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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLK Gene

protein-coding   GIFtS: 65
GCID: GC10P105716

STE20-Like Kinase

(Previous names: SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
STE20-Like Kinase1 2 3     LOSK2
Serine/Threonine-Protein Kinase 22 3     bA16H23.12
STK22 3     Long Ste20-Like Kinase2
CTCL Tumor Antigen Se20-92 3     se20-92
hSLK2 3     SNF1 (Sucrose Nonfermenting, Yeast, Homolog)-Like Kinase, SNF1 Sucrose
Nonfermenting Like Kinase2
STE20-Related Kinase2 3     SNF1 Sucrose Nonfermenting Like Kinase2
STE20-Related Serine/Threonine-Protein Kinase2 3     STE20-Like Serine/Threonine-Protein Kinase2
EC 2.7.11.13 8     Ste20-Related Serine/Threonine Kinase2
SNF1 (Sucrose Nonfermenting, Yeast, Homolog)-Like Kinase, SNF1 Sucrose
Nonfermenting Like Kinase (Yeast)1
     KIAA02043
STE20-Like Kinase (Yeast)1     EC 2.7.118

External Ids:    HGNC: 110881   Entrez Gene: 97482   Ensembl: ENSG000000656137   UniProtKB: Q9H2G23   

Export aliases for SLK gene to outside databases

Previous GC identifers: GC10P104620 GC00U905130 GC10P105392 GC10P099381


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLK Gene: 
SLK (STE20-like kinase) is a protein-coding gene. Diseases associated with SLK include uterine fibroid, and keratoconjunctivitis, and among its related super-pathways are Progesterone-mediated oocyte maturation. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
Function: Mediates apoptosis and actin stress fiber dissolution (By similarity)

Gene Wiki entry for SLK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLK gene promoter:
         GR   USF1   AP-1   ATF-2   E4BP4   Max   USF-1   GR-alpha   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLK promoter sequence
   Search SABiosciences Chromatin IP Primers for SLK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q25.1

SLK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLK gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105716:  view genomic region     (about GC identifiers)

Start:
105,726,959 bp from pter      End:
105,788,991 bp from pter
Size:
62,033 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2 (See protein sequence)
Recommended Name: STE20-like serine/threonine-protein kinase  
Size: 1235 amino acids; 142695 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAH47762.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence starting in position 611; Sequence=AAH47885.1; Type=Miscellaneous discrepancy; Note=Contaminating
sequence. Potential poly-A sequence starting in position 422; Sequence=AAH64804.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 614;
Sequence=BAA13195.2; Type=Frameshift; Positions=1172;
4 PDB 3D structures from and Proteopedia for SLK:
2J51 (3D)        2JFL (3D)        2JFM (3D)        2UV2 (3D)    
Secondary accessions: D3DRA0 D3DRA1 O00211 Q6P1Z4 Q86WU7 Q86WW1 Q92603 Q9NQL0 Q9NQL1
Alternative splicing: 2 isoforms:  Q9H2G2-1   Q9H2G2-2   

Explore the universe of human proteins at neXtProt for SLK: NX_Q9H2G2

Explore proteomics data for SLK at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically cleaved by caspase-3
  • UniProtKB: Autophosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2G2

  • 4/17 DME Specific Peptides for SLK (Q9H2G2) (see all 17)
     QLQNEKC  KLRPRKK  IIHRDLKA  LLQHPFVT 

    SLK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLK Protein Expression
    REFSEQ proteins: NP_055535.2  
    ENSEMBL proteins: 
     ENSP00000336824   ENSP00000358770  

    Human Recombinant Protein Products for SLK: 
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    Novus Biologicals SLK Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLK 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    SLK for ontologies           About GeneDecksing



    SLK Antibody Products: 
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    Cloud-Clone Corp. CLIAs for SLK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: STE20-like kinase 
    SLK subfamily

    5/7 InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR022165 PKK

    Graphical View of Domain Structure for InterPro Entry Q9H2G2

    ProtoNet protein and cluster: Q9H2G2

    UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UVR domain


    SLK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLK_HUMAN, Q9H2G2
    Function: Mediates apoptosis and actin stress fiber dissolution (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA18239682
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    SLK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLK:
     Decreased substrate adherent c 

