Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLITRK3 Gene

protein-coding GIFtS: 52
GCID: GC03M164904

SLIT and NTRK-like family, member 3

Explore 11 diseases affiliated with
SLITRK3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SLIT And NTRK-Like Family, Member 3¹ ²
KIAA0848¹ ³ ⁵
SLIT And NTRK-Like Protein 3²
Slit And Trk Like Gene 3²

External Ids:	HGNC: 23501¹	Entrez Gene: 22865²	Ensembl: ENSG00000121871⁷	OMIM: 609679⁵	UniProtKB: O94933³

Export aliases for SLITRK3 gene to outside databases

Previous GC identifers: GC03M166225 GC03M166387 GC03M162274

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLITRK3:

Members of the SLITRK family, such as SLITRK3, are integral membrane proteins with 2 N-terminal leucine-rich repeat

(LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK3, also have

C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed

predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 (PubMed 14557068)).(supplied

by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SLIK3_HUMAN, O94933

Function: Suppresses neurite outgrowth (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLITRK3 gene promoter:
HOXA9 E2F-4 E2F-3a E2F-5 Nkx2-5 E2F-2 FAC1 IRF-2 E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLITRK3 promoter sequence

Search SABiosciences Chromatin IP Primers for SLITRK3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLITRK3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.1 Ensembl cytogenetic band: 3q26.1 HGNC cytogenetic band: 3q26.1

SLITRK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLITRK3 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M164904: view genomic region (about GC identifiers)

Start:	164,904,508 bp from pter	End:	164,914,897 bp from pter
Size:	10,390 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SLIK3_HUMAN, O94933 (See protein sequence)

Recommended Name: SLIT and NTRK-like protein 3 precursor

Size: 977 amino acids; 108934 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Sequence caution: Sequence=BAA74871.2; Type=Erroneous initiation;

Secondary accessions: Q1RMY6

Explore the universe of human proteins at neXtProt for SLITRK3: NX_O94933

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94933

SLITRK3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055741.2

ENSEMBL proteins:

ENSP00000420091 ENSP00000241274 ENSP00000419611

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SLITRK3 OriGene Custom Protein Services for SLITRK3
	GenScript Custom Purified and Recombinant Proteins Services for SLITRK3
	Novus Biologicals SLITRK3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLITRK3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

SLITRK3 for ontologies About GeneDecksing

SLITRK3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SLITRK3
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): SLITRK3 OriGene Custom Antibody Services for SLITRK3
	GenScript Custom Superior Antibodies Services for SLITRK3
	Novus Biologicals SLITRK3 Antibody
	Search for Antibodies for SLITRK3 at Abcam
	Uscn Antibodies for SLITRK3
	ThermoFisher Antibodies for SLITRK3

Assay Products for SLITRK3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLITRK3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLITRK3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLITRK3 for domains About GeneDecksing

4 InterPro domains/families:

IPR000483 Cys-rich_flank_reg_C

IPR000372 LRR-contain_N

IPR001611 Leu-rich_rpt

IPR003591 Leu-rich_rpt_typical-subtyp

Graphical View of Domain Structure for InterPro Entry O94933

ProtoNet protein and cluster: O94933

2 Blocks protein families:

IPB000372 Cysteine-rich flanking region

IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: SLIK3_HUMAN, O94933

Similarity: Belongs to the SLITRK family

Similarity: Contains 12 LRR (leucine-rich) repeats

Similarity: Contains 2 LRRCT domains

Similarity: Contains 1 LRRNT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SLIK3_HUMAN, O94933

Function: Suppresses neurite outgrowth (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SLITRK3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLITRK3
		8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate SLITRK3 (see all 74):
		hsa-miR-323-3p hsa-miR-3130-5p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-146a hsa-miR-1245 hsa-miR-502-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SLITRK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLITRK3 (see all 7) OriGene shRNA RFP: SLITRK3 OriGene siRNA: SLITRK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLITRK3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SLITRK3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLITRK3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLITRK3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLITRK3 (NM_014926)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLITRK3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLITRK3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLITRK3
		Search LifeMap BioReagents cell lines for SLITRK3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLITRK3

1 GenomeRNAi human phenotype for SLITRK3:

Low eccentricity cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLITRK3

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SLITRK3 (O94933³ ENSP00000241274⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KDM5B	Q9UGL1³, ENSP00000356234⁴	I2D: score=1 STRING: ENSP00000356234
HDAC4	ENSP00000264606⁴	STRING: ENSP00000264606

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007409	axonogenesis	IEA	--

SLITRK3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLITRK3
Search CenterWatch for drugs/clinical trials and news about SLITRK3 / SLIK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLITRK3 gene:

NM_014926.2

Unigene Cluster for SLITRK3:

SLIT and NTRK-like family, member 3

Hs.101745 [show with all ESTs]

