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Aliases for SLMAP Gene

Aliases for SLMAP Gene

  • Sarcolemma Associated Protein 2 3
  • Sarcolemmal-Associated Protein 2 3 4
  • SLAP 3 4 6
  • Sarcolemmal Membrane-Associated Protein 3
  • KIAA1601 4

External Ids for SLMAP Gene

Summaries for SLMAP Gene

GeneCards Summary for SLMAP Gene

SLMAP (Sarcolemma Associated Protein) is a Protein Coding gene. Diseases associated with SLMAP include brugada syndrome. An important paralog of this gene is TRAF3IP3.

UniProtKB/Swiss-Prot for SLMAP Gene

  • May play a role during myoblast fusion.

Gene Wiki entry for SLMAP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLMAP Gene

Genomics for SLMAP Gene

Genomic Location for SLMAP Gene

Start:
57,755,450 bp from pter
End:
57,929,965 bp from pter
Size:
174,516 bases
Orientation:
Plus strand

Genomic View for SLMAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLMAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLMAP Gene

Regulatory Elements for SLMAP Gene

Proteins for SLMAP Gene

  • Protein details for SLMAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14BN4-SLMAP_HUMAN
    Recommended name:
    Sarcolemmal membrane-associated protein
    Protein Accession:
    Q14BN4
    Secondary Accessions:
    • Q14C95
    • Q6AI54
    • Q6UXC9
    • Q6ZVQ8
    • Q8NCW9
    • Q9H297
    • Q9HCH1
    • Q9Y681

    Protein attributes for SLMAP Gene

    Size:
    828 amino acids
    Molecular mass:
    95198 Da
    Quaternary structure:
    • Homodimer. Interacts with myosin (By similarity).
    SequenceCaution:
    • Sequence=AAQ88776.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH10369.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLMAP Gene

neXtProt entry for SLMAP Gene

Proteomics data for SLMAP Gene at MOPED

Post-translational modifications for SLMAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLMAP Gene

Domains for SLMAP Gene

Protein Domains for SLMAP Gene

UniProtKB/Swiss-Prot:

SLMAP_HUMAN
Domain:
  • Contains 1 FHA domain.:
    • Q14BN4
Family:
  • Belongs to the SLMAP family.:
    • Q14BN4
genes like me logo Genes that share domains with SLMAP: view

No data available for Gene Families for SLMAP Gene

Function for SLMAP Gene

Molecular function for SLMAP Gene

UniProtKB/Swiss-Prot Function: May play a role during myoblast fusion.

Gene Ontology (GO) - Molecular Function for SLMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23386615
GO:0051082 unfolded protein binding --
genes like me logo Genes that share ontologies with SLMAP: view

Phenotypes for SLMAP Gene

genes like me logo Genes that share phenotypes with SLMAP: view

miRNA for SLMAP Gene

miRTarBase miRNAs that target SLMAP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLMAP Gene

Localization for SLMAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLMAP Gene

Cell membrane, sarcolemma; Single-pass type IV membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z- and M-lines in cardiomyocytes. Centrosome. Localizes to the centrosomes in a microtubule- dependent manner (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLMAP Gene COMPARTMENTS Subcellular localization image for SLMAP gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
cytosol 3
cytoskeleton 2
peroxisome 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005790 smooth endoplasmic reticulum TAS 9405447
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton --
GO:0005887 integral component of plasma membrane TAS 9405447
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLMAP: view

Pathways for SLMAP Gene

SuperPathways for SLMAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding --
GO:0006936 muscle contraction IEA --
genes like me logo Genes that share ontologies with SLMAP: view

No data available for Pathways by source for SLMAP Gene

Transcripts for SLMAP Gene

Unigene Clusters for SLMAP Gene

Sarcolemma associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLMAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9: - - - - - - -
SP10: - -
SP11: - - -
SP12:
SP13:

ExUns: 17c · 17d · 17e ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SLMAP Gene