         1 MGI phenotypic allele for Slk (no phenotypes)

    SLK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLK 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLK
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SLK (see all 9):
    hsa-miR-1263 hsa-miR-429 hsa-miR-219-5p hsa-miR-340 hsa-miR-1305 hsa-miR-508-3p hsa-miR-200c hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidSLK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SLK

    Clone
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    GenScript: all cDNA clones in your preferred vector: SLK (NM_014720)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Oocyte meiosis
    Oocyte meiosis0.35
    2Mitotic Roles of Polo Like Kinases
    Mitotic Roles of Polo Like Kinases

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SLK
        Mitotic Roles of Polo Like Kinases



    1         Kegg Pathway  (Kegg details for SLK):
        Oocyte meiosis


    SLK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for SLK (Q9H2G23 ENSP000003587704) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KEAP1Q141453, ENSP000001711114I2D: score=2 STRING: ENSP00000171111
    CASP3P425743, ENSP000003110324I2D: score=1 STRING: ENSP00000311032
    PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
    CLSTN1O949853, ENSP000003665134I2D: score=2 STRING: ENSP00000366513
    IKBKEQ141643, ENSP000003560874I2D: score=1 STRING: ENSP00000356087
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process IEA--
    GO:0046777protein autophosphorylation IDA18239682

    SLK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLK

    2 HMDB Compounds for SLK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    2 DrugBank Compounds for SLK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235
    [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE-- --target--10592235

    2 Novoseek inferred chemical compound relationships for SLK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 44.6 2 9346925 (1), 10699464 (1)
    glucose 10.2 3 16316999 (1), 19640899 (1), 12965890 (1)

    Search CenterWatch for drugs/clinical trials and news about SLK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLK gene: 
    NM_014720.2  

    Unigene Cluster for SLK:

    STE20-like kinase
    Hs.591922  [show with all ESTs]
    Unigene Representative Sequence: D86959
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335753(uc001kxp.1) ENST00000369755(uc001kxo.1) ENST00000474260


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLK
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SLK (see all 9):
    hsa-miR-1263 hsa-miR-429 hsa-miR-219-5p hsa-miR-340 hsa-miR-1305 hsa-miR-508-3p hsa-miR-200c hsa-miR-651
    SwitchGear 3'UTR luciferase reporter plasmidSLK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLK
    Clone
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    OriGene clones in human, mouse for SLK (see all 7)
    OriGene ORF clones in mouse, rat for SLK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLK (NM_014720)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLK
    Sirion Biotech Customized lentivirus for stable overexpression of SLK 
                         Customized lentivirus expression plasmids for stable overexpression of SLK 
    Primer
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      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLK

    Additional mRNA sequence: 

    AF273048.1 AK302855.1 AK307389.1 BC008697.1 BC036736.1 BC047762.1 BC047885.1 BC064804.1 
    BC111565.1 BX648375.1 D86959.1 EF139853.1 

    5 DOTS entries:

    DT.92433300  DT.417305  DT.40193723  DT.100792601  DT.75180494 

    24/330 AceView cDNA sequences (see all 330):

    AA974368 AI124895 BM470785 AI682543 AA772218 AI018333 BQ011651 BF222802 
    BU608402 T36207 CF528474 AA782186 AI085766 AA362324 CA311504 AI375419 
    AL134377 AA724517 AI478214 BE463768 BM423404 BE888211 BI793331 AI188477 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLK    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                                                                        -                           
    SP2:                                                                                      -                 -                           
    SP3:                                                                                      -                                             


    ECgene alternative splicing isoforms for SLK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLK expression in normal human tissues (normalized intensities)      SLK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGTCCTG
    SLK Expression
    About this image


    SLK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles

    See SLK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLK

    SOURCE GeneReport for Unigene cluster: Hs.591922

    UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
    Tissue specificity: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including SLK: 
              DNA Repair in human mouse rat

