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Aliases for SLITRK5 Gene

Aliases for SLITRK5 Gene

  • SLIT And NTRK Like Family Member 5 2 3 5
  • Leucine-Rich Repeat-Containing Protein 11 3 4
  • SLIT And NTRK-Like Family, Member 5 2 3
  • Leucine Rich Repeat Containing 11 2 3
  • LRRC11 3 4
  • Slit And Trk Like Gene 5 3
  • BA364G4.2 3
  • KIAA0918 4

External Ids for SLITRK5 Gene

Previous HGNC Symbols for SLITRK5 Gene

  • LRRC11

Previous GeneCards Identifiers for SLITRK5 Gene

  • GC13P086022
  • GC13P087122
  • GC13P088324
  • GC13P068910

Summaries for SLITRK5 Gene

Entrez Gene Summary for SLITRK5 Gene

  • Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLITRK5 Gene

SLITRK5 (SLIT And NTRK Like Family Member 5) is a Protein Coding gene. Diseases associated with SLITRK5 include Supratentorial Primitive Neuroectodermal Tumor. An important paralog of this gene is SLITRK4.

UniProtKB/Swiss-Prot for SLITRK5 Gene

  • Suppresses neurite outgrowth.

Gene Wiki entry for SLITRK5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLITRK5 Gene

Genomics for SLITRK5 Gene

Regulatory Elements for SLITRK5 Gene

Enhancers for SLITRK5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLITRK5 on UCSC Golden Path with GeneCards custom track

Promoters for SLITRK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLITRK5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLITRK5 Gene

87,671,232 bp from pter
87,696,272 bp from pter
25,041 bases
Plus strand

Genomic View for SLITRK5 Gene

Genes around SLITRK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLITRK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLITRK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLITRK5 Gene

Proteins for SLITRK5 Gene

  • Protein details for SLITRK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLIT and NTRK-like protein 5
    Protein Accession:
    Secondary Accessions:
    • B3KNB8
    • B4DSH5
    • Q5VT81

    Protein attributes for SLITRK5 Gene

    958 amino acids
    Molecular mass:
    107486 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA74941.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLITRK5 Gene


neXtProt entry for SLITRK5 Gene

Proteomics data for SLITRK5 Gene at MOPED

Post-translational modifications for SLITRK5 Gene

  • Glycosylation at Asn 103, Thr 366, and Asn 644
  • Modification sites at PhosphoSitePlus

Other Protein References for SLITRK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLITRK5 Gene

Domains & Families for SLITRK5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 LRRCT domains.
  • Belongs to the SLITRK family.
  • Contains 12 LRR (leucine-rich) repeats.
  • Contains 2 LRRCT domains.
  • Contains 1 LRRNT domain.
  • Belongs to the SLITRK family.
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SLITRK5: view

No data available for Gene Families for SLITRK5 Gene

Function for SLITRK5 Gene

Molecular function for SLITRK5 Gene

UniProtKB/Swiss-Prot Function:
Suppresses neurite outgrowth.
genes like me logo Genes that share phenotypes with SLITRK5: view

Animal Models for SLITRK5 Gene

MGI Knock Outs for SLITRK5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLITRK5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLITRK5 Gene

Localization for SLITRK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLITRK5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SLITRK5 Gene COMPARTMENTS Subcellular localization image for SLITRK5 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLITRK5 Gene

Pathways & Interactions for SLITRK5 Gene

SuperPathways for SLITRK5 Gene

No Data Available

Interacting Proteins for SLITRK5 Gene

Gene Ontology (GO) - Biological Process for SLITRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IEA,IBA --
GO:0007625 grooming behavior IEA --
GO:0009410 response to xenobiotic stimulus IEA --
GO:0030534 adult behavior IEA --
GO:0043588 skin development IEA --
genes like me logo Genes that share ontologies with SLITRK5: view

No data available for Pathways by source and SIGNOR curated interactions for SLITRK5 Gene

