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SLITRK4 Gene

protein-coding   GIFtS: 53
GCID: GC0XM142715

SLIT And NTRK-Like Family, Member 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SLIT And NTRK-Like Family, Member 41 2
SLIT And NTRK-Like Protein 42
Slit And Trk Like Gene 42

External Ids:    HGNC: 235021   Entrez Gene: 1390652   Ensembl: ENSG000001795427   OMIM: 3005625   UniProtKB: Q8IW523   

Export aliases for SLITRK4 gene to outside databases

Previous GC identifers: GC0XM141409 GC0XM142441 GC0XM142543 GC0XM131814


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLITRK4 Gene:
This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two
N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as
well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest
that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, May 2010)

GeneCards Summary for SLITRK4 Gene:
SLITRK4 (SLIT and NTRK-like family, member 4) is a protein-coding gene. An important paralog of this gene is SLITRK5.

UniProtKB/Swiss-Prot: SLIK4_HUMAN, Q8IW52
Function: Suppresses neurite outgrowth (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLITRK4 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   E2F-2   E4BP4   E2F   E2F-1   FOXO4   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLITRK4 promoter sequence
   Search Chromatin IP Primers for SLITRK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLITRK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27.3   Ensembl cytogenetic band:  Xq27.3   HGNC cytogenetic band: Xq27.3

SLITRK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLITRK4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM142715:  view genomic region     (about GC identifiers)

Start:
142,710,595 bp from pter      End:
142,723,926 bp from pter
Size:
13,332 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SLIK4_HUMAN, Q8IW52 (See protein sequence)
Recommended Name: SLIT and NTRK-like protein 4 precursor  
Size: 837 amino acids; 94331 Da
Sequence caution: Sequence=BAB71535.1; Type=Erroneous initiation;
Secondary accessions: Q5JXG3 Q8TCM8 Q96DL3

Explore the universe of human proteins at neXtProt for SLITRK4: NX_Q8IW52

Explore proteomics data for SLITRK4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn81, Thr301, Thr306, Thr307, Asn325
  • Modification sites at PhosphoSitePlus

  • See SLITRK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171678.1  NP_001171679.1  NP_775101.1  

    ENSEMBL proteins: 
     ENSP00000336627   ENSP00000349400   ENSP00000371198  

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    antibodies-online proteins for SLITRK4 (3 products) 

     
    antibodies-online peptides for SLITRK4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q8IW52

    ProtoNet protein and cluster: Q8IW52

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: SLIK4_HUMAN, Q8IW52
    Similarity: Belongs to the SLITRK family
    Similarity: Contains 12 LRR (leucine-rich) repeats
    Similarity: Contains 2 LRRCT domains
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with SLITRK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLIK4_HUMAN, Q8IW52
    Function: Suppresses neurite outgrowth (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SLITRK4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SLITRK4:
     G0/1 arrest  Increased G1 DNA content  Increased cell size 

         1 MGI phenotypic allele for Slitrk4 (no phenotypes)

    Find genes that share phenotypes with SLITRK4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLITRK4

    miRNA
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    miRTarBase miRNAs that target SLITRK4:
    hsa-mir-124-3p (MIRT022913)

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    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-188-5p hsa-miR-146a hsa-miR-485-3p hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidSLITRK4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLIK4_HUMAN, Q8IW52: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum2
    extracellular2
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLITRK4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLITRK4
    Interactions:

        Search GeneGlobe Interaction Network for SLITRK4

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007409axonogenesis IEA--

    Find genes that share ontologies with SLITRK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLITRK4 (SLIK4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLITRK4 gene (3 alternative transcripts): 
    NM_001184749.2  NM_001184750.2  NM_173078.4  

    Unigene Cluster for SLITRK4:

    SLIT and NTRK-like family, member 4
    Hs.272284  [show with all ESTs]
    Unigene Representative Sequence: NM_001184749
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338017 ENST00000356928 ENST00000381779(uc022cfl.1 uc004fbx.3 uc004fby.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat SLITRK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLITRK4 (see all 116):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-188-5p hsa-miR-146a hsa-miR-485-3p hsa-miR-605
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      QuantiTect SYBR Green Assays in human, mouse, rat SLITRK4
      QuantiFast Probe-based Assays in human, mouse, rat SLITRK4

    Additional mRNA sequence: 

    AK057619.1 AK092016.1 AK315044.1 AL713693.1 BC040986.1 

    6 DOTS entries:

    DT.100745075  DT.40286606  DT.310721  DT.310720  DT.75137716  DT.95217044 

    14 AceView cDNA sequences:

    NM_173078 AK057619 BU101650 AL713693 AX747312 BI861424 BC040986 BM697757 
    BX505258 AK092016 AA341475 BE089592 BV184022 BG699088 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLITRK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCAGGTG
    SLITRK4 Expression
    About this image


