Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLK Gene

protein-coding   GIFtS: 60
GCID: GC10P105716

STE20-like kinase

(Previous names: SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase,...)
 Explore 6 diseases affiliated with
SLK via our new
 Human Malady Compendium 
Biological research products
for SLK
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
STE20-Like Kinase1 2 3     SNF1 (Sucrose Nonfermenting, Yeast, Homolog)-Like Kinase, SNF1 Sucrose
Nonfermenting Like Kinase (Yeast)1
STK21 2 3     STE20-Like Kinase (Yeast)1
Se20-91     LOSK2
KIAA02041 3     BA16H23.11
Serine/Threonine-Protein Kinase 22 3     Long Ste20-Like Kinase2
CTCL Tumor Antigen Se20-92 3     SNF1 (Sucrose Nonfermenting, Yeast, Homolog)-Like Kinase, SNF1 Sucrose
Nonfermenting Like Kinase2
HSLK1     SNF1 Sucrose Nonfermenting Like Kinase2
STE20-Related Kinase2 3     STE20-Like Serine/Threonine-Protein Kinase2
STE20-Related Serine/Threonine-Protein Kinase2 3     Ste20-Related Serine/Threonine Kinase2
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 110881   Entrez Gene: 97482   Ensembl: ENSG000000656137   UniProtKB: Q9H2G23   

Export aliases for SLK gene to outside databases

Previous GC identifers: GC10P104620 GC00U905130 GC10P105392 GC10P099381


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
Function: Mediates apoptosis and actin stress fiber dissolution (By similarity)

Gene Wiki entry for SLK


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLK gene promoter:
         GR   USF1   AP-1   ATF-2   E4BP4   Max   USF-1   GR-alpha   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLK promoter sequence
   Search SABiosciences Chromatin IP Primers for SLK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q25.1

SLK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLK gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105716:  view genomic region     (about GC identifiers)

Start:
105,726,959 bp from pter      End:
105,788,991 bp from pter
Size:
62,033 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2 (See protein sequence)
Recommended Name: STE20-like serine/threonine-protein kinase  
Size: 1235 amino acids; 142695 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAH47762.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence starting in position 611; Sequence=AAH47885.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.
Potential poly-A sequence starting in position 422; Sequence=AAH64804.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence starting in position 614; Sequence=BAA13195.2; Type=Frameshift;
Positions=1172;
4 PDB 3D structures from and Proteopedia for SLK:
2J51 (3D)        2JFL (3D)        2JFM (3D)        2UV2 (3D)    
Secondary accessions: D3DRA0 D3DRA1 O00211 Q6P1Z4 Q86WU7 Q86WW1 Q92603 Q9NQL0 Q9NQL1
Alternative splicing: 2 isoforms:  Q9H2G2-1   Q9H2G2-2   

Explore the universe of human proteins at neXtProt for SLK: NX_Q9H2G2

Post-translational modifications:

  • Proteolytically cleaved by caspase-31
  • Autophosphorylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H2G2

  • 4/17 DME Specific Peptides for SLK (Q9H2G2) (see all 17)
     QLQNEKC  KLRPRKK  IIHRDLKA  LLQHPFVT 

    SLK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055535.2  
    ENSEMBL proteins: 
     ENSP00000336824   ENSP00000358770  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for SLK 
    GenScript Custom Purified and Recombinant Proteins Services for SLK
    Novus Biologicals SLK Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLK

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--


    SLK for ontologies           About GeneDecksing



    SLK Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLK 
    GenScript Custom Superior Antibodies Services for SLK
    Novus Biologicals SLK Antibodies
    Search for Antibodies for SLK at Abcam  
    Uscn Antibodies for SLK
    ThermoFisher Antibodies for SLK

    Assay Products for SLK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLK
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SLK


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLK for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR022165 PKK

    Graphical View of Domain Structure for InterPro Entry Q9H2G2

    ProtoNet protein and cluster: Q9H2G2

    UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UVR domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
    Function: Mediates apoptosis and actin stress fiber dissolution (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: SLK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLK
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SLK (see all 9):
    hsa-miR-1263 hsa-miR-429 hsa-miR-219-5p hsa-miR-340 hsa-miR-1305 hsa-miR-508-3p hsa-miR-200c hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidSLK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLK (see all 7)
    OriGene shRNA RFP: SLK
    OriGene siRNA: SLK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLK

