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Aliases for SLITRK5 Gene

Aliases for SLITRK5 Gene

  • SLIT And NTRK-Like Family, Member 5 2 3
  • Leucine-Rich Repeat-Containing Protein 11 3 4
  • Leucine Rich Repeat Containing 11 2 3
  • KIAA0918 4 6
  • LRRC11 3 4
  • SLIT And NTRK-Like Protein 5 3
  • Slit And Trk Like Gene 5 3
  • BA364G4.2 3

External Ids for SLITRK5 Gene

Previous Symbols for SLITRK5 Gene

  • LRRC11

Summaries for SLITRK5 Gene

Entrez Gene Summary for SLITRK5 Gene

  • Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLITRK5 Gene

SLITRK5 (SLIT And NTRK-Like Family, Member 5) is a Protein Coding gene. An important paralog of this gene is SLITRK3.

UniProtKB/Swiss-Prot for SLITRK5 Gene

  • Suppresses neurite outgrowth.

Gene Wiki entry for SLITRK5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLITRK5 Gene

Genomics for SLITRK5 Gene

Genomic Location for SLITRK5 Gene

Start:
87,671,034 bp from pter
End:
87,696,272 bp from pter
Size:
25,239 bases
Orientation:
Plus strand

Genomic View for SLITRK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLITRK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLITRK5 Gene

Regulatory Elements for SLITRK5 Gene

Proteins for SLITRK5 Gene

  • Protein details for SLITRK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94991-SLIK5_HUMAN
    Recommended name:
    SLIT and NTRK-like protein 5
    Protein Accession:
    O94991
    Secondary Accessions:
    • B3KNB8
    • B4DSH5
    • Q5VT81

    Protein attributes for SLITRK5 Gene

    Size:
    958 amino acids
    Molecular mass:
    107486 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74941.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLITRK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLITRK5 Gene

Proteomics data for SLITRK5 Gene at MOPED

Post-translational modifications for SLITRK5 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn103, Thr366, and Asn644

Other Protein References for SLITRK5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLITRK5 Gene

Domains for SLITRK5 Gene

UniProtKB/Swiss-Prot:

SLIK5_HUMAN
Domain:
  • Contains 2 LRRCT domains.:
    • O94991
  • Contains 1 LRRNT domain.:
    • O94991
Family:
  • Belongs to the SLITRK family.:
    • O94991
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.:
    • O94991
genes like me logo Genes that share domains with SLITRK5: view

No data available for Gene Families for SLITRK5 Gene

Function for SLITRK5 Gene

Molecular function for SLITRK5 Gene

UniProtKB/Swiss-Prot Function: Suppresses neurite outgrowth.

Gene Ontology (GO) - Molecular Function for SLITRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLITRK5: view
genes like me logo Genes that share phenotypes with SLITRK5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLITRK5 Gene

Localization for SLITRK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLITRK5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLITRK5 Gene COMPARTMENTS Subcellular localization image for SLITRK5 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLITRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with SLITRK5: view

Pathways for SLITRK5 Gene

SuperPathways for SLITRK5 Gene

No Data Available

Interacting Proteins for SLITRK5 Gene

Gene Ontology (GO) - Biological Process for SLITRK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission IEA --
GO:0007409 axonogenesis IEA --
GO:0007625 grooming behavior IEA --
GO:0009410 response to xenobiotic stimulus IEA --
GO:0021756 striatum development IEA --
genes like me logo Genes that share ontologies with SLITRK5: view

No data available for Pathways by source for SLITRK5 Gene

Transcripts for SLITRK5 Gene

mRNA/cDNA for SLITRK5 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLITRK5 Gene

SLIT and NTRK-like family, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLITRK5 Gene

No ASD Table

Relevant External Links for SLITRK5 Gene

GeneLoc Exon Structure for
SLITRK5
ECgene alternative splicing isoforms for
SLITRK5

Expression for SLITRK5 Gene

mRNA expression in normal human tissues for SLITRK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLITRK5 Gene

This gene is overexpressed in Brain - Cortex (6.4), Brain - Frontal Cortex (BA9) (6.4), Brain - Anterior cingulate cortex (BA24) (5.5), and Brain - Nucleus accumbens (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLITRK5 Gene

SOURCE GeneReport for Unigene cluster for SLITRK5 Gene Hs.591208

mRNA Expression by UniProt/SwissProt for SLITRK5 Gene

O94991-SLIK5_HUMAN
Tissue specificity: Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla.
genes like me logo Genes that share expressions with SLITRK5: view

Orthologs for SLITRK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLITRK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLITRK5 36
  • 99.69 (n)
  • 99.9 (a)
SLITRK5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLITRK5 36
  • 91.78 (n)
  • 95.55 (a)
SLITRK5 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLITRK5 36
  • 93.77 (n)
  • 98.33 (a)
SLITRK5 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slitrk5 36
  • 90.34 (n)
  • 96.97 (a)
Slitrk5 16
Slitrk5 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLITRK5 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLITRK5 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slitrk5 36
  • 90.31 (n)
  • 96.86 (a)
chicken
(Gallus gallus)
Aves SLITRK5 36
  • 79.67 (n)
  • 85.05 (a)
SLITRK5 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLITRK5 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slitrk5 36
  • 72.76 (n)
  • 77.98 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16352 36
LOC101882841 36
  • 67.68 (n)
  • 70.44 (a)
SLITRK5 (2 of 2) 37
  • 70 (a)
OneToMany
slitrk5b 37
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sli 37
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea slt-1 37
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
OneToMany
Species with no ortholog for SLITRK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLITRK5 Gene

ENSEMBL:
Gene Tree for SLITRK5 (if available)
TreeFam:
Gene Tree for SLITRK5 (if available)

Paralogs for SLITRK5 Gene

Selected SIMAP similar genes for SLITRK5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLITRK5: view

Variants for SLITRK5 Gene

Sequence variations from dbSNP and Humsavar for SLITRK5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs7992735 -- 87,674,964(+) GGGGG(G/T)GGGGG intron-variant
rs9582390 -- 87,673,491(+) GCGGG(A/G)AAGCA intron-variant, utr-variant-5-prime
rs9582391 -- 87,673,922(+) AGAAA(A/C)GGCAT intron-variant
rs9582397 -- 87,679,812(+) GTATA(C/T)ATATA downstream-variant-500B
rs11840163 -- 87,677,778(+) GCAGC(A/C)GCCGC reference, missense

Relevant External Links for SLITRK5 Gene

HapMap Linkage Disequilibrium report
SLITRK5

No data available for Structural Variations from Database of Genomic Variants (DGV) for SLITRK5 Gene

Disorders for SLITRK5 Gene

(1) University of Copenhagen DISEASES for SLITRK5 Gene

genes like me logo Genes that share disorders with SLITRK5: view

No data available for UniProtKB/Swiss-Prot for SLITRK5 Gene

Publications for SLITRK5 Gene

  1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PMID: 14557068) Aruga J. … Mikoshiba K. (Gene 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLITRK5 Gene

Sources for SLITRK5 Gene

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