    SLITRK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    SLITRK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLITRK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272284

    UniProtKB/Swiss-Prot: SLIK4_HUMAN, Q8IW52
    Tissue specificity: Expressed in the cerebral cortex of the brain and at higher levels in some astrocytic brain
    tumors such as astrocytomas, glioblastomas and primitive neuroectodermal tumors

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLITRK4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slitrk41 , 5 SLIT and NTRK-like family, member 41, 5 90.96(n)1
    97.25(a)1
      X (34.57 cM)5
    2454461  NM_178740.41  NP_848855.21 
     642648855 
    chicken
    (Gallus gallus)
    Aves SLITRK41 SLIT and NTRK-like family, member 4 81.24(n)
    91.04(a)
      422287  XM_004940725.1  XP_004940782.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLITRK46
    SLIT and NTRK-like family, member 4
    89(a)
    1 ↔ 1
    AAWZ02038772(4783-7290)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slitrk41 SLIT and NTRK-like family, member 4 75.52(n)
    85.41(a)
      100497316  XM_002933551.2  XP_002933597.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slitrk41 SLIT and NTRK-like family, member 4 68.96(n)
    73.91(a)
      558123  XM_005157225.1  XP_005157282.1 


    ENSEMBL Gene Tree for SLITRK4 (if available)
    TreeFam Gene Tree for SLITRK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLITRK4 gene
    SLITRK52  ISLR2  SLIT12  SLIT32  SLITRK62  LRRC382  SLIT22  LRRC262  
    SLITRK12  LRTM12  LRRC522  LRRC172  SLITRK22  LRTM22  SLITRK32  LRRC552  
    ISLR22  LRRC242  
    7 SIMAP similar genes for SLITRK4 using alignment to 2 protein entries:     SLIK4_HUMAN (see all proteins):
    SLITRK1    SLITRK3    SLITRK2    DKFZp451E1911    SLITRK6    SLITRK5
    LRIG3

    Find genes that share paralogs with SLITRK4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLITRK4 (see all 250)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0366024
    A colorectal cancer sample4--see VAR_0366022 V I mis40--------
    rs1815273591,2
    --142665087(+) AATCTC/TAAGAC 3 -- ds50010--------
    rs1857529751,2
    --142665090(+) CTCAAC/GACAAC 3 -- ds50010--------
    rs1466109461,2
    --142665162(+) ACAAAC/GTGGTC 3 -- ds50010--------
    rs21443391,2
    C,F,A--142665196(-) TTTTTC/TTTTTC 3 -- ds50016--NA EA 366
    rs1134645411,2
    C,F--142665256(+) AGGTGC/GTCAAG 3 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs169794681,2
    C,F,H--142665437(+) AAACCA/GGACTA 3 -- ds500114Minor allele frequency- G:0.02NA NS EA 1491
    rs1830392391,2
    --142665875(+) TGAAGC/GCCTCA 3 -- ut310--------
    rs735773791,2
    C--142666078(+) ATTCTG/CAATAG 3 -- ut311Minor allele frequency- C:0.50WA 2
    rs2009715171,2
    --142666181(+) AAATT-/AAAAAA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SLITRK4 (142710595 - 142723926 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLITRK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1403e199CNV Deletion23128226
    esv2740547CNV Deletion23290073

    Locus Specific Mutation Databases (LSDB): SLITRK4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLITRK4
    DNA2.0 Custom Variant and Variant Library Synthesis for SLITRK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300562    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SLITRK4:
    Supratentorial primitive neuroectodermal tumor

    Find genes that share disorders with SLITRK4           About GenesLikeMe


    Export disorders for SLITRK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLITRK4 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SLITRK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PubMed id 14557068)1, 2, 3, 9 Aruga J.... Mikoshiba K. (Gene 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    5. Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas. (PubMed id 21812955)1 Haakensen V.D....Helland A.8. (BMC Cancer 2011)
    6. A transcriptional profile of the decidua in preeclampsia. (PubMed id 20934677)1 LA...Austgulen R. (Am. J. Obstet. Gynecol. 2011)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 139065 HGNC: 23502 AceView: SLITRK4 Ensembl:ENSG00000179542 euGenes: HUgn139065
    ECgene: SLITRK4 H-InvDB: SLITRK4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLITRK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLITRK4 gene:
    Search GeneIP for patents involving SLITRK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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