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Aliases for SLMAP Gene

Aliases for SLMAP Gene

  • Sarcolemma Associated Protein 2 3
  • Sarcolemmal-Associated Protein 2 4
  • SLAP 3 4
  • KIAA1601 4

External Ids for SLMAP Gene

Previous GeneCards Identifiers for SLMAP Gene

  • GC03P056698
  • GC03P057181
  • GC03P057598
  • GC03P057784
  • GC03P057700

Summaries for SLMAP Gene

Entrez Gene Summary for SLMAP Gene

  • This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for SLMAP Gene

SLMAP (Sarcolemma Associated Protein) is a Protein Coding gene. Diseases associated with SLMAP include brugada syndrome. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is TRAF3IP3.

UniProtKB/Swiss-Prot for SLMAP Gene

  • May play a role during myoblast fusion.

Gene Wiki entry for SLMAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLMAP Gene

Genomics for SLMAP Gene

Regulatory Elements for SLMAP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLMAP Gene

Chromosome:
3
Start:
57,755,450 bp from pter
End:
57,930,003 bp from pter
Size:
174,554 bases
Orientation:
Plus strand

Genomic View for SLMAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLMAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLMAP Gene

Proteins for SLMAP Gene

  • Protein details for SLMAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14BN4-SLMAP_HUMAN
    Recommended name:
    Sarcolemmal membrane-associated protein
    Protein Accession:
    Q14BN4
    Secondary Accessions:
    • Q14C95
    • Q6AI54
    • Q6UXC9
    • Q6ZVQ8
    • Q8NCW9
    • Q9H297
    • Q9HCH1
    • Q9Y681

    Protein attributes for SLMAP Gene

    Size:
    828 amino acids
    Molecular mass:
    95198 Da
    Quaternary structure:
    • Homodimer. Interacts with myosin (By similarity).
    SequenceCaution:
    • Sequence=AAQ88776.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH10369.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLMAP Gene

neXtProt entry for SLMAP Gene

Proteomics data for SLMAP Gene at MOPED

Post-translational modifications for SLMAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLMAP Gene

Domains & Families for SLMAP Gene

Protein Domains for SLMAP Gene

Graphical View of Domain Structure for InterPro Entry

Q14BN4

UniProtKB/Swiss-Prot:

SLMAP_HUMAN :
  • Contains 1 FHA domain.
  • Belongs to the SLMAP family.
Domain:
  • Contains 1 FHA domain.
Family:
  • Belongs to the SLMAP family.
genes like me logo Genes that share domains with SLMAP: view

No data available for Gene Families for SLMAP Gene

Function for SLMAP Gene

Molecular function for SLMAP Gene

UniProtKB/Swiss-Prot Function:
May play a role during myoblast fusion.

Gene Ontology (GO) - Molecular Function for SLMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23386615
GO:0051082 unfolded protein binding --
genes like me logo Genes that share ontologies with SLMAP: view

Phenotypes for SLMAP Gene

MGI mutant phenotypes for SLMAP:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLMAP:
genes like me logo Genes that share phenotypes with SLMAP: view

Animal Model Products

miRNA for SLMAP Gene

miRTarBase miRNAs that target SLMAP

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLMAP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLMAP Gene

Localization for SLMAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLMAP Gene

Cell membrane, sarcolemma; Single-pass type IV membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z- and M-lines in cardiomyocytes. Centrosome. Localizes to the centrosomes in a microtubule- dependent manner (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLMAP Gene COMPARTMENTS Subcellular localization image for SLMAP gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 4
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SLMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005790 smooth endoplasmic reticulum TAS 9405447
GO:0005815 microtubule organizing center IEA --
GO:0005887 integral component of plasma membrane TAS 9405447
GO:0016021 integral component of membrane --
GO:0016272 prefoldin complex --
genes like me logo Genes that share ontologies with SLMAP: view

Pathways & Interactions for SLMAP Gene

SuperPathways for SLMAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLMAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding --
GO:0006936 muscle contraction TAS 9405447
genes like me logo Genes that share ontologies with SLMAP: view

No data available for Pathways by source and SIGNOR curated interactions for SLMAP Gene

Drugs & Compounds for SLMAP Gene

No Compound Related Data Available

Transcripts for SLMAP Gene

Unigene Clusters for SLMAP Gene

Sarcolemma associated protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLMAP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLMAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9: - - - - - - -
SP10: - -
SP11: - - -
SP12:
SP13:

