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Aliases for SLMAP Gene

Aliases for SLMAP Gene

  • Sarcolemma Associated Protein 2 3 5
  • Sarcolemmal-Associated Protein 2 4
  • SLAP 3 4
  • Sarcolemmal Membrane-Associated Protein 3
  • KIAA1601 4

External Ids for SLMAP Gene

Previous GeneCards Identifiers for SLMAP Gene

  • GC03P056698
  • GC03P057181
  • GC03P057598
  • GC03P057784
  • GC03P057700

Summaries for SLMAP Gene

Entrez Gene Summary for SLMAP Gene

  • This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for SLMAP Gene

SLMAP (Sarcolemma Associated Protein) is a Protein Coding gene. Diseases associated with SLMAP include Brugada Syndrome. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is CCDC136.

UniProtKB/Swiss-Prot for SLMAP Gene

  • May play a role during myoblast fusion.

Gene Wiki entry for SLMAP Gene

Additional gene information for SLMAP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLMAP Gene

Genomics for SLMAP Gene

Regulatory Elements for SLMAP Gene

Enhancers for SLMAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H058056 1.6 Ensembl ENCODE dbSUPER 22 +304.7 304728 7.3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 FOS SP5 ZHX2 SLMAP FLNB FLNB-AS1 GC03P058010
GH03H057706 0.8 Ensembl ENCODE 15.9 -48.8 -48835 1 JUND JUNB FOS ATF7 ATF2 SLMAP DNAH12 ASB14 ACOX2 DENND6A GC03P057753
GH03H058004 1.2 Ensembl ENCODE dbSUPER 10 +250.3 250254 2.6 TBP SOX13 JUN CEBPG RAD21 POLR2A SCRT2 FOS SOX5 RFX1 FLNB FLNB-AS1 DNASE1L3 SLMAP RPP14 ARF4 GC03M057992
GH03H057966 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.3 +216.0 215968 9.4 FOXA2 ARID4B SIN3A DMAP1 BRCA1 TCF12 ELK1 ATF7 FOS SP5 FLNB SLMAP FLNB-AS1 PDHB PXK LOC105377104 GC03M057992
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLMAP on UCSC Golden Path with GeneCards custom track

Promoters for SLMAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000153102 1850 3801 HDGF MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766

Genomic Locations for SLMAP Gene

Genomic Locations for SLMAP Gene
174,554 bases
Plus strand

Genomic View for SLMAP Gene

Genes around SLMAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLMAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLMAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLMAP Gene

Proteins for SLMAP Gene

  • Protein details for SLMAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sarcolemmal membrane-associated protein
    Protein Accession:
    Secondary Accessions:
    • Q14C95
    • Q6AI54
    • Q6UXC9
    • Q6ZVQ8
    • Q8NCW9
    • Q9H297
    • Q9HCH1
    • Q9Y681

    Protein attributes for SLMAP Gene

    828 amino acids
    Molecular mass:
    95198 Da
    Quaternary structure:
    • Homodimer. Interacts with myosin (By similarity).
    • Sequence=AAQ88776.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH10369.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLMAP Gene

neXtProt entry for SLMAP Gene

Post-translational modifications for SLMAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLMAP Gene

Domains & Families for SLMAP Gene

Gene Families for SLMAP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SLMAP Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLMAP family.
  • Belongs to the SLMAP family.
genes like me logo Genes that share domains with SLMAP: view

Function for SLMAP Gene

Molecular function for SLMAP Gene

UniProtKB/Swiss-Prot Function:
May play a role during myoblast fusion.

Phenotypes From GWAS Catalog for SLMAP Gene

Gene Ontology (GO) - Molecular Function for SLMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17353931
genes like me logo Genes that share ontologies with SLMAP: view
genes like me logo Genes that share phenotypes with SLMAP: view

miRNA for SLMAP Gene

miRTarBase miRNAs that target SLMAP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLMAP Gene

Localization for SLMAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLMAP Gene

Cell membrane, sarcolemma; Single-pass type IV membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z- and M-lines in cardiomyocytes. Centrosome. Localizes to the centrosomes in a microtubule- dependent manner (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLMAP gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
cytosol 4
cytoskeleton 3
peroxisome 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005790 smooth endoplasmic reticulum TAS 9405447
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with SLMAP: view

Pathways & Interactions for SLMAP Gene

SuperPathways for SLMAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction IEA,TAS --
GO:0072659 protein localization to plasma membrane IMP 23064965
GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential IMP 23064965
GO:1902305 regulation of sodium ion transmembrane transport IMP 23064965
GO:1905150 regulation of voltage-gated sodium channel activity IMP 23064965
genes like me logo Genes that share ontologies with SLMAP: view

No data available for Pathways by source and SIGNOR curated interactions for SLMAP Gene

