 Ensembl cytogenetic band: 20q13.32 HGNC cytogenetic band: 20q13.32SLMO2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M057608: view genomic region
(about GC identifiers)
Start:
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57,608,200 bp from pter |
End:
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57,617,964 bp from pter |
Size:
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9,765 bases |
Orientation:
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minus strand |
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Proteins
for SLMO2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SLMO2_HUMAN, Q9Y3B1 (See
protein sequence)Recommended Name: Protein slowmo homolog 2 Size: 194 amino acids; 21495 Da
Sequence caution: Sequence=AAD34102.1; Type=Frameshift; Positions=192;
Secondary accessions: E1P5I8 Q5JX17 Q9NUL0Alternative splicing: 2 isoforms: Q9Y3B1-1 Q9Y3B1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLMO2: NX_Q9Y3B1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3B1
SLMO2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243332.1 NP_057129.2
ENSEMBL proteins: ENSP00000348206 ENSP00000360072 ENSP00000431440
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
SLMO2 for ontologies About GeneDecksing
SLMO2 Antibody Products:
Assay Products for SLMO2: |
Protein
Domains /
Families
for SLMO2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLMO2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y3B1ProtoNet protein and cluster: Q9Y3B1 UniProtKB/Swiss-Prot: SLMO2_HUMAN, Q9Y3B1Similarity: Belongs to the slowmo familySimilarity: Contains 1 PRELI/MSF1 domain |
Function
for SLMO2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLMO2 (NM_016045) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLMO2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLMO2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLMO2 |
|
Pathways & Interactions
for SLMO2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLMO2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/31 Interacting proteins for SLMO2 (Q9Y3B13 ENSP000003482064) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
|
Drugs & Compounds
for SLMO2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLMO2
Search CenterWatch for drugs/clinical trials and news about SLMO2
|
Transcripts
for SLMO2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLMO2 gene (2 alternative transcripts): NM_001256403.1 NM_016045.2 Unigene Cluster for SLMO2: Slowmo homolog 2 (Drosophila) Hs.656865 [show with all ESTs]Unigene Representative Sequence: BC0139694 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355937(uc021wfq.1 uc021wfr.1 uc002yam.3 uc010zzv.2)
ENST00000371033 ENST00000463057 ENST00000466051
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLMO2 (NM_016045) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLMO2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLMO2 |
Additional cDNA sequence: AF151865.1 AK002157.1 AK298135.1 AK314449.1 BC010649.1 BC013969.2 NR_037929.1 NR_037930.1 20 DOTS entries: DT.97807573 DT.418524 DT.95153016 DT.99969657 DT.100819275 DT.101966859 DT.120805466 DT.102834574 DT.120805458 DT.100819271 DT.100686215 DT.120805430 DT.91971655 DT.92445316 DT.92445317 DT.100686219 DT.101987288 DT.449876 DT.95099539 DT.95324298 24/926 AceView cDNA sequences (see all 926): CB107604 BQ647025 BQ049156 F24415 AA973174 CB106537 BU683041 BU070542 BU741435 AI446044 BU786133 CD678542 BM850722 AA767760 BQ065655 AA977143 CR595852 BI962769 CB156235 F19035 AI421464 AI653758 AA442417 AI223418
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLMO2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
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| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for SLMO2
|
Expression
for SLMO2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLMO2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCCTATCC
About this image
See SLMO2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLMO2
SOURCE GeneReport for Unigene cluster: Hs.656865
SABiosciences Custom PCR Arrays for SLMO2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLMO2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLMO2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLMO2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLMO2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLMO2 |
Orthologs
for SLMO2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLMO2 gene from 9/28 species (see all 28) About this table
ENSEMBL Gene Tree for SLMO2 (if available)
TreeFam Gene Tree for SLMO2 (if available) |
Paralogs
for SLMO2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLMO2 gene
- SLMO12 PRELID22
2 SIMAP similar genes for SLMO2 using alignment to 2 protein entries: SLMO2_HUMAN (see all proteins):SLMO1 PRELID1
SLMO2 for paralogs About GeneDecksing
5/11 Pseudogenes.org Pseudogenes for SLMO2 (see all 11)
PGOHUM00000248594 PGOHUM00000237470 PGOHUM00000245212 PGOHUM00000235208 PGOHUM00000235209
|
Genomic Variants
for SLMO2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLMO2 (57608200 - 57617964 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLMO2
2 CNVs: 79252 90628 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLMO2 |
|
Disorders
/ Diseases
for SLMO2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLMO2 for disorders About MalaCards
SLMO2 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SLMO2 (1 document)
Export disorders for SLMO2 gene to outside databases
|
Publications
for SLMO2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLMO2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLMO2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- A meta-analysis and genome-wide association study of p latelet count and mean platelet volume in african americans. (PubMed id 22423221)1 Qayyum R....Reiner A.P. (2012)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SLMO2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLMO2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLMO2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLMO2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLMO2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLMO2 gene:
Search GeneIP for patents involving SLMO2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLMO2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLMO2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLMO2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLMO2 | | | OriGene Protein Over-expression Lysate for SLMO2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLMO2 | | OriGene 3'-UTR Clone for SLMO2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLMO2 | | OriGene Custom Protein Services for SLMO2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLMO2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLMO2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLMO2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLMO2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLMO2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLMO2 |
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| | | | Search Tocris compounds for SLMO2 |
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 | | | SLMO2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLMO2 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLMO2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLMO2 |
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