GeneLoc Exon Structure for
SLMAP
ECgene alternative splicing isoforms for
SLMAP

Expression for SLMAP Gene

mRNA expression in normal human tissues for SLMAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLMAP Gene

SOURCE GeneReport for Unigene cluster for SLMAP Gene Hs.476432

genes like me logo Genes that share expressions with SLMAP: view

Orthologs for SLMAP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLMAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLMAP 36
  • 99.67 (n)
  • 99.75 (a)
SLMAP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLMAP 36
  • 95.15 (n)
  • 97.41 (a)
SLMAP 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLMAP 36
  • 96.14 (n)
  • 98.15 (a)
SLMAP 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slmap 36
  • 88.97 (n)
  • 90.64 (a)
Slmap 16
Slmap 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLMAP 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLMAP 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slmap 36
  • 89.44 (n)
  • 91.41 (a)
chicken
(Gallus gallus)
Aves gga-mir-1787 37
  • 80 (a)
OneToOne
SLMAP 36
  • 82.82 (n)
  • 88.13 (a)
lizard
(Anolis carolinensis)
Reptilia SLMAP 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18053 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slmap 36
  • 71.87 (n)
  • 75.34 (a)
Str.18769 36
zebrafish
(Danio rerio)
Actinopterygii slmapa 36
  • 66.41 (n)
  • 69.82 (a)
slmapa 37
  • 65 (a)
OneToOne
wufa03e05 36
fruit fly
(Drosophila melanogaster)
Insecta CG17494 37
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M4.1 37
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR10 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8207 37
  • 46 (a)
OneToMany
Species with no ortholog for SLMAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLMAP Gene

ENSEMBL:
Gene Tree for SLMAP (if available)
TreeFam:
Gene Tree for SLMAP (if available)

Paralogs for SLMAP Gene

Paralogs for SLMAP Gene

genes like me logo Genes that share paralogs with SLMAP: view

Variants for SLMAP Gene

Sequence variations from dbSNP and Humsavar for SLMAP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13400 -- 57,757,610(-) AAAGA(C/G)GAGTT utr-variant-5-prime, nc-transcript-variant
rs182055 -- 57,816,444(-) AAATT(C/T)ggctg intron-variant
rs266837 -- 57,820,559(-) CTCGC(A/G)TTTAC intron-variant
rs266838 -- 57,819,545(-) AAAAA(G/T)TTCCA intron-variant
rs266839 -- 57,808,726(-) gaata(C/T)acatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLMAP Gene

Variant ID Type Subtype PubMed ID
nsv834701 CNV Loss 17160897
nsv822101 CNV Loss 20364138
esv2725310 CNV Deletion 23290073
esv9643 CNV Loss 19470904
esv2668341 CNV Deletion 23128226
nsv822102 CNV Loss 20364138
nsv876830 CNV Gain 21882294

Relevant External Links for SLMAP Gene

HapMap Linkage Disequilibrium report
SLMAP
Human Gene Mutation Database (HGMD)
SLMAP

Disorders for SLMAP Gene

(1) MalaCards Diseases for SLMAP Gene

Search for SLMAP Gene in MalaCards »
genes like me logo Genes that share disorders with SLMAP: view

No data available for UniProtKB/Swiss-Prot for SLMAP Gene

Publications for SLMAP Gene

  1. Molecular cloning, expression, and chromosomal assignment of sarcolemmal-associated proteins. A family of acidic amphipathic alpha-helical proteins associated with the membrane. (PMID: 9405447) Wigle J.T. … Tuana B.S. (J. Biol. Chem. 1997) 2 3 23
  2. Alternative splicing, expression, and genomic structure of the 3' region of the gene encoding the sarcolemmal-associated proteins (SLAPs) defines a novel class of coiled-coil tail-anchored membrane proteins. (PMID: 10986292) Wielowieyski P.A. … Tuana B.S. (J. Biol. Chem. 2000) 3 4 23
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for SLMAP Gene

Sources for SLMAP Gene

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