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SLK Gene

protein-coding   GIFtS: 68
GCID: GC10P105716

STE20-Like Kinase

(Previous names: SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
STE20-Like Kinase1 2 3     LOSK2
Serine/Threonine-Protein Kinase 22 3     bA16H23.12
STK22 3     Long Ste20-Like Kinase2
CTCL Tumor Antigen Se20-92 3     se20-92
hSLK2 3     SNF1 (Sucrose Nonfermenting, Yeast, Homolog)-Like Kinase, SNF1 Sucrose
Nonfermenting Like Kinase2
STE20-Related Kinase2 3     SNF1 Sucrose Nonfermenting Like Kinase2
STE20-Related Serine/Threonine-Protein Kinase2 3     STE20-Like Serine/Threonine-Protein Kinase2
EC 2.7.11.13 8     Ste20-Related Serine/Threonine Kinase2
SNF1 (Sucrose Nonfermenting, Yeast, Homolog)-Like Kinase, SNF1 Sucrose
Nonfermenting Like Kinase (Yeast)1
     KIAA02043
STE20-Like Kinase (Yeast)1     EC 2.7.118

External Ids:    HGNC: 110881   Entrez Gene: 97482   Ensembl: ENSG000000656137   UniProtKB: Q9H2G23   

Export aliases for SLK gene to outside databases

Previous GC identifers: GC10P104620 GC00U905130 GC10P105392 GC10P099381


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLK Gene:
SLK (STE20-like kinase) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
Function: Mediates apoptosis and actin stress fiber dissolution (By similarity)

Gene Wiki entry for SLK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLK gene promoter:
         GR   USF1   AP-1   ATF-2   E4BP4   Max   USF-1   GR-alpha   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLK promoter sequence
   Search Chromatin IP Primers for SLK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q25.1

SLK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLK gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105716:  view genomic region     (about GC identifiers)

Start:
105,726,959 bp from pter      End:
105,788,991 bp from pter
Size:
62,033 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2 (See protein sequence)
Recommended Name: STE20-like serine/threonine-protein kinase  
Size: 1235 amino acids; 142695 Da
Sequence caution: Sequence=AAH47762.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence starting in position 611; Sequence=AAH47885.1; Type=Miscellaneous discrepancy; Note=Contaminating
sequence. Potential poly-A sequence starting in position 422; Sequence=AAH64804.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 614;
Sequence=BAA13195.2; Type=Frameshift; Positions=1172;
4 PDB 3D structures from and Proteopedia for SLK:
2J51 (3D)        2JFL (3D)        2JFM (3D)        2UV2 (3D)    
Secondary accessions: D3DRA0 D3DRA1 O00211 Q6P1Z4 Q86WU7 Q86WW1 Q92603 Q9NQL0 Q9NQL1
Alternative splicing: 2 isoforms:  Q9H2G2-1   Q9H2G2-2   

Explore the universe of human proteins at neXtProt for SLK: NX_Q9H2G2

Explore proteomics data for SLK at MOPED

Post-translational modifications: 

  • Proteolytically cleaved by caspase-31
  • Autophosphorylated1
  • Ubiquitination2 at Lys179
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SLK (Q9H2G2) (see all 17)
     QLQNEKC  KLRPRKK  IIHRDLKA  LLQHPFVT 


    See SLK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055535.2  
    ENSEMBL proteins: 
     ENSP00000336824   ENSP00000358770  

    SLK Human Recombinant Protein Products:

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    Novus Biologicals SLK Protein
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLK

     
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    SLK Antibody Products:

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    SLK Assay Products:

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    Cloud-Clone Corp. CLIAs for SLK
    Search eBioscience for ELISAs for SLK 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: STE20-like kinase
    SLK subfamily

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2G2

    ProtoNet protein and cluster: Q9H2G2

    UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UVR domain


    Find genes that share domains with SLK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLK_HUMAN, Q9H2G2
    Function: Mediates apoptosis and actin stress fiber dissolution (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA18239682
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SLK           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLK:
     Decreased substrate adherent c 

         1 MGI phenotypic allele for Slk (no phenotypes)

    Find genes that share phenotypes with SLK           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLK

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLK:
    hsa-let-7c-5p (MIRT051774), hsa-mir-21-5p (MIRT031072), hsa-mir-484 (MIRT042026), hsa-mir-615-3p (MIRT040336)