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLK (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLK (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLK (NM_014720)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLK 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLK
    Search LifeMap BioReagents cell lines for SLK

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLK

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA18239682
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0042803protein homodimerization activity IDA18239682


    SLK for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLK:
     Decreased substrate adherent c 

    Animal Models:
         1 MGI phenotypic allele for Slk (no phenotypes)

    SLK for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Oocyte meiosis
    Oocyte meiosis1.00
    2Mitotic Roles of Polo Like Kinases
    Mitotic Roles of Polo Like Kinases1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SLK
        Mitotic Roles of Polo Like Kinases


    1         Kegg Pathway  (Kegg details for SLK):
        Oocyte meiosis


    SLK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for SLK (Q9H2G23 ENSP000003587704) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KEAP1Q141453, ENSP000001711114I2D: score=2 STRING: ENSP00000171111
    CASP3P425743, ENSP000003110324I2D: score=1 STRING: ENSP00000311032
    PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
    CLSTN1O949853, ENSP000003665134I2D: score=2 STRING: ENSP00000366513
    IKBKEQ141643, ENSP000003560874I2D: score=1 STRING: ENSP00000356087
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process IEA--
    GO:0046777protein autophosphorylation IDA18239682


    SLK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLK

    2 HMDB Compounds for SLK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for SLK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235
    [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE-- --target--10592235

    2 Novoseek chemical compound relationships for SLK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 44.6 2 9346925 (1), 10699464 (1)
    glucose 10.2 3 16316999 (1), 19640899 (1), 12965890 (1)

    Search CenterWatch for drugs/clinical trials and news about SLK 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLK gene: 
    NM_014720.2  

    Unigene Cluster for SLK:

    STE20-like kinase
    Hs.591922  [show with all ESTs]
    Unigene Representative Sequence: D86959
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335753(uc001kxp.1) ENST00000369755(uc001kxo.1) ENST00000474260


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: SLK
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLK
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SLK (see all 9):
    hsa-miR-1263 hsa-miR-429 hsa-miR-219-5p hsa-miR-340 hsa-miR-1305 hsa-miR-508-3p hsa-miR-200c hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidSLK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLK (see all 7)
    OriGene shRNA RFP: SLK
    OriGene siRNA: SLK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLK
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLK (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLK (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SLK (NM_014720)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLK 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLK
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLK

    Additional cDNA sequence: 

    AF273048.1 AK302855.1 AK307389.1 BC008697.1 BC036736.1 BC047762.1 BC047885.1 BC064804.1 
    BC111565.1 BX648375.1 D86959.1 EF139853.1 

    5 DOTS entries:

    DT.92433300  DT.417305  DT.40193723  DT.100792601  DT.75180494 

    24/330 AceView cDNA sequences (see all 330):

    CK821145 AI559709 AL134377 BM423404 AI085766 AA505137 AA362324 AA974368 
    CF528474 BM090927 BX483334 BP363405 BQ011651 BQ937615 BE463768 AA724517 
    BM470785 AA621484 CA311504 AI018333 AI124895 AA131682 AA782572 AI758698 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLK    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                                                                        -                           
    SP2:                                                                                      -                 -                           
    SP3:                                                                                      -                                             


    ECgene alternative splicing isoforms for SLK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGGTCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SLK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLK

    SOURCE GeneReport for Unigene cluster: Hs.591922

    UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
    Tissue specificity: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including SLK: 
              DNA Repair in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLK
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLK
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLK gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLK1 STE20-like kinase 73.81(n)
    74.22(a)
      423878  XM_421743.3  XP_421743.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLK6
    --
    71(a)
    1 ↔ 1
    3(41369674-41407836)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL893587.22   -- 77.73(n)    AL893587.2 
    zebrafish
    (Danio rerio)
    Actinopterygii slka1 STE20-like kinase a 65.07(n)
    66.9(a)
      568838  NM_001145601.1  NP_001139073.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45273
    slik1
    protein amino acid phosphorylation receptor
    signaling more3
    Sterile20-like kinase1
    40(a)3
    44.12(n)1
    35.11(a)1
      378931  NM_206213.11  NP_995935.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C04A11.33
    gck-41
    serine/threonine kinase3
    Protein GCK-41
    48(a)3
    46.42(n)1
    33.91(a)1
      X(13712484-13717302)3
    1814881  NM_077889.11  NP_510290.11 


