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Aliases for SLITRK5 Gene

Aliases for SLITRK5 Gene

  • SLIT And NTRK Like Family Member 5 2 3 5
  • Leucine-Rich Repeat-Containing Protein 11 3 4
  • Leucine Rich Repeat Containing 11 2 3
  • LRRC11 3 4
  • SLIT And NTRK-Like Family, Member 5 2
  • SLIT And NTRK-Like Protein 5 3
  • Slit And Trk Like Gene 5 3
  • BA364G4.2 3
  • KIAA0918 4

External Ids for SLITRK5 Gene

Previous HGNC Symbols for SLITRK5 Gene

  • LRRC11

Previous GeneCards Identifiers for SLITRK5 Gene

  • GC13P086022
  • GC13P087122
  • GC13P088324
  • GC13P068910

Summaries for SLITRK5 Gene

Entrez Gene Summary for SLITRK5 Gene

  • Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLITRK5 Gene

SLITRK5 (SLIT And NTRK Like Family Member 5) is a Protein Coding gene. An important paralog of this gene is SLITRK2.

UniProtKB/Swiss-Prot for SLITRK5 Gene

  • Suppresses neurite outgrowth.

Gene Wiki entry for SLITRK5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLITRK5 Gene

Genomics for SLITRK5 Gene

Regulatory Elements for SLITRK5 Gene

Enhancers for SLITRK5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G087670 0.9 ENCODE 0.7 0.0 -1 1.2 TBP PKNOX1 ZSCAN4 SIN3A ZNF48 RAD21 RFX5 YY1 GLIS2 ZNF366 SLITRK5 MIR4500
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLITRK5 on UCSC Golden Path with GeneCards custom track

Promoters for SLITRK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000272785 668 1801 PKNOX1 SIN3A ZNF48 YY1 GLIS2 ELK1 ZNF143 SMARCB1 GLIS1 KDM1A
ENSR00000064348 1868 201 RNF2 L3MBTL2 ZNF366 ZNF384 RBBP5 ZNF398 EZH2

Genomic Location for SLITRK5 Gene

Chromosome:
13
Start:
87,671,232 bp from pter
End:
87,696,272 bp from pter
Size:
25,041 bases
Orientation:
Plus strand

Genomic View for SLITRK5 Gene

Genes around SLITRK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLITRK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLITRK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLITRK5 Gene

Proteins for SLITRK5 Gene

  • Protein details for SLITRK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94991-SLIK5_HUMAN
    Recommended name:
    SLIT and NTRK-like protein 5
    Protein Accession:
    O94991
    Secondary Accessions:
    • B3KNB8
    • B4DSH5
    • Q5VT81

    Protein attributes for SLITRK5 Gene

    Size:
    958 amino acids
    Molecular mass:
    107486 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74941.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLITRK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLITRK5 Gene

Post-translational modifications for SLITRK5 Gene

  • Glycosylation at isoforms=103, isoforms=2366, and Asn644
  • Modification sites at PhosphoSitePlus

Other Protein References for SLITRK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLITRK5 Gene

Domains & Families for SLITRK5 Gene

Graphical View of Domain Structure for InterPro Entry

O94991

UniProtKB/Swiss-Prot:

SLIK5_HUMAN :
  • Belongs to the SLITRK family.
Family:
  • Belongs to the SLITRK family.
genes like me logo Genes that share domains with SLITRK5: view

No data available for Gene Families for SLITRK5 Gene

Function for SLITRK5 Gene

Molecular function for SLITRK5 Gene

UniProtKB/Swiss-Prot Function:
Suppresses neurite outgrowth.
genes like me logo Genes that share phenotypes with SLITRK5: view

Animal Models for SLITRK5 Gene

MGI Knock Outs for SLITRK5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLITRK5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLITRK5 Gene

Localization for SLITRK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLITRK5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLITRK5 gene
Compartment Confidence
plasma membrane 3
nucleus 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLITRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with SLITRK5: view

Pathways & Interactions for SLITRK5 Gene

SuperPathways for SLITRK5 Gene

No Data Available

Interacting Proteins for SLITRK5 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366283%0d%0a9606.ENSP00000349932%0d%0a9606.ENSP00000348812%0d%0a9606.ENSP00000353030%0d%0a9606.ENSP00000254667%0d%0a9606.ENSP00000377047%0d%0a
Selected Interacting proteins: O94991-SLIK5_HUMAN ENSP00000366283 for SLITRK5 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLITRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission IEA --
GO:0007409 axonogenesis IEA,IBA --
GO:0007625 grooming behavior IEA --
GO:0009410 response to xenobiotic stimulus IEA --
GO:0021756 striatum development IEA --
genes like me logo Genes that share ontologies with SLITRK5: view