    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLK
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    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLK gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slk1 , 5 STE20-like kinase (yeast)5
    STE20-like kinase1
    84.52(n)1
    84.65(a)1
      19 (39.77 cM)5
    208741  NM_009289.31  NP_033315.21 
     475796785 
    chicken
    (Gallus gallus)
    Aves SLK1 STE20-like kinase 73.81(n)
    74.22(a)
      423878  XM_421743.3  XP_421743.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLK6
    STE20-like kinase
    68(a)
    1 ↔ 1
    3(41369698-41407836)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL893587.22   -- 77.73(n)    AL893587.2 
    zebrafish
    (Danio rerio)
    Actinopterygii slka1 STE20-like kinase a 65.07(n)
    66.9(a)
      568838  NM_001145601.1  NP_001139073.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG45273
    slik1
    protein amino acid phosphorylation
    receptor signaling more3
    Sterile20-like kinase1
    40(a)3
    44.12(n)1
    35.11(a)1
      378931  NM_206213.11  NP_995935.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C04A11.33
    gck-41
    serine/threonine kinase3
    Protein GCK-41
    48(a)3
    46.42(n)1
    33.91(a)1
      X(13712484-13717302)3
    1814881  NM_077889.11  NP_510290.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKM16
    CLA46
    Member of the PAK family of serine/threonine prote...
    Cdc42p-activated signal transducing kinase of the ...
    16(a)
    13(a)
    many ↔ many
    many ↔ many
    XV(104326-106293)
    XIV(68915-71443)


    ENSEMBL Gene Tree for SLK (if available)
    TreeFam Gene Tree for SLK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLK gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  
    MAP4K42  STK102  TAOK12  MINK12  
    7 SIMAP similar genes for SLK using alignment to 2 protein entries:     SLK_HUMAN (see all proteins):
    STK25    STK24    MST4    STK10    STK4    MAP2K6
    MAP2K5

    SLK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1243 SNPs in SLK are shown (see all 1243)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410824
    An ovarian serous carcinoma sample4--see VAR_0410822 E Q mis40--------
    VAR_0410804
    A lung adenocarcinoma sample4--see VAR_0410802 Q K mis40--------
    rs673382791,2
    C--99406501(+) TGAAC-/CT/TC 
            
    TTACT
    1 -- int11NA 2
    rs1835646961,2
    --105725531(+) AATATA/GTACAT 1 -- us2k10--------
    rs1178437511,2
    C,F--105725551(+) CTGCTC/TCAGAT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1874547121,2
    --105725608(+) GCCAGA/GAATGT 1 -- us2k10--------
    rs1923057041,2
    --105725620(+) GCCGGA/GTACTT 1 -- us2k10--------
    rs107488591,2
    C,F,H--105725722(+) CAACGC/TCCACA 1 -- us2k114Minor allele frequency- T:0.20NA WA CSA EA 379
    rs122624991,2
    H--105725783(+) TGGGGG/CCCTTA 1 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs108839551,2
    C--105725995(+) ACCCCA/GTCTCT 1 -- us2k12Minor allele frequency- G:0.25WA NA 4

    HapMap Linkage Disequilibrium report for SLK (105726959 - 105788991 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLK:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7532CNV Insertion18451855
    nsv895982CNV Loss21882294
    esv259448OTHER Complex20981092
    esv259962OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for SLK:    About MalaCards
    uterine fibroid    keratoconjunctivitis    cutaneous t cell lymphoma    nephritis
    alzheimer's disease    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for SLK:
    Lupus erythematosus     Nephritis

    SLK for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for SLK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure acute ischemic 78.3 2 16316999 (1), 17003224 (1)

    Genetic Association Database (GAD): SLK
    Human Genome Epidemiology (HuGE) Navigator: SLK (25 documents)

    Export disorders for SLK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLK gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with SLK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. (PubMed id 10699464)1, 2, 9 Yamada E.... Yamamoto H. (2000)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2 Eichmueller S....Schadendorf D. (2001)
    6. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    7. A yeast gene that is essential for release from glucose repression encodes a protein kinase. (PubMed id 3526554)1, 3 Celenza J.L. and Carlson M. (1986)
    8. Ste20-related Protein Kinase LOSK (SLK) Controls Microtubule Radial Array in Interphase. (PubMed id 18287541)1, 9 Burakov A.V....Nadezhdina E.S. (2008)
    9. Proteomic analysis of ubiquitin ligase KEAP1 reveals a ssociated proteins that inhibit NRF2 ubiquitination. (PubMed id 23382044)1 Hast B.E....Major M.B. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9748 HGNC: 11088 AceView: SLK Ensembl:ENSG00000065613 euGenes: HUgn9748
    ECgene: SLK Kegg: 9748 H-InvDB: SLK

    (According to HUGE)
    About This Section
    HUGE: KIAA0204

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLK gene:
    Search GeneIP for patents involving SLK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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