SLMO1 Gene
protein-coding GIFtS: 41
GCID: GC18P012407
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|
slowmo homolog 1 (Drosophila)(Previous name: chromosome 18 open reading frame 43 )
(Previous symbol: C18orf43)
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Aliases
for SLMO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Slowmo Homolog 1 (Drosophila)1 2 | | FLJ314841 | | C18orf431 2 3 | | Chromosome 18 Open Reading Frame 431 | | HFL-EDDG11 2 | | Erythroid Differentiation And Denucleation Factor 12 | | PRELID3A1 2 | | Protein Slowmo Homolog 12 |
Export aliases for SLMO1 gene to outside databasesPrevious GC identifers: GC18P012400 GC18P012361 |
Summaries
for SLMO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLMO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLMO1 gene promoter:
c-Fos AP-1 FOXF2 Fra-1 FosB RORalpha2 PPAR-gamma1 PPAR-gamma2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLMO1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLMO1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.21 Ensembl cytogenetic band: 18p11.21 HGNC cytogenetic band: 18p11.21SLMO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P012407: view genomic region
(about GC identifiers)
Start:
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12,407,895 bp from pter |
End:
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12,432,237 bp from pter |
Size:
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24,343 bases |
Orientation:
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plus strand |
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Proteins
for SLMO1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SLMO1_HUMAN, Q96N28 (See
protein sequence)Recommended Name: Protein slowmo homolog 1 Size: 172 amino acids; 19247 Da
Secondary accessions: B0YJ10 D3DUJ1 Q6AHX2Explore the universe of human proteins at neXtProt for SLMO1: NX_Q96N28
SLMO1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001135877.1 NP_006544.2
ENSEMBL proteins: ENSP00000467026 ENSP00000338988 ENSP00000467896 ENSP00000467261 ENSP00000467457 ENSP00000466737 ENSP00000465996 ENSP00000464848 ENSP00000404700
Human Recombinant Protein Products for SLMO1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
SLMO1 for ontologies About GeneDecksing
SLMO1 Antibody Products:
Assay Products for SLMO1: |
Protein
Domains /
Families
for SLMO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLMO1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96N28ProtoNet protein and cluster: Q96N28 UniProtKB/Swiss-Prot: SLMO1_HUMAN, Q96N28Similarity: Belongs to the slowmo familySimilarity: Contains 1 PRELI/MSF1 domain |
Function
for SLMO1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SLMO1 (NM_001142405) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLMO1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLMO1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLMO1 |
|
Pathways & Interactions
for SLMO1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLMO1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SLMO1 (ENSP000003389884) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SLMO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLMO1
Search CenterWatch for drugs/clinical trials and news about SLMO1
|
Transcripts
for SLMO1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLMO1 gene (3 alternative transcripts): NM_001142406.1 NM_001142405.1 NM_006553.3 Unigene Cluster for SLMO1: Slowmo homolog 1 (Drosophila) Hs.514718 [show with all ESTs]Unigene Representative Sequence: NM_0011424059 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000590956 ENST00000336990 ENST00000588729 ENST00000589565 ENST00000589952
ENST00000592149 ENST00000587862 ENST00000587735 ENST00000440960(uc002kra.3 uc010wzu.2 uc010wzv.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLMO1 (NM_001142405) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLMO1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLMO1 |
Additional cDNA sequence: AF048849.1 AK056046.1 AK303325.1 BC007528.1 BC106750.2 BT007092.1 CR627465.1 4 DOTS entries: DT.95159133 DT.100751940 DT.95159132 DT.100751939 24/35 AceView cDNA sequences (see all 35): BM832867 BE504894 CA446199 BM793418 BI757289 BF114832 BQ645268 NM_006553 BT007092 AW149131 BE910458 BX114288 CR627465 AK056046 BQ441069 BM822541 BI547749 CB155200 AW071121 AL359942 AA412674 BM746533 BI752100 BC007528
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SLMO1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|
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| SP1: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLMO1
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Expression
for SLMO1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLMO1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTATGGTTA
About this image
See SLMO1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLMO1
SOURCE GeneReport for Unigene cluster: Hs.514718
SABiosciences Custom PCR Arrays for SLMO1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLMO1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLMO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLMO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLMO1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLMO1 |
Orthologs
for SLMO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLMO1 gene from 7/26 species (see all 26) About this table
ENSEMBL Gene Tree for SLMO1 (if available)
TreeFam Gene Tree for SLMO1 (if available) |
Paralogs
for SLMO1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLMO1 gene
- SLMO22 PRELID22
18/34 SIMAP similar genes for SLMO1 using alignment to 7 protein entries: SLMO1_HUMAN (see all proteins)
(see all similar genes):ACTR10 SLMO2 FLJ00047 NCKAP1L NDC80 ZNF559
ADCK1 CALCOCO2 FRG1 RQCD1 pp12301 C14orf105
HC6 IRF2 MLL5 EEF1E1 NEK4 COQ5
SLMO1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SLMO1
PGOHUM00000249742
|
Genomic Variants
for SLMO1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLMO1 (12407895 - 12432237 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for SLMO1
4 CNVs: 4052 30859 49956 5890 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLMO1 |
|
Disorders
/ Diseases
for SLMO1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SLMO1 for disorders About MalaCards
SLMO1 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SLMO1 (1 document)
Export disorders for SLMO1 gene to outside databases
|
Publications
for SLMO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLMO1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLMO1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLMO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLMO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLMO1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLMO1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLMO1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLMO1 gene:
Search GeneIP for patents involving SLMO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLMO1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLMO1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLMO1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLMO1 | | | OriGene Protein Over-expression Lysate for SLMO1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLMO1 | | OriGene 3'-UTR Clone for SLMO1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLMO1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLMO1 | | OriGene Custom Protein Services for SLMO1 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLMO1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLMO1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLMO1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLMO1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLMO1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLMO1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SLMO1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLMO1 |
|  |  |  |  | | | | ThermoFisher Antibodies for SLMO1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLMO1 |
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