Drugs & Compounds for SLMAP Gene

No Compound Related Data Available

Transcripts for SLMAP Gene

Unigene Clusters for SLMAP Gene

Sarcolemma associated protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLMAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9: - - - - - - -
SP10: - -
SP11: - - -

ExUns: 17c · 17d · 17e ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP3: -

Relevant External Links for SLMAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLMAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLMAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLMAP Gene

This gene is overexpressed in Seminal vesicle (17.0) and Urinary Bladder (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLMAP Gene

Protein tissue co-expression partners for SLMAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLMAP Gene:


SOURCE GeneReport for Unigene cluster for SLMAP Gene:


Evidence on tissue expression from TISSUES for SLMAP Gene

  • Heart(4.5)
  • Nervous system(4.5)
  • Blood(4.3)
  • Muscle(3.1)
  • Eye(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLMAP Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • cardiovascular
  • nervous
Head and neck:
  • brain
  • ear
  • head
  • heart
  • heart valve
  • blood
  • blood vessel
  • red blood cell
genes like me logo Genes that share expression patterns with SLMAP: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLMAP Gene

Orthologs for SLMAP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLMAP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLMAP 33 34
  • 99.67 (n)
(Canis familiaris)
Mammalia SLMAP 33 34
  • 96.14 (n)
(Bos Taurus)
Mammalia SLMAP 33 34
  • 95.15 (n)
(Rattus norvegicus)
Mammalia Slmap 33
  • 89.44 (n)
(Mus musculus)
Mammalia Slmap 33 16 34
  • 88.97 (n)
(Monodelphis domestica)
Mammalia SLMAP 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia SLMAP 34
  • 80 (a)
(Gallus gallus)
Aves SLMAP 33
  • 82.82 (n)
gga-mir-1787 34
  • 80 (a)
(Anolis carolinensis)
Reptilia SLMAP 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slmap 33
  • 71.87 (n)
Str.18769 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18053 33
(Danio rerio)
Actinopterygii slmapa 33 34
  • 66.41 (n)
wufa03e05 33
fruit fly
(Drosophila melanogaster)
Insecta CG17494 34
  • 17 (a)
(Caenorhabditis elegans)
Secernentea M4.1 34
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR10 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8207 34
  • 46 (a)
Species where no ortholog for SLMAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLMAP Gene

Gene Tree for SLMAP (if available)
Gene Tree for SLMAP (if available)

Paralogs for SLMAP Gene

Paralogs for SLMAP Gene

genes like me logo Genes that share paralogs with SLMAP: view

Variants for SLMAP Gene

Sequence variations from dbSNP and Humsavar for SLMAP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs149548827 Uncertain significance 57,864,644(+) AACAG(A/G)AGCTC nc-transcript-variant, reference, missense
rs869025527 Uncertain significance 57,912,702(+) GCAAG(A/G)TGAAT intron-variant, downstream-variant-500B, splice-donor-variant
rs111294347 Benign 57,871,712(+) AGAGT(A/G)TTTTT intron-variant
rs149758819 Benign 57,849,792(+) GAACT(A/G)TTCCA nc-transcript-variant, reference, synonymous-codon
rs2306056 Benign 57,860,850(-) TTTTT(A/G/T)ATTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLMAP Gene

Variant ID Type Subtype PubMed ID
nsv834701 CNV loss 17160897
nsv822102 CNV loss 20364138
nsv822101 CNV loss 20364138
nsv1136726 CNV deletion 24896259
nsv1008684 CNV gain 25217958
nsv1000081 CNV gain 25217958
esv9643 CNV loss 19470904
esv3596237 CNV loss 21293372
esv2725310 CNV deletion 23290073
esv2668341 CNV deletion 23128226

Variation tolerance for SLMAP Gene

Residual Variation Intolerance Score: 7.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLMAP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLMAP Gene

Disorders for SLMAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLMAP Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
brugada syndrome
  • bangungut
- elite association - COSMIC cancer census association via MalaCards
Search SLMAP in MalaCards View complete list of genes associated with diseases

Relevant External Links for SLMAP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLMAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLMAP Gene

Publications for SLMAP Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 60
  2. Alternative splicing, expression, and genomic structure of the 3' region of the gene encoding the sarcolemmal-associated proteins (SLAPs) defines a novel class of coiled-coil tail-anchored membrane proteins. (PMID: 10986292) Wielowieyski PA … Tuana BS (The Journal of biological chemistry 2000) 3 4 22 60
  3. Molecular cloning, expression, and chromosomal assignment of sarcolemmal-associated proteins. A family of acidic amphipathic alpha-helical proteins associated with the membrane. (PMID: 9405447) Wigle JT … Tuana BS (The Journal of biological chemistry 1997) 2 3 22 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for SLMAP Gene

Sources for SLMAP Gene

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