ExUns: 17c · 17d · 17e ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SLMAP Gene

GeneLoc Exon Structure for
SLMAP
ECgene alternative splicing isoforms for
SLMAP

Expression for SLMAP Gene

mRNA expression in normal human tissues for SLMAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLMAP Gene

This gene is overexpressed in Seminal vesicle (17.0) and Urinary Bladder (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLMAP Gene



SOURCE GeneReport for Unigene cluster for SLMAP Gene Hs.476432

genes like me logo Genes that share expression patterns with SLMAP: view

Protein tissue co-expression partners for SLMAP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLMAP Gene

Orthologs for SLMAP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLMAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLMAP 35
  • 95.15 (n)
  • 97.41 (a)
SLMAP 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLMAP 35
  • 96.14 (n)
  • 98.15 (a)
SLMAP 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slmap 35
  • 88.97 (n)
  • 90.64 (a)
Slmap 16
Slmap 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLMAP 35
  • 99.67 (n)
  • 99.75 (a)
SLMAP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slmap 35
  • 89.44 (n)
  • 91.41 (a)
oppossum
(Monodelphis domestica)
Mammalia SLMAP 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLMAP 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLMAP 35
  • 82.82 (n)
  • 88.13 (a)
gga-mir-1787 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLMAP 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slmap 35
  • 71.87 (n)
  • 75.34 (a)
Str.18769 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.18053 35
zebrafish
(Danio rerio)
Actinopterygii slmapa 35
  • 66.41 (n)
  • 69.82 (a)
wufa03e05 35
slmapa 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17494 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M4.1 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR10 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8207 36
  • 46 (a)
OneToMany
Species with no ortholog for SLMAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLMAP Gene

ENSEMBL:
Gene Tree for SLMAP (if available)
TreeFam:
Gene Tree for SLMAP (if available)

Paralogs for SLMAP Gene

Paralogs for SLMAP Gene

genes like me logo Genes that share paralogs with SLMAP: view

Variants for SLMAP Gene

Sequence variations from dbSNP and Humsavar for SLMAP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13400 -- 57,757,610(-) AAAGA(C/G)GAGTT utr-variant-5-prime, nc-transcript-variant
rs182055 -- 57,816,444(-) AAATT(C/T)ggctg intron-variant
rs266837 -- 57,820,559(-) CTCGC(A/G)TTTAC intron-variant
rs266838 -- 57,819,545(-) AAAAA(G/T)TTCCA intron-variant
rs266839 -- 57,808,726(-) gaata(C/T)acatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLMAP Gene

Variant ID Type Subtype PubMed ID
nsv834701 CNV Loss 17160897
nsv822101 CNV Loss 20364138
esv2725310 CNV Deletion 23290073
esv9643 CNV Loss 19470904
esv2668341 CNV Deletion 23128226
nsv822102 CNV Loss 20364138
nsv876830 CNV Gain 21882294

Variation tolerance for SLMAP Gene

Residual Variation Intolerance Score: 7.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLMAP Gene

HapMap Linkage Disequilibrium report
SLMAP
Human Gene Mutation Database (HGMD)
SLMAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLMAP Gene

Disorders for SLMAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLMAP Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
brugada syndrome
  • sudden unexpected nocturnal death syndrome
- elite association
Search SLMAP in MalaCards View complete list of genes associated with diseases

Relevant External Links for SLMAP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLMAP
genes like me logo Genes that share disorders with SLMAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLMAP Gene

Publications for SLMAP Gene

  1. Molecular cloning, expression, and chromosomal assignment of sarcolemmal-associated proteins. A family of acidic amphipathic alpha-helical proteins associated with the membrane. (PMID: 9405447) Wigle J.T. … Tuana B.S. (J. Biol. Chem. 1997) 2 23 67
  2. Evidence of genetic underexpression in chorionic villi samples of euploid fetuses with increased nuchal translucency at 10-11 weeks' gestation. (PMID: 16470729) Farina A. … Rizzo N. (Prenat. Diagn. 2006) 23 67
  3. Alternative splicing, expression, and genomic structure of the 3' region of the gene encoding the sarcolemmal-associated proteins (SLAPs) defines a novel class of coiled-coil tail-anchored membrane proteins. (PMID: 10986292) Wielowieyski P.A. … Tuana B.S. (J. Biol. Chem. 2000) 23 67
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for SLMAP Gene

Sources for SLMAP Gene

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