    ENSEMBL Gene Tree for SLK (if available)
    TreeFam Gene Tree for SLK (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLK gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  
    MAP4K42  TAOK12  STK102  MINK12  
    7 SIMAP similar genes for SLK using alignment to 2 protein entries:     SLK_HUMAN (see all proteins):
    STK25    STK24    MST4    STK10    STK4    MAP2K6
    MAP2K5

    SLK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1023 NCBI SNPs in SLK are shown (see all 1023    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835646961,2
    --105725531(+) AATATA/GTACAT 1 -- us2k10--------
    rs1178437511,2
    F,--105725551(+) CTGCTC/TCAGAT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1874547121,2
    --105725608(+) GCCAGA/GAATGT 1 -- us2k10--------
    rs1923057041,2
    --105725620(+) GCCGGA/GTACTT 1 -- us2k10--------
    rs107488591,2
    C,F,H,--105725722(+) CAACGC/TCCACA 1 -- us2k114Minor allele frequency- T:0.20NA WA CSA EA 379
    rs122624991,2
    H--105725783(+) TGGGGG/CCCTTA 1 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs108839551,2
    C,--105725995(+) ACCCCA/GTCTCT 1 -- us2k12Minor allele frequency- G:0.25WA NA 4
    rs108839561,2
    A--105726041(+) cgggcC/Gcctgt 1 -- us2k10--------
    rs1833285371,2
    --105726081(+) GAGAAA/TAGCGT 1 -- us2k10--------
    rs1880672951,2
    --105726141(+) CCAGCC/TTGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLK (105726959 - 105788991 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLK: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLK
    DNA2.0 Custom Variant and Variant Library Synthesis for SLK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLK for disorders           About GeneDecksing

    6 diseases for SLK:    About MalaCards
    uterine fibroid    cutaneous t cell lymphoma    keratoconjunctivitis    lupus erythematosus
    alzheimer's disease    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for SLK:
    Lupus erythematosus     Nephritis

    1 Novoseek disease relationship for SLK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure acute ischemic 78.3 2 16316999 (1), 17003224 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLK (25 documents)

    Export disorders for SLK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLK gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with SLK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. (PubMed id 10699464)1, 2, 9 Yamada E.... Yamamoto H. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    4. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2 Eichmueller S....Schadendorf D. (2001)
    5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    6. A yeast gene that is essential for release from glucose repression encodes a protein kinase. (PubMed id 3526554)1, 3 Celenza J.L. and Carlson M. (1986)
    7. Ste20-related Protein Kinase LOSK (SLK) Controls Microtubule Radial Array in Interphase. (PubMed id 18287541)1, 9 Burakov A.V....Nadezhdina E.S. (2008)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Local phosphocycling mediated by LOK/SLK restricts ezr in function to the apical aspect of epithelial cells. (PubMed id 23209304)1 Viswanatha R....Bretscher A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9748 HGNC: 11088 AceView: SLK Ensembl:ENSG00000065613 euGenes: HUgn9748
    ECgene: SLK Kegg: 9748 H-InvDB: SLK

    (According to HUGE)
    About This Section
    HUGE: KIAA0204

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLK gene:
    Search GeneIP for patents involving SLK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SLK  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLK   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLK  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SLK   OriGene 3'-UTR Clone for SLK  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLK   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLK  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLK   OriGene Custom Protein Services for SLK  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLK
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLK
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLK
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLK
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLK
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLK
     GenScript Custom Purified and Recombinant Proteins Services for SLK GenScript cDNA clones with any tag delivered in your preferred vector for SLK
     GenScript Custom Assay Services for SLK GenScript Custom Superior Antibodies Services for SLK
     GenScript Custom overexpressing Cell Line Services for SLK CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLK promoter
     Search Chromatin IP Primers for SLK
     RT2 qPCR Primer Assay in human, mouse, rat SLK
     GNC Network for SLK
     SABiosciences PCR Arrays including human, mouse, rat SLK
     Search Tocris compounds for SLK
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLK antibodies
     SLK proteins
     Search for Antibodies for SLK at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SLK Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SLK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLK
     SwitchGear 3'UTR luciferase reporter plasmids for SLK
     SwitchGear Promoter luciferase reporter plasmids for SLK
     ThermoFisher Antibodies for SLK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLK
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLK gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4