    Block miRNA regulation of human, mouse, rat SLK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLK (see all 9):
    hsa-miR-1263 hsa-miR-429 hsa-miR-219-5p hsa-miR-340 hsa-miR-1305 hsa-miR-508-3p hsa-miR-200c hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidSLK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLK
    Predesigned siRNA for gene silencing in human, mouse, rat SLK

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for SLK
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    GenScript: all cDNA clones in your preferred vector: SLK (NM_014720)
    Sino Biological Human cDNA Clone for SLK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLK

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SLK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLK_HUMAN, Q9H2G2: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    nucleus2
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane ----
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SLK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLK About    
    See pathways by source

    SuperPathContained pathways About
    1Oocyte meiosis
    Oocyte meiosis0.35
    2Mitotic Roles of Polo Like Kinases
    Mitotic Roles of Polo Like Kinases


    Find genes that share SuperPaths with SLK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLK
        Mitotic Roles of Polo Like Kinases



    1 Kegg Pathway  (Kegg details for SLK):
        Oocyte meiosis

        Pathway & Disease-focused RT2 Profiler PCR Array including SLK: 
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLK (Q9H2G21, 3 ENSP000003587704) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KEAP1Q141453, ENSP000001711114I2D: score=2 STRING: ENSP00000171111
    CASP3P425743, ENSP000003110324I2D: score=1 STRING: ENSP00000311032
    PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
    CLSTN1O949853, ENSP000003665134I2D: score=2 STRING: ENSP00000366513
    IKBKEQ141643, ENSP000003560874I2D: score=1 STRING: ENSP00000356087
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process IEA--
    GO:0023014signal transduction by phosphorylation IBA--
    GO:0046777protein autophosphorylation IDA18239682

    Find genes that share ontologies with SLK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLK

    2 HMDB Compounds for SLK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for SLK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235
    [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE-- --target--10592235

    2 Novoseek inferred chemical compound relationships for SLK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 44.6 2 9346925 (1), 10699464 (1)
    glucose 10.2 3 16316999 (1), 19640899 (1), 12965890 (1)



    Find genes that share compounds with SLK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLK gene: 
    NM_014720.2  

    Unigene Cluster for SLK:

    STE20-like kinase
    Hs.591922  [show with all ESTs]
    Unigene Representative Sequence: D86959
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335753(uc001kxp.1) ENST00000369755(uc001kxo.1) ENST00000474260

    miRNA
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    Block miRNA regulation of human, mouse, rat SLK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLK (see all 9):
    hsa-miR-1263 hsa-miR-429 hsa-miR-219-5p hsa-miR-340 hsa-miR-1305 hsa-miR-508-3p hsa-miR-200c hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidSLK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLK
    Clone
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    OriGene clones in human, mouse for SLK (see all 8)
    OriGene ORF clones in mouse, rat for SLK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLK (NM_014720)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLK
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SLK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLK
      QuantiTect SYBR Green Assays in human, mouse, rat SLK
      Search QuantiFast Probe-based Assays in human, mouse, rat SLK

    Additional mRNA sequence: 

    AF273048.1 AK302855.1 AK307389.1 BC008697.1 BC036736.1 BC047762.1 BC047885.1 BC064804.1 
    BC111565.1 BX648375.1 D86959.1 EF139853.1 

    5 DOTS entries:

    DT.92433300  DT.417305  DT.40193723  DT.100792601  DT.75180494 

    Selected AceView cDNA sequences (see all 330):

    BF222802 AA307061 AI399795 BC036736 AF273048 AI421215 AI338645 BE889763 
    AL134564 AA493393 BE328630 N59633 NM_014720 BE550225 BU677532 AI186648 
    BU632420 AI186654 BC008697 CB136129 F13095 AI192156 BC047762 AL120836 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLK    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                                                                        -                           
    SP2:                                                                                      -                 -                           
    SP3:                                                                                      -                                             


    ECgene alternative splicing isoforms for SLK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGTCCTG
    SLK Expression
    About this image


    SLK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Esophagus (Gastrointestinal Tract)
    SLK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591922

    UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
    Tissue specificity: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including SLK: 
              DNA Repair in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLK
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    Search QuantiFast Probe-based Assays in human, mouse, rat SLK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLK gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slk1 , 5 STE20-like kinase (yeast)5
    STE20-like kinase1
    84.6(n)1
    84.65(a)1
      19 (39.77 cM)5
    208741  NM_009289.31  NP_033315.21 
     475796785 
    chicken
    (Gallus gallus)
    Aves SLK1 STE20-like kinase 73.99(n)
    74.63(a)
      423878  XM_004942265.1  XP_004942322.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLK6
    STE20-like kinase
    69(a)
    1 ↔ 1
    3(41369698-41407836)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL893587.22   -- 77.73(n)    AL893587.2 
    zebrafish
    (Danio rerio)
    Actinopterygii slka1 STE20-like kinase a 73.21(n)
    81.2(a)
      568838  NM_001145601.1  NP_001139073.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45273 protein amino acid phosphorylation
    receptor signaling more
    40(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea C04A11.33 serine/threonine kinase 48(a)   X(13712484-13717302)   --


    ENSEMBL Gene Tree for SLK (if available)
    TreeFam Gene Tree for SLK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLK gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  
    MAP4K42  STK102  TAOK12  MINK12  
    7 SIMAP similar genes for SLK using alignment to 2 protein entries:     SLK_HUMAN (see all proteins):
    STK25    STK24    MST4    STK10    STK4    MAP2K6
    MAP2K5

    Find genes that share paralogs with SLK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLK (see all 1243)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410824
    An ovarian serous carcinoma sample4--see VAR_0410822 E Q mis40--------
    VAR_0410804
    A lung adenocarcinoma sample4--see VAR_0410802 Q K mis40--------
    rs673382791,2
    C--99406501(+) TGAAC-/CT/TC 
            
    TTACT
    1 -- int11NA 2
    rs1835646961,2
    --105725531(+) AATATA/GTACAT 1 -- us2k10--------
    rs1178437511,2
    C,F--105725551(+) CTGCTC/TCAGAT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1874547121,2
    --105725608(+) GCCAGA/GAATGT 1 -- us2k10--------
    rs1923057041,2
    --105725620(+) GCCGGA/GTACTT 1 -- us2k10--------
    rs107488591,2
    C,F,H--105725722(+) CAACGC/TCCACA 1 -- us2k114Minor allele frequency- T:0.20NA WA CSA EA 379
    rs122624991,2
    H--105725783(+) TGGGGG/CCCTTA 1 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs108839551,2
    C--105725995(+) ACCCCA/GTCTCT 1 -- us2k12Minor allele frequency- G:0.25WA NA 4

    HapMap Linkage Disequilibrium report for SLK (105726959 - 105788991 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7532CNV Insertion18451855
    nsv895982CNV Loss21882294
    esv259448OTHER Complex20981092
    esv259962OTHER Complex20981092

    Human Gene Mutation Database (HGMD): SLK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLK
    DNA2.0 Custom Variant and Variant Library Synthesis for SLK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases from the University of Copenhagen DISEASES database for SLK:
    Lupus erythematosus     Nephritis

    Find genes that share disorders with SLK           About GenesLikeMe

    1 Novoseek inferred disease relationship for SLK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure acute ischemic 78.3 2 16316999 (1), 17003224 (1)

    Genetic Association Database (GAD): SLK
    Human Genome Epidemiology (HuGE) Navigator: SLK (25 documents)

    Export disorders for SLK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLK gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with SLK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. (PubMed id 10699464)1, 2, 9 Yamada E.... Yamamoto H. (Biochim. Biophys. Acta 2000)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2 Eichmueller S....Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    6. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    7. A yeast gene that is essential for release from glucose repression encodes a protein kinase. (PubMed id 3526554)1, 3 Celenza J.L. and Carlson M. (Science 1986)
    8. Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase. (PubMed id 18287541)1, 9 Burakov A.V....Nadezhdina E.S. (Mol. Biol. Cell 2008)
    9. Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. (PubMed id 23382044)1 Hast B.E....Major M.B. (Cancer Res. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9748 HGNC: 11088 AceView: SLK Ensembl:ENSG00000065613 euGenes: HUgn9748
    ECgene: SLK Kegg: 9748 H-InvDB: SLK

    (According to HUGE)
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    HUGE: KIAA0204

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLK gene:
    Search GeneIP for patents involving SLK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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