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Aliases for SLK Gene

Aliases for SLK Gene

  • STE20-Like Kinase 2 3 4
  • STE20-Related Serine/Threonine-Protein Kinase 3 4
  • Serine/Threonine-Protein Kinase 2 3 4
  • CTCL Tumor Antigen Se20-9 3 4
  • STE20-Related Kinase 3 4
  • EC 2.7.11.1 4 63
  • STK2 3 4
  • HSLK 3 4
  • SNF1 (Sucrose Nonfermenting, Yeast, Homolog)-Like Kinase, SNF1 Sucrose Nonfermenting Like Kinase (Yeast) 2
  • SNF1 (Sucrose Nonfermenting, Yeast, Homolog)-Like Kinase, SNF1 Sucrose Nonfermenting Like Kinase 3
  • STE20-Like Serine/Threonine-Protein Kinase 3
  • SNF1 Sucrose Nonfermenting Like Kinase 3
  • Ste20-Related Serine/Threonine Kinase 3
  • STE20-Like Kinase (Yeast) 2
  • Long Ste20-Like Kinase 3
  • BA16H23.1 3
  • EC 2.7.11 63
  • KIAA0204 4
  • Se20-9 3
  • LOSK 3

External Ids for SLK Gene

Previous GeneCards Identifiers for SLK Gene

  • GC10P104620
  • GC00U905130
  • GC10P105392
  • GC10P105716
  • GC10P099381

Summaries for SLK Gene

GeneCards Summary for SLK Gene

SLK (STE20-Like Kinase) is a Protein Coding gene. Among its related pathways are Oocyte meiosis and Mitotic Roles of Polo Like Kinases. GO annotations related to this gene include protein homodimerization activity and protein serine/threonine kinase activity. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for SLK Gene

  • Mediates apoptosis and actin stress fiber dissolution.

Gene Wiki entry for SLK Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLK Gene

Genomics for SLK Gene

Regulatory Elements for SLK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLK Gene

Start:
103,967,185 bp from pter
End:
104,029,233 bp from pter
Size:
62,049 bases
Orientation:
Plus strand

Genomic View for SLK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLK Gene

Proteins for SLK Gene

  • Protein details for SLK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2G2-SLK_HUMAN
    Recommended name:
    STE20-like serine/threonine-protein kinase
    Protein Accession:
    Q9H2G2
    Secondary Accessions:
    • D3DRA0
    • D3DRA1
    • O00211
    • Q6P1Z4
    • Q86WU7
    • Q86WW1
    • Q92603
    • Q9NQL0
    • Q9NQL1

    Protein attributes for SLK Gene

    Size:
    1235 amino acids
    Molecular mass:
    142695 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47762.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 611.; Evidence={ECO:0000305}; Sequence=AAH47885.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 422.; Evidence={ECO:0000305}; Sequence=AAH64804.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 614.; Evidence={ECO:0000305}; Sequence=BAA13195.2; Type=Frameshift; Positions=1172; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLK Gene

    Alternative splice isoforms for SLK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLK Gene

Proteomics data for SLK Gene at MOPED

Post-translational modifications for SLK Gene

Other Protein References for SLK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SLK Gene

Gene Families for SLK Gene

Suggested Antigen Peptide Sequences for SLK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2G2

UniProtKB/Swiss-Prot:

SLK_HUMAN :
  • Q9H2G2
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 UVR domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with SLK: view

Function for SLK Gene

Molecular function for SLK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
Mediates apoptosis and actin stress fiber dissolution.

Enzyme Numbers (IUBMB) for SLK Gene

Gene Ontology (GO) - Molecular Function for SLK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 18239682
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLK: view

Phenotypes for SLK Gene

GenomeRNAi human phenotypes for SLK:
genes like me logo Genes that share phenotypes with SLK: view

Animal Model Products

miRNA for SLK Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SLK Gene

Localization for SLK Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLK Gene COMPARTMENTS Subcellular localization image for SLK gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLK: view

Pathways for SLK Gene

genes like me logo Genes that share pathways with SLK: view

Pathways by source for SLK Gene

1 Qiagen pathway for SLK Gene
1 KEGG pathway for SLK Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SLK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0006915 apoptotic process IEA --
GO:0023014 signal transduction by protein phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
GO:0046777 protein autophosphorylation IDA 18239682
genes like me logo Genes that share ontologies with SLK: view

