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Aliases for SLK Gene

Aliases for SLK Gene

  • STE20 Like Kinase 2 3 5
  • STE20-Like Kinase 2 3 4
  • STE20-Related Serine/Threonine-Protein Kinase 3 4
  • Serine/Threonine-Protein Kinase 2 3 4
  • CTCL Tumor Antigen Se20-9 3 4
  • STE20-Related Kinase 3 4
  • EC 2.7.11.1 4 63
  • STK2 3 4
  • HSLK 3 4
  • SNF1 (Sucrose Nonfermenting, Yeast, Homolog)-Like Kinase, SNF1 Sucrose Nonfermenting Like Kinase (Yeast) 2
  • SNF1 (Sucrose Nonfermenting, Yeast, Homolog)-Like Kinase, SNF1 Sucrose Nonfermenting Like Kinase 3
  • SNF1 Sucrose Nonfermenting Like Kinase 3
  • Ste20-Related Serine/Threonine Kinase 3
  • STE20-Like Kinase (Yeast) 2
  • Long Ste20-Like Kinase 3
  • BA16H23.1 3
  • EC 2.7.11 63
  • KIAA0204 4
  • Se20-9 3
  • LOSK 3

External Ids for SLK Gene

Previous GeneCards Identifiers for SLK Gene

  • GC10P104620
  • GC00U905130
  • GC10P105392
  • GC10P105716
  • GC10P099381

Summaries for SLK Gene

GeneCards Summary for SLK Gene

SLK (STE20 Like Kinase) is a Protein Coding gene. Diseases associated with SLK include Amyotrophic Lateral Sclerosis 9. Among its related pathways are Mitotic Roles of Polo Like Kinases and Oocyte meiosis. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for SLK Gene

  • Mediates apoptosis and actin stress fiber dissolution.

Gene Wiki entry for SLK Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLK Gene

Genomics for SLK Gene

Regulatory Elements for SLK Gene

Enhancers for SLK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLK on UCSC Golden Path with GeneCards custom track

Promoters for SLK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLK on UCSC Golden Path with GeneCards custom track

Genomic Location for SLK Gene

Chromosome:
10
Start:
103,967,182 bp from pter
End:
104,029,233 bp from pter
Size:
62,052 bases
Orientation:
Plus strand

Genomic View for SLK Gene

Genes around SLK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLK Gene

Proteins for SLK Gene

  • Protein details for SLK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2G2-SLK_HUMAN
    Recommended name:
    STE20-like serine/threonine-protein kinase
    Protein Accession:
    Q9H2G2
    Secondary Accessions:
    • D3DRA0
    • D3DRA1
    • O00211
    • Q6P1Z4
    • Q86WU7
    • Q86WW1
    • Q92603
    • Q9NQL0
    • Q9NQL1

    Protein attributes for SLK Gene

    Size:
    1235 amino acids
    Molecular mass:
    142695 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47762.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 611.; Evidence={ECO:0000305}; Sequence=AAH47885.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 422.; Evidence={ECO:0000305}; Sequence=AAH64804.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 614.; Evidence={ECO:0000305}; Sequence=BAA13195.2; Type=Frameshift; Positions=1172; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLK Gene

    Alternative splice isoforms for SLK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLK Gene

Proteomics data for SLK Gene at MOPED

Post-translational modifications for SLK Gene

Other Protein References for SLK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SLK Gene

Gene Families for SLK Gene

Suggested Antigen Peptide Sequences for SLK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2G2

UniProtKB/Swiss-Prot:

SLK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 UVR domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with SLK: view

Function for SLK Gene

Molecular function for SLK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Mediates apoptosis and actin stress fiber dissolution.

Enzyme Numbers (IUBMB) for SLK Gene

Gene Ontology (GO) - Molecular Function for SLK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SLK: view
genes like me logo Genes that share phenotypes with SLK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLK Gene

Localization for SLK Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLK Gene COMPARTMENTS Subcellular localization image for SLK gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
plasma membrane 2
chloroplast 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SLK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IBA 18287541
genes like me logo Genes that share ontologies with SLK: view

Pathways & Interactions for SLK Gene

genes like me logo Genes that share pathways with SLK: view

Pathways by source for SLK Gene

1 KEGG pathway for SLK Gene
1 Qiagen pathway for SLK Gene

SIGNOR curated interactions for SLK Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SLK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0023014 signal transduction by protein phosphorylation IBA --
GO:0030334 regulation of cell migration ISS --
GO:0031098 stress-activated protein kinase signaling cascade IBA --
genes like me logo Genes that share ontologies with SLK: view