Drugs & Compounds for SLITRK5 Gene

No Compound Related Data Available

Transcripts for SLITRK5 Gene

mRNA/cDNA for SLITRK5 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLITRK5 Gene

SLIT and NTRK-like family, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLITRK5 Gene

No ASD Table

Relevant External Links for SLITRK5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLITRK5 Gene

mRNA expression in normal human tissues for SLITRK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLITRK5 Gene

This gene is overexpressed in Brain - Cortex (x6.4), Brain - Frontal Cortex (BA9) (x6.4), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for SLITRK5 Gene

This gene is overexpressed in Prostate (32.9), Cardia (12.6), Heart (12.0), and Ovary (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLITRK5 Gene

SOURCE GeneReport for Unigene cluster for SLITRK5 Gene Hs.591208

mRNA Expression by UniProt/SwissProt for SLITRK5 Gene

Tissue specificity: Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla.
genes like me logo Genes that share expression patterns with SLITRK5: view

Primer Products

No data available for Protein tissue co-expression partners for SLITRK5 Gene

Orthologs for SLITRK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLITRK5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLITRK5 35
  • 91.78 (n)
  • 95.55 (a)
  • 95 (a)
(Canis familiaris)
Mammalia SLITRK5 35
  • 93.77 (n)
  • 98.33 (a)
  • 98 (a)
(Mus musculus)
Mammalia Slitrk5 35
  • 90.34 (n)
  • 96.97 (a)
Slitrk5 16
Slitrk5 36
  • 97 (a)
(Pan troglodytes)
Mammalia SLITRK5 35
  • 99.69 (n)
  • 99.9 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Slitrk5 35
  • 90.31 (n)
  • 96.86 (a)
(Monodelphis domestica)
Mammalia SLITRK5 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia SLITRK5 36
  • 89 (a)
(Gallus gallus)
Aves SLITRK5 35
  • 79.67 (n)
  • 85.05 (a)
  • 84 (a)
(Anolis carolinensis)
Reptilia SLITRK5 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slitrk5 35
  • 72.76 (n)
  • 77.98 (a)
(Danio rerio)
Actinopterygii Dr.16352 35
LOC101882841 35
  • 67.68 (n)
  • 70.44 (a)
SLITRK5 (2 of 2) 36
  • 70 (a)
slitrk5b 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta sli 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea slt-1 36
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
Species with no ortholog for SLITRK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLITRK5 Gene

Gene Tree for SLITRK5 (if available)
Gene Tree for SLITRK5 (if available)

Paralogs for SLITRK5 Gene

Paralogs for SLITRK5 Gene

(7) SIMAP similar genes for SLITRK5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLITRK5: view

Variants for SLITRK5 Gene

Sequence variations from dbSNP and Humsavar for SLITRK5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs7992735 -- 87,674,964(+) GGGGG(G/T)GGGGG intron-variant
rs9582390 -- 87,673,491(+) GCGGG(A/G)AAGCA intron-variant, utr-variant-5-prime
rs9582391 -- 87,673,922(+) AGAAA(A/C)GGCAT intron-variant
rs34214269 -- 87,677,253(+) TTCCA(A/C)GCCCA reference, missense
rs11840163 -- 87,677,778(+) GCAGC(A/C)GCCGC reference, missense

Variation tolerance for SLITRK5 Gene

Residual Variation Intolerance Score: 4.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLITRK5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLITRK5 Gene

Disorders for SLITRK5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLITRK5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
supratentorial primitive neuroectodermal tumor
  • ewings sarcoma-primitive neuroectodermal tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLITRK5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLITRK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLITRK5 Gene

Publications for SLITRK5 Gene

  1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PMID: 14557068) Aruga J. … Mikoshiba K. (Gene 2003) 2 3 4 23 67
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  3. Association study of the SLITRK5 gene and Tourette syndrome. (PMID: 25426764) Zhang K. … Barr C.L. (Psychiatr. Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3

Products for SLITRK5 Gene

Sources for SLITRK5 Gene