Unigene Representative Sequence: BC040491

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000475390(uc003fej.4) ENST00000241274(uc003fek.3) ENST00000497724

miRNA Products:		OriGene 3'-UTR Clone: SLITRK3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLITRK3
		8/74 QIAGEN miScript miRNA Assays for microRNAs that regulate SLITRK3 (see all 74):
		hsa-miR-323-3p hsa-miR-3130-5p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-146a hsa-miR-1245 hsa-miR-502-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SLITRK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLITRK3 (see all 7) OriGene shRNA RFP: SLITRK3 OriGene siRNA: SLITRK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLITRK3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLITRK3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLITRK3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLITRK3 (NM_014926)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLITRK3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLITRK3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLITRK3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLITRK3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLITRK3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLITRK3

Additional cDNA sequence:

AB020655.1 AK290024.1 BC040491.1 BC114621.1

2 DOTS entries:

DT.40218702 DT.95321836

16 AceView cDNA sequences:

AI056431 NM_014926 AI199201 AB020655 AL119949 BX952090 BX281090 AI939296

BC040491 BX643255 AI500372 AI201676 BF525830 BI603999 H19422 H19423

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLITRK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAAAATGG

About this image

SLITRK3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See SLITRK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLITRK3

SOURCE GeneReport for Unigene cluster: Hs.101745

UniProtKB/Swiss-Prot: SLIK3_HUMAN, O94933

Tissue specificity: Expressed in the occipital lobe of the cerebral cortex of the brain. Expressed at higher levels in

some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive

neuroectodermal tumors

SABiosciences Custom PCR Arrays for SLITRK3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLITRK3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLITRK3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLITRK3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLITRK3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLITRK3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SLITRK3 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLITRK3¹	SLIT and NTRK-like family, member 3	78.5(n) 89.01(a)		771488 XM_001234765.2 XP_001234766.2
lizard (Anolis carolinensis)	Reptilia	SLITRK3⁶	--	86(a)	1 ↔ 1	3(10614291-10617143)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.16425²	Transcribed sequence with weak similarity to protein more	79.49(n)		137727816
zebrafish (Danio rerio)	Actinopterygii	LOC100334261¹	SLIT and NTRK-like protein 3-like	71.58(n) 79.84(a)		100334261 XM_002667843.2 XP_002667889.1

ENSEMBL Gene Tree for SLITRK3 (if available)
TreeFam Gene Tree for SLITRK3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLITRK3 gene

SLITRK5² SLITRK2² ELFN1² ELFN2² SLITRK1² LRRC19² SLITRK6² SLITRK4²

7 SIMAP similar genes for SLITRK3 using alignment to 2 protein entries: SLIK3_HUMAN (see all proteins):

SLITRK4 SLITRK1 SLITRK2 DKFZp451E1911 SLITRK5 LRRC4

SLITRK6

SLITRK3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62282364^1,2		--	164904018(+)	`TGATAT/CTTATT`	1	--	ds500¹		2		NA	122
rs200544120^1,2		--	164904043(+)	`TGTGT-/GGAAGC`	1	--	ds500¹		0	--	--	--	--
rs185092063^1,2		--	164904044(+)	`GTGTGA/GAAGCG`	1	--	ds500¹		0	--	--	--	--
rs189610173^1,2		--	164904046(+)	`GTGGAA/GGCGTG`	1	--	ds500¹		0	--	--	--	--
rs144266123^1,2		--	164904055(+)	`TGTGGG/TTGTGT`	1	--	ds500¹		0	--	--	--	--
rs146612478^1,2		--	164904102(+)	`ACAATA/GGCAAT`	1	--	ds500¹		0	--	--	--	--
rs140146263^1,2		--	164904160(+)	`ATCCTA/TGATTA`	1	--	ds500¹		0	--	--	--	--
rs117605029^1,2	F,	--	164904161(+)	`TCCTAG/CATTAT`	1	--	ds500¹		1		EA	120
rs117004457^1,2		--	164904183(+)	`TAATCC/TTGTAC`	1	--	ds500¹		1		EA	120
rs142391124^1,2		--	164904275(+)	`ATTCAA/TAATTC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLITRK3 (164904508 - 164914897 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLITRK3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLITRK3

DNA2.0 Custom Variant and Variant Library Synthesis for SLITRK3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLITRK3 for disorders           About GeneDecksing

OMIM gene information: 609679    OMIM disorders: --

11 diseases for SLITRK3:    About MalaCards

supratentorial primitive neuroectodermal tumor primitive neuroectodermal tumor neuroectodermal tumors ganglioglioma

oligodendroglioma hepatitis b astrocytoma glioblastoma

hepatitis cerebritis neuronitis

1 disease from the University of Copenhagen DISEASES database for SLITRK3:

Supratentorial primitive neuroectodermal tumor

Human Genome Epidemiology (HuGE) Navigator: SLITRK3 (1 document)

Export disorders for SLITRK3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLITRK3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLITRK3)