Compounds for SLK Gene

(2) HMDB Compounds for SLK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Novoseek inferred chemical compound relationships for SLK Gene

Compound -log(P) Hits PubMed IDs
threonine 44.6 2
glucose 10.2 3
genes like me logo Genes that share compounds with SLK: view

Transcripts for SLK Gene

Unigene Clusters for SLK Gene

STE20-like kinase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: - -
SP3: -

Relevant External Links for SLK Gene

GeneLoc Exon Structure for
SLK
ECgene alternative splicing isoforms for
SLK

Expression for SLK Gene

mRNA expression in normal human tissues for SLK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SLK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLK Gene

SOURCE GeneReport for Unigene cluster for SLK Gene Hs.591922

mRNA Expression by UniProt/SwissProt for SLK Gene

Q9H2G2-SLK_HUMAN
Tissue specificity: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.
genes like me logo Genes that share expressions with SLK: view

Expression partners for SLK Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLK Gene

Orthologs for SLK Gene

This gene was present in the common ancestor of animals.

Orthologs for SLK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLK 35
  • 90.35 (n)
  • 88.65 (a)
SLK 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLK 35
  • 91.44 (n)
  • 90.69 (a)
SLK 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slk 35
  • 84.6 (n)
  • 84.65 (a)
Slk 16
Slk 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLK 35
  • 99.73 (n)
  • 99.6 (a)
SLK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slk 35
  • 83.79 (n)
  • 82.09 (a)
oppossum
(Monodelphis domestica)
Mammalia SLK 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLK 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLK 35
  • 73.99 (n)
  • 74.63 (a)
SLK 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLK 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slka 35
  • 73.21 (n)
  • 81.2 (a)
slka 36
  • 61 (a)
OneToMany
slkb 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4527 37
  • 40 (a)
slik 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C04A11.3 37
  • 48 (a)
gck-4 36
  • 28 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14840 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8272 36
  • 38 (a)
OneToMany
Species with no ortholog for SLK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLK Gene

ENSEMBL:
Gene Tree for SLK (if available)
TreeFam:
Gene Tree for SLK (if available)

Paralogs for SLK Gene

Selected SIMAP similar genes for SLK Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLK: view

Variants for SLK Gene

Sequence variations from dbSNP and Humsavar for SLK Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3124 -- 104,029,147(-) AATCT(A/C/G/T)AAACA utr-variant-3-prime
rs6787 -- 104,028,988(+) TATTC(C/T)GTTGC utr-variant-3-prime
rs805646 -- 104,010,170(+) GGCTT(A/G)GCTTA intron-variant
rs805647 -- 104,011,251(+) ACATA(A/C)AAATA intron-variant
rs805648 -- 104,011,432(+) TATTA(A/C)GTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLK Gene

Variant ID Type Subtype PubMed ID
nsv895982 CNV Loss 21882294
nsv7532 CNV Insertion 18451855
esv259448 OTHER Complex 20981092
esv259962 OTHER Complex 20981092

Relevant External Links for SLK Gene

HapMap Linkage Disequilibrium report
SLK
Human Gene Mutation Database (HGMD)
SLK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLK Gene

Disorders for SLK Gene

(2) University of Copenhagen DISEASES for SLK Gene

(1) Novoseek inferred disease relationships for SLK Gene

Disease -log(P) Hits PubMed IDs
renal failure acute ischemic 78.3 2

Relevant External Links for SLK

Genetic Association Database (GAD)
SLK
Human Genome Epidemiology (HuGE) Navigator
SLK
genes like me logo Genes that share disorders with SLK: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for SLK Gene

Publications for SLK Gene

  1. Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. (PMID: 10699464) Yamada E. … Yamamoto H. (Biochim. Biophys. Acta 2000) 3 4 23
  2. Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase. (PMID: 18287541) Burakov A.V. … Nadezhdina E.S. (Mol. Biol. Cell 2008) 3 23
  3. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4
  4. A yeast gene that is essential for release from glucose repression encodes a protein kinase. (PMID: 3526554) Celenza J.L. … Carlson M. (Science 1986) 2 3
  5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4

Products for SLK Gene

Sources for SLK Gene

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