Drugs & Compounds for SLK Gene

(4) Drugs for SLK Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE Experimental Pharma Target 0
5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE Experimental Pharma Target 0

(2) Additional Compounds for SLK Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with SLK: view

Transcripts for SLK Gene

Unigene Clusters for SLK Gene

STE20-like kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: - -
SP3: -

Relevant External Links for SLK Gene

GeneLoc Exon Structure for
SLK
ECgene alternative splicing isoforms for
SLK

Expression for SLK Gene

mRNA expression in normal human tissues for SLK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLK Gene



SOURCE GeneReport for Unigene cluster for SLK Gene Hs.591922

mRNA Expression by UniProt/SwissProt for SLK Gene

Q9H2G2-SLK_HUMAN
Tissue specificity: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.
genes like me logo Genes that share expression patterns with SLK: view

Protein tissue co-expression partners for SLK Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SLK Gene

Orthologs for SLK Gene

This gene was present in the common ancestor of animals.

Orthologs for SLK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLK 35
  • 90.35 (n)
  • 88.65 (a)
SLK 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLK 35
  • 91.44 (n)
  • 90.69 (a)
SLK 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slk 35
  • 84.6 (n)
  • 84.65 (a)
Slk 16
Slk 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLK 35
  • 99.73 (n)
  • 99.6 (a)
SLK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slk 35
  • 83.79 (n)
  • 82.09 (a)
oppossum
(Monodelphis domestica)
Mammalia SLK 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLK 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLK 35
  • 73.99 (n)
  • 74.63 (a)
SLK 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLK 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slka 35
  • 73.21 (n)
  • 81.2 (a)
slka 36
  • 61 (a)
OneToMany
slkb 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4527 37
  • 40 (a)
slik 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C04A11.3 37
  • 48 (a)
gck-4 36
  • 28 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14840 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8272 36
  • 38 (a)
OneToMany
Species with no ortholog for SLK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLK Gene

ENSEMBL:
Gene Tree for SLK (if available)
TreeFam:
Gene Tree for SLK (if available)

Paralogs for SLK Gene

Paralogs for SLK Gene

(7) SIMAP similar genes for SLK Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLK: view

Variants for SLK Gene

Sequence variations from dbSNP and Humsavar for SLK Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_041080 A lung adenocarcinoma sample
rs805657 - 104,002,833(+) AACAT(A/G)TGAGG intron-variant, reference, missense
VAR_041082 An ovarian serous carcinoma sample
rs56400929 - 104,003,151(+) GGTGG(C/G)TGATA intron-variant, reference, missense
rs34326537 - 104,003,214(+) TCAGA(C/T)AGATA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLK Gene

Variant ID Type Subtype PubMed ID
nsv895982 CNV Loss 21882294
nsv7532 CNV Insertion 18451855
esv259448 OTHER Complex 20981092
esv259962 OTHER Complex 20981092

Variation tolerance for SLK Gene

Residual Variation Intolerance Score: 10.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.46; 77.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLK Gene

Human Gene Mutation Database (HGMD)
SLK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLK Gene

Disorders for SLK Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLK Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 9
  • amyotrophic lateral sclerosis type 9
- elite association - COSMIC cancer census association via MalaCards
Search SLK in MalaCards View complete list of genes associated with diseases

Relevant External Links for SLK

Genetic Association Database (GAD)
SLK
Human Genome Epidemiology (HuGE) Navigator
SLK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLK
genes like me logo Genes that share disorders with SLK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLK Gene

Publications for SLK Gene

  1. Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. (PMID: 10699464) Yamada E. … Yamamoto H. (Biochim. Biophys. Acta 2000) 3 4 23 67
  2. Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase. (PMID: 18287541) Burakov A.V. … Nadezhdina E.S. (Mol. Biol. Cell 2008) 3 23
  3. A yeast gene that is essential for release from glucose repression encodes a protein kinase. (PMID: 3526554) Celenza J.L. … Carlson M. (Science 1986) 2 3
  4. SLK/LOSK kinase regulates cell motility independently of microtubule organization and Golgi polarization. (PMID: 26818812) Fokin A.I. … Burakov A.V. (Cytoskeleton (Hoboken) 2016) 3
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3

Products for SLK Gene

Sources for SLK Gene

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