Utopia: connect your pdf to the dynamic
world of online information

Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. (PubMed id 14557068)^{1, 2, 3, 9} Aruga J.... Mikoshiba K. (2003)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2, 3} Nagase T....Ohara O. (1998)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor. (PubMed id 19336002)¹ Zhou W....Zhang L. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth. (PubMed id 14550773)¹ Aruga J. and Mikoshiba K. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22865	HGNC: 23501	AceView: SLITRK3	Ensembl:ENSG00000121871	euGenes: HUgn22865
ECgene: SLITRK3	H-InvDB: SLITRK3

(According to HUGE)
About This Section

HUGE: KIAA0848

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLITRK3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLITRK3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLITRK3 gene:
Search GeneIP for patents involving SLITRK3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of SLITRK3
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for SLITRK3		OriGene shRNA RFP for SLITRK3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLITRK3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLITRK3
	OriGene Protein Over-expression Lysate for SLITRK3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SLITRK3		OriGene 3'-UTR Clone for SLITRK3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLITRK3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLITRK3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SLITRK3		OriGene Custom Protein Services for SLITRK3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLITRK3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLITRK3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLITRK3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLITRK3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLITRK3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLITRK3

	GenScript Custom Purified and Recombinant Proteins Services for SLITRK3		GenScript cDNA clones with any tag delivered in your preferred vector for SLITRK3
	GenScript Custom Assay Services for SLITRK3		GenScript Custom Superior Antibodies Services for SLITRK3
	GenScript Custom overexpressing Cell Line Services for SLITRK3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SLITRK3 promoter
	Search Chromatin IP Primers for SLITRK3
	RT² qPCR Primer Assay in human, mouse, rat SLITRK3
	Search GNC Networks for SLITRK3
	SABiosciences Custom PCR Arrays for SLITRK3

Search Tocris compounds for SLITRK3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SLITRK3 antibodies
	SLITRK3 lysates

	Search for Antibodies for SLITRK3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SLITRK3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SLITRK3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SLITRK3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLITRK3

	SwitchGear 3'UTR luciferase reporter plasmids for SLITRK3
	SwitchGear Promoter luciferase reporter plasmids for SLITRK3

ThermoFisher Antibodies for SLITRK3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLITRK3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SLITRK3 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SLITRK3 Gene

SLIT and NTRK-like family, member 3

Aliases
for SLITRK3 gene

Summaries
for SLITRK3 gene

Genomic Views
for SLITRK3 gene

Proteins
for SLITRK3 gene

Protein Domains /
Families
for SLITRK3 gene

Function
for SLITRK3 gene

Pathways & Interactions
for SLITRK3 gene

Drugs & Compounds
for SLITRK3 gene

Transcripts
for SLITRK3 gene

Expression
for SLITRK3 gene

Orthologs
for SLITRK3 gene

Paralogs
for SLITRK3 gene

Genomic Variants
for SLITRK3 gene

Disorders / Diseases
for SLITRK3 gene

Publications
for SLITRK3 gene

External Searches for SLITRK3 gene

Genome Databases showing SLITRK3 gene

Other Databases showing SLITRK3 gene

Specialized Databases showing SLITRK3 gene

Intellectual Property
for SLITRK3 gene

Products
for SLITRK3 gene

View Random Gene

Advanced Search

Export list of displayed genes

SLITRK3 Gene

SLIT and NTRK-like family, member 3

Aliasesfor SLITRK3 gene

Summariesfor SLITRK3 gene

Genomic Viewsfor SLITRK3 gene

Proteinsfor SLITRK3 gene

Protein Domains /Familiesfor SLITRK3 gene

Functionfor SLITRK3 gene

Pathways & Interactionsfor SLITRK3 gene

Drugs & Compoundsfor SLITRK3 gene

Transcriptsfor SLITRK3 gene

Expression for SLITRK3 gene

Orthologsfor SLITRK3 gene

Paralogsfor SLITRK3 gene

Genomic Variantsfor SLITRK3 gene

Disorders / Diseasesfor SLITRK3 gene

Publicationsfor SLITRK3 gene

External Searches for SLITRK3 gene

Genome Databases showing SLITRK3 gene

Other Databases showing SLITRK3 gene

Specialized Databases showing SLITRK3 gene

Intellectual Propertyfor SLITRK3 gene

Productsfor SLITRK3 gene

View Random Gene

Aliases
for SLITRK3 gene

Summaries
for SLITRK3 gene

Genomic Views
for SLITRK3 gene

Proteins
for SLITRK3 gene

Protein Domains /
Families
for SLITRK3 gene

Function
for SLITRK3 gene

Pathways & Interactions
for SLITRK3 gene

Drugs & Compounds
for SLITRK3 gene

Transcripts
for SLITRK3 gene

Expression
for SLITRK3 gene

Orthologs
for SLITRK3 gene

Paralogs
for SLITRK3 gene

Genomic Variants
for SLITRK3 gene

Disorders / Diseases
for SLITRK3 gene

Publications
for SLITRK3 gene

Intellectual Property
for SLITRK3 gene

Products
for SLITRK3 gene