No data available for Pathways by source and SIGNOR curated interactions for SLITRK5 Gene

Drugs & Compounds for SLITRK5 Gene

No Compound Related Data Available

Transcripts for SLITRK5 Gene

mRNA/cDNA for SLITRK5 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLITRK5 Gene

SLIT and NTRK-like family, member 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLITRK5 Gene

No ASD Table

Relevant External Links for SLITRK5 Gene

GeneLoc Exon Structure for
SLITRK5
ECgene alternative splicing isoforms for
SLITRK5

Expression for SLITRK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLITRK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLITRK5 Gene

This gene is overexpressed in Brain - Cortex (x6.4), Brain - Frontal Cortex (BA9) (x6.4), Brain - Anterior cingulate cortex (BA24) (x5.5), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for SLITRK5 Gene

This gene is overexpressed in Prostate (32.9), Cardia (12.6), Heart (12.0), and Ovary (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLITRK5 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLITRK5 Gene:

SLITRK5

SOURCE GeneReport for Unigene cluster for SLITRK5 Gene:

Hs.591208

mRNA Expression by UniProt/SwissProt for SLITRK5 Gene:

O94991-SLIK5_HUMAN
Tissue specificity: Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla.

Evidence on tissue expression from TISSUES for SLITRK5 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SLITRK5: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLITRK5 Gene

Orthologs for SLITRK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLITRK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLITRK5 34 35
  • 99.69 (n)
oppossum
(Monodelphis domestica)
Mammalia SLITRK5 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLITRK5 34 35
  • 93.77 (n)
cow
(Bos Taurus)
Mammalia SLITRK5 34 35
  • 91.78 (n)
mouse
(Mus musculus)
Mammalia Slitrk5 34 16 35
  • 90.34 (n)
rat
(Rattus norvegicus)
Mammalia Slitrk5 34
  • 90.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLITRK5 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLITRK5 34 35
  • 79.67 (n)
lizard
(Anolis carolinensis)
Reptilia SLITRK5 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slitrk5 34
  • 72.76 (n)
zebrafish
(Danio rerio)
Actinopterygii SLITRK5 (2 of 2) 35
  • 70 (a)
OneToMany
LOC101882841 34
  • 67.68 (n)
slitrk5b 35
  • 57 (a)
OneToMany
Dr.16352 34
fruit fly
(Drosophila melanogaster)
Insecta sli 35
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea slt-1 35
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for SLITRK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLITRK5 Gene

ENSEMBL:
Gene Tree for SLITRK5 (if available)
TreeFam:
Gene Tree for SLITRK5 (if available)

Paralogs for SLITRK5 Gene

Paralogs for SLITRK5 Gene

(7) SIMAP similar genes for SLITRK5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLITRK5: view

Variants for SLITRK5 Gene

Sequence variations from dbSNP and Humsavar for SLITRK5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000212859 -- 87,671,166(+) TCATC(C/T)GTTCC upstream-variant-2KB
rs1000486817 -- 87,672,887(+) TGTGT(A/G)TGTGT intron-variant, upstream-variant-2KB
rs1000553700 -- 87,671,947(+) CCCTC(A/T)CTACC upstream-variant-2KB, utr-variant-5-prime
rs1000583114 -- 87,672,156(+) GGAGG(A/G)GGCGG upstream-variant-2KB, utr-variant-5-prime
rs1000652540 -- 87,671,311(+) AGGGG(A/G)CCCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLITRK5 Gene

Variant ID Type Subtype PubMed ID
nsv1044071 CNV loss 25217958
nsv1112636 CNV deletion 24896259

Variation tolerance for SLITRK5 Gene

Residual Variation Intolerance Score: 4.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLITRK5 Gene

Human Gene Mutation Database (HGMD)
SLITRK5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLITRK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLITRK5 Gene

Disorders for SLITRK5 Gene

Relevant External Links for SLITRK5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLITRK5

No disorders were found for SLITRK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLITRK5 Gene

Publications for SLITRK5 Gene

  1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PMID: 14557068) Aruga J. … Mikoshiba K. (Gene 2003) 2 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SLITRK5 Gene

Sources for SLITRK5 Gene

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